Alpha 1-microglobulin: Clinical laboratory aspects and applications

Clinica Chimica Acta

Volumn 346, Issue 2, 2004, Pages 107-118

  Penders, Joris ^a   Delanghe, Joris R ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

A1M; alpha 1 microglobulin; Heavy metal intoxication; IgA; IL; immunoglobulin A; interleukin; Proteinuria; Renal disease; Tubular function; ulinastatin; Urinary tract infection; UT

Indexed keywords

ALPHA 1 MICROGLOBULIN; BETA 2 MICROGLOBULIN; BIOLOGICAL MARKER; CLARA CELL PROTEIN; N ACETYL BETA GLUCOSAMINIDASE; RETINOL BINDING PROTEIN;

ADSORPTION; ANALYTIC METHOD; BACTERIUM ADHERENCE; COMPLEX FORMATION; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; DIAGNOSTIC VALUE; DISEASE MARKER; ELECTROIMMUNOASSAY; GENETIC ANALYSIS; HUMAN; IMMUNOASSAY; IMMUNODIFFUSION; IMMUNORADIOMETRIC ASSAY; KIDNEY DISEASE; KIDNEY DYSFUNCTION; LABORATORY TEST; LIVER DYSFUNCTION; MOLECULAR WEIGHT; MOOD DISORDER; NEPHROLITHIASIS; NEPHROTOXICITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; PROTEIN URINE LEVEL; PROTEINURIA; REVIEW; SYSTEMATIC REVIEW; URINARY EXCRETION; URINARY TRACT DISEASE;

ALPHA-GLOBULINS; BIOLOGICAL MARKERS; CLINICAL LABORATORY TECHNIQUES; IMMUNOASSAY; KIDNEY DISEASES; KIDNEY FUNCTION TESTS; KIDNEY TUBULES, PROXIMAL; LIVER; PROTEASE INHIBITORS; URINARY TRACT INFECTIONS;

BACTERIA (MICROORGANISMS);

EID: 3142562245     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cccn.2004.03.037     Document Type: Review

References (119)

1. Kaumeyer J.F., Polazzi J.O., Kotick M.P. The mRNA for a proteinase inhibitor related to HI-30 domain of inter-alpha-trypsin inhibitor also encodes alpha-1-microglobulin (protein HC). Nucleic Acids Res. 14:1986;7839-7850
2. Akerstrom B., Logdberg L.E., Berggard I., Osmark P., Lindqvist A. α1-Microglobulin: a yellow-brown lipocalin. Biochim. Biophys. Acta. 1482:2000;172-184
3. Diarra-Mehrpour M., Bourguignon J., Sesboue R., Salier J.P., Leveilard T., Martin J.P. Structural analysis of the human inter-alpha-trypsin inhibitor light-chin gene. Eur. J. Biochem. 191:1990;131-139
4. Diarra-Mehrpour M., Bourguignon J., Sesboue R., et al. Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes. J. Biochem. 179:1989;147-154
5. Rouet P., Raguenez G., Tronche F., Yaniv M., N'Guyen C., Salier J.P. A potent enhancer made of clustered liver-specific elements in the transcription of control sequences of human alpha 1-microglobulin/bikunin gene. J. Biol. Chem. 267:1992;20765-20773
6. Falkenberg C., Blom A., Fries E., et al. Alpha 1-microglobulin and bikunin in rats with collagen II-induced arthritis: plasma levels and liver mRNA content. Scand. J. Immunol. 46:1997;122-128
7. Daveau M., Jean L., Soury E., et al. Hepatic and extra-hepatic transcription of inter-alpha-inhibitor family genes under normal or acute inflammatory conditions in rat. Arch. Biochem. Biophys. 350:1998;315-323
8. Vincent C., Marceau M., Blangarin P., Bouic P., Madjar J.J., Revillard J.P. Purification of alpha 1-microglobulin produced by human hepatoma cell lines. Biochemical characterization and comparison with alpha 1-microglobulin synthesized by human hepatocytes. Eur. J. Biochem. 165:1987;699-704
9. Ekstrom B., Berggard I. Human α1-microglobulin: purification procedure, chemical and physicochemical properties. J. Biol. Chem. 252:1977;8048-8057
