메뉴 건너뛰기




Volumn 176, Issue 2, 2006, Pages 1122-1130

Modified pulmonary surfactant is a potent adjuvant that stimulates the mucosal IgA production in response to the influenza virus antigen

Author keywords

[No Author keywords available]

Indexed keywords

ADJUVANT; CD40 ANTIGEN; CD86 ANTIGEN; CHOLERA TOXIN B SUBUNIT; CYTOKINE; GLYCOPROTEIN P 15095; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; LUNG SURFACTANT; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NEUTRALIZING ANTIBODY; SURFACTANT TA; TRANSFORMING GROWTH FACTOR BETA1; VACCINE; VIRUS ANTIGEN; VIRUS HEMAGGLUTININ;

EID: 30744461365     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.2.1122     Document Type: Article
Times cited : (46)

References (49)
  • 1
    • 0001387044 scopus 로고    scopus 로고
    • Orthomyxoviruses
    • B. N. Field and D. N. Knipe, eds. Lippincott-Raven, Philadelphia
    • Murphy, B. R., and R.G. Webster. 1996. Orthomyxoviruses. In Virology. B. N. Field and D. N. Knipe, eds. Lippincott-Raven, Philadelphia, pp. 1397-1445.
    • (1996) Virology , pp. 1397-1445
    • Murphy, B.R.1    Webster, R.G.2
  • 3
    • 0016270010 scopus 로고
    • Immunity to infections on secretory surfaces
    • Waldman, R. H., and R. Ganguly. 1974. Immunity to infections on secretory surfaces. J. Infect. Dis. 130: 419-440.
    • (1974) J. Infect. Dis. , vol.130 , pp. 419-440
    • Waldman, R.H.1    Ganguly, R.2
  • 4
    • 0021343130 scopus 로고
    • Cross-protection in mice infected with influenza A virus by the respiratory route is correlated with local IgA Ab rather than serum Ab or cytotoxic T cell reactivity
    • Liew, F. Y., S. M. Russell, G. Appleyard, C. M. Brand, and J. Beale. 1984. Cross-protection in mice infected with influenza A virus by the respiratory route is correlated with local IgA Ab rather than serum Ab or cytotoxic T cell reactivity. Eur. J. Immunol. 14: 350-356.
    • (1984) Eur. J. Immunol. , vol.14 , pp. 350-356
    • Liew, F.Y.1    Russell, S.M.2    Appleyard, G.3    Brand, C.M.4    Beale, J.5
  • 5
    • 0024529561 scopus 로고
    • The systemic and mucosal immune response of humans to influenza a virus
    • Murphy, B. R., and M. L. Clements. 1989. The systemic and mucosal immune response of humans to influenza A virus. Curr. Top. Microbiol. Immunol. 146: 107-116.
    • (1989) Curr. Top. Microbiol. Immunol. , vol.146 , pp. 107-116
    • Murphy, B.R.1    Clements, M.L.2
  • 6
    • 0002199008 scopus 로고
    • Passive immunization: Systemic and mucosal
    • P. L. Ogra, M. E. Lamm, J. R. McGhee, J. Mestecky, W. Strober, and J. Bienenstock, eds. Academic Press, San Diego
    • Renenger, K. B., and P. A. Small, Jr. 1994. Passive immunization: systemic and mucosal. In Handbook of Mucosal Immunology. P. L. Ogra, M. E. Lamm, J. R. McGhee, J. Mestecky, W. Strober, and J. Bienenstock, eds. Academic Press, San Diego, pp. 333-343.
    • (1994) Handbook of Mucosal Immunology , pp. 333-343
    • Renenger, K.B.1    Small Jr., P.A.2
  • 7
    • 0041837498 scopus 로고    scopus 로고
    • New generation of mucosal adjuvants for the induction of protective immunity
    • Yuki, Y., and H. Kiyono. 2003. New generation of mucosal adjuvants for the induction of protective immunity. Rev. Med. Virol. 13: 293-310.
