5-HTTLPR variants not associated with autistic spectrum disorders

Neurogenetics

Volumn 2, Issue 2, 1999, Pages 129-131

  Zhong, Nan ^a   Ye, Lingling ^a   Ju, Weina ^a   Tsiouris, John ^a   Cohen, Ira ^a   Brown, W Ted ^a  

^a NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

Author keywords

Autism; Fragile X syndrome; Genotypes; Polymorphism; Serotonin transporter

Indexed keywords

DNA; SEROTONIN TRANSPORTER;

ARTICLE; AUTISM; CONTROLLED STUDY; FRAGILE X SYNDROME; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; POPULATION RESEARCH; PRIORITY JOURNAL;

ALLELES; AUTISTIC DISORDER; CARRIER PROTEINS; CHILD; CONTINENTAL POPULATION GROUPS; ETHNIC GROUPS; FRAGILE X SYNDROME; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GERMANY; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; POLYMORPHISM, GENETIC; REFERENCE VALUES; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; UNITED STATES; VARIATION (GENETICS);

EID: 0032904498     PISSN: 13646745     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100480050064     Document Type: Article

References (22)

1. American Psychiatric Association (1994) Diagnostic and statistical manaul of mental disorders, 4th edn. American Psychiatric Association Press, Washington. D.C.
2. Smalley SL, Asamow RF, Spence A (1988) Autism and genetics. Arch Gen Psychiatry 45:953-961
3. Brown WT, Jenkins EC, Friedman E, Brooks J, Wisniewski K, Raguthu S, French J (1982) Autism is associated with the fragile X syndrome. J Autism Dev Disord 12:303-308
4. Smalley SL (1997) Genetic influences in childhood-onset psychiatric disorders: autism and attention-deficit/hyperactivity disorder. Am J Hum Genet 60:1276-1282
5. Kuperman S, Beeghly JHL, Burns TL, Tsai LY (1985) Serotonin relationships of autistic probands and their first-degree relatives. J Am Acad Child Adolesc Psychiatry 24:186-190
6. Gordon CT, State RC, Nelson JE, Hamburger SD, Rapoport JL (1993) A double-blind comparison of clomipramine, desi-pramine, and placebo in the treatment of autistic disorder. Arch Gen Psychiatry 50:441-447
7. McDougle CJ, Naylor ST, Cohen DJ, Volkman FR, Price LH (1996) A double-blind, placebo-controlled study of fluvoxam-ine in adults with autistic disorder. Arch Gen Psychiatry 53:1001-1008
8. Anderson GM, Freedman DX, Cohen DJ, Volkmar FR, Hoder EL, McPhedran P, Minderaa RB, Hansen CR, Young JG (1987) Whole blood serotonin in autistic and normal sub-jects. J Child Psychol Psychiatry 28:885-900
9. Abramson RK, Wright HH, Carpenter R, Brennan W, Lum-puy O, Cole E, Young SR (1989) Elevated blood serotonin in autistic probands and their first-degree relatives. J Autism DevDisord 19:397-407
10. Meltzer H, Arora R, Baber R, Tricou B (1981) Serotonin up-take in blood platelets of psychiatric patients. Arch Gen Psychiatry 38:1322-1329
11. Owen MJ, Nemeroff CB (1994) The role of serotonin in the pathophysiology of depression: focus on the serotonin trans-porter. Clin Chem 40:288-295
12. Lesch KP, Balling U, Gross J, Strauss K, Wolozin BL, Mur-phy DL, Riederer P (1994) Organization of human serotonin transporter gene. J Neural Transm 95:157-164
13. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, Lesch KP (1996) Allelic variation of human serotonin trans-porter gene expression. J Neurochem 66:2621-2624
14. Lesch K-P, Bengel D, Heils A, Sabol SZ, Greenberg BD, Pe-tri S, Benjamin J, Muler CR, Hamer DH, Murphy DL (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531
15. Cook EH, Courchesne R, Lord C, Cox NJ, Yan S, Lincoln A, Haas R, Courchesne E, Leventhal BL (1997) Evidence of linkage between the serotonin transporter and autistic disorder. Mol Psychiatry 2:247-250
16. Klauck SM, Poustka F, Benner A, Lesch K-P, Poustka A (1997) Serotonin transporter (5-HTT) gene variants associated with autism? Hum Mol Genet 6:2233-2238
17. Zhong N, Ye L, Dobkin C, Brown WT (1994) Fragile X founder chromosome effects: linkage disequilibrium or microsatellite heterogeneity? Am J Med Genet 51:405-411
18. Brown WT, Houck GE Jr, Jeziorowska A, Levinson FN, Ding X-H, Dobkin C, Zhong N, Henderson J, Sklower-Brooks S, Jenkins EC (1993) Rapid fragile X carrier screening and prenatal diagnosis using a nonradioactive PCR test. JAMA 270:1569-1575
19. Zhong N, Dobkin C, Brown WT (1993) A complex mutable polymorphism located within the fragile X gene. Nat Genet 5:248-253
20. Brown WT, Jenkins EC, Cohen IL, Fisch GS, Wolf-Schein EG, Gross A, Waterhouse L, Fein D, Mason-Broghers A, Ritvo E, Ruttenberg BA, Castells S, Buckley W (1986) Fragile X and autism: a multicenter survey. Am J Med Genet 23:341-352
21. Heils A, Teufel A, Petri S, Stoeber G, Riederer P, Bengel D, Lesch KP (1996) Allelic variation of human serotonin transporter gene expression. J Neurochem 66:2621-2624
22. International Molecular Genetic Study of Autism Consortium (1998) A full genome screen for autism with evidence for linkage to a region on chromosome 7q. Hum Mol Genet 7:571-578