10. Ekstro B., Peterson P.A., Berggard I. A urinary and plasma α1-glycoprotein of low molecular weight: isolation and some properties. Biochem. Biophys. Res. Commun. 65:1975;1427-1433
11. Akerstrom B., Logdberg L.E. An intriguing member of lipocain protein family: α1-microglobulin. Trends Biochem. Sci. 15:1990;240-243
12. Tejler L., Grubb A.O. A complex-forming glycoprotein heterogeneous in charge and present in human plasma, urine, and cerebrospinal fluid. Biochim. Biophys. Acta. 139:1976;82-94
13. Seon B.K., Pressman D. Unique human glycoprotein, alpha1- microglycoprotein: isolation from the urine of a cancer patient and its characterization. Biochemistry. 17:1978;2815-2821
14. Grubb A.O., Lopez C., Tejler L., Mendez E. Isolation of human complex-forming glycoprotein heterogeneous in charge (protein HC) and its IgA complex from plasma. Physicochemical and immunochemical properties, normal plasma concentration. J. Biol. Chem. 258:1983;14698-14707
15. Akerstrom B. Immunological analysis of alpha 1-microglobulin in different mammalian and chicken serum. Alpha 1-microglobulin is 5-8 kilodaltons larger in primates. J. Biol. Chem. 260:1985;4839-4844
16. Kawahara A., Hikosaka A., Sasado T., Hirota K. Dev. Genes Evol. 206:1997;355-362
17. Leaver M.J., Wright J., George S.G. Comp. Biochem. Physiol. 108B:1994;275-281
18. Toh H., Kubodera H., Nakajima N., et al. Glutathione-independent prostaglandin D synthase as a lead molecule for designing new functional proteins. Protein Eng. 9:1996;1067-1082
19. Sansom C.E., North A.C.T., Sawyer L. Biochim. Biophys. Acta. 1208:1994;247-255
20. Berggard T., Cohen A., Persson P. α1-Microglobulin chromosomes are located to three lysine residues semiburied in the lipocalin pocket and associated with a novel lipophilic compound. Protein Sci. 8:1999;2611-2620
21. Calero M., Escribano J., Soriano F., Grubb A., Brew K., Mendez E. Spectroscopic characterization by photodiode array detection of human urinary and amniotic protein HC subpopulations fractionated by anion-exchange and size-exclusion high-performance liquid chromatography. J. Chromatogr., A. 719:1996;149-157
22. Escribano J., Grubb A., Mendez E. Identification of retinol as one of the protein HC chromophores. Biochem. Biophys. Res. Commun. 155:1988;1424-1429
23. Escribano J., Lopez-Otin C., Hjerpe A., Grubb A., Mendez E. Location and characterization of the three carbohydrate prosthetic groups of human protein HC. FEBS Lett. 266:1990;167-170
24. Amoresamo A., Minichiotti L., Cosulich M.E., et al. Structural characterization of the oligosaccharide chains of human α1-microglobulin from urine and amniotic fluid. Eur. J. Biochem. 267:2000;2105-2112
25. Grubb A., Mendez E., Fernandez-Luna J.L., Lopez C., Mihaesco E., Vaerman J.P. The molecular organization of the protein HC-IgA. J. Biol. Chem. 261:1986;14313-14320
26. Calero M., Escribano J., Grubb A., Mendez E. Location of a novel type of interpolypeptide chain linkage in the human protein HC-IgA complex (HC-IgA) and identification of a heterogenous chromophore associated with the complex. J. Biol. Chem. 269:1994;384-389
27. Berggard T., Thelin N., Falkenberg C., Enghild J.J., Akerstrom B. Prothrombin, albumin and immunoglobulin A form covalent complexes with α1-microglobulin in human plasma. Eur. J. Biochem. 245:1997;676-683
28. Falkenberg C., Enghild J.J., Thogersen I.B., Salvesen G., Akerstrom B. Isolation and characterization of fibronectin-alpha 1-microglobulin complex in rat plasma. Biochem. J. 301:1994;745-751
