Serum erythropoietin levels in patients with sepsis and septic shock

European Journal of Haematology

Volumn 57, Issue 5, 1996, Pages 359-363

  Abel, Jörg ^a   Spannbrucker, Nestor ^a   Fandrey, Joachim ^a   Jelkmann, Wolfgang ^b  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Acute phase proteins; Cytokines; Erythropoietin; Immune activation; Infection; Sepsis

Indexed keywords

ACUTE PHASE PROTEIN; ERYTHROPOIETIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; PROGNOSIS; SEPSIS; SEPTIC SHOCK;

EID: 0030478414     PISSN: 09024441     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0609.1996.tb01393.x     Document Type: Article

References (24)

1. MEANS RT, KRANTZ SB. Progress in understanding the pathogenesis of the anemia of chronic disease. Blood 1992: 80: 1639-1647.
2. FAQUIN WC, SCHNEIDER TJ, GOLDBERG MA. Effect of inflammatory cytokines on hypoxia-induced erythropoietin production. Blood 1992: 79: 1987-1994.
3. JELKMANN W, PAGEL H, WOLFF M, FANDREY J. Monokines inhibiting erythropoietin production in human hepatoma cultures and in isolated perfused rat kidneys. Life Sci 1992: 50: 301-308.
4. FANDREY J, HUWILER A, FREDE S, PFEILSCHIFTER J, JELKMANN W. Distinct signaling pathways mediate phorbol-ester-induced and cytokine-induced inhibition of erythropoietin gene expression. Eur J Biochem 1994: 226: 335-340.
5. PARRILLO JE. Pathogenetic mechanisms of septic shock. N Engl J Med 1993: 328: 1471-1477.
6. MOLLOY RG, MANNICK JA, RODRICK ML. Cytokines, sepsis and immunomodulation. Br J Surg 1993: 80: 289-297.
7. BONE RC, FISHER JC, CLEMMER TP, et al. Sepsis syndrome: a valid clinical entitiy. Crit Care Med 1989: 17: 389-393.
8. KNAUS W, DRAPER E, WAGNER EP, ZIMMERMANN EJ. APACHE II: a severity of disease classification system. Crit Care Med 1985: 13: 818-829.
9. BONE RC. Sepsis, the septic syndrome, multi-organ failure: a plea for comparable definitions. Ann Intern Med 1991: 114: 332-333.
10. FERNANDEZ-BOTRAN R. Soluble cytokine receptors: their role in immunoregulation. FASEB J 1991: 5: 2567-2574.
11. WAAGE A, BRANDTZAEG P, HALSTENSEN A, KIERULF P, ESPEVIK T. The complex pattern of cytokines in serum from patients with meningococcal septic shock. J Exp Med 1989: 169: 333-338.
12. CALANDRA T, BAUMGARTNER J-D, GRAU GE, et al. Prognostic values of tumor necrosis factor/cachectin, interleukin-1, interferon-α, and interferon-γ in the serum of patients with septic shock. J Infect Dis 1990: 161: 982-987.
13. OFFNER F, PHILIPPÉ J, VOGELAERS D, et al. Serum tumor necrosis factor levels in patients with infectious disease and septic shock. J Lab Clin Med 1990: 116: 100-105.
14. CANNON JG, TOMPKINS RG, GELFAND JA, et al. Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever. J Infect Diseases 1990: 161: 79-84.
15. ENDO S, INADA K, INOUE Y, et al. Two types of septic shock classified by the plasma levels of cytokines and endotoxin. Circ Shock 1992: 38: 264-274.
16. DAMAS P, LEDOUX D, NYS M, et al. Cytokine serum level during severe sepsis in human IL-6 as a marker of severity. Ann Surg 1992: 215: 356-362.
17. BIENVENU J, COULON L, DOCHE C, GUTOWSKI M-C, GRAU GE. Analytical performances of commercial ELISA-kits for IL-2, IL-6 and TNFα. A WHO study. Eur Cytokine Netw 1993: 4: 477-451.
18. LUGER A, GRAF H, SCHWARZ H-P, STUMMVOLL H-K, LUGER TA. Decreased serum interleukin 1 activity and monocyte interleukin 1 production in patients with fatal sepsis. Crit Care Med 1986: 14: 458-461.
19. CALANDRA T, GERAIN J, HEUMANN D, et al. High circulating levels of interleukin-6 in patients with septic shock: evolution during sepsis, prognostic value, and interplay with other cytokines. Am J Med 1991: 91: 23-29.
20. HACK E, DEGROOT E, FELT-BERSMA R, et al. Increased plasma levels of interleukin 6 in sepsis. Blood 1989: 74: 1704-1710.
21. JELKMANN W. Erythropoietin: structure, control of production, and function. Physiol Rev 1992: 72: 449-489.
22. SOBOLEVA MK, MANAKOVA TE. Plasma erythropoietin activity in infants with sepsis. Bull Exp Biol Med 1993: 115: 545-548.
23. JELKMANN W, FANDREY J, FREDE S, PAGEL H. Inhibition of erythropoietin production by cytokines. Implications for the anemia involved in inflammatory states. Ann NY Acad Sci 1994: 718: 300-309.
24. WENGER RH, ROLFS A, MARTI HH, BAUER C, GASSMANN M. Hypoxia, a novel inducer of acute phase gene expression in a human hepatoma cell line. J Biol Chem 1995: 270: 27865-27870.