Evaluation of pediatric nephropathies by a computerized Urine Protein Expert System (UPES)

Pediatric Nephrology

Volumn 13, Issue 9, 1999, Pages 900-906

  Lun, Andreas ^a   Ivandic, Miroslav ^b   Priem, Friedrich ^a   Filler, Guido ^a   Kirschstein, Martin ^c   Ehrich, Jochen H H ^a,d   Guder, Walter G ^b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b KLINIKUM BOGENHAUSEN   (Germany)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^d HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Decision support; Evaluation; Expert system; Knowledge based system; Proteinuria

Indexed keywords

ALBUMIN; ALPHA 1 MICROGLOBULIN; CREATININE; ESTERASE; IMMUNOGLOBULIN G; N ACETYL BETA GLUCOSAMINIDASE; PEROXIDASE; PROTEIN;

ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL FEATURE; CLINICAL TRIAL; COMPUTER ANALYSIS; COMPUTER PROGRAM; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; DIPSTICK; GLOMERULOPATHY; GLOMERULUS FILTRATION; HUMAN; KIDNEY DISEASE; KIDNEY FUNCTION; LABORATORY TEST; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN URINE LEVEL; PROTEINURIA; URINALYSIS;

ADOLESCENT; ALBUMINURIA; ALGORITHMS; ALPHA-GLOBULINS; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CREATININE; DIAGNOSIS, COMPUTER-ASSISTED; HUMANS; INFANT; KIDNEY DISEASES; PROTEINURIA; SOFTWARE;

EID: 0032762368     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004670050724     Document Type: Article

References (19)

1. Hofmann W, Guder WG (1989) A diagnostic programme for quantitative analysis of proteinuria. J Clin Chem Clin Biochem 27:589-600
2. Hofmann W, Rossmüller B, Guder WG, Edel HH (1992) A new strategy for characterising proteinuria and hematuria from a single pattern of defined proteins in urine. Eur J Clin Chem Clin Biochem 30:707-712
3. Guder WG, Hofmann W (1993) Differentiation of proteinuria and hematuria by single protein analysis in urine. Clin Biochem 26:277-282
4. Ivandic M, Hofmann W, Guder WG (1996) Development and evaluation of a urine protein expert system. Clin Chem 42:1214-1222
5. Ivandic M, Hofmann W, Guder WG (1996) Eine Akzeptanzstudie zur Befundinterpretation in der labormedizinischen Spezialdiagnostik am Beispiel der Urineiweißdifferenzierung. Klin Chem Mitt 27:159-165
6. Schwartz GJ, Haycock GB, Edelmann CB, Spitzer A (1976) A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 58:259-263
7. Trendelenburg C, Pohl B (1995) Pro.M.D. - medical diagnostics with expert systems, 1st edn. Medisoft Verlag, Frankfurt
8. Ogurol Y, Zhao J, Wischnewsky MB, Ivandic M, Hofmann W, Guder WG, Bepperling C, Hehrmann R, Plank C, Pohl B, Karch H, Adamowicz M, Trendelenburg C (1998) WILAS - ein wissensbasiertes System zur labormedizinischen Anforderung und Spezialbefundung. Informatik, Biometrie und Epidemiologie in Medizin und Biologie 29:3-11
9. Hofmann W, Lehn P, Blaufuss H, Guder WG (1996) Laboratory diagnostics in urinary tract infections: are additional informations provided by analysis of urinary protein pattern? Nieren- Hochdruckkrankh 25:558-562
10. Hofmann W, Schmidt D, Guder WG, Edel H (1991) Differentiation of hematuria by quantitative determination of urinary marker proteins. Klin Wochenschr 69:68-75
11. Boege F, Koehler B, Liebermann F (1990) Identification and quantification of Bence-Jones proteinuria by automated nephelometric screening. J Clin Chem Clin Biochem 28:34-42
12. Guder WG, Ivandic M, Hofmann W (1998) Physiopathology of proteinuria and laboratory diagnostic strategy based on single protein analysis. Clin Chem Lab Med 36:935-939
13. Bohle A, Mackensen-Haen S, Gise H von, Grund KE, Wehrmann M, Batz C, Bogenschütz O, Schmitt H, Nagy J, Müller C. Müller G (1990) The consequences of tubulo-interstitital changes for renal function in glomerulopathies - a morphometric and cytological analysis. Pathol Res Pract 186:135-144
14. Ziyadeh FN (1996) Significance of tubulointerstitial changes in diabetic renal disease. Kidney Int 49 [Suppl 54]:S10-13
15. Hofmann W, Edel H, Guder WG (1995) A mathematical equation to discriminate overload proteinuria from tubulo-interstitial involvement in glomerular diseases. Clin Nephrol 44:28-31
16. Cockcroft SW, Gault HM (1976) Prediction of creatinine clearances from serum creatinine. Nephron 16:31-41
17. Filler G, Witt I, Priem F, Ehrich JHH, Jung K (1997) Are cystatin C and β2-microglobulin better markers than serum creatinine for prediction of a normal glomerular filtration rate in pediatric subjects? Clin Chem 43:1077-1078
18. Ivandic M, Hofmann W, Guder WG (1996) Eine Akzeptanzstudie zur Befundinterpretation in der labormedizinischen Spezialdiagnostik am Beispiel der Urineiweißdifferenzierung. Klin Chem Mitt 27:159-165
19. Ivandic M, Hofmann W, Guder WG (1998) UPES-Infosystem. WWW: http://WILAS.ZAIT.UNI.BREMEN.DE/UPES/MAIN. HTM