Use of exogenous erythropoietin in critically ill patients

Journal of Clinical Pharmacy and Therapeutics

Volumn 29, Issue 3, 2004, Pages 195-208

  MacLaren, R ^a   Gasper, J ^a   Jung, R ^a   Vandivier, R W ^b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Anaemia; Critical care; Erythropoietin; Hematocrit; Hemoglobin; Transfusion

Indexed keywords

IRON; RECOMBINANT ERYTHROPOIETIN;

ANEMIA; BURN; COST EFFECTIVENESS ANALYSIS; CRITICAL ILLNESS; EMBASE; ERYTHROCYTE APLASIA; ERYTHROCYTE TRANSFUSION; ERYTHROPOIESIS; HEMOGLOBIN DETERMINATION; HUMAN; HYPERTENSION; INJURY; INTENSIVE CARE; INTENSIVE CARE UNIT; MEDLINE; REVIEW; SEIZURE; THROMBOSIS;

CRITICAL ILLNESS; ERYTHROPOIETIN, RECOMBINANT; HUMANS; RANDOMIZED CONTROLLED TRIALS;

EID: 3142521645     PISSN: 02694727     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2710.2004.00552.x     Document Type: Review

References (78)

1. Corwin HL (2001) Anemia in the critically ill: the role of erythropoietin. Seminars in Hematology, 38 (Suppl. 7), 24-32.
2. Hebert PC, Wells G, Blajchman MA et al. (1999) A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. New England Journal of Medicine, 340, 409-417.
3. Corwin HL, Krantz SB (2000) Anemia of the critically ill: "acute" anemia of chronic disease. Critical Care Medicine, 28, 3098-3099.
4. Ba VN, Bota DP, Melot C, Vincent JL (2003) Time course of hemoglobin concentrations in nonbleeding intensive care unit patients. Critical Care Medicine, 31, 406-410.
5. von Ashen N, Muller C, Serke S, Frei U, Kai-Uwe E (1999) Important role of nondiagnostic blood loss and blunted erythropoietic response in the anemia of medical intensive care patients. Critical Care Medicine, 27, 2630-2639.
6. Vincent JL, Baron JF, Reinhart K et al. (2002) Anemia and blood transfusion in critically ill patients. JAMA, 288, 1499-1507.
7. Hebert PC, Wells G, Tweeddale M et al. (1997) Does transfusion practice affect mortality in critically ill patients? Transfusions requirements in critical care (TRICC) investigators and the Canadian critical care trials group. American Journal of Respiratory and Critical Care Medicine, 155, 1618-1623.
8. Goodnough LT, Brecher ME, Kanter MH, Aubuchon JP (1999) Transfusion medicine. Blood transfusion. New England Journal of Medicine, 340, 438-447.
9. French CJ, Bellomo R, Finfer SR, Lipman J, Chapman M, Boyce NW (2002) Appropriateness of red blood cell transfusion in Australasian intensive care practice. Medical Journal of Australia, 177, 548-551.
10. Corwin HL, Parsonnet KC, Gettinger A (1995) RBC transfusion in the ICU: is there a reason? Chest, 108, 767-771.
11. Hebert PC, Wells G, Martin C et al. (1999) Variation in red cell transfusion practice in the intensive care unit: a multicentre cohort study. Critical Care, 3, 57-63.
12. Innes G (1998) Guidelines for red blood cells and plasma transfusion for adults and children: an emergency physician's overview of the 1997 Canadian blood transfusion guidelines. Journal of Emergency Medicine, 16, 129-132.
13. American College of Physicians (1992) Practice strategies for elective red blood cell transfusion. Annals of Internal Medicine, 116, 403-406.
14. Consensus Conference (1988) Perioperative red blood cell transfusion. JAMA, 260, 2700-2703.
15. Expert Working Group (1997) Guidelines for red blood cell and plasma transfusions for adults and children. Canadian Medical Association Journal, 156 (Suppl. 11), S1-S24.
16. Hebert PC, Wells G, Martin C et al. (1998) A Canadian survey of transfusion practices in critically ill patients. Critical Care Medicine, 26, 482-487.
