Nitric oxide/cGMP-mediated effects in the outflow region of the lower urinary tract - Is there a basis for pharmacological targeting of cGMP?

World Journal of Urology

Volumn 23, Issue 6, 2005, Pages 362-367

  Hedlund, Petter ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Phosphodiesterases; Prostate; Relaxation; Smooth muscle; Urethra

Indexed keywords

CYCLIC GMP; NITRIC OXIDE;

BLADDER; ENZYMOLOGY; HUMAN; MALE; MUSCLE CONTRACTION; PHYSIOLOGY; PROSTATE; PROSTATE HYPERTROPHY; REVIEW; SMOOTH MUSCLE; URETHRA;

CYCLIC GMP; HUMANS; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NITRIC OXIDE; PROSTATE; PROSTATIC HYPERPLASIA; URETHRA; URINARY BLADDER;

EID: 31144438087     PISSN: 07244983     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00345-005-0019-1     Document Type: Review

References (69)

1. Andersson KE (2002) Alpha-adrenoceptors and benign prostatic hyperplasia: Basic principles for treatment with alpha-adrenoceptor antagonists. World J Urol 19:390-396 12022707
2. Andersson KE, Wein AJ (2004) Pharmacology of the lower urinary tract: basis for current and future treatments of urinary incontinence. Pharmacol Rev 56:581-631 10.1124/pr.56.4.4
3. Andersson KE (2001) Neurotransmission and drug effects in urethral smooth muscle. Scand J Urol Nephrol Suppl 207:26-34 10.1080/ 003655901750174854
4. Persson K, Alm P, Johansson K, Larsson B, Andersson KE (1993) Nitric oxide synthase in pig lower urinary tract: Immunohistochemistry, NADPH diaphorase histochemistry and functional effects. Br J Pharmacol 110:521-530 7694752
5. Dixon JS, Jen PY (1995) Development of nerves containing nitric oxide synthase in the human male urogenital organs. Br J Urol 76:719-725 8535715
6. Hedlund P, Ekstrom P, Larsson B, Alm P, Andersson KE (1997) Heme oxygenase and NO-synthase in the human prostate-relation to adrenergic, cholinergic and peptide-containing nerves. J Auton Nerv Syst 63(3):115-126 10.1016/S0165-1838(96)00139-7
7. Lincoln TM, Cornwell TL (1993) Intracellular cyclic GMP receptor proteins. FASEB J 7:328-338 7680013
8. Rand MJ, Li CG (1995) Nitric oxide as a neurotransmitter in peripheral nerves: Nature of transmitter and mechanism of transmission. Annu Rev Physiol 57:659-682 10.1146/annurev.ph.57.030195.003303
9. Dixon JS, Jen PY, Gosling JA (1997) A double-label immunohistochemical study of intramural ganglia from the human male urinary bladder neck. J Anat 190:125-134 10.1046/j.1469-7580.1997.19010125.x
10. Alm P, Larsson B, Ekblad E, Sundler F, Andersson KE (1993) Immunohistochemical localization of peripheral nitric oxide synthase-containing nerves using antibodies raised against synthesized C- and N-terminal fragments of a cloned enzyme from rat brain. Acta Physiol Scand 148:421-429 7692702
11. Alm P, Zygmunt PK, Iselin C, Larsson B, Uvelius B, Werner S, Andersson KE (1995) Nitric oxide synthase-immunoreactive, adrenergic, cholinergic, and peptidergic nerves of the female rat urinary tract: A comparative study. J Auton Nerv Syst 56:105-114 10.1016/0165-1838(95)00042-7
12. Takeda M, Lepor H (1995) Nitric oxide synthase in dog urethra: A histochemical and pharmacological analysis. Br J Pharmacol 116:2517-2523 8581293
13. Smet PJ, Jonavicius J, Marshall VR, de Vente J (1996) Distribution of nitric oxide synthase-immunoreactive nerves and identification of the cellular targets of nitric oxide in guinea-pig and human urinary bladder by cGMP immunohistochemistry. Neuroscience 71:337-348 10.1016/ 0306-4522(95)00453-X
14. Burnett AL, Lowenstein CJ, Bredt DS, Chang TS, Snyder SH (1992) Nitric oxide: A physiologic mediator of penile erection. Science 17:401-403
15. Ehren I, Iversen H, Jansson O, Adolfsson J, Wiklund NP (1994) Localization of nitric oxide synthase activity in the human lower urinary tract and its correlation with neuroeffector responses. Urology 44(5):683-687 10.1016/S0090-4295(94)80206-8
