Enantioselective Michael reaction of ketone lithium enolates using a chiral ligand

Tetrahedron Letters

Volumn 37, Issue 35, 1996, Pages 6343-6346

  Yasuda, Kosuke ^a,b   Shindo, Mitsuru ^a   Koga, Kenji ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

KETONE;

ARTICLE; CHIRALITY; DRUG SYNTHESIS; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0030603064     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)01367-6     Document Type: Article

References (30)

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21. 3)
22. 3).
23. 2, 93% in 2 steps).
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25. 3), 77% ee, (Ar=2-naphthyl). Enantiomeric excess was determined by HPLC using the conditions described in the footnotes to Table 1.
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27. 3, rt, 70 min, 81%). Enantiomeric excess was determined by HPLC using the conditions described in the footnotes to Table 1.
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29. 2O, reflux, 5 days, 60% in 2 steps). Enantiomeric excess was determined by HPLC using the conditions described in the footnotes to Table 1.
30. 2), optical purity 59%.