The aberrant expression of the gastric inhibitory polypeptide (GIP) receptor in adrenal hyperplasia: Does chronic adrenocorticotropin exposure stimulate up-regulation of GIP receptors in Cushing's disease?

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 5, 2005, Pages 3009-3016

  Swords, F M ^a   Aylwin, S ^b   Perry, L ^c   Arola, J ^d   Grossman, A B ^a   Monson, J P ^a   Clark, A J L ^a,e  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b KING S COLLEGE HOSPITAL   (United Kingdom)

^c BARTS HEALTH NHS TRUST   (United Kingdom)

^d UNIVERSITY OF HELSINKI   (Finland)

^e ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; GASTRIC INHIBITORY POLYPEPTIDE; GASTRIC INHIBITORY POLYPEPTIDE RECEPTOR; HORMONE RECEPTOR; HYDROCORTISONE; KETOCONAZOLE; METYRAPONE; UNCLASSIFIED DRUG;

ADRENAL CORTEX ADENOMA; ADRENAL HYPERPLASIA; ADRENALECTOMY; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CUSHING DISEASE; DIET RESTRICTION; FEMALE; FOOD INTAKE; HORMONAL REGULATION; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; IN VITRO STUDY; PATHOGENESIS; POSTPRANDIAL STATE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHOOL CHILD; SIGNAL TRANSDUCTION; TRANSSPHENOIDAL SURGERY;

ADRENAL CORTEX; ADRENOCORTICOTROPIC HORMONE; ADULT; AGED; CELLS, CULTURED; CHILD; FEMALE; GASTRIC INHIBITORY POLYPEPTIDE; GENE EXPRESSION REGULATION; HUMANS; HYDROCORTISONE; HYPERPLASIA; MIDDLE AGED; PITUITARY ACTH HYPERSECRETION; RECEPTORS, CORTICOTROPIN; RECEPTORS, GASTROINTESTINAL HORMONE; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 18844367137     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2004-0946     Document Type: Article

References (33)