    • (2003) Rev. Med. Virol. , vol.13 , pp. 293-310
    • Yuki, Y.1    Kiyono, H.2
  • 8
    • 0034901713 scopus 로고    scopus 로고
    • Serum and mucosal immunologic responses in children following the administration of a new inactivated intranasal anti-influenza vaccine
    • Greenbaum, E., A. Furst, A. Kiderman, B. Stewart, R. Levy, M. Schlesinger, A. Morag, and Z. Zakay-Rones. 2001. Serum and mucosal immunologic responses in children following the administration of a new inactivated intranasal anti-influenza vaccine. J. Med. Virol. 65: 178-184.
    • (2001) J. Med. Virol. , vol.65 , pp. 178-184
    • Greenbaum, E.1    Furst, A.2    Kiderman, A.3    Stewart, B.4    Levy, R.5    Schlesinger, M.6    Morag, A.7    Zakay-Rones, Z.8
  • 9
    • 0034826521 scopus 로고    scopus 로고
    • Recent developments in adjuvants for vaccines against infectious diseases
    • O'Hagan, D. T., M. L. MacKichan, and M. Singh. 2001. Recent developments in adjuvants for vaccines against infectious diseases. Biomol. Eng. 18: 69-85.
    • (2001) Biomol. Eng. , vol.18 , pp. 69-85
    • O'Hagan, D.T.1    MacKichan, M.L.2    Singh, M.3
  • 10
    • 0028220582 scopus 로고
    • Synergistic action of cholera toxin B subunit (and Escherichia coli heat-labile toxin B subunit) and a trace amount of cholera whole toxin as an adjuvant for nasal influenza vaccine
    • Tamura, S., A. Yamanaka, M. Shimohara, T. Tomita, K. Komase, Y. Tsuda, Y. Suzuki, T. Nagamine, K. Kawahara, and H. Danbara. 1994. Synergistic action of cholera toxin B subunit (and Escherichia coli heat-labile toxin B subunit) and a trace amount of cholera whole toxin as an adjuvant for nasal influenza vaccine. Vaccine 12: 419-426.
    • (1994) Vaccine , vol.12 , pp. 419-426
    • Tamura, S.1    Yamanaka, A.2    Shimohara, M.3    Tomita, T.4    Komase, K.5    Tsuda, Y.6    Suzuki, Y.7    Nagamine, T.8    Kawahara, K.9    Danbara, H.10
  • 11
    • 0034072432 scopus 로고    scopus 로고
    • Safety and immunogenicity of intranasally administered inactivated trivalent virosome-formulated influenza vaccine containing Escherichia coli heat-labile toxin as a mucosal adjuvant
    • Gluck, R., R. Mischler, P. Durrer, E. Purer, A. B. Lang, C. Herzog, and S. J. Cryz, Jr. 2000. Safety and immunogenicity of intranasally administered inactivated trivalent virosome-formulated influenza vaccine containing Escherichia coli heat-labile toxin as a mucosal adjuvant. J. Infect. Dis. 181: 1129-1132.
    • (2000) J. Infect. Dis. , vol.181 , pp. 1129-1132
    • Gluck, R.1    Mischler, R.2    Durrer, P.3    Purer, E.4    Lang, A.B.5    Herzog, C.6    Cryz Jr., S.J.7
  • 12
    • 0025319074 scopus 로고
    • Whole cholera toxin and B subunit act synergistically as an adjuvant for the mucosal immune response of mice to keyhole limpet haemocyanin
    • Wilson, A. D., C. J. Clarke, and C. R. Stokes. 1990. Whole cholera toxin and B subunit act synergistically as an adjuvant for the mucosal immune response of mice to keyhole limpet haemocyanin. Scand. J. Immunol. 31: 443-451.
    • (1990) Scand. J. Immunol. , vol.31 , pp. 443-451
    • Wilson, A.D.1    Clarke, C.J.2    Stokes, C.R.3
  • 13
    • 0028169640 scopus 로고
    • Escherichia coli heat-labile enterotoxin B subunits supplemented with a trace amount of the holotoxin as an adjuvant for nasal influenza vaccine
    • Tamura, S., H. Asanuma, T. Tomita, K. Komase, K. Kawahara, H. Danbara, N. Hattori, K. Watanabe, Y. Suzuki, and T. Nagamine. 1994. Escherichia coli heat-labile enterotoxin B subunits supplemented with a trace amount of the holotoxin as an adjuvant for nasal influenza vaccine. Vaccine 12: 1083-1089.
