Biology and pathobiology of cardiac connexins: From cell to bedside

Heart Rhythm

Volumn 3, Issue 1, 2006, Pages 102-107

  Saffitz, Jeffrey E ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cell cell communication; Conduction; Connexins; Douglas Zipes Lecture; Gap junctions

Indexed keywords

GAP JUNCTION PROTEIN;

ARTICLE; CELL COMMUNICATION; GAP JUNCTION; GENE DELETION; GENE SEQUENCE; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION SYSTEM; HEART MUSCLE ISCHEMIA; HEART VENTRICLE ARRHYTHMIA; HUMAN; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SUDDEN DEATH; TISSUE DISTRIBUTION; CELL JUNCTION; ELECTROPHYSIOLOGY; HEART; PHYSIOLOGY;

CELL COMMUNICATION; CONNEXINS; ELECTROPHYSIOLOGY; GAP JUNCTIONS; HEART; HEART CONDUCTION SYSTEM; HUMANS; MYOCYTES, CARDIAC;

EID: 30444456209     PISSN: 15475271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hrthm.2005.10.021     Document Type: Article

References (26)

1. A. Phelan T.A. Starich Innexins get into the gap Bioessays 23 2001 388-396
2. A. Baranova D. Ivanov N. Petrash A. Pestova M. Skoblov I. Kelmanson D. Shagin S. Nazarenko E. Geraymovych O. Litvin A. Tiunova T.L. Born N. Usman D. Staroverov S. Lukyanov Y. Panchin The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins Genomics 83 2004 706-716
3. C. Stout D.A. Goodenough D.L. Paul Connexins: Functions without junctions Curr Opin Cell Biol 16 2004 507-512
4. J. Neijssen C. Herberts J.W. Drijfhout E. Reits L. Jannsen J. Neefjes Cross-presentation by intercellular peptide transfer through gap junctions Nature 434 2005 27-28
5. E.C. Beyer D.L. Paul D.A. Goodenough Connexin43: A protein from rat heart homologous to a gap junction protein from liver J Cell Biol 105 1987 2621-2629
6. G. Sohl K. Willecke Gap junctions and the connexin protein family Cardiovasc Res 62 2004 228-232
7. J.E. Saffitz D.L. Lerner K.A. Yamada Gap junction distribution and regulation in the heart In: D.P. Zipes J. Jalife Cardiac Electrophysiology From Cell to Bedside Fourth Edition 2004 WB Saunders Philadelphia 181-191
8. M.M. Kreutzberg G. Sohl J.S. Kim V.K. Verselis K. Willecke F.F. Bukauskas Functional properties of mouse connexin30.2 expressed in the conduction system of the heart Circ Res 96 2005 1169-1177
9. P.A. Nielson N.M. Kumar Differences in expression patterns between mouse connexin-30.2 (Cx30.2) and its putative human orthologue, connexin-31.9 FEBS Lett 540 2003 151-156
10. A. Plum G. Hallas T. Magin F. Dombrowski A. Hagendorff B. Schumacker C. Wolpert J. Kim W.H. Lamers M. Evert P. Meda O. Traub K. Willecke Unique and shared functions of different connexins in mice Curr Biol 10 2000 1083-1091
11. A.G. Reaume P.A. de Sousa S. Kulkarni B.L. Langiolle D. Shu T.C. Davies S.C. Juneja G.M. Kidder J. Rossant Cardiac malformation in neonatal mice lacking connexin43 Science 267 1995 1831-1834
12. G.Y. Huang E.S. Cooper K. Waldo M.L. Kirby N.B. Gilula C.W. Lo Gap junction-mediated cell-cell communication modulates mouse neural crest migration J Cell Biol 143 1998 1725-1734
13. D.L. Lerner K.A. Yamada R.B. Schuessler J.E. Saffitz Accelerated onset and increased incidence of ventricular arrhythmias induced by ischemia in Cx43-deficient mice Circulation 101 2000 547-552
14. D.E. Gutstein G.E. Morley H. Tamaddon D. Vaidya M.D. Schnieder J. Chen K.R. Chien H. Stuhlmann G.I. Fishman Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43 Circ Res 88 2001 333-339
15. P. Beauchamp C. Choby T. Desplantez K. de Peyer K. Green K. Yamada R. Weingart J.E. Saffitz A.G. Kléber Electrical propagation in synthetic ventricular myocyte strands from germline connexin43 knockout mice Circ Res 95 2004 170-178
16. N.S. Peters J. Coromilas N.J. Severs A.L. Wit Disturbed connexin43 gap junction distribution correlates with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventricular tachycardia Circulation 95 1997 988-996
17. D. Xing A.L. Kjolbye M.S. Nielsen J.S. Petersen K.W. Harlow N.H. Holstein-Rathlou J.B. Martins ZP123 increases gap junctional conductance and prevents reentrant ventricular tachycardia during myocardial ischemia in open chest dogs J Cardiovasc Electrophysiol 14 2003 510-520
18. B.C. Eloff E. Gilat X. Wan D.S. Rosenbaum Pharmacological modulation of cardiac gap junctions to enhance cardiac conduction: Evidence supporting a novel target for antiarrhythmic therapy Circulation 108 2003 3157-3163
19. S. Kanno A. Kovacs K.A. Yamada J.E. Saffitz Connexin43 as a determinant of infarct size following coronary occlusion in mice J Am Coll Cardiol 41 2003 681-686
20. M.A. Beardslee D.L. Lerner P.N. Tadros J.G. Laing E.C. Beyer K.A. Yamada A.G. Kléber R.B. Schuessler J.E. Saffitz Dephosphorylation and intracellular redistribution of ventricular Cx43 during electrical uncoupling induced by ischemia Circ Res 87 2000 656-662
21. B.G. Petrich X. Gong D. Lerner X. Wang J. Heller Brown J.E. Saffitz Y. Wang c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes Circ Res 91 2002 640-647
22. M. Delmar W. Coombs P. Sorgen H.S. Duffy S.M. Taffet Structural bases for the chemical regulation of connexin43 channels Cardiovasc Res 62 2004 268-275
23. G.N. Giepmans Gap junctions and connexin-interacting proteins Cardiovasc Res 62 2004 233-245
24. C.J. Wei X. Xu C.W. Lo Connexins and cell signaling in development and disease Ann Rev Cell Dev Biol 20 2004 811-838
25. T. Toyofuku M. Yabuki K. Otsu T. Kuyuzu M. Hori M. Tada Direct association of the gap junction protein connexin-43 with ZO-1 in cardiac myocytes J Biol Chem 273 1998 12725-12731
26. X. Ai S.M. Pogwizd Connexin 43 downregulation and dephosphorylation in nonischemic heart failure is associated with enhanced colocalized protein phosphatase type 2A Circ Res 96 2005 54-63