Thick filament proteins and performance in human heart failure

Heart Failure Reviews

Volumn 10, Issue 3, 2005, Pages 187-197

  Palmer, Bradley M ^a  

^a UNIVERSITY OF VERMONT   (United States)

Author keywords

Cardiomyopathy; Myosin; Myosin binding protein C; Titin

Indexed keywords

ADENOSINE TRIPHOSPHATASE (MAGNESIUM); CALCIUM ION; ISOPROTEIN; MUSCLE PROTEIN; MYOSIN ADENOSINE TRIPHOSPHATASE; MYOSIN HEAVY CHAIN ALPHA; MYOSIN HEAVY CHAIN BETA; MYOSIN LIGHT CHAIN;

GENE MUTATION; HEART ATRIUM; HEART DISEASE; HEART FAILURE; HEART MUSCLE; HEART MUSCLE CONTRACTILITY; HEART PERFORMANCE; HEART VENTRICLE; HUMAN; MYOFILAMENT; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVIEW;

CA(2+) MG(2+)-ATPASE; CALCIUM; CARDIOMYOPATHIES; CARRIER PROTEINS; HEART FAILURE, CONGESTIVE; HUMANS; KINETICS; MICROFILAMENT PROTEINS; MUSCLE PROTEINS; MUSCLE RELAXATION; MYOCARDIAL CONTRACTION; MYOFIBRILS; MYOSINS; PROTEIN KINASES;

EID: 30944461059     PISSN: 13824147     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10741-005-5249-1     Document Type: Review

References (104)

