Synthesis and first in vivo evaluation of new selective high affinity β1-adrenoceptor radioligands for SPECT based on ICI 89,406

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 15, 2004, Pages 4117-4132

  Wagner, Stefan ^a   Kopka, Klaus ^a   Law, Marilyn P ^a   Riemann, Burkhard ^a   Pike, Victor W ^b   Schober, Otmar ^a   Schäfers, Michael ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

3 Aryloxy 2 propanolamine; ICI 89,406; Selective 1 adrenoceptor ligand; SPECT radioligand

Indexed keywords

1 (2 CYANOPHENOXY) 3 [2 (3 PHENYLUREIDO)ETHYLAMINO] 2 PROPANOL; BETA 1 ADRENERGIC RECEPTOR; CYANOPINDOLOL I 125; N (4 CARBOXYPHENYL) N' [2 [3 (2 IODOPHENOXY) 2 HYDROXYPROPYLAMINO]ETHYL]UREA; RADIOLIGAND; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DRUG DESIGN; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; HEART VENTRICLE WALL; LIGAND BINDING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; RECEPTOR AFFINITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BINDING SITES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; ISOTOPE LABELING; LIGANDS; MALE; MICE; MICE, INBRED DBA; MICROSOMES; MOLECULAR CONFORMATION; PROPANOLAMINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA-1; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

ANIMALIA;

EID: 3042838323     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.05.027     Document Type: Article

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