Effects of lactoferrin supplementation on ileal and total tract nutrient digestibility, gastrointestinal microbial populations, and immune characteristics of ileal cannulated, healthy, adult dogs

Archives of Animal Nutrition

Volumn 60, Issue 1, 2006, Pages 10-22

  Pope, Lynda L ^a   Flickinger, Elizabeth A ^a   Karr Lilienthal, Lisa K ^a   Spears, Julie K ^a   Krammer, Stephanie ^b   Fahey Jr , George C ^a,c  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b DSM NUTRITIONAL PRODUCTS LTD   (Switzerland)

^c 216 Animal Sciences Laboratory   (United States)

Author keywords

Digestibility; Digestive tract; Dog; Immunology; Lactoferrin; Microbial flora

Indexed keywords

AZO REDUCTASE; LACTOFERRIN; OXIDOREDUCTASE;

ANIMAL; ANIMAL DISEASE; ANIMAL FOOD; ARTICLE; BACTERIUM; CHEMISTRY; DIET SUPPLEMENTATION; DIGESTION; DOG; DOSE RESPONSE; DRUG EFFECT; FECES; FEMALE; GROWTH, DEVELOPMENT AND AGING; ILEUM; IMMUNOLOGY; LEUKOCYTE COUNT; METABOLISM; MICROBIOLOGY; RANDOMIZATION;

ANIMAL FEED; ANIMAL NUTRITION PHYSIOLOGY; ANIMALS; BACTERIA; DIETARY SUPPLEMENTS; DIGESTION; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; FECES; FEMALE; ILEUM; LACTOFERRIN; LEUKOCYTE COUNT; NADH, NADPH OXIDOREDUCTASES; RANDOM ALLOCATION;

ANIMALIA; BACTERIA (MICROORGANISMS); BOVINAE; CAMPYLOBACTER; CANIS FAMILIARIS; CLOSTRIDIUM; ESCHERICHIA COLI; LACTOBACILLUS; STAPHYLOCOCCUS; STREPTOCOCCUS;

EID: 30944447477     PISSN: 1745039X     EISSN: 14772817     Source Type: Journal    
DOI: 10.1080/17450390500353390     Document Type: Article

References (36)