1. Kako K, Bing RJ. Contractility of actomyosin bands prepared from normal and failing human hearts. J Clin Invest 1958;37(3):465-470. 1:CAS:528:DyaG1cXlslCjsQ%3D%3D
2. Alpert NR, Gordon MS. Myofibrillar adenosine triphosphatase activity in congestive heart failure. Am J Physiol 1962;202:940-946. 1:CAS:528:DyaF38Xkt1GrsL0%3D
3. de Tombe PP. Congestive heart failure: Role of cross-bridge cycle kinetics. Cardiovasc Res 1998;40(3):440-443.
4. Bennett PM, Furst DO, Gautel M. The C-protein (myosin binding protein C) family: Regulators of contraction and sarcomere formation? Rev Physiol Biochem Pharmacol 1999;138:203-234. 1:CAS:528:DyaK1MXktVejsb0%3D
5. Morano I. Tuning the human heart molecular motors by myosin light chains. J Mol Med 1999;77(7):544-555. 10.1007/s001099900031
6. Alpert NR, Mulieri LA, Warshaw D. The failing human heart. Cardiovasc Res 2002;54(1):1-10. 10.1016/S0008-6363(02)00248-1
7. van der Velden J, Papp Z, Boontje NM, Zaremba R, de Jong JW, Janssen PM, et al. The effect of myosin light chain 2 dephosphorylation on Ca2+ -sensitivity of force is enhanced in failing human hearts. Cardiovasc Res 2003;57(2):505-514. 1:CAS:528:DC%2BD3sXptFCmsg%3D%3D
8. Granzier HL, Labeit S. The giant protein titin: A major player in myocardial mechanics, signaling, and disease. Circ Res 2004;94(3):284-295. 10.1161/01.RES.0000117769.88862.F8
9. Schmid MF, Epstein HF. Muscle thick filaments are rigid coupled tubules, not flexible ropes. Cell Motil Cytoskeleton 1998;41(3):195-201. 10.1002/ (SICI)1097-0169(1998)41:3<195::AID-CM1>3.0.CO;2-7
10. Squire J, Cantino M, Chew M, Denny R, Harford J, Hudson L, et al. Myosin rod-packing schemes in vertebrate muscle thick filaments. J Struct Biol 1998;122(1/2):128-138. 1:CAS:528:DyaK1cXmtVSru70%3D
11. Higuchi H, Yanagida T, Goldman YE. Compliance of thin filaments in skinned fibers of rabbit skeletal muscle. Biophys J 1995;69(3):1000-1110. 1:CAS:528:DyaK2MXnsl2rt7s%3D
12. Huxley HE, Stewart A, Sosa H, Irving T. X-ray diffraction measurements of the extensibility of actin and myosin filaments in contracting muscle. Biophys J 1994;67(6):2411-2421. 1:CAS:528:DyaK2MXisVajurc%3D
13. Wakabayashi K, Sugimoto Y, Tanaka H, Ueno Y, Takezawa Y, Amemiya Y. X-ray diffraction evidence for the extensibility of actin and myosin filaments during muscle contraction. Biophys J 1994;67(6):2422-2435. 1:CAS:528:DyaK2MXisVaju74%3D
14. Tyska MJ, Warshaw DM. The myosin power stroke. Cell Motil Cytoskeleton 2002;51(1):1-15. 10.1002/cm.10014
15. Lymn RW, Taylor EW. Mechanism of adenosine triphosphate hydrolysis by actomyosin. Biochemistry 1971;10(25):4617-4624. 10.1021/bi00801a004
16. Eisenberg E, Hill TL. A cross-bridge model of muscle contraction. Prog Biophys Mol Biol 1978;33(1):55-82. 1:CAS:528:DyaE1cXhs1OitLw%3D
17. Hirzel HO, Tuchschmid CR, Schneider J, Krayenbuehl HP, Schaub MC. Relationship between myosin isoenzyme composition, hemodynamics, and myocardial structure in various forms of human cardiac hypertrophy. Circ Res 1985;57(5):729-740. 1:CAS:528:DyaL2MXmtFalsrY%3D
18. Pagani ED, Alousi AA, Grant AM, Older TM, Dziuban SW, Jr., Allen PD. Changes in myofibrillar content and Mg-ATPase activity in ventricular tissues from patients with heart failure caused by coronary artery disease, cardiomyopathy, or mitral valve insufficiency. Circ Res 1988;63(2):380-385. 1:CAS:528:DyaL1cXlt1Kktr0%3D
19. Unverferth DV, Lee SW, Wallick ET. Human myocardial adenosine triphosphatase activities in health and heart failure. Am Heart J 1988;115(1 Pt 1):139-146. 1:STN:280:BieC3czit1I%3D