    • (1994) Vaccine , vol.12 , pp. 1083-1089
    • Tamura, S.1    Asanuma, H.2    Tomita, T.3    Komase, K.4    Kawahara, K.5    Danbara, H.6    Hattori, N.7    Watanabe, K.8    Suzuki, Y.9    Nagamine, T.10
  • 14
    • 0036164394 scopus 로고    scopus 로고
    • An open-label comparison of the immunogenicity and tolerability of intranasal and intramuscular formulations of virosomal influenza vaccine in healthy adults
    • de, B., A. Zanasi, S. Ragusa, R. Gluck, and C. Herzog. 2002. An open-label comparison of the immunogenicity and tolerability of intranasal and intramuscular formulations of virosomal influenza vaccine in healthy adults. Clin. Ther. 24: 100-111.
    • (2002) Clin. Ther. , vol.24 , pp. 100-111
    • De, B.1    Zanasi, A.2    Ragusa, S.3    Gluck, R.4    Herzog, C.5
  • 15
    • 0348078299 scopus 로고    scopus 로고
    • Mucosal antibody response induced with a nasal virosome-based influenza vaccine
    • Durrer, P., U. Gluck, C. Spyr, A. B. Lang, R. Zurbriggen, C. Herzog, and R. Gluck. 2003. Mucosal antibody response induced with a nasal virosome-based influenza vaccine. Vaccine 21: 4328-4334.
    • (2003) Vaccine , vol.21 , pp. 4328-4334
    • Durrer, P.1    Gluck, U.2    Spyr, C.3    Lang, A.B.4    Zurbriggen, R.5    Herzog, C.6    Gluck, R.7
  • 16
    • 1342268100 scopus 로고    scopus 로고
    • Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland
    • Mutsch, M., W. Zhou, P. Rhodes, M. Bopp, R. T. Chen, T. Linder, C. Spyr, and R. Steffen. 2004. Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland. N. Engl. J. Med. 350: 896-903.
    • (2004) N. Engl. J. Med. , vol.350 , pp. 896-903
    • Mutsch, M.1    Zhou, W.2    Rhodes, P.3    Bopp, M.4    Chen, R.T.5    Linder, T.6    Spyr, C.7    Steffen, R.8
  • 17
    • 0035048532 scopus 로고    scopus 로고
    • Surfactant proteins A and D and pulmonary host defense
    • Crouch, E., and J. R. Wright. 2001. Surfactant proteins A and D and pulmonary host defense. Annu. Rev. Physiol. 63: 521-554.
    • (2001) Annu. Rev. Physiol. , vol.63 , pp. 521-554
    • Crouch, E.1    Wright, J.R.2
  • 19
    • 0034983007 scopus 로고    scopus 로고
    • Macrophage and type II cell catabolism of SP-A and saturated phosphatidylcholine in mouse lungs
    • Gurel, O., M. Ikegami, Z. C. Chroneos, and A. H. Jobe. 2001. Macrophage and type II cell catabolism of SP-A and saturated phosphatidylcholine in mouse lungs. Am. J. Physiol. 280: L1266-L1272.
    • (2001) Am. J. Physiol. , vol.280
    • Gurel, O.1    Ikegami, M.2    Chroneos, Z.C.3    Jobe, A.H.4
  • 20
    • 0027048351 scopus 로고
    • Surfactant replacement therapy in premature babies with respiratory distress syndrome: Factors affecting the response to surfactant and comparison of outcome from 1982-86 and 1987-91
    • Konishi, M., S. Chida, S. Shimada, T. Kasai, Y. Murakami, K. Cho, Y. Fujii, H. Maeta, and T. Fujiwara. 1992. Surfactant replacement therapy in premature babies with respiratory distress syndrome: factors affecting the response to surfactant and comparison of outcome from 1982-86 and 1987-91. Acta Paediatr. Jpn. 34: 617-630.
    • (1992) Acta Paediatr. Jpn. , vol.34 , pp. 617-630
    • Konishi, M.1    Chida, S.2    Shimada, S.3    Kasai, T.4    Murakami, Y.5    Cho, K.6    Fujii, Y.7    Maeta, H.8    Fujiwara, T.9
  • 21
    • 0001925693 scopus 로고
    • Comparisons of serologic and febrile responses in humans to vaccination with influenza a viruses or their hemagglutinins
    • Davenport, F. M., A. V. Hennessy, F. M. Brandon, R. G. Webster, C. D. Barrett, Jr., and G. O. Lease. 1964. Comparisons of serologic and febrile responses in humans to vaccination with influenza A viruses or their hemagglutinins. J. Lab. Clin. Med. 63: 5-13.