16. Garcia-Pascual A, Costa G, Labadia A, Persson K, Triguero D (1996) Characterization of nitric oxide synthase activity in sheep urinary tract: Functional implications. Br J Pharmacol 118:905-914 8799561
17. Radziszewski P, Ekblad E, Sundler F, Mattiasson A (1996) Distribution of neuropeptide-, tyrosine hydroxylase- and nitric oxide synthase containing nerve fibers in the external urethral sphincter of the rat. Scand J Urol Nephrol Suppl 179:81-85 8908670
18. Ho KM, McMurray G, Brading AF, Noble JG, Ny L, Andersson KE (1998) Nitric oxide synthase in the heterogeneous population of intramural striated muscle fibres of the human membranous urethral sphincter. J Urol 159:1091-1096 10.1097/00005392-199803000-00153
19. Ho KM, Ny L, McMurray G, Andersson KE, Brading AF, Noble JG (1999) Co-localization of carbon monoxide and nitric oxide synthesizing enzymes in the human urethral sphincter. J Urol 161:1968-1972 10.1097/ 00005392-199906000-00075
20. Andersson KE, Mattiasson A, Sjogren C (1983) Electrically induced relaxation of the noradrenaline contracted isolated urethra from rabbit and man. J Urol 129:210-214 6131147
21. Andersson KE, Garcia Pascual A, Forman A, Tottrup A (1991) Non-adrenergic, non-cholinergic nerve-mediated relaxation of rabbit urethra is caused by nitric oxide. Acta Physiol Scand 141:133-134 2053441
22. Garcia-Pascual A, Costa G, Garcia-Sacristan A, Andersson KE (1991) Relaxation of sheep urethral muscle induced by electrical stimulation of nerves: Involvement of nitric oxide. Acta Physiol Scand 141:53153-53159
23. Hashimoto S, Kigoshi S, Muramatsu I (1993) Nitric oxide-dependent and-independent neurogenic relaxation of isolated dog urethra. Eur J Pharmacol 231:209-214 10.1016/0014-2999(93)90451-M
24. Takeda M, Lepor H (1995) Nitric oxide synthase in dog urethra: A histochemical and pharmacological analysis. Br J Pharmacol 116:2517-2523 8581293
25. Werkstrom V, Persson K, Ny L, Bridgewater M, Brading AF, Andersson KE (1995) Factors involved in the relaxation of female pig urethra evoked by electrical field stimulation. Br J Pharmacol 116:1599-1604 8564225
26. Thornbury KD, Hollywood MA, McHale NG (1992) Mediation by nitric oxide of neurogenic relaxation of the urinary bladder neck muscle in sheep. J Physiol 451:133-144 1403808
27. Garcia-Pascual A, Costa G, Labadia A, Jimenez E, Triguero D (1999) Differential mechanisms of urethral smooth muscle relaxation by several NO donors and nitric oxide. Naunyn Schmiedebergs Arch Pharmacol 360:80-91 10.1007/s002109900038
28. Bennett BC, Kruse MN, Roppolo JR, Flood HD, Fraser M, de Groat WC (1995) Neural control of urethral outlet activity in vivo: Role of nitric oxide. J Urol 153:2004-2009 10.1097/00005392-199506000-00092
29. Reitz A, Bretscher S, Knapp PA, Muntener M, Wefer B, Schurch B (2004) The effect of nitric oxide on the resting tone and the contractile behaviour of the external urethral sphincter: A functional urodynamic study in healthy humans. Eur Urol 45:367-373 10.1016/j.eururo.2003.10.002
30. Persson K, Alm P, Uvelius B, Andersson KE (1998) Nitrergic and cholinergic innervation of the rat lower urinary tract after pelvic ganglionectomy. Am J Physiol 274:R389-R397 9486296
31. Moncada S, Rees DD, Schulz R, Palmer RM (1991) Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo. Proc Natl Acad Sci USA 88:2166-2170 1848694
32. Mumtaz FH, Sullivan ME, Thompson CS, Dashwood MR, Naseem KM, Bruckdorfer KR, Mikhailidis DP, Morgan RJ (1999) Alterations in the nitric oxide synthase binding sites and non-adrenergic, non-cholinergic mediated smooth muscle relaxation in the diabetic rabbit bladder outlet: Possible relevance to the pathogenesis of diabetic cystopathy. J Urol 162(2):558-566 10.1097/00005392-199908000-00087
33. Masuda H, Tsujii T, Okuno T, Kihara K, Goto M, Azuma H (2001) Involvement of accumulated endogenous NOS inhibitors and decreased NOS activity in the impaired neurogenic relaxation of the rabbit proximal urethra with ischaemia. Br J Pharmacol 133:97-106 10.1038/sj.bjp.0704050