29. Falkenberg C., Grubb A., Alkerstrom B. Isolation of rat serum alpha 1-microglobulin. Identification of a complex with alpha 1-inhibitor-3, a rat alpha 2-macroglobulin homologue. J. Biol. Chem. 265:1990;16150-16157
30. Wojcik E.G., van den Berg M., van der Linden I.K., Poort S.R., Cupers R., Bertina R.M. Factor IX Zutphen: a Cys18→Arg mutation results in formation of a heterodimer with alpha 1-microglobulin and the inability to form a calcium-induced conformation. Biochem. J. 311:1995;753-759
31. Kondo S., Tokunaga F., Kawano S., Oono Y., Kumagai S., Koide T. Factor XII Tenri, a novel cross-reacting material negative factor XII deficiency, occurs through a proteasome-mediated degradation. Blood. 93:1999;4300-4308
32. Wojcik E.G., Simioni P., de Berg M., Girolami A., Bertina R.M. Mutations which introduce free cysteine residues in the Gla-domain if vitamin K-dependent proteins result in the formation of complexes with alpha 1-microglobulin. Thromb. Haemost. 75:1996;70-75
33. Bouic P., Vincent C., Revillard J.P. Localization of alpha 1-microglobulin (HC protein) in normal human tissues: an immunohistochemical study using monoclonal antibodies. Histochem. J. 16:1984;1311-1324
34. Verroust P.J., Birn H., Nielsen R., Kozyraki R., Christensen E.I. The tandem endocytic receptors megalin and cubulin are important proteins in renal pathology. Kidney Int. 62:2002;745-756
35. Akerstrom B. Tissue distribution of guinea pig alpha 1-microglobulin. Cell. Mol. Biol. 29:1983;489-495
36. Logdberg L.E., Akerstrom B., Badve S. Tissue distribution of the lipocalin alpha 1-microglobulin in the developing human fetus. J. Histochem. Cytochem. 48:2000;1545-1552
37. Berggard I., Enghild J.J., Badve S., Salafia C.M., Logdberg L.E., Akerstrom B. Histologic distribution and biochemical properties of α1-microglobulin in human placenta. Am. J. Reprod. Immunol. 41:1999;52-60
38. Allhorn M., Berggard I., Nordberg J., Olsson M.L., Akerstrom B. Processing of the lipocalin α1-microglobulin by hemoglobin induces heme-binding and heme-degradation properties. Blood. 99:2002;1894-1901
39. Odum L., Nielsen H.W. Human protein HC (α1-microglobulin) and inter-alpha-trypsin inhibitor in connective tissue. Histochem. J. 26:1994;799-803
40. Berggard T., Oury T.D., Thorgersen I.B., Akerstrom B., Enghlid J.J. α1-Microglobulin is found both in blood and in most tissues. J. Histochem. Cytochem. 46:1998;887-893
41. Allhorn M., Lundqvist K., Schmidtchen A., Akerstrom B. Heme-scavenging role of alpha1-microglobulin in chronic ulcers. J. Invest. Dermatol. 121:2003;640-646
42. 125I-labelled α1-microglobulin in rats after intravenous injection. J. Lab. Clin. Med. 137:2001;165-175
43. Santin M., Cannas M. Collagen-bound alpha 1-microglobulin in normal and healed tissues and its effect on immunocompetent cells. Scand. J. Immunol. 50:1999;289-295
44. Logdberg L.E., Akerstrom B. Immunosuppressive properties of alpha 1-microglobulin. Scand. J. Immunol. 13:1981;383-390
45. Logdberg L.E., Akerstrom B., Shevach E.M. Alpha 1-microglobulin is mitogenic for guinea pig lymphocytes. Scand. J. Immunol. 24:1986;575-581
46. Wester L., Michaelsson E., Holmdahl R., Olofsson T., Akerstrom B. Scand. J. Immunol. 48:1998;1-7