17. Boralessa H, Rao MP, Morgan C et al. (2002) A survey of physicians' attitudes to transfusion practice in critically ill patients in the UK. Anaesthesia, 57, 584-605.
18. Rao MP, Boralessa H, Morgan C et al. (2002) Blood component use in critically ill patients. Anaesthesia, 57, 530-534.
19. Corwin HL, Gettinger A, Pearl RG et al. (2004) The CRIT Study: anemia and blood transfusion in the critically ill - current clinical practice in the United States. Critical Care Medicine, 32, 39-52.
20. Groeger JS, Guntupalli KK, Strosberg M, Halpern N, Raphaely RC, Cerra F, Kaye W (1993) Descriptive analysis of critical care units in the United States: patient characteristics and intensive care unit utilization. Critical Care Medicine, 21, 279-291.
21. Vamvakas EC (1996) Epidemiology of red blood cell utilization. Transfusion Medicine Reviews, 10, 44-61.
22. Taylor RW, Manganaro L, O'Brien J, Trottier SJ, Parkar N, Veremakis C (2002) Impact of allogenic packed red blood cell transfusion on nosocomial infection rates in the critically ill patients. Critical Care Medicine, 30, 2249-2254.
23. Hebert PC, Yetisir E, Martin C, Blajchman MA, Wells G, Marshall J, Tweeddale M (2001) Is a low transfusion threshold safe in critically ill patients with cardiovascular diseases? Critical Care Medicine, 29, 227-232.
24. Hebert PC, Blajchman MA, Cook DJ, Yetisir E, Wells G, Marshall J, Schweitzer I (2001) Do blood transfusions improve outcomes related to mechanical ventilation? Chest, 119, 1850-1857.
25. Carson JL, Hill S, Carless P, Hebert P, Henry D (2002) Transfusion triggers: a systematic review of the literature. Transfusion Medicine Reviews, 16, 187-199.
26. Corwin HL, Krantz SB (2000) Anemia of the critically ill: acute anemia of chronic disease. Critical Care Medicine, 28, 3098-3099.
27. Alvarez G, Hebert PC, Szick S (2001) Debate: transfusing to normal hemoglobin levels will not improve outcome. Critical Care, 5, 56-63.
28. Haupt MT (2001) Debate: transfusing to normal hemoglobin levels improves outcome. Critical Care, 5, 64-66.
29. Blumberg N, Heal JM (1989) Transfusion and host defenses against cancer recurrence and infection. Transfusion, 29, 236-245.
30. Dellinger EP, Oreskovich MR, Wertz MJ, Hamasaki V, Lennard ES (1984) Risk of infection following laparotomy for penetrating abdominal injury. Archives of Surgery, 119, 20-27.
31. Nichols RL, Smith JW, Klein DB, Trunkey DD, Cooper RH, Adinolfi MF, Mills J (1984) Risk of infection after penetrating abdominal trauma. New England Journal of Medicine, 311, 1065-1070.
32. Moore FA, Moore EE, Sauaia A (1997) Blood transfusion. An independent risk factor for postinjury multiple organ failure. Archives of Surgery, 132, 620-624.
33. Graves TA, Cioffi WG, Mason AD, Jr, McManus WF, Pruitt BA, Jr (1989) Relationship of transfusion and infection in a burn population. Journal of Trauma, 29, 948-952.
34. Edna TH, Bjerkeset Y (1992) Association between blood transfusion and infection in injured patients. Journal of Trauma, 33, 659-661.
35. Braga M, Vignali A, Radaelli G, Gianotti L, Di Carlo V (1992) Association between perioperative blood transfusion and postoperative infection in patients having elective operations for gastrointestinal cancer. European Journal of Surgery, 158, 531-536.
36. Dawes LG, Aprahamian C, Condon RE, Malangoni MA (1986) The risk of infection after colon injury. Surgery, 100, 796-803.
