Neurobiology of serotonin function in autism

Autism Spectrum Disorders

Volumn , Issue , 2003, Pages 199-220

  McDougle, Christopher J ^a   Posey, David J ^b   Potenza, Marc N ^c  

^a RILEY HOSPITAL FOR CHILDREN   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 31144453682     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (50)

1. Whitaker-Azmitia PM. The role of serotonin and serotonin receptors in development of the mammalian nervous system. In: Zagon IS, McLaughlin PJ, eds. Receptors in the Developing Nervous System. Vol 2. Neurotransmitters. London: Chapman & Hall, 1993:43-53.
2. Cook EH Jr, Leventhal BL. The serotonin system in autism. Curr Opin Pediatr 1996; 8:348-354.
3. Anderson GM, Hoshino Y. Neurochemical studies of autism. In: Cohen DJ, Volkmar FR, eds. Handbook of Autism and Pervasive Developmental Disorders. Toronto: John Wiley & Sons, 1997:325-343.
4. Potenza MN, McDougle CJ. The role of serotonin in autism-spectrum disorders. CNS Spectrums 1997; 2(5):25-42.
5. Schain RJ, Freedman DX. Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children. J Pediatr 1961; 58:315-320.
6. Sutton HE, Read JH. Abnormal amino acid metabolism in a case suggesting autism. Am J Dis Child 1958; 96:23-28.
7. Pare CM, Sandler M, Stacey RS. 5-Hydroxytryptamine deficiency in phenylketonuria. Lancet 1957; 1:551-553.
8. Pare CM, Sandler M, Stacey RS. Decreased 5-hydroxytryptophan decarboxylase activity in phenylketonuria. Lancet 1958; 2:1099-1101.
9. Pare CM, Sandler M, Stacey RS. The relationship between decreased 5-hydroxyindole metabolism and mental defect in phenylketonuria. Arch Dis Child 1959; 34: 422-425.
10. Woolley DW. Manipulation of cerebral serotonin and its relationship to mental disorders. Science 1957; 125:752.
11. Armstrong MD, Robinson KS. Abnormal metabolites in phenylketonuria. Fed Proc 1954; 13:175.
12. Armstrong MD, Robinson KS. On the excretion of indole derivatives in phenylketonuria. Arch Biochem 1954; 52:287.
13. Marrazzi AS. The action of psychotogens and a neurophysiological theory of hallucination. Am J Psychiatry 1960; 116:911.
14. Ritvo ER, Yuwiler A, Geller E, Ornitz EM, Saeger K, Plotkin S. Increased blood serotonin and platelets in early infantile autism. Arch Gen Psychiatry 1970; 23: 566-572.
15. Anderson GM, Freedman DX, Cohen DJ, Volkmar FR, Hoder EL, McPhedran P, Minderaa RB, Hansen CR, Young JG.Whole blood serotonin in autistic and normal subjects. J Child Psychol Psychiatry 1987; 28:885-900.
16. McBride PA, Anderson GM, Hertzig ME, Snow ME, Thompson SM, Khait VD, Shapiro T, Cohen DJ. Effects of diagnosis, race, and puberty on platelet serotonin levels in autism and mental retardation. J Am Acad Child Adolesc Psychiatry 1998; 37(7):767-776.
17. Croonenberghs J, Delmeire L, Verkerk R, Lin AH, Meskal A, Neels H, Van der Planken M, Schcarpe S, Deboutte D, Maes M. Peripheral markers of serotonergic and noradrenergic function in post-pubertal, caucasian males with autistic disorder. Neuropsychopharmacology 2000; 22(3):275-283.
18. Leboyer M, Philippe A, Bouvard M, Guilloud-Bataille M, Dondoux D, Tabuteau F, Feingold J, Mouren-Simeoni M-C, and Launay J-M. Whole blood serotonin and plasma beta-endorphin in autistic probands and their first-degree relatives. Biol Psychiatry 1999; 45:158-163.