47. Mendez E., Fernandez-Luna J.L., Grubb A., Leyva-Cobian F. Human protein HC and its IgA complex are inhibitors of neutrophil chemotaxis. Proc. Natl. Acad. Sci. U. S. A. 83:1986;1472-1475
48. Babiker-Mohamed H., Akerstrom B., Logdberg L.E. Mitogenic effect of alpha 1-microglobulin on mouse lymphocytes. Evidence of T- and B-cell cooperation, B-cell proliferation and a low-affinity receptor on mononuclear cells. Scand. J. Immunol. 32:1990;37-44
49. Babiker-Mohamed H., Olsson M.L., Boketoft A., Logdberg L.E., Akerstrom B. Alpha 1-microglobulin is mitogenic to human peripheral blood lymphocytes. Regulation by both enhancing and suppressive serum factors. Immunobiology. 180:1990;221-234
50. Akerstrom B., Lodgberg E. Alpha 1-microglobulin glycopeptides inhibit antigen-specific stimulation of human peripheral blood leucocytes. Scand. J. Immunol. 20:1984;559-563
51. Wester L., Fast J., Labuda T., et al. Carbohydrate groups of α1-microglobulin are important for secretion and tissue localization but not for immunological properties. Glycobiology. 10:2000;891-900
52. Fernandez-Luna J.L., Leyva-Cobian F., Mollinedo F. Identification of the protein HC receptor. FEBS Lett. 236:1988;471-474
53. Wassal M.A., Santin M., Peluso G., Denyer S.P. Possible role of alpha 1-microglobulin in mediating bacterial attachment to model surfaces. J. Biomed. Mater. Res. 40:1998;365-370
54. Santin M., Wassal M.A., Peluso G., Denyer S.P. Adsorption of alpha-1-microglobulin from biological fluids onto polymer surfaces. Biomaterials. 18:1997;823-827
55. Tardivel S., Medetognon J., Ranoux C., et al. Alpha-1-microglobulin: inhibitory effect on calcium oxalate crystallization in vitro and decreased urinary concentration in calcium oxalate stone formers. Urol. Res. 27:1999;243-249
56. Itoh Y., Enamoto H., Takagi K., Obayashi T., Kawai T. Human alpha 1-microglobulin levels in neurological disorders. Eur. Neurol. 22:1983;1-6
57. Takagi K., Kin K., Itoh Y., Enomoto H., Kawai T. Human alpha 1-microglobulin levels in various body fluids. J. Clin. Pathol. 33:1980;786-791
58. Itoh Y., Enomoto H., Takagi K., Kawai T., Yamanaka T. Human alpha 1-microglobulin in various hepatic disorders. Digestion. 27:1983;75-80
59. Straub J.P., Baard M.A., du Jour H.A., Verplanke A.J., Herber R.F. The determination of alpha 1-microglobulin by means of an automated latex immunoassay. Eur. J. Clin. Chem. Clin. Biochem. 33:1995;425-431
60. Fernandez-Luna J.L., Moneo I., Grubb A., Mendez E. A sensitive and rapid enzyme-linked immunosorbent assay using monoclonal antibodies for simultaneous quantitation of free and IgA-complexed protein HC. J. Immunol. Methods. 82:1985;101-110
61. Vincent C., Revillard J.P. Differential, measurement by ELISA of free and IgA bound alpha 1-microglobulin in human serum without prior fractionation. J. Immunol. Methods. 82:1985;111-119
62. DeMars D.D., Katzmann J.A., Kimlinger T.K., Calore J.D., Tracy R.P. Simultaneous measurement of total and IgA-conjugated alpha 1-microglobulin by a combined immunoenzyme/immunoradiometric assay technique. Clin. Chem. 35:1989;766-772
63. Magnotti R.A. Jr., Eberly J.P., Khoury P.R., et al. Profile of renal permselectivity by simultaneous enzyme-linked immunosorbent assay of albumin, transferrin, IgG, and alpha-1-microglobulin with a new microplate reader. Clin Chem. 38:1992;636-641
64. Pugia M., Newman D.J., Lott J.A., et al. Detection of low-molecular-weight in urine by dipsticks. Clin. Chim. Acta. 326:2002;177-183