34. Holmquist F, Persson K, Bodker A, Anderson KE (1994) Some pre- and post-junctional effects of castration in rabbit isolated corpus cavernosum and urethra. J Urol 152:1011-1016 8051724
35. Burnett AL, Calvin DC, Chamness SL, Liu JX, Nelson RJ, Klein SL, Dawson VL, Dawson TM, Snyder SH (1997) Urinary bladder-urethral sphincter dysfunction in mice with targeted disruption of neuronal nitric oxide synthase models idiopathic voiding disorders in humans. Nat Med 3:571-574 10.1038/nm0597-571
36. Lucas KA, Pitari GM, Kazerounian S, Ruiz-Stewart I, Park J, Schulz S, Chepenik KP, Waldman SA (2000) Guanylyl cyclases and signaling by cyclic GMP. Pharmacol Rev 52:375-414 10977868
37. Persson K, Andersson KE (1994) Non-adrenergic, non-cholinergic relaxation and levels of cyclic nucleotides in rabbit lower urinary tract. Eur J Pharmacol 268:159-167 10.1016/0922-4106(94)90185-6
38. Garcia-Pascual A, Triguero D (1994) Relaxation mechanisms induced by stimulation of nerves and by nitric oxide in sheep urethral muscle. J Physiol 476:333-347 8046647
39. Dokita S, Smith SD, Nishimoto T, Wheeler MA, Weiss RM (1994) Involvement of nitric oxide and cyclic GMP in rabbit urethral relaxation. Eur J Pharmacol 266:269-275 10.1016/0922-4106(94)90136-8
40. Hedlund P, Aszodi A, Pfeifer A, Alm P, Hofmann F, Ahmad M, Fassler R, Andersson KE (2000) Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice. Proc Natl Acad Sci USA 97:2349-2354 10.1073/ pnas.030419997
41. Persson K, Pandita RK, Aszodi A, Ahmad M, Pfeifer A, Fassler R, Andersson KE (2000) Functional characteristics of urinary tract smooth muscles in mice lacking cGMP protein kinase type I. Am J Physiol Regul Integr Comp Physiol 279:R1112-R1120 10956273
42. Malmqvist U, Hedlund P, Sward K, Andersson KE (2004) Female pig urethral tone is dependent on Rho guanosine triphosphatases and Rho-associated kinase. J Urol 171:1955-1958 10.1097/01.ju.0000121601.95857.5a
43. Komalavilas P, Lincoln TM (1994) Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase. J Biol Chem 269:8701-8107 8132598
44. Sawada N, Itoh H, Yamashita J, Doi K, Inoue M, Masatsugu K, Fukunaga Y, Sakaguchi S, Sone M, Yamahara K, Yurugi T, Nakao K (2001) cGMP-dependent protein kinase phosphorylates and inactivates RhoA. Biochem Biophys Res Commun 280:798-805 10.1006/bbrc.2000.4194
45. Bonnevier J, Arner A (2004) Actions downstream of cyclic GMP/protein kinase G can reverse protein kinase C-mediated phosphorylation of CPI-17 and Ca(2+) sensitization in smooth muscle. Biol Chem 279:28998-289003 10.1074/jbc.M404259200
46. Chang S, Hypolite JA, Velez M, Changolkar A, Wein AJ, Chacko S, DiSanto ME (2004) Downregulation of cGMP-dependent protein kinase-1 activity in the corpus cavernosum smooth muscle of diabetic rabbits. Am J Physiol Regul Integr Comp Physiol 287:R950-R960 15205187
47. Wheeler MA, Pontari M, Dokita S, Nishimoto T, Cho YH, Hong KW, Weiss RM (1997) Age-dependent changes in particulate and soluble guanylyl cyclase activities in urinary tract smooth muscle. Mol Cell Biochem 169:115-124 10.1023/A:1006823611864
48. Stasch JP, Becker EM, Alonso-Alija C, Apeler H, Dembowsky K, Feurer A, Gerzer R, Minuth T, Perzborn E, Pleiss U, Schroder H, Schroeder W, Stahl E, Steinke W, Straub A, Schramm M (2001) NO-independent regulatory site on soluble guanylate cyclase. Nature 410:212-215 10.1038/35065611
49. Schroder A, Hedlund P, Andersson KE (2004) Carbon monoxide relaxes the female pig urethra as effectively as nitric oxide in the presence of YC-1. J Urol 167:1892-1896
50. Thornbury KD, Donaghy KM, Peake J (1995) Characteristics of the NANC post-stimulus ('rebound') contraction of the urinary bladder neck muscle in sheep. Br J Pharmacol 116:2451-2456 8581284