19. Kuperman S, Beeghly JH, Burns TL, Tsai LY. Serotonin relationships of autistic probands and their first-degree relatives. J Am Acad Child Adolesc Psychiatry 1985; 24(2):186-190.
20. Abramson RK, Wright HH, Carpenter R, Brennan W, Lumpuy O, Cole E, Young SR. Elevated blood serotonin in autistic probands and their first-degree relatives. J Autism Dev Disord 1989; 19(3):397-407.
21. Cook EH, Leventhal BL, Heller W, Metz J, Wainwright M, Freedman DX. Autistic children and their first-degree relatives: relationships between serotonin and norepinephrine levels and intelligence. J Neuropsychiatry Clin Neurosci 1990; 2(3):268-274.
22. Leventhal BL, Cook EH, Morford M, Ravitz A. Relationships of whole blood serotonin and plasma norepinephrine within families. J Autism Dev Disord 1990; 20: 499-511.
23. Piven J, Tsai GC, Nehme E, Coyle JT, Chase GA, Folstein SE. Platelet serotonin, a possible marker for familial autism. J Autism Dev Disord 1991; 21:51-59.
24. Minderaa RB, Anderson GM, Volkmar FR, Akkerhuis GW, Cohen DJ. Urinary 5-hydroxyindoleacetic acid and whole blood serotonin and tryptophan in autistic and normal subjects. Biol Psychiatry 1987; 22(8):933-940.
25. Gillberg C, Svennerholm L, Hamilton-Hellberg C. Childhood psychosis and monoamine metabolites in spinal fluid. J Autism Dev Disord 1983; 13:383-396.
26. Gillberg C, Svennerholm L. CSF monoamines in autistic syndromes and other pervasive developmental disorders of early childhood. Br J Psychiatry 1987; 151:89-94.
27. Narayan M, Srinath S, Anderson GM, Meundi DB. Cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid in autism. Biol Psychiatry 1993; 33:630-635.
28. Cohen DJ, Shaywitz BA, Johnson WT, Bowers MB. Biogenic amines in autistic and atypical children: Cerebrospinal fluid measures of homovanillic acid and 5-hydroxyindoleacetic acid. Arch Gen Psychiatry 1974; 31:845-853.
29. Cohen DJ, Caparulo BK, Shaywitz BA, Bowers MB. Dopamine and serotonin metabolism in neuropsychiatrically disturbed children: CSF homovanillic acid and 5-hydroxyindoleacetic acid. Arch Gen Psychiatry 1977; 34:545-550.
30. Hoshino Y, Watanabe M, Tachibana R, Murata S, Kancko M, Yashima Y, Kumoshiro H. A study of the hypothalamus-pituitary function in autistic children by the loading test of 5HTP, TRH and LH-RH. Jpn J Brain Res 1983; 9:94-95.
31. Hoshino Y, Tachibana JR, Watanabe M, Murata S, Yokoyama F, Kaneko M, Yashima Y, Kumoshiro H. Serotonin metabolism and hypothalamic-pituitary function in children with infantile autism and minimal brain dysfunction. Jpn J Psychiatry Neurol 1984; 26:937-945.
32. McBride PA, Anderson GM, Hertzig ME, Sweeney JA, Kream J, Cohen DJ, Mann JJ. Serotonergic responsivity in male young adults with autistic disorder: results of a pilot study. Arch Gen Psychiatry 1989; 46:213-221.
33. McDougle CJ, Naylor ST, Cohen DJ, Aghajanian GK, Heninger GR, Price LH. Effects of tryptophan depletion in drug-free adults with autistic disorder. Arch Gen Psychiatry 1996; 53:993-1000.
34. Carpenter LL, Anderson GM, Pelton GH, Gudin JA, Kirwin PDS, Price LH, Heninger GR, McDougle CJ. Tryptophan depletion during continuous CSF sampling in healthy human subjects. Neuropsychopharmacology 1998; 19:26-35.
35. Novotny S, Hollander E, Allen A, Mosovich S, Aronowitz B, Cartwright C, DeCaria C, Dolgoff-Kaspar R. Increased growth hormone response to sumatriptan challenge in adult autistic disorders. Psychiatry Res 2000; 94:173-177.
