Dissimilar effects of LY 294002 and PD 098059 in IGF-I- mediated inhibition of TGF-β1 expression and apoptosis in bovine mammary epithelial cells

Journal of Physiology and Pharmacology

Volumn 56, Issue SUPPL. 3, 2005, Pages 181-193

  Zarzynska J ^a   Motyl, T ^a  

^a WARSAW UNIVERSITY OF LIFE SCIENCES   (Poland)

Author keywords

BME UV1; IGF I signaling pathway; LY 294002; PD 098059; TGF 1

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; APOPTOSIS; BREAST CELL; CELL COUNT; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME INHIBITION; EPITHELIUM CELL; LASER SCANNING CYTOMETRY; MAMMARY GLAND; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; CATTLE; CELL LINE; CHROMONES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; FLAVONOIDS; INSULIN-LIKE GROWTH FACTOR I; LASER SCANNING CYTOMETRY; MAMMARY GLANDS, ANIMAL; MAP KINASE KINASE KINASES; MORPHOLINES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 31144462046     PISSN: 08675910     EISSN: 08675910     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (28)

1. 1-induced programmed cell death of HC11 mouse mammary epithelial cells. Cel Mol Biol 2000; 46: 175-185.
2. 1-induced apoptosis in HC11 mouse mammary epithelial cells (MEC). Cell Mol Biol 2001; 47: 197-208.
3. 1. Eur J Cell Biol 2003b; 82: 303-312.
4. 1 in bovine mammary epithelial BME-UV1 cells. Comp Biochem Physiol C 2003a; 134: 417-430.
5. 1- induced apoptosis in bovine mammary epithelial BME-UV1 cells. Comp Biochem Physiol C 2004; 139: 65-75.
6. Nickerson T, Huynh H, Pollak M. Insulin-like growth factor binding protein-3 induces apoptosis in MCF-7 breast cancer cells. Biochem Biophys Res Commun 1997; 237: 690-693.
7. Ricort J-M, Binoux M. Insulin-like growth factor-binding protein-3 activates a phosphotyrosine phosphatase. J Biol Chem 2002; 277: 19448-19454.
8. Tonner E, Barber MC, Travers MT, Logan A, Flint DJ. Hormonal control of insulin-like growth factor binding protein-5 (IGFBP-5) production in the involuting mammary gland of the rat. Endocrinology 1997; 138: 5101-5107.
9. 1 expression in bovine mammary gland. Proceedings of International COST B20 Conference on "Physiology and Pathology of mammary cell proliferation and death" 2004; Warsaw, Poland, p. 37.
10. Marsham E, Green KA, Flint DJ, White A, Streuli CH, Westwood M. Insulin-like growth factor binding protein 5 and apoptosis in mammary epithelial cells. J Cell Sci 2003; 116: 675-682.
11. Tonner E, Barber MC, Allan GJ et al. Insulin-like growth factor binding protein-5 (IGFBP-5) induces premature cell death in the mammary glands of transgenic mice. Development 2002; 129: 4547-4557.
12. Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 1999; 286: 1358-1362.
13. Scheid MP, Schubert KM, Duronio V. Regulation of Bad phosphorylation and association with Bcl-XL by MAPK/Erk kinase. J Biol Chem 1999; 274: 31108-31113.
14. Fang X, Yu S, Eder A et al. Regulation of BAD phosphorylation at serine 112 by Rasmitogen-activated protein kinase pathway. Oncogene 1999; 18: 6635-6640.
15. Atwood CS, Ikeda M, Vonderhaar BK. Involution of mouse mammary glands in whole organ culture: a model for studying programmed cell death. Biochem Biophys Res Commun 1995; 207: 860-867.
16. Greichen R, Liu DX, Sun Y, Lee KO, Lobie PE. Autocrine Human Growth Hormone inhibits Placental TGF-β gene transcription to prevent apoptosis and allow cell cycle progression of human mammary carcinoma cells. J Biol Chem 2002; 277 (29): 26662-26672.
17. Huynh H, Beamer W, Pollack M, Chan TWMG. Modulation of TGF-β1 gene expression in the mammary gland by insulin-like growth factor -I and octeotide. Int J Oncol 2000; 16: 277-281.
18. 1 expression in normal and malignant mammary epithelial cells. Anticancer Res 1998; 18: 2449-2454.
19. 1 gene. J Cell Biol 1993; 120: 253-260.
20. 1 expression in bovine mammary gland. J Dairy Res 2005; 72 (1): 39-48.
21. Zavizion B, van Duffelen M, Schaeffer W, Politits I. Establishment and characterization of bovine mammary epithelial cell line with unique properties. In Vitro Cell Dev Biol Anim 1996; 32: 138-148.
22. Kauffman-Zeh A, Rodriguez Viciana P, Ulrichy E et al. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(S)K and PKB. Nature 1997; 385: 544-8.
23. Kulik G, Weber MJ. Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I. Mol Cell Biol 1998; 18: 6711-6718.
24. Parrizas M, Saltiel AR, LeRoith D. Insulin-like growth factor I inhibits apoptosis using the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways. J Biol Chem 1997; 272: 154-161.
25. Plath A, Einspanier R, Peters F, Sinowatz F, Schams D. Expression of transforming growth factors alpha and beta-1 messenger RNA in the bovine mammary gland during different stages of development and lactation. J Endocrinol 1997; 155: 501-511.
26. Liu W, Chin-Chance C, Lee E-J, Lowe Jr, W L,. Activation of Phosphatidylinositol 3-Kinase contributes to Insulin- Like Growth Factor I-mediated inhibition of pancreatic β-cell death. Endocrinology 2002; 143(10): 3802-3812.
27. 1 by Phosphatidylinositol 3-Kinase/Akt dependent suppression of the activation of Smad3 but not Smad2. J Biol Chem 2003; 278: 38342-38351.
28. Alessi D R, Cuenda A, Cohen P, Dudleyi D T, Saltieli A R. PD 098059 is a specific inhibitor of the activation of Mitogen-activated Protein Kinase Kinase in vitro and in vivo. J Biol Chem 1995; 270: 27489-27494.