    • (1964) J. Lab. Clin. Med. , vol.63 , pp. 5-13
    • Davenport, F.M.1    Hennessy, A.V.2    Brandon, F.M.3    Webster, R.G.4    Barrett Jr., C.D.5    Lease, G.O.6
  • 23
    • 0021915287 scopus 로고
    • Effects of a surfactant-associated protein and calcium ions on the structure and surface activity of lung surfactant lipids
    • Hawgood, S., B. J. Benson, and R. L. Hamilton, Jr. 1985. Effects of a surfactant-associated protein and calcium ions on the structure and surface activity of lung surfactant lipids. Biochemistry 24: 184-190.
    • (1985) Biochemistry , vol.24 , pp. 184-190
    • Hawgood, S.1    Benson, B.J.2    Hamilton Jr., R.L.3
  • 25
    • 0021048252 scopus 로고
    • Lung surfactants. I. Comparison of surfactants prepared from lungs of calf, ox, dog and rabbit
    • Tanaka, Y., and T. Takei. 1983. Lung surfactants. I. Comparison of surfactants prepared from lungs of calf, ox, dog and rabbit. Chem. Pharm. Bull (Tokyo). 31: 4091-4099.
    • (1983) Chem. Pharm. Bull (Tokyo) , vol.31 , pp. 4091-4099
    • Tanaka, Y.1    Takei, T.2
  • 26
    • 0037019886 scopus 로고    scopus 로고
    • Characterization of protective immune responses induced by nasal influenza vaccine containing mutant cholera toxin as a safe adjuvant (CT112K)
    • Watanabe, I., Y. Hagiwara, S. E. Kadowaki, T. Yoshikawa, K. Komase, C. Aizawa, H. Kiyono, Y. Takeda, J. R. McGhee, J. Chiba, et al. 2002. Characterization of protective immune responses induced by nasal influenza vaccine containing mutant cholera toxin as a safe adjuvant (CT112K). Vaccine 20: 3443-3455.
    • (2002) Vaccine , vol.20 , pp. 3443-3455
    • Watanabe, I.1    Hagiwara, Y.2    Kadowaki, S.E.3    Yoshikawa, T.4    Komase, K.5    Aizawa, C.6    Kiyono, H.7    Takeda, Y.8    McGhee, J.R.9    Chiba, J.10
  • 27
    • 0016801782 scopus 로고
    • Plaque assay and primary isolation of influenza a viruses in an established line of canine kidney cells (MDCK) in the presence of trypsin
    • Tobita, K., A. Sugiura, C. Enomote, and M. Furuyama. 1975. Plaque assay and primary isolation of influenza A viruses in an established line of canine kidney cells (MDCK) in the presence of trypsin. Med. Microbiol. Immunol. 162: 9-14.
    • (1975) Med. Microbiol. Immunol. , vol.162 , pp. 9-14
    • Tobita, K.1    Sugiura, A.2    Enomote, C.3    Furuyama, M.4
  • 29
    • 0035145423 scopus 로고    scopus 로고
    • Characterization of murine lung dendritic cells infected with Mycobacterium tuberculosis
    • Gonzalez-Juarrero, M., and I. M. Orme. 2001. Characterization of murine lung dendritic cells infected with Mycobacterium tuberculosis. Infect. Immun. 69: 1127-1133.
    • (2001) Infect. Immun. , vol.69 , pp. 1127-1133
    • Gonzalez-Juarrero, M.1    Orme, I.M.2
  • 30
    • 0036014553 scopus 로고    scopus 로고
    • Ambroxol suppresses influenza-virus proliferation in the mouse airway by increasing antiviral factor levels
    • Yang, B., D. F. Yao, M. Ohuchi, M. Ide, M. Yano, Y. Okumura, and H. Kido. 2002. Ambroxol suppresses influenza-virus proliferation in the mouse airway by increasing antiviral factor levels. Eur. Respir. J. 19: 952-958.