1. Newell-Price J, Jorgensen JO, Grossman A 1999 The diagnosis and differential diagnosis of Cushing's syndrome. Horm Res 51(Suppl 3):81-94
2. Stratakis CA, Kirschner LS 1998 Clinical and genetic analysis of primary bilateral adrenal diseases (micro- and macronodular disease) leading to Cushing's syndrome. Horm Metab Res 30:456-463
3. Weinstein LS, Shenker A, Gejman PV, Merino MJ, Friedman E, Spiegel AM 1991 Activating mutations of the stimulatory G protein in the McCune Albright syndrome. N Engl J Med 325:1688-1695
4. Kirschner LS, Carney JA, Pack D, Taymans SE, Giatzakis C, Cho YS, Cho-Chung YS, Stratakis CA 2000 Mutations of the gene encoding the protein kinase A type 1-α regulatory subunit in patients with the Carney complex. Nat Genet 26:89-92
5. Casey M, Vaughan CJ, He J, Hatcher CJ, Winter JM, Weremowicz S, Montgomery K, Kucherlapati R, Morton CC, Basson CT 2000 Mutations of the gene encoding the protein kinase A type 1-α regulatory subunit cause familial cardiac myxomas and Carney complex. J Clin Invest 106:R31-R38
6. Groussin L, Jullian E, Perlemoine K, Louvel A, Leheup B, Luton JP, Bertagna X, Bertherat J 2002 Mutations of the PRKAR1A gene in Cushing's syndrome due to sporadic primary pigmented nodular adrenocortical disease. J Clin Endocrinol Metab 87:4324-4329
7. Swords FM, Baig A, Malchoff DM, Malchoff CD, Thorner MO, Hunyady L, Clark AJL 2002 Constitutive activation of the ACTH receptor associated with defective receptor desensitisation and sequestration. Mol Endocrinol 16:2746-2753
8. Lacroix A, N'Diaye N, Tremblay J, Hamet P 2001 Ectopic and abnormal hormone receptors in adrenal Cushing's syndrome. Endocr Rev 22:75-110
9. Miyamura N, Taguchi T, Murata Y, Taketa K, Iwashita S, Matsumoto K, Nishikawa T, Toyonaga T, Sakakida M, Araki E 2002 Inherited adrenocorticotropin- independent macronodular adrenal hyperplasia with abnormal cortisol secretion by vasopressin and catecholamines: detection of the aberrant hormone receptors on adrenal gland. Endocrine 9:319-326
10. Imohl M, Koditz R, Stachon A, Muller KM, Nicolas V, Pfeilschifter J, Krieg M 2002 Catecholamine-dependent hereditary Cushing's syndrome: follow-up after unilateral adrenalectomy. Med Klin (Munich) 97:747-753
11. Lee S, Jun S, Hong SW, Kim DJ, Rhee Y, Lim S, Familial adrenocorticotropin-Independent macronodular adrenal hyperplasia: ectopic expression of vasopressin V1b, V2 receptors in the adrenal gland. Program of the 86th Annual Meeting of The Endocrine Society, New Orleans, LA, 2004, p 566 (Abstract P3-417)
12. Lacroix A, Bolte E, Tremblay J, Dupre J, Poitras P, Fournier H, Garon J, Garrel D, Bayard F, Taillefer R, Flanagan RJ, Hamet P 1992 Gastric inhibitory polypeptide-dependent cortisol hypersecretion: a new cause for Cushing's syndrome. N Engl J Med 327:974-980
13. Reznik Y, Allali-Zerah V, Chayvialle JA, Leroyer R, Leymarie P, Travert G, Lebrethon MC, Budi I, Balliere AM, Mahoudeau J 1992 Food-dependent Cushing's syndrome mediated by aberrant adrenal sensitivity to gastric inhibitory polypeptide. N Engl J Med 327:981-986
14. N'Diaye N, Tremblay J, Hamet P, De Herder WW, Lacroix A 1998 Adrenocortical overexpression of gastric inhibitory polypeptide receptor underlies food-dependent Cushing's syndrome. J Clin Endocrinol Metab 83:2781-2785
15. Luton JP, Nertherat J, Kuhn J, Bertagna X 1998 Aberrant expression of the GIPR in an adrenal cortical adenoma responsible for a case of food-dependent Cushing's syndrome. Bull Acad Natl Med 182:1839-1850
16. Tsagarakis S, Tsigos C, Vassiliou V, Tsiotra P, Pratsinis H, Kletsas D, Trivizas P, Nikou A, Mavromatis T, Sotsiou F, Raptis S, Thalassinos N 2001 Food-dependent androgen and cortisol secretion by a gastric inhibitory polypeptide-receptor expressive adrenocortical adenoma leading to hirsutism and subclinical Cushing's syndrome: in vivo and in vitro studies. J Clin Endocrinol Metab 86:583-589
17. Lacroix A, Tremblay J, Rousseau G, Bouvier M, Hamet P 1997 Propanolol therapy for ectopic β-adrenergic receptors in adrenal Cushing's syndrome. N Engl J Med 337:1429-1434