20. Hasenfuss G, Mulieri LA, Leavitt BJ, Allen PD, Haeberle JR, Alpert NR. Alteration of contractile function and excitation-contraction coupling in dilated cardiomyopathy. Circ Res 1992;70(6):1225-1232. 1:STN:280:By2B2cfos1A%3D
21. Alpert NR, Leavitt BJ, Ittleman FP, Hasenfuss G, Pieske B, Mulieri LA. A mechanistic analysis of the force-frequency relation in non-failing and progressively failing human myocardium. Basic Res Cardiol 1998;93 (Suppl 1):23-32. 9833127
22. Alousi AA, Grant AM, Etzler JR, Cofer BR, Van der Bel-Kahn J, Melvin D. Reduced cardiac myofibrillar Mg-ATPase activity without changes in myosin isozymes in patients with end-stage heart failure. Mol Cell Biochem 1990;96(1):79-88. 10.1007/BF00228455
23. Nguyen TT, Hayes E, Mulieri LA, Leavitt BJ, ter Keurs HE, Alpert NR, et al. Maximal actomyosin ATPase activity and in vitro myosin motility are unaltered in human mitral regurgitation heart failure. Circ Res 1996;79(2):222-226. 1:CAS:528:DyaK28Xkslyiurs%3D
24. van der Velden J, Klein LJ, van der Bijl M, Huybregts MA, Stooker W, Witkop J, et al. Isometric tension development and its calcium sensitivity in skinned myocyte-sized preparations from different regions of the human heart. Cardiovasc Res 1999;42(3):706-719. 10.1016/ S0008-6363(98)00337-X
25. Noguchi T, Camp P, Jr., Alix SL, Gorga JA, Begin KJ, Leavitt BJ, et al. Myosin from failing and non-failing human ventricles exhibit similar contractile properties. J Mol Cell Cardiol 2003;35(1):91-97. 10.1016/ S0022-2828(02)00282-1
26. Alpert NR, Brosseau C, Federico A, Krenz M, Robbins J, Warshaw DM. Molecular mechanics of mouse cardiac myosin isoforms. Am J Physiol Heart Circ Physiol 2002;283(4):H1446-1454.
27. Mercadier JJ, Bouveret P, Gorza L, Schiaffino S, Clark WA, Zak R, et al. Myosin isoenzymes in normal and hypertrophied human ventricular myocardium. Circ Res 1983;53(1):52-62. 1:CAS:528:DyaL3sXks1ynsrk%3D
28. Gorza L, Mercadier JJ, Schwartz K, Thornell LE, Sartore S, Schiaffino S. Myosin types in the human heart. An immunofluorescence study of normal and hypertrophied atrial and ventricular myocardium. Circ Res 1984;54(6):694-702. 1:CAS:528:DyaL2MXht12kuro%3D
29. Bouvagnet P, Mairhofer H, Leger JO, Puech P, Leger JJ. Distribution pattern of alpha and beta myosin in normal and diseased human ventricular myocardium. Basic Res Cardiol 1989;84(1):91-102. 10.1007/ BF01907006
30. Miyata S, Minobe W, Bristow MR, Leinwand LA. Myosin heavy chain isoform expression in the failing and nonfailing human heart. Circ Res 2000;86(4):386-390. 1:CAS:528:DC%2BD3cXhvVektLY%3D
31. Reiser PJ, Portman MA, Ning XH, Schomisch Moravec C. Human cardiac myosin heavy chain isoforms in fetal and failing adult atria and ventricles. Am J Physiol Heart Circ Physiol 2001;280(4):H1814-1820. 1:CAS:528:DC%2BD3MXjtV2itL4%3D
32. Schaub MC, Tuchschmid CR, Srihari T, Hirzel HO. Myosin isoenzymes in human hypertrophic hearts. Shift in atrial myosin heavy chains and in ventricular myosin light chains. Eur Heart J 1984;5 (Suppl F):85-93. 1:CAS:528:DyaL2MXkt1Slt74%3D
33. VanBuren P, Harris DE, Alpert NR, Warshaw DM. Cardiac V1 and V3 myosins differ in their hydrolytic and mechanical activities in vitro. Circ Res 1995;77(2):439-444. 1:CAS:528:DyaK2MXntFartLc%3D
34. Metzger JM, Wahr PA, Michele DE, Albayya F, Westfall MV. Effects of myosin heavy chain isoform switching on Ca2+-activated tension development in single adult cardiac myocytes. Circ Res 1999;84(11):1310-1317. 1:CAS:528:DyaK1MXjslelt7k%3D
35. Herron TJ, McDonald KS. Small amounts of alpha-myosin heavy chain isoform expression significantly increase power output of rat cardiac myocyte fragments. Circ Res 2002;90(11):1150-1152. 10.1161/ 01.RES.0000022879.57270.11
