Genetics of Schizophrenia: A review of linkage findings

Israel Journal of Psychiatry and Related Sciences

Volumn 39, Issue 4, 2002, Pages 240-251

  Kohn, Yoav ^a   Lerer, Bernard ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 3042838979     PISSN: 03337308     EISSN: 26172402     Source Type: Journal    
DOI: None     Document Type: Review

References (69)

1. Noy S, Achiron A, Laor N. Schizophrenia and autoimmunity - a possible etiological mechanism? Neuropsychobiology 1994;30: 157-119.
2. Susser E, Neugebauer R, Hoek HW, Brown AS, Lin S, Labovitz D, Gorman JM. Schizophrenia after prenatal famine. Further evidence. Arch Gen Psychiatry 1996;53:25-31.
3. Kunugi H, Nanko S, Murray RM. Obstetric complications and schizophrenia: Prenatal underdevelopment and subsequent neurodevelopmental impairment. Br J Psychiatry Suppl 2001;40:s25-29.
4. Cardno AG, Marshall EJ, Coid B, et al. Heritability estimates for psychotic disorders: The Maudsley twin psychosis series. Arch Gen Psychiatry 1999;56:162-168.
5. Gottesman I. Schizophrenia genesis. New York: W.H. Freeman, 1991.
6. Lowing PA, Mirsky AF, Pereira R. The inheritance of schizophrenia spectrum disorders: A reanalysis of the Danish adoptee study data. Am J Psychiatry 1983;140:1167-1171.
7. Vogler GP, Gottesman II, McGue MK, Rao DC. Mixed-model segregation analysis of schizophrenia in the Lindelius Swedish pedigrees. Behav Genet 1990;20:461-472.
8. Risch N. Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet 1990;46:222-228.
9. Lander ES, Schork NJ. Genetic dissection of complex traits. Science 1994;265:2037-2048.
10. Lander E, Kruglyak L. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results. Nat Genet 1995;11:241-247.
11. Meyer J, Huberth A, Ortega G, et al. A missense mutation in a novel gene encoding a putative cation channel is associated with catatonic schizophrenia in a large pedigree. Mol Psychiatry 2001;6:302-306.
12. Riley BP, McGuffin P. Linkage and associated studies of schizophrenia. Am J Med Genet 2000;97:23-44.
13. Pulver AE. Search for schizophrenia susceptibility genes. Biol Psychiatry 2000;47:221-230.
14. Baron M. Genetics of schizophrenia and the new millennium: Progress and pitfalls. Am J Hum Genet 2001;68:299-312.
15. St Clair D, Blackwood D, Muir W, Carothers A, Walker M, Spowart G, Gosden C, Evans HJ. Association within a family of a balanced autosomal translocation with major mental illness. Lancet 1990;336:13-16.
16. Hovatta I, Varilo T, Suvisaari J, et al. A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci. Am J Hum Genet 1999;65:1114-1124.
17. Gurling HM, Kalsi G, Brynjolfson J, et al. Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23. Am J Hum Genet 2001;68:661-673.
18. Brzustowicz LM, Hodgkinson KA, Chow EW, Honer WG, Bassett AS. Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22. Science 2000;288:678-682.
19. Shaw SH, Kelly M, Smith AB, et al. A genome-wide search for schizophrenia susceptibility genes. Am J Med Genet 1998;81:364-376.
20. Dror V, Shamir E, Ghanshani S, et al. hKCa3/KCNN3 potassium channel gene: Association of longer CAG repeats with schizophrenia in Israeli Ashkenazi Jews, expression in human tissues and localization to chromosome 1q21. Mol Psychiatry 1999;4: 254-260.
21. Moises HW, Yang L, Kristbjarnarson H, et al. An international two-stage genome-wide search for schizophrenia susceptibility genes. Nat Genet 1995;11:321-324.
22. Maziade M, Debraekeleer M, Genest P, et al. A balanced 2:18 translocation and familial schizophrenia: falling short of an association. Arch Gen Psychiatry 1993;50:73-75.
23. Pulver AE, Lasseter VK, Kasch L, et al. Schizophrenia: A genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes. Am J Med Genet 1995;60: 252-260.
24. Levinson DF, Mahtani MM, Nancarrow DJ, et al. Genome scan of schizophrenia. Am J Psychiatry 1998;155:741-750.
25. Williams J, Spurlock G, Holmans P, et al. A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia. Mol Psychiatry 1998;3:141-149.