1. AACC. 1983. Approved methods. 8th ed. St Paul, MN: American Association of Cereal Chemists.
2. AOAC. 1995. Official Methods of Analysis. 15th edition. Arlington, VA: Association of Official Analytical Chemists.
3. Arnold RR, Cole MF, McGhee JR. 1977. A bactericidal effect for human lactoferrin. Science 197:263-265.
4. Artym J, Zimecki M, Kruzel ML. 2004. Enhanced clearance of Escherichia coli and Staphylococcus aureus in mice treated with cyclophosphamide and lactoferrin. Int Immunopharm 4:1149-1157.
5. Blumel S, Knackmuss H, Stolz A. 2002. Molecular cloning and characterization of the gene coding for the aerobic azoreductase from Xenophilus azovorans KF46F. Appl Environ Microbiol 68:3948-3955.
6. Brock JH. 2002. The physiology of lactoferrin. Biochem Cell Biol 80:1-6.
7. Bryant MP, Burkey LA. 1953. Cultural methods and some characteristics of some of the more numerous groups of bacteria in the bovine rumen. J Dairy Sci 36:205-217.
8. Budde EF. 1952. The determination of fat in baked biscuit type dog foods. J Assoc Off Agric Chem 35:799-805.
9. Chaney AL, Marbach EP. 1962. Modified reagents for determining urea and ammonia. Clin Chem 8:130-132.
10. Chen H, Wang R, Cerniglia CE. 2004. Molecular cloning, overexpression, purification, and characterization of an aerobic FMN-dependent azoreductase from Enterococcus faecalis. Prot Express Purif 34:302-310.
11. Debbabi H, Dubarry M, Ranntureau M, Tome D. 1998. Bovine lactoferrin induces both mucosal and systemic immune response in mice. J Dairy Res 65:283-293.
12. Food and Drug Administration. 1992. Bacteriological Analytical Manual, Method #196. 7th edition. Arlington, VA.
13. Flickinger EA, Schreijen EMWC, Patil AR, Hussein HS, Merchen NR, Fahey GC Jr. 2003. Nutrient digestibilities, microbial populations, and fecal and urinary odor components as affected by fructan supplementation of dog diets. J Anim Sci 81:2008-2018.
14. Francesca B, Ajello M, Bosso P, Morea C, Andrea P, Giovanni A, Piera V. 2004. Both lactoferrin and iron influence aggregation and biofilm formation in Streptococcus mutans. Biometals 17:271-278.
15. Gibson GR, Roberfroid MB. 1995. Dietary modulation of the human colonie microbiota: Introducing the concept of prebiotics. J Nutr 125:1401-1412.
16. Harada E, Sugiyama A, Takeuchi T, Sitizyo K, Syuto B, Yajima T, Kuwata T. 1999. Characteristic transfer of colostral components into cerebrospinal fluid via serum in neonatal pigs. Biol Neonate 76:33-43.
17. Hutchens TW, Henry JF, Yip T, Hachey DL, Schanler RJ, Motil KJ, Garza C. 1991. Origin of intact lactoferrin and its DNA-binding fragments found in the urine of human milk-fed preterm infants. Evaluation by stable isotopic enrichment. Pediatr Res 29:243-250.
18. Legrand D, Elass E, Pierce A, Mazurier J. 2004. Lactoferrin and host defence: An overview of its immunomodulating and anti-inflammatory properties. Biometals 17:225-229.
19. Liepke C, Adermann K, Raida M, Magert H, Forssmann W, Zucht H. 2002. Human milk provides peptides highly stimulating the growth of bifidobacteria. Eur J Biochem 269:712-718.
20. Lonnerdal B. 2003. Nutritional and physiologic significance of human milk proteins. Am J Clin Nutr 77:1537S-1543S.
21. Miehlke S, Reddy R, Osato MS, Ward PP, Conneely OM, Graham DY. 1996. Direct activity of recombinant human lactoferrin against Helicobacter pylori. J Clin Microbiol 34: 2593-2594.
22. Muńoa FJ, Pares R. 1988. Selective medium for isolation and enumeration of Bifidobacterium spp. Appl Environ Microbiol 54:1715-1718.
23. Nakanishi M, Yatome C, Ishida N, Kitade Y. 2001. Putative ACP phosphodiesterase gene (acpD) encodes an azoreductase. J Biol Chem 276:46394-46399.
24. Nara PL, Winters K, Rice JB, Olsen RG, Krakowka S. 1983. Systemic and local intestinal antibody response in dogs given both infective and inactivated canine parvovirus. Am J Vet Res 44:1989-1995.
25. Rafii F, Coleman T. 1999. Cloning and expression in E. coli of an azoreductase gene from Clostridium spp. and comparison with azoreductase genes from other bacteria. J Basic Microbiol 39:29-35.
26. Singh PK, Parsek MR, Greenberg EP, Welsh MJ. 2002. A component of innate immunity prevents bacterial biofilm development. Nature 417: 552-555.
27. Suzuki Y, Yoda T, Ruhul A, Sugiura W. 2001. Molecular cloning and characterization of the gene coding for azoreductase from Bacillus sp. OY1-2 isolated from soil. J Biol Chem 276:9059-9065.
28. Swanson KS, Fahey GC. 2003. An assessment of prebiotic use in companion animal diets. Comp Cont Educ Prac Vet 26:40S-49S.
29. Teraguchi S, Shin K, Ogata T, Kingaku M, Kaino A, Miyauchi H, Fukuwatari Y, Shimamura S. 1995a. Orally administered bovine lactoferrin inhibits bacterial translocation in mice fed bovine milk. Appl Environ Microbiol 61:4131-4134.
30. Teraguchi S, Shin K, Ozawa K, Nakamura S, Fukuwatari Y, Tsuyuki S, Namihira H, Shimamura S. 1995b. Bacteriostatic effect of orally administered bovine lactoferrin on proliferation of Clostridium species in the gut of mice fed bovine milk. Appl Environ Microbiol 61:501-506.
31. Teraguchi S, Wakabayashi H, Kutawa H, Yamauchi K, Tamura Y. 2004. Protection against infections by oral lactoferrin: Evaluation in animal models. Biometals 17:231-234.
32. Togawa J, Nagase H, Tanaka K, Inamori M, Nakajima A, Ueno N, Saito T, Sekihara, H. 2002. Oral administration of lactoferrin reduces colitis in rats via modulation of the immune system and correction of cytokine balance. J Gastroenterol Hepatol 17:1291-1298.
33. Wakabayashi H, Kuwata H, Yamauchi K, Teraguchi S, Tamura Y. 2004. No detectable transfer of dietary lactoferrin or its functional fragments to portal blood in healthy adult rats. Biosci Biotechnol Biochem 68:853-860.
34. Walker JA, Harmon DL, Gross KL, Collins GF. 1994. Evaluation of nutrient utilization in the canine using the ileal cannulation technique. J Nutr 124:2672-2676S.
35. Williams CH, David DJ, Iismaa O. 1962. The determination of chromic oxide in faeces samples by atomic absorption spectrophotometry. J Agric Sci 59:381-385.
36. Wise A, Mallet AK, Rowland IR. 1982. Dietary fibre, bacterial metabolism and toxicity of nitrate in the rat. Xenobiotica 12:111-118.