36. Korte FS, Herron TJ, Rovetto MJ, McDonald KS. Power output is linearly related to MyHC content in rat skinned myocytes and isolated working hearts. Am J Physiol Heart Circ Physiol 2005;289(2):H801-812.
37. Carniel E, Taylor MR, Sinagra G, Di Lenarda A, Ku L, Fain PR, et al. Alpha-myosin heavy chain: A sarcomeric gene associated with dilated and hypertrophic phenotypes of cardiomyopathy. Circulation 2005;112(1):54-59. 10.1161/CIRCULATIONAHA.104.507699
38. Lowes BD, Minobe W, Abraham WT, Rizeq MN, Bohlmeyer TJ, Quaife RA, et al. Changes in gene expression in the intact human heart. Downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium. J Clin Invest 1997;100(9):2315-2324. 1:CAS:528:DyaK2sXnt1GgsLc%3D
39. Nakao K, Minobe W, Roden R, Bristow MR, Leinwand LA. Myosin heavy chain gene expression in human heart failure. J Clin Invest 1997;100(9):2362-2370. 1:CAS:528:DyaK2sXnt1Ggsbs%3D
40. Abraham WT, Gilbert EM, Lowes BD, Minobe WA, Larrabee P, Roden RL, et al. Coordinate changes in Myosin heavy chain isoform gene expression are selectively associated with alterations in dilated cardiomyopathy phenotype. Mol Med 2002;8(11):750-760. 1:CAS:528:DC%2BD3sXps1Wkuw%3D%3D
41. Hwang JJ, Allen PD, Tseng GC, Lam CW, Fananapazir L, Dzau VJ, et al. Microarray gene expression profiles in dilated and hypertrophic cardiomyopathic end-stage heart failure. Physiol Genomics 2002;10(1):31-44. 1:CAS:528:DC%2BD38XmsFait74%3D
42. Sucharov CC, Helmke SM, Langer SJ, Perryman MB, Bristow M, Leinwand L. The Ku protein complex interacts with YY1, is up-regulated in human heart failure, and represses alpha myosin heavy-chain gene expression. Mol Cell Biol 2004;24(19):8705-8715. 10.1128/MCB.24.19.8705-8715.2004
43. James J, Robbins J. Molecular remodeling of cardiac contractile function. Am J Physiol 1997;273(5 Pt 2):H2105-2118. 1:CAS:528:DyaK2sXnsVClu7Y%3D
44. Morano I, Hadicke K, Haase H, Bohm M, Erdmann E, Schaub MC. Changes in essential myosin light chain isoform expression provide a molecular basis for isometric force regulation in the failing human heart. J Mol Cell Cardiol 1997;29(4):1177-1187. 10.1006/jmcc.1996.0353
45. Morano M, Zacharzowski U, Maier M, Lange PE, Alexi-Meskishvili V, Haase H, et al. Regulation of human heart contractility by essential myosin light chain isoforms. J Clin Invest 1996;98(2):467-473. 1:CAS:528:DyaK28XksFCltrg%3D
46. Schaub MC, Hefti MA, Zuellig RA, Morano I. Modulation of contractility in human cardiac hypertrophy by myosin essential light chain isoforms. Cardiovasc Res 1998;37(2):381-404. 10.1016/S0008-6363(97)00258-7
47. Morano I, Haase H. Different actin affinities of human cardiac essential myosin light chain isoforms. FEBS Lett 1997;408(1):71-74. 10.1016/ S0014-5793(97)00390-6
48. van der Velden J, Klein LJ, Zaremba R, Boontje NM, Huybregts MA, Stooker W, et al. Effects of calcium, inorganic phosphate, and pH on isometric force in single skinned cardiomyocytes from donor and failing human hearts. Circulation 2001;104(10):1140-1146. 1:STN:280:DC%2BD3MvpvFOnsw%3D%3D
49. van der Velden J, Papp Z, Zaremba R, Boontje NM, de Jong JW, Owen VJ, et al. Increased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins. Cardiovasc Res 2003;57(1):37-47. 1:CAS:528:DC%2BD38XpslSlsrg%3D
50. Morano I, Bachle-Stolz C, Katus A, Ruegg JC. Increased calcium sensitivity of chemically skinned human atria by myosin light chain kinase. Basic Res Cardiol 1988;83(4):350-359. 10.1007/BF02005820
51. Makarenko I, Opitz CA, Leake MC, Neagoe C, Kulke M, Gwathmey JK, et al. Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts. Circ Res 2004;95(7):708-716. 10.1161/01.RES.0000143901.37063.2f
