Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 13, 2005, Pages 3296-3301

  Biftu, Tesfaye ^a   Feng, Dennis ^a   Ponpipom, Mitree ^a   Girotra, Narindar ^a   Liang, Gui Bai ^a   Qian, Xiaoxia ^a   Bugianesi, Robert ^a   Simeone, Joseph ^a   Chang, Linda ^a   Gurnett, Anne ^a   Liberator, Paul ^a   Dulski, Paula ^a   Leavitt, Penny Sue ^a   Crumley, Tami ^a   Misura, Andrew ^a   Murphy, Terence ^a   Rattray, Sandra ^a   Samaras, Samantha ^a   Tamas, Tamas ^a   Mathew, John ^a   Brown, Christine ^a   Thompson, Don ^a   Schmatz, Dennis ^a   Fisher, Michael ^a   Wyvratt, Matthew ^a   more..

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

COCCIDIOSTATIC AGENT; CYCLIC GMP DEPENDENT PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PYRROLE DERIVATIVE; SALINOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; EIMERIA TENELLA; IN VIVO STUDY; LIPOPHILICITY; NONHUMAN; PROTOZOAL INFECTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; BIOLOGICAL AVAILABILITY; CHICKENS; COCCIDIOSIS; COCCIDIOSTATS; CYCLIC GMP-DEPENDENT PROTEIN KINASES; EIMERIA; HALF-LIFE; INHIBITORY CONCENTRATION 50; PROTOZOAN PROTEINS; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EIMERIA TENELLA;

EID: 20444426848     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.04.060     Document Type: Article

References (12)

1. Hyatt, D. The U.S. Poultry Industry. Web version by the TAMU Poultry Network Administration Team 1995
2. T. Cosgrove, and S.M. Shane Poultry 9 2001 10
3. R.F. Shumard, and M.E. Callender Poult. Sci. 48 1969 1870
4. McDougald, L. R. In Coccidiosis of Man and Domestic Animals; Long, P. L. Ed.; Boca Raton, FL, 1990; pp 307-320
5. G.F. Mathis, L.R. McDougald, and B. McMurray Avian Dis. 28 1984 453
6. H.D. Chapman, and M.W. Shirley Res. Vet. Sci. 46 1989 114
7. Jeffers, T.K., 1989 In Vth International Coccidiosis Conference; Ed. INRA Publ.; Tours, France, 1989; pp 295-308
8. A. Rotibi, L.R. McDougald, and J. Solis Avian Dis. 33 1989 365
9. T. Tamas, and D.A. Ostlind Poultry Sci. 73 1994 15 (Abstr.)
10. A.M. Gurnett, P.A. Liberator, P.M. Dulski, S.P. Salowe, R.G.K. Donald, J.W. Anderson, J. Wiltsie, C.A. Diaz, G. Harris, B. Chang, S.J. Darkin-Rattray, B. Nare, T. Crumley, P.S. Blum, A.S. Misura, T. Tamas, M.K. Sardana, J. Yuan, T. Biftu, and D.M. Schmatz J. Biol. Chem 277 2002 15913
11. H.I. Wiersmaa, S.E. Galuskaa, F.M. Tomleyb, L.D. Sibleyc, P.A. Liberator, and R.G.K. Donald Int. J. Parasitol. 34 2004 369
12. S. de-Laszlo, D. Visco, and L. Agarwal Bioorg. Med. Chem. Lett. 8 19 1998 2689