    • (2002) Eur. Respir. J. , vol.19 , pp. 952-958
    • Yang, B.1    Yao, D.F.2    Ohuchi, M.3    Ide, M.4    Yano, M.5    Okumura, Y.6    Kido, H.7
  • 31
    • 10344252269 scopus 로고    scopus 로고
    • The lung collectins, SP-A and SP-D, modulate pulmonary innate immunity
    • Sano, H., and Y. Kuroki. 2005. The lung collectins, SP-A and SP-D, modulate pulmonary innate immunity. Mol. Immunol. 42: 279-287.
    • (2005) Mol. Immunol. , vol.42 , pp. 279-287
    • Sano, H.1    Kuroki, Y.2
  • 32
    • 0023575418 scopus 로고
    • Metabolism and turnover of lung surfactant
    • Wright, J. R., and J. A. Clements. 1987. Metabolism and turnover of lung surfactant. Am. Rev. Respir. Dis. 136: 426-444.
    • (1987) Am. Rev. Respir. Dis. , vol.136 , pp. 426-444
    • Wright, J.R.1    Clements, J.A.2
  • 34
    • 0038316325 scopus 로고    scopus 로고
    • Anatomical basis of tolerance and immunity to intestinal antigens
    • Mowat, A. M. 2003. Anatomical basis of tolerance and immunity to intestinal antigens. Nat. Rev. Immunol. 3: 331-341.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 331-341
    • Mowat, A.M.1
  • 35
    • 0033564665 scopus 로고    scopus 로고
    • Direct effects on antigen-presenting cells and T lymphocytes explain the adjuvanticity of a nontoxic cholera toxin mutant
    • Yamamoto, M., H. Kiyono, S. Yamamoto, E. Batanero, M. N. Kweon, S. Otake, M. Azuma, Y. Takeda, and J. R. McGhee. 1999. Direct effects on antigen-presenting cells and T lymphocytes explain the adjuvanticity of a nontoxic cholera toxin mutant. J. Immunol. 162: 7015-7021.
    • (1999) J. Immunol. , vol.162 , pp. 7015-7021
    • Yamamoto, M.1    Kiyono, H.2    Yamamoto, S.3    Batanero, E.4    Kweon, M.N.5    Otake, S.6    Azuma, M.7    Takeda, Y.8    McGhee, J.R.9
  • 36
    • 0031296660 scopus 로고    scopus 로고
    • The mucosal adjuvanticity of cholera toxin involves enhancement of costimulatory activity by selective upregulation of B7.2 expression
    • Cong, Y., C. T. Weaver, and C. O. Elson. 1997. The mucosal adjuvanticity of cholera toxin involves enhancement of costimulatory activity by selective upregulation of B7.2 expression. J. Immunol. 159: 5301-5308.
    • (1997) J. Immunol. , vol.159 , pp. 5301-5308
    • Cong, Y.1    Weaver, C.T.2    Elson, C.O.3
  • 38
    • 0022465625 scopus 로고
    • Production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth
    • Kehrl, J. H., L. M. Wakefield, A. B. Roberts, S. Jakowlew, M. Alvarez-Mon, R. Derynck, M. B. Sporn, and A. S. Fauci. 1986. Production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth. J. Exp. Med. 163: 1037-1050.
    • (1986) J. Exp. Med. , vol.163 , pp. 1037-1050
    • Kehrl, J.H.1    Wakefield, L.M.2    Roberts, A.B.3    Jakowlew, S.4    Alvarez-Mon, M.5    Derynck, R.6    Sporn, M.B.7    Fauci, A.S.8
  • 39
    • 0028299062 scopus 로고
    • + T cells requires the coordinate action of interleukin-12 and interferon-γ and is inhibited by transforming growth factor-β
    • + T cells requires the coordinate action of interleukin-12 and interferon-γ and is inhibited by transforming growth factor-β. Eur. J. Immunol. 24: 793-798.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 793-798
    • Schmitt, E.1    Hoehn, P.2    Huels, C.3    Goedert, S.4    Palm, N.5    Rude, E.6    Germann, T.7
  • 41
    • 0027500836 scopus 로고
    • Transforming growth factor β1 (TGF-β1) controls expression of major histocompatibility genes in the postnatal mouse: Aberrant histocompatibility antigen expression in the pathogenesis of the TGF-β1 null mouse phenotype
    • Geiser, A. G., J. J. Letterio, A. B. Kulkarni, S. Karlsson, A. B. Roberts, and M. B. Sporn. 1993. Transforming growth factor β1 (TGF-β1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-β1 null mouse phenotype. Proc. Natl. Acad. Sci. USA 90: 9944-9948.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 9944-9948
    • Geiser, A.G.1    Letterio, J.J.2    Kulkarni, A.B.3    Karlsson, S.4    Roberts, A.B.5    Sporn, M.B.6
  • 42
    • 0032519412 scopus 로고    scopus 로고
    • TGF-β promotes immune deviation by altering accessory signals of antigen-presenting cells
    • Takeuchi, M., P. Alard, and J. W. Streilein. 1998. TGF-β promotes immune deviation by altering accessory signals of antigen-presenting cells. J. Immunol. 160: 1589-1597.