37. Ottino G, De Paulis R, Pansini S et al. (1987) Major sternal wound infection after open-heart surgery: a multivariate analysis of risk factors in 2,579 consecutive operative procedures. Annals of Thoracic Surgery, 44, 173-179.
38. Tartter PI (1988) Blood transfusion and infectious complications following colorectal cancer surgery. British Journal of Surgery, 75, 789-792.
39. Offner PJ, Moore EE, Biffl WL, Johnson JL, Silliman CC (2002) Increased rate of infection associated with transfusion of old blood after severe injury. Archives of Surgery, 137, 711-716.
40. Vamvakas EC, Carven JH (1998) Allogeneic blood transfusion, hospital charges, and length of hospitalization: a study of 487 consecutive patients undergoing colorectal cancer resection. Archives of Pathology and Laboratory Medicine, 122, 145-151.
41. Jurado RL (1997) Iron, infections, and anemia of inflammation. Clinical Infectious Diseases, 25, 888-895.
42. Landers DF, Hill GE, Wong KC, Fox IJ (1996) Blood transfusion-induced immunomodulation. Anesthesia and Analgesia, 82, 187-204.
43. Blumberg N, Heal JM (1996) Immunomodulation by blood transfusion: an evolving scientific and clinical challenge. American Journal of Medicine, 101, 299-308.
44. Hebert PC (1998) Transfusion requirements in critical care (TRICC): a multicenter, randomized, controlled clinical study. British Journal of Anaesthesia, 81 (Suppl. 1), 25-33.
45. Marik PE, Sibbald WJ (1993) Effect of stored-blood transfusion on oxygen delivery in patients with sepsis. JAMA, 269, 3024-3029.
46. Zallen G, Offner PJ, Moore EE et al. (1999) Age of transfused blood is an independent risk factor for postinjury multiple organ failure. American Journal of Surgery, 178, 570-572.
47. Goodnough LT, Brecher ME, Kanter MH, Aubuchon JP (1999) Transfusion medicine. Blood conservation. New England Journal of Medicine, 340, 525-533.
48. Goodnough LT (2001) Erythropoietin therapy versus red cell transfusion. Current Opinion in Hematology, 8, 405-410.
49. Gabriel A, Sibylle K, Chiari A (1998) High-dose recombinant erythropoietin stimulates reticulocyte production in patients with multiple organ dysfunction syndrome. Journal of Trauma, 44, 361-367.
50. Van Iperen CE, Gaillard CA, Kraaijenhagen RJ, Braam BG, Marx JJ, van de Wiel A (2000) Response to erythropoiesis and iron metabolism to recombinant human erythropoietin in intensive care unit patients. Critical Care Medicine, 28, 2773-2778.
51. Rodriguez RM, Corwin HL, Gettinger A, Corwin MJ, Gubler D, Pearl RG (2001) Nutritional deficiencies and blunted erythropoietin response as causes of the anemia of critical illness. Journal of Critical Care, 16, 36-41.
52. Van Iperen CE, Biesma DH, van de Wiel A, Marx JJ (1998) Erythropoietic response to acute and chronic anaemia: focus on postoperative anaemia. British Journal of Anaesthesia, 81 (Suppl. 1), 2-5.
53. Rogiers P, Zhang H, Leeman M, Nagler J, Neels H, Melot C, Vincent JL (1997) Erythropoietin response is blunted in critically ill patients. Intensive Care Medicine, 23, 159-162.
54. Weiss G, Widner B, Zoller H, Schobersberger W, Fuchs D (1998) Immune response and iron metabolism. British Journal of Anaesthesia, 81 (Suppl. 1), 6-9.
55. Hobisch-Hagen P, Wiedermann F, Fries D, Jelkmann W, Fuchs D, Hasibeder W, Mutz N (2001) Blunted erythropoietic response to anemia in multiply traumatized patients. Critical Care Medicine, 29, 743-747.
56. Jelkman W (1998) Proinflammatory cytokines lowering erythropoietin production. Journal of Interferon and Cytokine Research, 18, 555-559.
57. Faquin WC, Scheider TJ, Goldberg MA (1992) Effect of inflammatory cytokines on hypoxia-induced erythropoietin production. Blood, 79, 1987-1994.
