Clinical significance of telomerase and its associate genes expression in the maintenance of telomere length in squamous cell carcinoma of the esophagus

World Journal of Gastroenterology

Volumn 11, Issue 44, 2005, Pages 6941-6947

  Hsu, Chung Ping ^a,b   Lee, Li Wen ^a   Shai, Sen Ei ^a   Chen, Chih Yi ^a  

^a TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Esophageal cancer; hTERT; Telomerase; Telomere; Terminal restriction fragment length

Indexed keywords

MYC PROTEIN; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; TELOMERIC REPEAT BINDING FACTOR 1; TELOMERIC REPEAT BINDING FACTOR 2; THYMOSTIMULIN;

ADULT; AGED; ARTICLE; CANCER STAGING; CANCER SURVIVAL; CHROMOSOME SIZE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; FEMALE; GENDER; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; METASTASIS POTENTIAL; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; TELOMERE; TELOMERIC REPEAT AMPLIFICATION PROTOCOL; TISSUE DISTRIBUTION; TUMOR DIFFERENTIATION;

EID: 31144440237     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v11.i44.6941     Document Type: Article

References (27)

1. Allshire RC, Dempster M, Hastie ND. Human telomeres contain at least three types of G-rich repeat distributed non-randomly. Nucleic Acids Res 1989; 17: 4611-4627
2. Moyzis RK, Buckingham JM, Cram LS, Dani M, Deaven LL, Jones MD, Meyne J, Ratliff RL, Wu JR. A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci U S A 1988; 85: 6622-6626
3. Cross SH, Allshire RC, McKay SJ, McGill NI, Cooke HJ. Cloning of human telomeres by complementation in yeast. Nature 1989; 338: 771-774
4. Vaziri H, Schachter F, Uchida I, Wei L, Zhu X, Effros R, Cohen D, Harley CB. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet 1993; 52: 661-667
5. Buchkovich KJ, and Greider CW. Telomerase regulation during entry into the cell cycle in normal human T cells. Mol Biol Cell 1996; 7: 1443-1454
6. Harley CB. Telomere loss: mitotic clock or genetic time bomb? Mutat Res 1991; 256: 271-282
7. Stansel RM, de Lange T, Griffith JD. T-loop assembly in vitro involves binding of TRF2 near the 3′ telomeric overhang. EMBO J 2001; 20: 5532-5540
8. Griffith JD, Comeau L, Rosenfield S, Stansel RM, Bianchi A, Moss H, de Lange T. Mammalian telomeres end in a large duplex loop. Cell 1999; 97: 503-514
9. Hsu CP, Miaw J, Hsia JY, Shai SE, Chen CY. Concordant expression of the telomerase-associated genes in non-small cell lung cancer. Eur J Surg Oncol 2003; 29: 594-599
10. Wu TC, Lin P, Hsu CP, Huang YJ, Chen CY, Chung WC, Lee H Ko JL. Loss of telomerase activity may be a potential favorable prognostic marker in lung carcinomas. Lung Cancer 2003; 41: 163-169
11. Hsu CP, Miaw J, Shai SE, Chen CY. Correlation between telomerase expression and terminal restriction fragment length ratio in non-small cell lung cancer-an adjusted measurement and its clinical significance. Eur J Cardiothorac Surg 2004; 26: 425-431
12. Greene FL, Page DL Fleming ID Fritz AG Balch CM Haller DG Morrow M. AJCC Cancer Staging Handbook. 6th ed. New York, Springer-Verlag Inc, 2002: 191-203
13. Wright WE, Shay JW, Piatyszek MA. Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity. Nucleic Acids Res 1995; 23: 3794-3795
14. de Lange T, Shiue L, Myers RM, Cox DR, Naylor SL, Killery AM, Varmus HE. Structure and variability of human chromosome ends. Mol Cell Biol 1990; 10: 518-527
15. Counter CM, Avilion AA, LeFeuvre CE, Stewart NG, Greider CW, Harley CB, Bacchetti S. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J 1992; 11: 1921-1929
16. Wright WE, Shay JW. Cellular senescence as a tumor-protection mechanism: the essential role of counting. Curr Opin Genet Dev. 2001; 11: 98-103
17. Schreiber-Agus N, DePinho RA. Repression by the Mad(Mxi1)-Sin3 complex. Bioessays 1998; 20: 808-818
18. Ayer DE, Kretzner L, Eisenman RN. Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell 1993; 72: 211-222
19. van Steensel B, Smogorzewska A, de Lange T. TRF2 protects human telomeres from end-to-end fusions. Cell 1998; 92: 401-413
20. van Steensel B, de Lange T. Control of telomere length by the human telomeric protein TRF1. Nature 1997; 385: 740-743
21. Smith S, Giriat I, Schmitt A, de Lange T. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science 1998; 282: 1484-1487
22. Ikeguchi M, Unate H, Maeta M, Kaibara N. Detection of telomerase activity in esophageal squamous cell carcinoma and normal esophageal epithelium. Langenbecks Arch Surg 1999; 384: 550-555
23. Koyanagi K, Ozawa S, Ando N, Kitagawa Y, Ueda M, and Kitajima M. Clinical significance of telomerase activity in peripheral blood of patients with esophageal squamous cell carcinoma. Ann Thorac Surg 2002; 73: 927-932
24. Koyanagi K, Ozawa S, Ando N, Kitagawa Y, Ueda M, Kitajima M. Clinical significance of telomerase activity in peripheral blood of patients with esophageal squamous cell carcinoma. Ann Thorac Surg 2002; 73: 927-932
25. Bryan TM, Englezou A, Gupta J, Bacchetti S, Reddel RR. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J 1995; 14: 4240-4248
26. Bryan TM, Englezou A, Dalla-Pozza L, Dunham MA, Reddel RR. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat Med 1997; 3: 1271-1274
27. Karlseder J, Smogorzewska A, de Lange T. Senescence induced by altered telomere state, not telomere loss. Science 2002; 295: 2446-2449