    • (1998) J. Immunol. , vol.160 , pp. 1589-1597
    • Takeuchi, M.1    Alard, P.2    Streilein, J.W.3
  • 43
    • 0030035509 scopus 로고    scopus 로고
    • Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-β1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients
    • Fukaura, H., S. C. Kent, M. J. Pietrusewicz, S. J. Khoury, H. L. Weiner, and D. A. Hafler. 1996. Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-β1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. J. Clin. Invest. 98: 70-77.
    • (1996) J. Clin. Invest. , vol.98 , pp. 70-77
    • Fukaura, H.1    Kent, S.C.2    Pietrusewicz, M.J.3    Khoury, S.J.4    Weiner, H.L.5    Hafler, D.A.6
  • 44
    • 0035061328 scopus 로고    scopus 로고
    • Mucosal immune network in the gut for the control of infectious diseases
    • Iijima, H., I. Takahashi, and H. Kiyono. 2001. Mucosal immune network in the gut for the control of infectious diseases. Rev. Med. Virol. 11: 117-133.
    • (2001) Rev. Med. Virol. , vol.11 , pp. 117-133
    • Iijima, H.1    Takahashi, I.2    Kiyono, H.3
  • 45
    • 0033697670 scopus 로고    scopus 로고
    • TGF-β receptor controls B cell responsiveness and induction of IgA in vivo
    • Cazac, B. B., and J. Roes. 2000. TGF-β receptor controls B cell responsiveness and induction of IgA in vivo. Immunity 13: 443-451.
    • (2000) Immunity , vol.13 , pp. 443-451
    • Cazac, B.B.1    Roes, J.2
  • 47
    • 0002189999 scopus 로고
    • Pharmacological regulation of the production of inflammatory cytokines TNF-α and IL-1-β
    • B. Aggarwal and R. K. Puri, eds. Blackwell Science Oxford
    • Allison, A. C., J. C. Lee, and E. M. Eguchi. 1995. Pharmacological regulation of the production of inflammatory cytokines TNF-α and IL-1-β. In Human Cytokines: Their Role in Disease and Therapy. B. Aggarwal and R. K. Puri, eds. Blackwell Science Oxford, pp. 689-713.
    • (1995) Human Cytokines: Their Role in Disease and Therapy , pp. 689-713
    • Allison, A.C.1    Lee, J.C.2    Eguchi, E.M.3
  • 48
    • 0032532196 scopus 로고    scopus 로고
    • Identification of functional subsets by flow cytometry: Intracellular detection of cytokine expression
    • Maino, V. C., and L. J. Picker. 1998. Identification of functional subsets by flow cytometry: intracellular detection of cytokine expression. Cytometry 34: 207-215.
    • (1998) Cytometry , vol.34 , pp. 207-215
    • Maino, V.C.1    Picker, L.J.2
  • 49
    • 0035051599 scopus 로고    scopus 로고
    • Alveolar macrophages, surfactant lipids, and surfactant protein B regulate the induction of immune responses via the airways
    • van Iwaarden, J. F., E. Claassen, S. H. Jeurissen, H. P. Haagsman, and G. Kraal. 2001. Alveolar macrophages, surfactant lipids, and surfactant protein B regulate the induction of immune responses via the airways. Am. J. Respir. Cell. Mol. Biol. 24: 452-458.
    • (2001) Am. J. Respir. Cell. Mol. Biol. , vol.24 , pp. 452-458
    • Van Iwaarden, J.F.1    Claassen, E.2    Jeurissen, S.H.3    Haagsman, H.P.4    Kraal, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.