Effect of different sterilisation methods on the properties of bioadhesive powders and ocular minitablets, and clinical evaluation

European Journal of Pharmaceutical Sciences

Volumn 23, Issue 1, 2004, Pages 77-87

  Weyenberg, W ^a   Vermeire, A ^b   D'Haese, E ^c   Vanhaelewyn, G ^b   Kestelyn, P ^d   Callens, F ^b   Nelis, H J ^c   Remon, J P ^b   Ludwig, A ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c GHENT UNIVERSITY   (Belgium)

^d GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Ciprofloxacin; EPR ESR; Gamma irradiation and dry heat sterilisation; In vitro release; In vivo study; Ocular minitablet

Indexed keywords

ADHESIVE AGENT; CARBOMER; CIPROFLOXACIN; FUMARIC ACID DERIVATIVE; POLYMER; RADICAL; SODIUM STEARYLFUMARATE; STARCH; UNCLASSIFIED DRUG;

ADULT; ANTIBACTERIAL ACTIVITY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; CRUSHING STRENGTH; DRUG RELEASE; DRY POWDER; FEMALE; FLOW KINETICS; GAMMA IRRADIATION; HUMAN; MAIZE; MALE; MICROBIAL ACTIVITY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR WEIGHT; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SUSTAINED DRUG RELEASE; TABLET COMPRESSION; TABLET FORMULATION; TABLET FRIABILITY; TABLET PROPERTY; TEAR FILM;

ADHESIVES; ADULT; BACTERIA; CHROMATOGRAPHY, GEL; ELECTRON SPIN RESONANCE SPECTROSCOPY; EXCIPIENTS; FEMALE; HUMANS; INDICATORS AND REAGENTS; KINETICS; MALE; MOLECULAR WEIGHT; POWDERS; RHEOLOGY; STARCH; STERILIZATION; TABLETS; WATER;

EID: 8444230029     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2004.05.010     Document Type: Article

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