52. Opitz CA, Kulke M, Leake MC, Neagoe C, Hinssen H, Hajjar RJ, et al. Damped elastic recoil of the titin spring in myofibrils of human myocardium. Proc Natl Acad Sci USA 2003;100(22):12688-12693. 10.1073/ pnas.2133733100
53. Neagoe C, Kulke M, del Monte F, Gwathmey JK, de Tombe PP, Hajjar RJ, et al. Titin isoform switch in ischemic human heart disease. Circulation 2002;106(11):1333-1341. 10.1161/01.CIR.0000029803.93022.93
54. Nagueh SF, Shah G, Wu Y, Torre-Amione G, King NM, Lahmers S, et al. Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy. Circulation 2004;110(2):155-162. 10.1161/01.CIR.0000135591.37759.AF
55. Granzier H, Helmes M, Cazorla O, McNabb M, Labeit D, Wu Y, et al. Mechanical properties of titin isoforms. Adv Exp Med Biol 2000;481:283-300; discussion 300-304.
56. Morano I, Hadicke K, Grom S, Koch A, Schwinger RH, Bohm M, et al. Titin, myosin light chains and C-protein in the developing and failing human heart. J Mol Cell Cardiol 1994;26(3):361-368. 10.1006/jmcc.1994.1045
57. McDonald KS, Herron TJ. It takes "heart" to win: What makes the heart powerful? News Physiol Sci 2002;17:185-190. 12270954
58. Alpert NR, LeWinter MM, Mulieri LA, Hasenfuss G. Chemomechanical energy transduction in the failing heart. Heart Failure Reviews 1999;4:281-295. 10.1023/A:1009818225222
59. Litten RZ, 3rd, Martin BJ, Low RB, Alpert NR. Altered myosin isozyme patterns from pressure-overloaded and thyrotoxic hypertrophied rabbit hearts. Circ Res 1982;50(6):856-864. 1:STN:280:Bi2B3cbgtVw%3D
60. Sugiura S, Yamashita H. Functional characterization of cardiac myosin isoforms. Jpn J Physiol 1998;48(3):173-179. 10.2170/jjphysiol.48.173
61. Malmqvist UP, Aronshtam A, Lowey S. Cardiac myosin isoforms from different species have unique enzymatic and mechanical properties. Biochemistry 2004;43(47):15058-15065. 10.1021/bi0495329
62. McDonald KS, Moss RL. Strongly binding myosin crossbridges regulate loaded shortening and power output in cardiac myocytes. Circ Res 2000;87(9):768-773. 1:CAS:528:DC%2BD3cXnvVOlu70%3D
63. Fitzsimons DP, Patel JR, Moss RL. Role of myosin heavy chain composition in kinetics of force development and relaxation in rat myocardium. J Physiol 1998;513 (Pt 1):171-183. 1:CAS:528:DyaK1cXotFCitrc%3D
64. Finer JT, Simmons RM, Spudich JA. Single myosin molecule mechanics: Piconewton forces and nanometre steps. Nature 1994;368(6467):113-119. 10.1038/368113a0
65. Tawada K, Sekimoto K. Protein friction exerted by motor enzymes through a weak-binding interaction. J Theor Biol 1991;150(2):193-200. 1:CAS:528:DyaK3MXmtVWgtbs%3D
66. Schoenberg M. Equilibrium muscle cross-bridge behavior. Theoretical considerations. II. Model describing the behavior of strongly-binding cross-bridges when both heads of myosin bind to the actin filament. Biophys J 1991;60(3):679-689. 1:CAS:528:DyaK3MXlvVSgtrw%3D
67. Rundell VL, Manaves V, Martin AF, de Tombe PP. Impact of beta-myosin heavy chain isoform expression on cross-bridge cycling kinetics. Am J Physiol Heart Circ Physiol 2005;288(2):H896-903. 1:CAS:528:DC%2BD2MXhsFelsrs%3D
68. Yamashita H, Sugiura S, Serizawa T, Sugimoto T, Iizuka M, Katayama E, et al. Sliding velocity of isolated rabbit cardiac myosin correlates with isozyme distribution. Am J Physiol 1992;263(2 Pt 2):H464-472. 1:CAS:528:DyaK38Xls1ymsro%3D
69. Sugiura S, Kobayakawa N, Fujita H, Yamashita H, Momomura S, Chaen S, et al. Comparison of unitary displacements and forces between 2 cardiac myosin isoforms by the optical trap technique: Molecular basis for cardiac adaptation. Circ Res 1998;82(10):1029-1034. 1:CAS:528:DyaK1cXjslSjtrs%3D