18. Lacroix A, Hamet P, Boutin JM 1999 Leuprolide acetate therapy in luteinizing hormone-dependent Cushing's syndrome. N Engl J Med 341:1577-1581
19. Lacroix A, Tremblay J, Touyz RM, Deng LY, Lariviere R, Cusson JR, Schriffin EL, Hamet P1997 Abnormal adrenal and vascular responses to vasopressin mediated by a V1-vasopressin receptor in a patient with adrenocorticotropin- independent macronodular adrenal hyperplasia, Cushing's syndrome, and orthostatic hypotension. J Clin Endocrinol Metab 82:2414-2422
20. Matsukora S, Kakita T, Sueoka S, Yoshimi H, Hirata Y, Yokota M, Fujita T 1980 Multiple hormone receptors in the adenylate cyclase of human adrenocortical tumours. Cancer Res 40: 3768-3771
21. Louiset E, Contesse V, Cartier D, Bertherat J, Duparc C, Barrande G, Groussin L, Vaudry H, Lefebvre H 2004 Pharmacological profile and coupling mechanisms of illegitimate receptors in ACTH-independent macronodular bilateral adrenal hyperplasia causing Cushing's syndrome. Program of the 86th Annual Meeting of The Endocrine Society, New Orleans, LA, 2004 (Abstract P3-410)
22. Antonini SR, N'Diaye N, Baldacchino V, Hamet P, Tremblay J, Lacroix A 2004 An analysis of the putative regulatory region of the GIP receptor gene in food-dependent Cushing's syndrome. J Steroid Biochem Mol Biol 91:171-177
23. Lebrethon MC, Avallet O, Reznik Y, Archambeaud F, Combes J, Usdin TB, Narboni G, Mahoudeau J, Saez JM 1998 Food-dependent Cushing's syndrome: characterization and functional role of gastric inhibitory polypeptide receptor in the adrenals of three patients. J Clin Endocrinol Metab 83:4514-4519
24. Croughs RJ, Zelissen PM, Van Vroonhoven TJ, Hofland LJ, N'Diaye N, Lacroix A, De Herder WW 2000 GIP dependent adrenal Cushing's syndrome with incomplete suppression of ACTH. Clin Endocrinol 52:235-240
25. Chabre O, Liakos P, Vivier J, Chaffonjon P, Labat-Moleur F, Martinie M, Bottari SP, Bachelot I, Chambaz EM, Defaye G, Feige JJ 1998 Cushing's syndrome due to a gastric inhibitory polypeptide-dependent adrenal adenoma: insights into hormonal control of adrenocortical tumorigenesis. J Clin Endocrinol Metab 83:3134-3143
26. Brown BL, Albano JD, Ekins RP, Sgherzi AM, Tampion W1971 A simple and sensitive saturation assay method for the measurement of adenosine 3′:5′-cyclic monophosphate. Biochem J 121:561-562
27. Baig AH, Swords FM, Noon LA, King PJ, Hunyady L, Clark AJ 2001 Desensitization of the Y1 cell adrenocorticotropin receptor: evidence for a restricted heterologous mechanism implying a role for receptor-effector complexes. J Biol Chem 276:44792-44797
28. Groussin L, Perlemoine K, Contesse V, Lefebvre H, Tabarin A, Thieblot P, Schlienger JL, Luton JP, Bertagna X, Bertherat J 2002 The ectopic expression of the gastric inhibitory polypeptide receptor is frequent in adrenocorticotropin- independent bilateral macronodular adrenal hyperplasia, but rare in unilateral tumors. J Clin Endocrinol Metab 87:1980-1985
29. Usdin TB, Mezey E, Button DC, Brownstein MJ, Bonner TI 1993 Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain. Endocrinology 133:2861-2870
30. Mazzocchi G, Rebuffat P, Meneghelli V, Malendowicz LK, Tortoralla C, Gottardo G, Nussdorfer GG 1999 Gastric inhibitory polypeptide stimulated glucocorticoid secretion in rats, acting through specific receptors coupled with the adenylate cyclase-dependent signaling pathway. Peptides 20:589-594
31. Antonini SR, N'Diaye N, Hamet P, Tremblay J, Lacroix A 2002 Analysis of the putative promoter region of the GIP receptor gene (GIPR) in GIP-dependent Cushing's syndrome. Endocr Res 28:755-756
32. Nussdorfer GG, Bahcelioglu M, Neri G, Malendowicz LK 2000 Secretin, gastric inhibitory polypeptide, parathyroid hormone and related peptides in the regulation of the hypothalamus-pituitary-adrenal axis. Peptides 21:309-324
33. Tseng CC, Zhang XY 2000 Role of G protein-coupled receptor kinases in glucose-dependent insulinotropic polypeptide receptor signaling. Endocrinology 141:947-952