Physical mapping of the serotonin 5-HT7 receptor gene (HTR7) to chromosome 10 and pseudogene (HTR7P) to chromosome 12, and testing of linkage disequilibrium between HTR7 and autistic disorder

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 88, Issue 5, 1999, Pages 472-475

  Lassig, J P ^a   Vachirasomtoon, K ^a   Hartzell, K ^a   Leventhal, M ^a   Courchesne, E ^b,c   Courchesne, R ^b   Lord, C ^a   Leventhal, B L ^a   Cook Jr , E H ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b RADY CHILDREN'S HOSPITAL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Autism; HTR7; Mapping; Polymorphism; Pseudogene; Serotonin receptors

Indexed keywords

ARTICLE; AUTISM; CHROMOSOME 10; CHROMOSOME 12P; GENE LINKAGE DISEQUILIBRIUM; GENE LOCATION; GENE LOCUS; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PSEUDOGENE;

AUTISTIC DISORDER; CHROMOSOMES, HUMAN, PAIR 10; CHROMOSOMES, HUMAN, PAIR 12; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; PARENTS; PHYSICAL CHROMOSOME MAPPING; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PSEUDOGENES; RECEPTORS, SEROTONIN;

EID: 0033569904     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(19991015)88:5<472::AID-AJMG7>3.0.CO;2-G     Document Type: Article

References (28)

1. Anderson GM, Feibel FC, Cohen DJ. 1987. Determination of serotonin in whole blood, platelet-rich plasma, platelet-poor plasma and plasma ultrafiltrate. Life Sci 40:1063-1070.
2. 7) positively coupled to adenylate cyclase. J Biol Chem 268:23422-23426.
3. Castiglione CM, Deinard AS, Speed WC, Sirugo G, Rosenbaum HC, Zhang Y, Grandy DK, Grigorenko EL, Bonne-Tamir B, Pakstis AJ, Kidd JR, Kidd KK. 1995. Evolution of haplotypes at the DRD2 locus. Am J Hum Genet 57:1445-1456.
4. Cook E, Courchesne R, Lord C, Cox N, Yan S, Lincoln A, Haas R, Courchesne E, Leventhal BL. 1997. Evidence of linkage between the serotonin transporter and autistic disorder. Mol Psychiatry 2:247-250.
5. Cook EH, Courchesne R, Cox NJ, Lord C, Gonen D, Guter SJ, Lincoln A, Nix K, Haas R, Leventhal BL, Courchesne E. 1998. Linkage disequilibrium mapping with 15q11-13 markers in autistic disorder. Am J Hum Genet 62:1077-1083.
6. Cook E, Leventhal B. 1996. The serotonin system in autism. Curr Opin Pediatr 8:348-354.
7. Cook EH, Leventhal BL, Freedman DX. 1988. Free serotonin in plasma: autistic children and their first-degree relatives. Biol Psychiatry 24:488-491.
8. 7 receptor: orphan found. Trends Pharmacol Sci 18:104-107.
9. 7) receptor gene: genomic organization and systematic mutation screening in schizophrenia and bipolar disorder. Mol Psychiatry 1:392-397.
10. Ewens W, Spielman R. 1995. The transmission/disequilibrium test: history, subdivision, and admixture. Am J Hum Genet 57:455-464.
11. Gelernter J, Rao P, Pauls D, Hamblin M, Sibley D, Kidd K. 1995. Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of linkage with Tourette syndrome. Genomics 26:207-209.
12. Gordon C, State R, Nelson J, Hamburger S, Rapoport J. 1993. A double-blind comparison of clomipramine, desipramine, and placebo in the treatment of autistic disorder. Arch Gen Psychiatry 50:441-447.
13. Lander E, Schork N. 1994. Genetic dissection of complex traits. Science 265:2037-2048.
14. Lord C, Rutter M, Goode S, Heemsbergen J, Jordan H, Mawhood L, Schopler E. 1989. Autism Diagnostic Observation Schedule: a standardized observation of communicative and social behavior. J Autism Develop Disord 19:185-212.
15. Lord C, Rutter M, Le Couteur A. 1994. Autism Diagnostic Interview -Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 24:659-685.
16. 5B receptors define a new family of serotonin receptors, cloning, functional expression, and chromosomal localization. Mol Pharmacol 43:313-319.
17. McBride PA, Anderson GM, Hertzig ME, Sweeney JA, Kream J, Cohen DJ, Mann JJ. 1989. Serotonergic responsivity in male young adults with autistic disorder. Arch Gen Psychiatry 46:205-212.
18. McDougle C, Naylor S, Cohen D, Volkmar F, Heninger G, Price L. 1996. A double-blind, placebo-controlled study of fluvoxamine in adults with autistic disorder. Arch Gen Psychiatry 53:1001-1008.
19. McDougle CJ, Holmes JP, Carlson DC, Pelton GH, Cohen DJ, Price LH. 1998. A double-blind, placebo-controlled study of risperidone in adults with autistic disorder and other pervasive developmental disorders. Arch Gen Psychiatry 55:633-41.
20. Monsma Jr F, Shen Y, Ward R, Hamblin M, Sibley D. 1993. Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol 43:320-327.
21. Nam D, Qian IH, Kusumi I, Ulpian C, Tallerico T, Liu IS, Seeman P. 1998. The human serotonin-7 receptor pseudogene: variation and chromosome location. J Psychiatry Neurosci 23:214-216.
22. Qian IH, Kusumi I, Ulpian C, Tallerico T, Nam D, Liu IS, Seeman MV, Seeman P. 1998. A human serotonin-7 receptor pseudogene. Brain Res Mol Brain Res 53, 339-43.
23. Purdon SE, Lit W, Labelle A, Jones BD. 1994. Risperidone in the treatment of pervasive developmental disorder. Can J Psychiatry 39:400-405.
24. Roth B, Craigo S, Choudhary S, Uluer A, Monsma Jr F, Hen Y, Meltzer H, Sibley D. 1994. Binding of typical and atypical antipsychotic drugs to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther 268:1403-1410.
25. Schain RJ, Freedman DX. 1961. Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children. J Pediatr 58:315-320.
26. Spielman R, Ewens W. 1996. The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet 59:983-989.
27. Spielman RS, McGinnis RE, Ewens WJ. 1993. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-516.
28. Walter M, Spillett D, Thomas P, Weissenbach J, Goodfellow P. 1994. A method for constructing radiation hybrid maps of whole genomes. Nature Genet 7:22-28.