65. Jung K., Pergande M., Priem F., Becker S., Klotzek S. Rapid screening of low molecular mass proteinuria: evaluation of the first immunochemical test strip for the detection of alpha-1-microglobulin in urine. Eur. J. Clin. Chem. Clin. Biochem. 31:1993;683-687
66. Dati F., Lammers M. Nierenschädigungen: früherkennung durch neue methoden zum nachweis einer proteinurie. Diagn. Lab. 24:1988;24-34
67. Kido T., Honda R., Yamada Y., Tsuritani I., Ishizaki M., Nogawa K. Alpha 1-microglobulin determination in urine for the early detection of renal tubular dysfunctions caused by exposure to cadmium. Toxicol. Lett. 24:1985;195-201
68. Donaldson M.D., Chambers R.E., Woolridge M.W., Whicher J.T. Stability of alpha 1-microglobulin, beta 2-microglobulin and retinol binding protein in urine. Clin. Chim. Acta. 179:1989;73-78
69. Ledue T.B., Collins M.F., Craig W.Y., Ritchie R.F. Effects of storage time, temperature and preservation of IgG, transferrin, albumin and alpha-1-microglobulin levels in urine. Clin. Chem. Suppl. 46(A48):2000;. [Abstract]
70. Payn M.M., Webb M.C., Lawrence D., Lamb E.J. Alpha1-microbulin is stable in human urine ex vivo. Clin. Chem. 2002;1136-1138
71. Tencer J., Thysell H., Andersson K., Grubb A. Long-term stability of albumin, protein HC, immunoglobulin G, kappa- and lambda-chain-immunoreactivity, orosmucoid and alpha 1-antitrypsin in urine stored at -20 degrees C. Scand. J. Urol. Nephrol. 31:1997;67-71
72. Takagi K., Itoh Y., Enomoto H., Koyamaishi Y., Maeda K., Kawai T. A comparative study of serum alpha 1-microglobulin and beta 2-microglobulin levels in cancerous and other diseases. Clin. Chim. Acta. 108:1980;277-283
73. Porstmann T., Schmechta H., Hentschel C., et al. Development of an immunoenzymometric assay for alpha 1-microglobulin and measurement of its serum concentration in normal and HIV-infected persons. J. Clin. Chem. Clin. Biochem. 28:1990;669-675
74. Vincent C., Kew M.C., Bouic P., Flacher M., Revillard J.P. Alpha 1-microglobulin (HC protein) in human hepatocellular carcinoma. Br. J. Cancer. 59:1989;415-416
75. Grubb A. Diagnostic value of analysis of cystatin C and protein HC in biological fluids. Clin. Nephrol. 38:1992;S20-S27
76. Kusano E., Suzuki M., Asano Y., Itoh Y., Takagi K., Kawai T. Human alpha 1-microglobulin and its relationship to renal function. Nephron. 41:1985;320-324
77. Corso A., Zappasodi P., Pascutto C., et al. Urinary proteins in multiple myeloma: correlation with clinical parameters and diagnostic implication. Ann. Hematol. 82:2003;487-491
78. Bernier I., Dautigny A., Glatthaar B.E., et al. Alpha 1-microglobulin from normal and pathological urines. Biochim. Biophys. Acta. 626:1980;188-196
79. Yu H., Yanagisawa Y., Forbes M.A., Cooper E.H., Crockson R.A., MacLennan I.C.M. Alpha-1-microglobulin: an inhibitor protein for renal tubular function. J. Clin. Pathol. 36:1983;253-259
80. Nogawa K., Kido T., Yamada Y., et al. Alpha 1-microglobulin in urine as an indicator of renal tubular damage caused by environmental cadmium exposure. Toxicol. Lett. 22:1984;63-68
81. Weber M.H., Verweibe R. α1-Microglobulin (protein HC): features of a promising indicator of proximal tubular dysfunction. Eur. J. Clin. Chem. Clin. Biochem. 30:1992;83-91
82. Xu S., Venge P. Lipocalins as biochemical markers of disease. Biochim. Biophys. Acta. 1482:2000;298-307
