Biological complexity and drug discovery: A practical systems biology approach

IEE Proceedings Systems Biology

Volumn 152, Issue 4, 2005, Pages 201-206

  Berg, E L ^a   Kunkel, E J ^a   Hytopoulos, E ^a  

^a BioSeek Inc   (United States)

Author keywords

Biological complexity; Biologically multiplexed activity profiling; Cellular biophysics; Complex engineering systems; Diseases; Drugs; Human cell based assay; Human disease biology; Inflammation drug discovery; Modularity; Molecular biophysics; Practical systems biology; Protein datasets; Proteins; Redundancy; Robustness; Statistical analysis

Indexed keywords

CELLS; DISEASES; DRUG PRODUCTS; PROTEINS; STATISTICAL METHODS;

BIOLOGICAL COMPLEXITY; BIOLOGICALLY MULTIPLEXED ACTIVITY PROFILING; DRUG DISCOVERY;

BIOLOGY;

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; ASTEMIZOLE; ATORVASTATIN; AZATHIOPRINE; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; BUDESONIDE; CAPTOPRIL; CLEMASTINE; COMPACTIN; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLOSPORIN; DEXAMETHASONE; ENALAPRILAT; GELDANAMYCIN; KENPAULLONE; KETOTIFEN FUMARATE; LEFLUNOMIDE; LISINOPRIL; MEVINOLIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PREDNISOLONE; PROPRANOLOL; RADICICOL; RAPAMYCIN; ROSCOVITINE; SIMVASTATIN; TACROLIMUS; TRIPROLIDINE; UNINDEXED DRUG; WORTMANNIN;

ARTICLE; BIOENGINEERING; CELL ASSAY; CELL CULTURE; DRUG MECHANISM; DRUG SELECTIVITY; ENDOTHELIUM CELL; FEEDBACK SYSTEM; HUMAN; MOLECULAR BIOLOGY; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION; STATISTICAL ANALYSIS; VALIDATION PROCESS;

ANIMALS; BIOLOGICAL ASSAY; CELL PHYSIOLOGY; COMPUTER SIMULATION; DRUG DESIGN; GENE EXPRESSION PROFILING; HUMANS; MODELS, BIOLOGICAL; PHARMACOLOGY; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY;

EID: 31144438009     PISSN: 17412471     EISSN: None     Source Type: Journal    
DOI: 10.1049/ip-syb:20050036     Document Type: Article

References (11)

1. Csete, M.E., and Doyle, J.C.: 'Reverse engineering of biological complexity', Science, 2002, 295, p. 1664-1669 0036-8075
2. Kitano, H.: 'TSystems biology: toward system-level understanding of biological systems', Kitano, H., Foundations of systems biology, (MIT Press, Cambridge, MA 2001), p. 1-29
3. Butcher, E.C., Berg, E.L., and Kunkel, E.J.: 'Systems biology in drug discovery', Nat. Biotechnol., 2004, 22, (10), p. 1253-1259
4. Berg, E.L., Hytopoulos, E., Plavec, I., and Kunkel, E.J.: 'Approaches to the analysis of cell signaling networks and their application in drug discovery', Curr. Opin. Drug Discov. Devel., 2005 8, (1), p. 107-114
5. Kunkel, E.J., Plavec, I., Nguyen, D., Melrose, J., Rosler, E.S. Kao, L.T., Wang, Y., Hytopoulos, E., Bishop, A.C., Bateman, R., Shokat, K.M., Butcher, E.C., and Berg, E.L.: 'Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based models', Assay Drug Dev. Technol., 2004, 2, (4), p. 431-441
6. Kunkel, E.J., Dea, M., Ebens, A., Hytopoulos, E., Melrose, J., Nguyen, D., Ota, K.S., Plavec, I., Wang, Y., Watson, S.R., Butcher, E.C., and Berg, E.L.: 'An integrative biology approach for analysis of drug action in models of human vascular inflammation', FASEB J., 2004, 18, (11), p. 1279-1281
7. Butcher, E.C.: 'Can cell systems biology rescue drug discovery?', Nat. Rev. Drug Discov., 2005, 4, (6), p. 461-467
8. Storey, J.D., and Tibshirani, R.: 'Statistical significance for genomewide studies', Proc. Natl. Acad. Sci. USA, 2003, 100, (16), p. 9440-9445 0027-8424
9. Kim, D., Aizawa, T., Wei, H., Pi, X., Rybalkin, S.D., Berk, B.C., and Yan, C.: 'Angiotensin II increases phosphodiesterase 5A expression in vascular smooth muscle cells: A mechanism by which angiotensin II antagonizes cGMP signaling', J. Mol. Cell Cardiol., 2005, 38, (1), p. 175-184
10. Mestas, J., and Hughes, C.: 'Of mice and men: Differences between mouse and human immunology', J. Immunol. 2004, 172,. p 2731-2738
11. Plavec, I., Sirenko, O., Privat, S., Wang, Y., Dajee, M., Melrose, J., Nakao, B., Hytopoulos, E., Berg, E.L., and Butcher, E.C.: 'Method for analyzing signaling networks in complex cellular systems', Proc. Natl. Acad. Sci. USA, 2004, 101, (5), p. 1223-1228 0027-8424