70. Palmiter KA, Tyska MJ, Dupuis DE, Alpert NR, Warshaw DM. Kinetic differences at the single molecule level account for the functional diversity of rabbit cardiac myosin isoforms. J Physiol 1999;519 (Pt 3):669-678.
71. Sugiura S, Yamashita H, Sata M, Momomura S, Serizawa T, Oiwa K, et al. Force-velocity relations of rat cardiac myosin isozymes sliding on algal cell actin cables in vitro. Biochim Biophys Acta 1995;1231(1):69-75. 7640292
72. Barany M. ATPase activity of myosin correlated with speed of muscle shortening. J Gen Physiol 1967;50(6):(Suppl):197-218. 4227924
73. Hasenfuss G, Mulieri LA, Blanchard EM, Holubarsch C, Leavitt BJ, Ittleman F, et al. Energetics of isometric force development in control and volume-overload human myocardium. Comparison with animal species. Circ Res 1991;68(3):836-846. 1:STN:280:By2D2snlslM%3D
74. Hasenfuss G, Mulieri LA, Leavitt BJ, Allen PD, Holubarsch C, Just H, et al. Contractile protein function in failing and nonfailing human myocardium. Basic Res Cardiol 1992;87 (Suppl 1):107-116. 1:CAS:528:DyaK3sXnvVemtg%3D%3D
75. Holubarsch C, Goulette RP, Litten RZ, Martin BJ, Mulieri LA, Alpert NR. The economy of isometric force development, myosin isoenzyme pattern and myofibrillar ATPase activity in normal and hypothyroid rat myocardium. Circ Res 1985;56(1):78-86. 1:STN:280:BiqD1MbnsFc%3D
76. Alpert NR, Mulieri LA. Heat, mechanics, and myosin ATPase in normal and hypertrophied heart muscle. Fed Proc 1982;41(2):192-198. 1:CAS:528:DyaL38XhtVWktbk%3D
77. Warshaw DM, Guilford WH, Freyzon Y, Krementsova E, Palmiter KA, Tyska MJ, et al. The light chain binding domain of expressed smooth muscle heavy meromyosin acts as a mechanical lever. J Biol Chem 2000;275(47):37167-37172. 10.1074/jbc.M006438200
78. Sanbe A, Gulick J, Hayes E, Warshaw D, Osinska H, Chan CB, et al. Myosin light chain replacement in the heart. Am J Physiol Heart Circ Physiol 2000;279(3):H1355-1364. 1:CAS:528:DC%2BD3cXmvV2qtL8%3D
79. Lange S, Xiang F, Yakovenko A, Vihola A, Hackman P, Rostkova E, et al. The kinase domain of titin controls muscle gene expression and protein turnover. Science 2005;308(5728):1599-1603. 10.1126/science.1110463
80. Freiburg A, Gautel M. A molecular map of the interactions between titin and myosin-binding protein C. Implications for sarcomeric assembly in familial hypertrophic cardiomyopathy. Eur J Biochem 1996;235(1/ 2):317-323. 1:CAS:528:DyaK28Xotlagug%3D%3D
81. Helmes M, Trombitas K, Granzier H. Titin develops restoring force in rat cardiac myocytes. Circ Res 1996;79(3):619-626. 1:CAS:528:DyaK28XlsVOns7s%3D
82. Kellermayer MS, Granzier HL. Elastic properties of single titin molecules made visible through fluorescent F-actin binding. Biochem Biophys Res Commun 1996;221(3):491-497. 10.1006/bbrc.1996.0624
83. Watanabe K, Nair P, Labeit D, Kellermayer MS, Greaser M, Labeit S, et al. Molecular mechanics of cardiac titin's PEVK and N2B spring elements. J Biol Chem 2002;277(13):11549-11558. 10.1074/jbc.M200356200
84. Li H, Linke WA, Oberhauser AF, Carrion-Vazquez M, Kerkvliet JG, Lu H, et al. Reverse engineering of the giant muscle protein titin. Nature 2002;418(6901):998-1002. 10.1038/nature00938
85. Linke WA, Kulke M, Li H, Fujita-Becker S, Neagoe C, Manstein DJ, et al. PEVK domain of titin: An entropic spring with actin-binding properties. J Struct Biol 2002;137(1/2):194-205. 1:CAS:528:DC%2BD38XksVygsLs%3D
86. Wu Y, Bell SP, Trombitas K, Witt CC, Labeit S, LeWinter MM, et al. Changes in titin isoform expression in pacing-induced cardiac failure give rise to increased passive muscle stiffness. Circulation 2002;106(11):1384-1389. 10.1161/01.CIR.0000029804.61510.02