51. Wibberley A, Nunn PA, Naylor AM, Ramage AG (2002) An investigation of the effects of zaprinast, a PDE inhibitor, on the nitrergic control of the urethra in anaesthetized female rats. Br J Pharmacol 136:399-414 10.1038/sj.bjp.0704735
52. Hedlund P, Larsson B, Alm P, Andersson KE (1996) Nitric oxide synthase-containing nerves and ganglia in the dog prostate: A comparison with other transmitters. Histochem J 28:635-642 8910034
53. Burnett AL, Maguire MP, Chamness SL, Ricker DD, Takeda M, Lepor H, Chang TS (1995) Characterization and localization of nitric oxide synthase in the human prostate. Urology 45:435-439 10.1016/S0090-4295(99)80012-0
54. Di Iulio JL, Li CG, Rand MJ (1997) Determination of nitric oxide synthase activity in rat, pig and rabbit prostate glands. Eur J Pharmacol 337:245-249 10.1016/S0014-2999(97)01269-7
55. Crone JK, Burnett AL, Chamness SL, Strandberg JD, Chang TS (1998) Neuronal nitric oxide synthase in the canine prostate: Aging, sex steroid, and pathology correlations. J Androl 19:358-364 9639053
56. Hayek OR, Shabsigh A, Kaplan SA, Kiss AJ, Chen MW, Burchardt T, Burchardt M, Olsson CA, Buttyan R (1997) Castration induces acute vasoconstriction of blood vessels in the rat prostate concomitant with a reduction of prostatic nitric oxide synthase activity. J Urol 162:1527-1531
57. Gradini R, Realacci M, Ginepri A, Naso G, Santangelo C, Cela O, Sale P, Berardi A, Petrangeli E, Gallucci M, Di Silverio F, Russo MA (1999) Nitric oxide synthases in normal and benign hyperplastic human prostate: immunohistochemistry and molecular biology. J Pathol 189:224-229 10547579
58. Lindberg C, Dizeyi N, Malmqvist U, Abrahamsson P-A, Andersson K-E, Hedlund P (2004) Increased expression of RhoA in prostates from spontaneously hypertensive rats. J Urol 171:348
59. Aikawa K, Yokota T, Okamura H, Yamaguchi O (2001) Endogenous nitric oxide-mediated relaxation and nitrinergic innervation in the rabbit prostate: The changes with aging. Prostate 48:40-46 10.1002/pros.1079
60. Takeda M, Tang R, Shapiro E, Burnett AL, Lepor H (1995) Effects of nitric oxide on human and canine prostates. Urology 45:440-446 10.1016/ S0090-4295(99)80013-2
61. Najbar-Kaszkiel AT, Di Iulio JL, Li CG, Rand MJ (1997) Characterisation of excitatory and inhibitory transmitter systems in prostate glands of rats, guinea pigs, rabbits and pigs. Eur J Pharmacol 337:251-258 10.1016/ S0014-2999(97)01270-3
62. Uckert S, Kuthe A, Jonas U, Stief CG (2001) Characterization and functional relevance of cyclic nucleotide phosphodiesterase isoenzymes of the human prostate. J Urol 166:2484-2490 10.1097/ 00005392-200112000-00127
63. Klotz T, Mathers MJ, Bloch W, Nayal W, Engelmann U (1999) Nitric oxide based influence of nitrates on micturition in patients with benign prostatic hyperplasia. Int Urol Nephrol 3:335-341 10.1023/A:1007174102953
64. Essayan DM (2001) Cyclic nucleotide phosphodiesterases. J Allergy Clin Immunol 108:671-680 10.1067/mai.2001.119555
65. Stacey P, Rulten S, Dapling A, Phillips SC (1998) Molecular cloning and expression of human cGMP-binding cGMP-specific phosphodiesterase (PDE5). Biochem Biophys Res Commun 247:249-254 10.1006/bbrc.1998.8769
66. Fawcett L, Baxendale R, Stacey P, McGrouther C, Harrow I, Soderling S, Hetman J, Beavo JA, Phillips SC (2000) Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. Proc Natl Acad Sci USA 97:3702-3707 10.1073/pnas.050585197
67. Sairam K, Kulinskaya E, McNicholas TA, Boustead GB, Hanbury DC (2002) Sildenafil influences lower urinary tract symptoms. BJU Int 90:836-839 10.1046/j.1464-410X.2002.03040.x
68. Chapple CR (2004) Pharmacological therapy of benign prostatic hyperplasia/lower urinary tract symptoms: An overview for the practising clinician. BJU Int 94:738-744 10.1111/j.1464-410X.2004.05022.x
69. Mamas MA, Reynard JM, Brading AF (2001) Augmentation of nitric oxide to treat detrusor-external sphincter dyssynergia in spinal cord injury. Lancet 357:1964-1967 10.1016/S0140-6736(00)05069-8