Induction of experimental autoimmune encephalomyelitis in transgenic mice expressing ovalbumin in oligodendrocytes

European Journal of Immunology

Volumn 36, Issue 1, 2006, Pages 207-215

  Cao, Yi ^a   Toben, Catherine ^a   Na, Shin Young ^a   Stark, Kirsten ^a   Nitschke, Lars ^a,d   Peterson, Alan ^b   Gold, Ralf ^c   Schimpl, Anneliese ^a   Hünig, Thomas ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Autoimmunity; EAE; Ovalbumin; Transgene

Indexed keywords

ANTIBODY; FREUND ADJUVANT; OVALBUMIN;

5' UNTRANSLATED REGION; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; BRAIN; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; MONONUCLEAR CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGODENDROGLIA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; SPINAL CORD; SYMPTOMATOLOGY; T LYMPHOCYTE; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; B-LYMPHOCYTES; BLOTTING, WESTERN; BRAIN; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENHANCER ELEMENTS (GENETICS); ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, TRANSGENIC; MYELIN BASIC PROTEINS; OLIGODENDROGLIA; OVALBUMIN; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); RECEPTORS, ANTIGEN, T-CELL; SPINAL CORD;

EID: 30944449259     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200535211     Document Type: Article

References (18)

1. Kurts, C., Heath, W. R., Carbone, F. R., Allison, J., Miller, J. F. and Kosaka, H., Constitutive class I-restricted exogenous presentation of self antigens in vivo. J. Exp. Med. 1996. 184: 923-930.
2. Gold, R., Hartung, H. P. and Toyka, K. V., Animal models for autoimmune demyelinating disorders of the nervous system. Mol. Med. Today 2000. 6: 88-91.
3. Lassmann, H. and Ransohoff, R. M., The CD4-Th1 model for multiple sclerosis: a critical [correction of crucial] re-appraisal. Trends Immunol. 2004. 25: 132-137.
4. Cabarrocas, J., Bauer, J., Piaggio, E., Liblau, R. and Lassmann, H., Effective and selective immune surveillance of the brain by MHC class I-restricted cytotoxic T lymphocytes. Eur. J. Immunol 2003. 33: 1174-1182.
5. Cabarrocas, J., Piaggio, E., Zappulla, J. P., Desbois, S., Mars, L. T., Lassmann, H. and Liblau, R. S., A transgenic mouse model for T cell ignorance of a glial autoantigen. J. Autoimmun. 2004. 22: 179-189.
6. Cornet, A., Savidge, T. C., Cabarrocas, J., Deng, W. L., Colombel, J. F., Lassmann, H., Desreumaux, P. and Liblau, R. S., Enterocolitis induced by autoimmune targeting of enteric glial cells: a possible mechanism in Crohn's disease? Proc. Natl. Acad. Sci. USA 2001. 98: 13306-13311.
7. Forghani, R., Garofalo, L., Foran, D. R., Farhadi, H. F., Lepage, P., Hudson, T. J., Tretjakoff, I. et al., A distal upstream enhancer from the myelin basic protein gene regulates expression in myelin-forming schwann cells. J. Neurosci 2001. 21: 3780-3787.
8. Farhadi, H. F., Lepage, P., Forghani, R., Friedman, H. C., Orfali, W., Jasmin, L., Miller, W. et al., A combinatorial network of evolutionarily conserved myelin basic protein regulatory sequences confers distinct glial-specific phenotypes. J. Neurosci. 2003. 23: 10214-10223.
9. Barnden, M. J., Allison, J., Heath, W. R. and Carbone, F. R., Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements. Immunol. Cell Biol. 1998. 76: 34-40.
10. Lyons, J. A., Ramsbottom, M. J. and Cross, A. H., Critical role of antigen-specific antibody in experimental autoimmune encephalomyelitis induced by recombinant myelin oligodendrocyte glycoprotein. Eur. J. Immunol. 2002. 32: 1905-1913.
11. Tuohy, V. R., Sobel, R. A. and Lees, M. B., Myelin proteolipid protein-induced experimental allergic encephalomyelitis. Variations of disease expression in different strains of mice. J. Immunol. 1988. 140: 1868-1873.
12. Vabulas, R. M., Pircher, H., Lipford, G. B., Hacker, H. and Wagner, H., CpG-DNA activates in vivo T cell epitope presenting dendritic cells to trigger protective antiviral cytotoxic T cell responses. J. Immunol. 2000. 164: 2372-2378.
13. Maurer, T., Heit, A., Hochrein, H., Ampenberger, F., O'Keeffe, M., Bauer, S., Lipford, G. B. et al., CpG-DNA aided cross-presentation of soluble antigens by dendritic cells. Eur. J. Immunol. 2002. 32: 2356-2364.
14. Furtado, G. C., De Lafaille, M. A., Kutchukhidze, N. and Lafaille, J. J., Interleukin 2 signaling is required for CD4(+) regulatory T cell function. J. Exp. Med. 2002. 196: 851-857.
15. Moore, M. W., Carbone, F. R. and Bevan, M. J., Introduction of soluble protein into the class I pathway of antigen processing and presentation. Cell 1988. 54: 777-785.
16. Baron, J. L., Madri, J. A., Ruddle, N. H., Hashim, G. and Janeway, C. A., Jr., Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma. J. Exp. Med. 1993. 177: 57-68.
17. Gold, R., Giegerich, G., Hartung, H. P. and Toyka, K. V., T cell receptor usage in Lewis rat experimental autoimmune encephalomyelitis: TCR β chain variable region Vβ8.2 positive T cells are not essential for induction and course of disease. Proc. Natl. Acad. Sci. USA 1995. 92: 5850-5854.
18. Linker, R. A., Maurer, M., Gaupp, S., Martini, R., Holtmann, B., Giess, R., Rieckmann, P., et al., CNTF is a major protective factor in demyenilating CNS disease: a neurotrophic cytokine as modulator in neuroinflammation. Nat. Med. 2002. 8: 620-624.