Polymorphisms of IL-4, IL-4Rα, and AICDA genes in adult allergic asthma

Journal of Huazhong University of Science and Technology - Medical Science

Volumn 23, Issue 2, 2003, Pages 134-137

  Cui, Tianpen ^a   Wang, Lin ^b   Wu, Jianmin ^a   Hu, Lihua ^a   Xie, Jungang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b WUHAN UNIVERSITY   (China)

Author keywords

Activation induced cytidine deaminase; Allergic asthma; Interleukin 4; Interleukin 4 receptor

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; ALLERGIC ASTHMA; INTERLEUKIN-4; INTERLEUKIN-4 RECEPTORS;

DISEASES; DNA; ENZYMES; MEDICAL COMPUTING; PULMONARY DISEASES;

GENES;

AICDA (ACTIVATION INDUCED CYTIDINE DEAMINASE); AICDA (ACTIVATION-INDUCED CYTIDINE DEAMINASE); CYTIDINE DEAMINASE; IMMUNOGLOBULIN E; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR;

ADULT; ALLELE; ARTICLE; ASTHMA; BLOOD; GENETICS; HUMAN; PHENOTYPE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RNA PROCESSING;

ADULT; ALLELES; ASTHMA; CYTIDINE DEAMINASE; HUMANS; IMMUNOGLOBULIN E; INTERLEUKIN-4; PHENOTYPE; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RECEPTORS, INTERLEUKIN-4; RNA PROCESSING, POST-TRANSCRIPTIONAL;

EID: 3142613028     PISSN: 0257716X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Shirakawa T, Deichmann K A, Izuhara K et al. Atopy and asthma: genetic variants of IL-4 and IL-13 signaling. Trends Immnnol, 2000,20:60
2. Okazaki I, Kinoshita K, Muramatsu M et al. The AID enzyme induces class switch recombination in fibroblasts. Nature, 2002,416:340
3. Zhang J, Chen H, Hu L et al. Correlation between polymorphism of IL-4 and IL-10 gene promoter and childhood asthma and their impact upon cytokine expression. Natl Med J China, 2002,82:114
4. Nakayama E E, Hoshino Y, Xin X et al. Polymorphism in the interleukin-4 promoter affects acquisition of human immunodificiency virus type 1 syncytium-inducing phenotype. J Virology, 2000,74:5452
5. Sandford A, Chagani J, Zhu s et al. Polymorphisms in the IL-4 IL-4RA, and FCERIβ genes and asthma severity. J Allergy Clin Immunol, 2000,106:135
6. Noguchi E, Shibasaki M, Inudou M, et al. Association between a new polymorphism in the activation-induced cytidine deaminase gene and atopic asthma and the regulation of total serum IgE levels. J Allergy Clin Immunol, 2001,108:382
7. Cookson W. The alliance of genes and environment in asthma and allergy. Nature, 1999,402:85
8. Howard T D, Koppelman G H, Xu J et al. Gene-Gene interaction in asthma: IL-4RA and IL-13 in a Dutch population with asthma. Am J Hum Genet, 2002,70:230
9. Chua K F, Alt F W, Manis J P. The function of AID in somatic mutation and class switch recombination: Upream or Downstream of DNA breaks. J Exp Med, 2002, 195:F37
10. Nanavaty U, Goldstein A D, Levine S J. Polymorphism in candidate asthma genes. Am J Med Sci, 2001,321:11