26. Kennedy JL, Macciardi FM. Chromosome 4 workshop. Psychiatr Genet 1998;8:67-71.
27. Kennedy JL, Basile VS, Macciardi FM. Chromosome 4 Workshop Summary: Sixth World Congress on Psychiatric Genetics, Bonn, Germany, October 6-10, 1998. Am J Med Genet 1999;88:224-228.
28. Sherrington R, Brynjolfsson J, Petursson H, et al. Localization of a susceptibility locus for schizophrenia on chromosome 5. Nature 1988;336:164-167.
29. Aschauer HN, Aschauer-Treiber G, Isenberg KE, et al. No evidence for linkage between chromosome 5 markers and schizophrenia. Hum Hered 1990;40:109-115.
30. Silverman JM, Greenberg DA, Altstiel LD, et al. Evidence of a locus for schizophrenia and related disorders on the short arm of chromosome 5 in a large pedigree. Am J Med Genet 1996;67:162-171.
31. Straub RE, MacLean CJ, O' Neill FA, Walsh D, Kendler KS. Support for a possible schizophrenia vulnerability locus in region 5q22-31 in Irish families. Mol Psychiatry 1997;2:148-155.
32. Schwab SG, Eckstein GN, Hallmayer J, et al. Evidence suggestive of a locus on chromosome 5q31 contributing to susceptibility for schizophrenia in German and Israeli families by multipoint affected sib-pair linkage analysis. Mol Psychiatry 1997;2:156-160.
33. Bennett RL, Karayiorgou M, Sobin CA, Norwood TH, Kay MA. Identification of an interstitial deletion in an adult female with schizophrenia, mental retardation, and dysmorphic features: Further support for a putative schizophrenia-susceptibility locus at 5q21-23.1. Am J Hum Genet 1997;61: 1450-1454.
34. Wang S, Sun CE, Walczak CA, Ziegle JS, Kipps BR, Goldin LR, Diehl SR. Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-p22. Nat Genet 1995; 10:41-46.
35. Straub RE, MacLean CJ, O'Neill FA, et al. A potential vulnerability locus for schizophrenia on chromosome 6p24-22: Evidence for genetic heterogeneity. Nat Genet 1995;11: 287-293.
36. Schwab SG, Albus M, Hallmayer J, et al. Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib-pair linkage analysis. Nat Genet 1995;11:325-327.
37. Schwab SG, Hallmayer J, Albus M, et al. A genome-wide autosomal screen for schizophrenia susceptibility loci in 71 families with affected siblings: Support for loci on chromosome 10p and 6. Mol Psychiatry 2000;5: 638-649.
38. Arolt V, Lencer R, Nolte A, et al. Eye tracking dysfunction is a putative phenotypic susceptibility marker of schizophrenia and maps to a locus on chromosome 6p in families with multiple occurrence of the disease. Am J Med Genet 1996;67:564-579.
39. Martinez M, Goldin LR, Cao Q, et al. Follow-up study on a susceptibility locus for schizophrenia on chromosome 6q. Am J Med Genet 1999;88:337-343.
40. Lindholm E, Ekholm B, Shaw S, et al. A schizophrenia-susceptibility locus at 6q25, in one of the world's largest reported pedigrees. Am J Hum Genet 2000;69:96-105.
41. Pulver AE, Mulle J, Nestadt G, et al. Genetic heterogeneity in schizophrenia: Stratification of genome scan data using co-segregating related phenotypes. Mol Psychiatry 2000;5:650-653.
42. Brzustowicz LM, Honer WG, Chow EW, Little D, Hogan J, Hodgkinson K, Bassett AS. Linkage of familial schizophrenia to chromosome 13q32. Am J Hum Genet 1999;65: 1096-1103.
43. Kendler KS, MacLean CJ, O'Neill FA, et al. Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish Study of High-Density Schizophrenia Families. Am J Psychiatry 1996;153:1534-1540.
44. Faraone SV, Matise T, Svrakic D, et al. Genome scan of European-American schizophrenia pedigrees: Results of the NIMH Genetics Initiative and Millennium Consortium. Am J Med Genet 1998;81:290-295.
45. Schwab SG, Hallmayer J, Albus M, et al. Further evidence for a susceptibility locus on chromosome 10p14-p11 in 72 families with schizophrenia by nonparametric linkage analysis. Am J Med Genet 1998;81:302-307.
46. Straub RE, MacLean CJ, Martin RB, et al. A schizophrenia locus may be located in region 10p15-p11. Am J Med Genet 1998;81:296-301.