83. Itoh Y., Enomoto H., Takagi K., Kawai T. Clinical usefulness of serum alpha 1-microglobulin as a sensitive indicator for renal insufficiency. Nephron. 33:1983;69-70
84. Fels L.M., Bundschuh I., Gwinner W., et al. Early urinary markers of target nephron segments as studied in cadmium toxicity. Kidney Int. 46:1994;S81-S88
85. Jung K., Pergande M., Graubaum H.J., Fels L.M., Endl U., Stolte H. Urinary proteins enzymes as early indicators of renal dysfunction in chronic exposure to cadmium. Clin. Chem. 39:1993;757-765
86. Moriguchi J., Ezaki T., Tsukahara T., et al. Comparative evaluation of four urinary tubular dysfunction markers, with special references to the effects of aging and correction for creatinine concentration. Toxicol. Lett. 143:2003;279-290
87. Lim Y.C., Chia K.S., Ong H.Y., Ng V., Chew Y.L. Renal dysfunction in workers exposed to inorganic lead. Ann. Acad. Med. Singap. 30:2001;112-117
88. Kobal A.B., Flisar Z., Miklavcic V., Dizdarevic T., Sesek-Briski A. Renal function in miners intermittently exposed to elemental mercury vapour. Arh. Hig. Rada Toksikol. 51:2000;369-380
89. Bruning T., Their R., Bolt H.M. Nephrotoxicity and nephrocarcinogenicity of dinitrotoluene: new aspects to be considered. Rev. Environ. Health. 17:2002;163-172
90. Cvoriscec D. Early diagnosis of endemic nephropathy. Clin. Chim. Acta. 297:2000;85-91
91. Bazzi C., Petrini C., Rizza V., et al. Urinary excretion of IgG and alpha(1)-microglobulin predicts clinical course better than extent of proteinuria in membranous nephropathy. Am. J. Kidney Dis. 38:2001;240-248
92. Hong C.Y., Hughes K., Chia K.S., Ng V., Ling S.L. Urinary alpha(1)-microglobulin as a marker of nephropathy in type 2 diabetic Asian subjects in Singapore. Diabetes Care. 26:2003;338-342
93. Marczewski K., Krawczyk W., Rozyc P., Raszewski G., Grzywna R., Klimek K. Day/night ratio of microproteinuria and blood pressure rhythm in type II diabetes. Diabetes Res. Clin. Pract. 33:1996;169-172
94. Backman L., Ringden O., Dati F. Serum levels of alpha-1-microglobulin in recipients of renal allografts. Transpl. Int. 2:1989;23-26
95. Duraj F.F., Backman L., Dati F., Ringden O. Serum levels of alpha-1-microglobulin and beta-2-microglobulin in bone marrow transplant recipients treated with cyclosporin A. Transpl. Int. 4:1991;146-150
96. Preuss R., Riek R., Steinhoff J., Fricke L., Hoyer J., Sack K. Does α1 microglobulin in urine predict renal function after transplantation? Transplant. Proc. 26:1994;1766-1767
97. Everaert K., Hoebeke P., Delanghe J. A review on urinary proteins in outflow disease of the upper urinary tract. Clin. Chim. Acta. 297:2000;183-189
98. Konda R., Sakai K., Ota S., Takeda A., Orikasa S. Follow-up study of renal function in children with reflux nephropathy after resolution of vesicoureteral reflux. J. Urol. 157:1997;975-979
99. Everaert K., Van Laecke E., Dekuyper P., et al. Impact of urinary tract infection and detrusor pressure on renal tubular function in patients with vesicoureteral reflux. Eur. Urol. 39:2001;337-342
100. Everaert K., Delanghe J., Vande Wiele C., et al. Urinary alpha 1-microglobulin detects uropathy. A prospective study in 483 urological patients. Clin. Chem. Lab. Med. 36:1998;309-315
101. Everaert K., Raes A., Hoebeke P., et al. Combined use or urinary alpha1-microglobulin and 99Tc scintigrapy in the diagnostic and follow-up of acute pyelonephritis and cystitis in children. Eur. Urol. 34:1998;486-491