87. Starr R, Offer G. Polypeptide chains of intermediate molecular weight in myosin preparations. FEBS Lett 1971;15(1):40-44. 10.1016/ 0014-5793(71)80075-3
88. Winegrad S. Cardiac myosin binding protein C. Circ Res 1999;84(10):1117-1126. 1:CAS:528:DyaK1MXjsVygsr0%3D
89. Bennett P, Craig R, Starr R, Offer G. The ultrastructural location of C-protein, X-protein and H-protein in rabbit muscle. J Muscle Res Cell Motil 1986;7(6):550-567. 10.1007/BF01753571
90. Craig R, Offer G. The location of C-protein in rabbit skeletal muscle. Proc R Soc Lond B Biol Sci 1976;192(1109):451-461. 1:STN:280:CSmC2snltVc%3D
91. Moos C, Offer G, Starr R, Bennett P. Interaction of C-protein with myosin, myosin rod and light meromyosin. J Mol Biol 1975;97(1):1-9. 1:CAS:528:DyaE2MXmtVaht7c%3D
92. Starr R, Offer G. The interaction of C-protein with heavy meromyosin and subfragment-2. Biochem J 1978;171(3):813-816. 1:CAS:528:DyaE1cXlslGhsrc%3D
93. Squire JM, Luther PK, Knupp C. Structural evidence for the interaction of C-protein (MyBP-C) with actin and sequence identification of a possible actin-binding domain. J Mol Biol 2003;331(3):713-724. 10.1016/ S0022-2836(03)00781-2
94. Kulikovskaya I, McClellan G, Flavigny J, Carrier L, Winegrad S. Effect of MyBP-C binding to actin on contractility in heart muscle. J Gen Physiol 2003;122(6):761-774. 10.1085/jgp.200308941
95. Moolman-Smook J, Flashman E, de Lange W, Li Z, Corfield V, Redwood C, et al. Identification of novel interactions between domains of Myosin binding protein-C that are modulated by hypertrophic cardiomyopathy missense mutations. Circ Res 2002;91(8):704-711. 10.1161/ 01.RES.0000036750.81083.83
96. Flashman E, Redwood C, Moolman-Smook J, Watkins H. Cardiac myosin binding protein C: Its role in physiology and disease. Circ Res 2004;94(10):1279-1289. 10.1161/01.RES.0000127175.21818.C2
97. Gilbert R, Kelly MG, Mikawa T, Fischman DA. The carboxyl terminus of myosin binding protein C (MyBP-C, C-protein) specifies incorporation into the A-band of striated muscle. J Cell Sci 1996;109 (Pt 1):101-111. 1:CAS:528:DyaK28XosVahuw%3D%3D
98. Harris SP, Bartley CR, Hacker TA, McDonald KS, Douglas PS, Greaser ML, et al. Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice. Circ Res 2002;90(5):594-601. 10.1161/ 01.RES.0000012222.70819.64
99. McClellan G, Kulikovskaya I, Flavigny J, Carrier L, Winegrad S. Effect of cardiac myosin-binding protein C on stability of the thick filament. J Mol Cell Cardiol 2004;37(4):823-835. 10.1016/j.yjmcc.2004.05.023
100. Palmer BM, McConnell BK, Li GH, Seidman CE, Seidman JG, Irving TC, et al. Reduced cross-bridge dependent stiffness of skinned myocardium from mice lacking cardiac myosin binding protein-C. Mol Cell Biochem 2004;263(1/2):73-80. 10.1023/B:MCBI.0000041849.60591.45
101. Palmer BM, Georgakopoulos D, Janssen PM, Wang Y, Alpert NR, Belardi DF, et al. Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening. Circ Res 2004;94(9):1249-1255. 10.1161/ 01.RES.0000126898.95550.31
102. Korte FS, McDonald KS, Harris SP, Moss RL. Loaded shortening, power output, and rate of force redevelopment are increased with knockout of cardiac myosin binding protein-C. Circ Res 2003;93(8):752-758. 10.1161/ 01.RES.0000096363.85588.9A
103. Gautel M, Zuffardi O, Freiburg A, Labeit S. Phosphorylation switches specific for the cardiac isoform of myosin binding protein-C: A modulator of cardiac contraction? Embo J 1995;14(9):1952-1960. 1:CAS:528:DyaK2MXlvVCqsr8%3D
104. Konhilas JP, Irving TC, Wolska BM, Jweied EE, Martin AF, Solaro RJ, et al. Troponin I in the murine myocardium: Influence on length-dependent activation and interfilament spacing. J Physiol 2003;547(Pt 3):951-961. 1:CAS:528:DC%2BD3sXjt1Slt7g%3D