47. Blouin JL, Dombroski BA, Nath SK, et al. Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nat Genet 1998;20: 70-73.
48. Lin MW, Sham P, Hwu HG, Collier D, Murray R, Powell JF. Suggestive evidence for linkage of schizophrenia to markers on chromosome 13 in Caucasian but not Oriental populations. Hum Genet 1997;99:417-420.
49. Freedman R, Coon H, Myles-Worsley M, et al. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc Natl Acad Sci USA 1997;94:587-592.
50. Stober G, Saar K, Ruschendorf F, et al. Splitting schizophrenia: Periodic catatonia-susceptibility locus on chromosome 15q15. Am J Hum Genet 2000;67:1201-1207.
51. Coon H, Jensen S, Holik J, et al. Genomic scan for genes predisposing to schizophrenia. Am J Med Genet 1994;54:59-71.
52. Leonard S, Gault J, Moore T, et al. Further investigation of a chromosome 15 locus in schizophrenia: Analysis of affected sibpairs from the NIMH Genetics Initiative. Am J Med Genet 1998;81:308-312.
53. Schwab SG, Hallmayer J, Lerer B, et al. Support for a chromosome 18p locus conferring susceptibility to functional psychoses in families with schizophrenia, by association and linkage analysis. Am J Hum Genet 1998; 63:1139-1152.
54. Berrettini WH, Ferraro TN, Goldin LR, Weeks DE, Detera-Wadleigh S, Nurnberger JI Jr, Gershon ES. Chromosome 18 DNA markers and manic-depressive illness: Evidence for a susceptibility gene. Proc Natl Acad Sci USA 1994;91:5918-5921.
55. Pulver AE, Karayiorgou M, Wolyniec PS, et al. Sequential strategy to identify a susceptibility gene for schizophrenia: Report of potential linkage on chromosome 22q12-q13.1: Part 1. Am J Med Genet 1994;54:36-43.
56. Coon H, Holik J, Hoff M, et al. Analysis of chromosome 22 markers in nine schizophrenia pedigrees. Am J Med Genet 1994;54:72-79.
57. Pulver AE, Karayiorgou M, Lasseter VK, et al. Follow-up of a report of a potential linkage for schizophrenia on chromosome 22q12-q13.1: Part 2. Am J Med Genet 1994; 54:44-50.
58. Pulver AE, Nestadt G, Goldberg R, et al. Psychotic illness in patients diagnosed with velo-cardio-facial syndrome and their relatives. J Nerv Ment Dis 1994;182:476-478.
59. Dann J, DeLisi LE, Devoto M, et al. A linkage study of schizophrenia to markers within Xp11 near the MAOB gene. Psychiatry Res 1997;70:131-143.
60. Paterson AD. Sixth World Congress of Psychiatric Genetics X Chromosome Workshop. Am J Med Genet 1999;88:279-286.
61. Berrettini WH. Are schizophrenic and bipolar disorders related? A review of family and molecular genetic studies. Biological Psychiatry 2000;48:531-538.
62. Te Meerman GJ, van der Meulen MA, Sandkuijl LA. Perspectives of identity by descent (IBD) mapping in founder populations. Clinical and Experimental Allergy 1995;25: 97-102.
63. Nystrom-Lahti M, Sistonen P, Mecklin JP, et al. Close linkage to chromosome 3p and conservation of ancestral founding haplotype in hereditary nonpolyposis colorectal cancer families. Proc Natl Acad Sci USA 1994;91: 6054-6058.
64. Houwen RHJ, Baharloo S, Blankenship K, Raeymaekers P, Juyn J, Sandkuijl LA, Freimer NB. Genome screening by searching for shared segments: Mapping a gene for benign recurrent intrahepatic cholestasis. Nat Genet 1994;8:380-386.
65. Puffenberger EG, Kauffman ER, Bolk S, et al. Identity-by-descent and association mapping of a recessive gene for Hirschprung disease on human chromosome 13q22. Human Molecular Genetics 1994;3:1217-1225.
66. Escamilla MA, McInnes LA, Service SK, et al. Genome screening for linkage disequilibrium in a Costa Rican sample of patients with bipolar-I disorder: A follow-up study on chromosome 18. Am J Med Genet 2001;105: 207-213.
67. Motulsky AG. Jewish diseases and origins. Nat Genet 1995;9:99-101.
68. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. Parametric and nonparametric linkage analysis: A unified multipoint approach. Am J Hum Genet 1996;58:1347-1363.
69. Rice JP. The role of meta-analysis in linkage studies of complex traits. Am J Med Genet 1997;74:112-114.