102. Everaert K., Oostra C., Delanghe J., Vande Walley J., Van Laere M., Oosterlinck W. Diagnostic and localization of a complicated urinar in neurogenic bladder disease by tubular proteinuria and serum prostate specific antigen. Spinal Cord. 36:1998;33-38
103. Mantur M., Kemona H., Dabrowska M., Dabrowska J. Alpha1-microglobubin as a maker of proximal tubular damage in urinary tract infection in children. Clin. Nephrol. 41:2003;79-84
104. Everaert K., Delanghe J., Vanderkelen M., et al. Urinary plasma protein in acute prostatitis. Clin. Chem. Lab. Med. 41:2003;79-84
105. Shikimi T., Kaku K., Uegaki J., et al. Serum contents of the free forms of alpha(1)-microglubin and ulninastatin: relation to diseased states in patients with mood disorders. Neuropsychobiology. 43:2001;145-149
106. Shikimi T., Uegaki J., Inagaki T., Mitsuoka S. Changes in the regression slope correlating between urinary contents of alpha-1-microglobubin and ulinastatin and its relation to severity in mood disorders. Nurs. Health Sci. 3:2001;95-100
107. Uegaki J., Shikimi T., Kaku K., Takaori S. Change in the equilibrium of the levels of free and bound forms of alpha-1-microglobubin and urinastatin in patients with mood disorders. Neuropsychobiology. 45:2002;62-66
108. Inagaki T., Shikimi T., Matsubara K., et al. Non-existence of a positive correlation between urinary levels of alpha-1-microglobulin and ulinastatin in patients with Parkinson's disease. Psychiatry Clin. Neurosci. 50:1996;231-233
109. Fernandez-Luna J.L., Leyva-Cobian F., Mendez E. Measurement of protein HC (alpha 1-microglubulin) and protein HC-IgA complex in different body fluids. J. Clin. Pathol. 41:1988;1176-1179
110. Kouri T., Harmoinen A., Laurila K., Ala-Houhala I., Koivula T., Pasternack A. Reference intervals for the markers of proteinuria with a standardised bed-rest collection of urine. Clin. Chem. Lab. Med. 39:2001;245-247
111. Jung K., Pergande M., Schreiber G., Thierfelder W. Reference intervals for α1-microglobulin in urine. [Letter] Clin. Chim. Acta. 206:1992;245-247
112. Gulder W.G., Hofmann W. Differentiation of proteinuria and haematuria by single protein analysis in urine. Clin. Biochem. 26:1993;277-282
113. Hofmann W., Rossmüller B., Guder W.G., Edel H.H. A new strategy for characterizing proteinuria and haematuria from a single pattern of defined proteins in urine. Eur. J. Clin. Chem. Clin. Biochem. 30:1992;707-712
114. Ivandic M., Hofmann W., Guder W.G. Development and evaluation of urinary protein expert system. Clin. Chem. 42:1996;1214-1222
115. Lun A., Ivandic M., Priem F., et al. Evaluation of pediatric nephropathies by a computerized Urine Protein Expert System (UPES). Pediatr. Nephrol. 13:1999;900-906
116. Ivandic M., Hofmann W., Guder W.G. The use of knowledge-based systems to improve medical knowledge about urine analysis. Clin. Chim. Acta. 297:2000;251-260
117. Ivandic M., Ogurol Y., Hofmann W., Guder W.G. From a urinalysis strategy to an evaluated urine protein expert system. Methods Inf. Med. 39:2000;93-98
118. Regeniter A., Siede W.H., Scholer A., Huber P., Frischmuth N., Steiger J.U. Interpreting complex urinary patterns with MDI LABLINK: a statistical evaluation. Clin. Chim. Acta. 301:2000;229-230
119. Itoh Y., Enomoto H., Kawai T. Alpha 1-microglobulin in cadmium poisoning. Nephron. 35:1983;211-212