36. Hollander E, Novotny S, Allen A, Aronowitz B, Cartwright C, DeCaria C. The relationship between repetitive behaviors and growth hormone response to sumatriptan challenge in adult autistic disorder. Neuropsychopharmacology 2000; 22:163-167.
37. Chugani DC, Muzik O, Rothermel R, Behen M, Chakraborty P, Mangner T, da Silva EA, Chugani HT. Altered serotonin synthesis in the dentatothalamocortical pathway in autistic boys. Ann Neurol 1997; 42:666-669.
38. Chugani DC, Muzik O, Behen M, Rothermel R, Janisse JJ, Lee J, Chugani HT. Developmental changes in brain serotonin synthesis capacity in autistic and nonautistic children. Ann Neurol 1999; 45:287-295.
39. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, Lesch KP. Allelic variation of human serotonin transporter gene expression. J Neurochem 1996; 66: 2621-2624.
40. Lesch KP, Balling U, Gross J, Strauss K, Wolozin BL, Murphy DL, Riederer P. Organization of the human serotonin transporter gene. J Neural Transmission 1994; 95:157-162.
41. Cook EH, Courchesne R, Lord C, Cox NJ, Yan S, Lincoln A, Haas R, Courchesne E. Evidence of linkage between the serotonin transporter and autistic disorder. Mol Psychiatry 1997; 2:247-250.
42. Spielman RS, Ewens WJ. The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet 1996; 59:983-989.
43. Klauck SM, Poustka F, Benner A, Lesch KP, Poustka A. Serotonin transporter (5-HTT) gene variants associated with autism? Hum Mol Genet 1997; 6(13):2233-2238.
44. Zhong N, Ye L, Ju W, Tsiouris J, Cohen I, Brown WT. 5-HTTLPR variants not associated with autistic spectrum disorders. Neurogenetics 1999; 2:129-131.
45. International Molecular Genetic Study of Autism (IMGSA) Consortium. A full genome screen for autism with evidence for linkage to a region on chromosome 7q. Hum Mol Genet 1998; 7(3):571-578.
46. Maestrini E, Lai C, Marlow A, Matthews N, Wallace S, Bailey A, Cook EH, Weeks DE, Monaco AP, International Molecular Genetic Study of Autism (IMGSA) Consortium. Serotonin transporter (5-HTT) and K-aminobutyric acid receptor subunit 3 (GABRB3) gene polymorphisms are not associated with autism in the IMGSA families. Am J Med Genet (Neuropsychiatric Genetics) 1999; 88:492-496.
47. Persico AM, Militerni B, Bravaccio C, Schneider C, Melmed R, Conciatori M, Damiani V, Baldi A, Keller F. Lack of association between serotonin transporter gene promoter variants and autistic disorder in two ethnically distinct samples. Am J Med Genet 2000; 96:123-127.
48. Lassig JP, Vachirasomtoon K, Hartzell K, Leventhal M, Courchesne E, Courchesne R, Lord C, Leventhal BL, Cook EH Jr. Physical mapping of the serotonin 5-HT7 receptor gene (HTR7) to chromosome 10 and pseudogene (HTR7P) to chromosome 12, and testing of linkage disequilibrium between HTR7 and autistic disorder. Am J Med Genet 1999; 88:472-475.
49. McDougle CJ, Naylor ST, Cohen DJ, Volkmar FR, Heninger GR, Price LH. A double-blind, placebo-controlled study of fluvoxamine in adults with autistic disorder. Arch Gen Psychiatry 1996; 53:1001-1008.
50. McDougle CJ, Kresch L, Posey DJ. Repetitive thoughts and behavior in pervasive developmental disorders: treatment with serotonin reuptake inhibitors. J Autism Dev Disord 2000; 30(5):427-435.