58. Abel J, Spanbrucker N, Fandrey J, Jelkmann W (1996) Serum erythropoietin levels in patients with sepsis and septic shock. European Journal of Haematology, 57, 359-363.
59. Krafte-Jacobs B, Levetown ML, Bray GL, Ruttimann UE, Pollack MM (1994) Erythropoietin response to critical illness. Critical Care Medicine, 22, 821-826.
60. Bauer A, Tronche F, Wessely O et al. (1999) The glucocorticoid receptor is required for stress erythropoiesis. Genes and Development, 13, 2996-3002.
61. Darveau M, Notebaert E, Denault AY, Belisle S (2002) Recombinant human erythropoietin use in intensive care. Annals of Pharmacotherapy, 36, 1068-1074.
62. Sela S, Shurtz-Swirski R, Sharon R et al. (2001) The polymorphonuclear leukocyte - a new target for erythropoietin. Nephron, 88, 205-210.
63. Gorio A, Gokmen N, Erbayraktar S et al. (2002) Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma. Proceedings of the National Academy of Sciences of the United States of America, 99, 9450-9455.
64. Celik M, Gokmen N, Erbayraktar S et al. (2002) Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury. Proceedings of the National Academy of Sciences of the United States of America, 99, 2258-2263.
65. Brines ML, Ghezzi P, Keenan S et al. (2000) Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proceedings of the National Academy of Sciences of the United States of America, 97, 10526-10531.
66. Cazzola M, Mercuriali F, Brugnara C (1997) Use of recombinant human erythropoietin outside the setting of uremia. Blood, 89, 4248-4267.
67. Cazzola M (1998) How and when to use erythropoietin. Current Opinion in Hematology, 5, 103-108.
68. Anonymous (2003) Prescribing Information. Available at: http://www.procrit.com (Last accessed June 2003).
69. Corwin HL, Gettinger A, Rodriguez RM et al. (1999) Efficacy of recombinant human erythropoietin in the critically ill patient: a randomized, double-blind, placebo-controlled trial. Critical Care Medicine, 27, 2346-2350.
70. Corwin HL, Gettinger A, Pearl RG et al. (2002) Efficacy of recombinant human erythropoietin in critically ill patients: a randomized, controlled trial. JAMA, 288, 2827-2835.
71. Silver M, Bazan A (2002) Randomized double blind placebo controlled trial of recombinant human erythropoietin in long term acute care patients. Critical Care Medicine, 30 (Suppl. 12), A153.
72. Poletes GP, Miller SF, Finley RK, Lincks J (1994) Blood use in the burn unit: a possible role for erythropoietin. Journal of Burn Care and Rehabilitation, 15, 37-41.
73. Still JM, Jr, Belcher K, Law EJ et al. (1995) A double-blinded prospective evaluation of recombinant human erythropoietin in acutely burned patients. Journal of Trauma, 38, 233-236.
74. Sherman DS, Holian TM (2001) Effect of erythropoietin on transfusions in the intensive care unit. Poster session Presentations: Hematology II (abstract). Critical Care Medicine, 29 (Suppl. 12), A99.
75. Vasko SD, Burdge JJ, Ruberg RL, Verghese AS (1991) Evaluation of erythropoietin levels in the anemia of thermal injury. Journal of Burn Care and Rehabilitation, 12, 437-441.
76. Sanders R, Garcia J, Sheldon GF, Schooley J, Fuchs R, Carpenter G (1976) Erythropoietin elevation in anemia of thermal injury. Surgical Forum, 27, 71-72.
77. Robinson H, Monafo WW, Saver SM, Gallagher NI (1973) The role of erythropoietin in the anemia of thermal injury. Annals of Surgery, 178, 565-572.
78. Carson JL (2002) Should patients in intensive care units receive erythropoietin? JAMA, 288, 2884-2886.