Differential blockade of nerve injury-induced thermal and tactile hypersensitivity by systemically administered brain-penetrating and peripherally restricted local anesthetics

Journal of Pain

Volumn 5, Issue 5, 2004, Pages 281-289

  Chen, Qingmin ^a   King, Tamara ^a   Vanderah, Todd W ^a   Ossipov, Michael H ^a   Malan Jr , T Philip ^a   Lai, Josephine ^a   Porreca, Frank ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Lidocaine; neuropathic pain; QX 222; QX 314; tactile allodynia; thermal hyperalgesia

Indexed keywords

LIDOCAINE; LIDOCAINE ETHOBROMIDE; LOCAL ANESTHETIC AGENT; N [(2,6 DIMETHYLPHENYL)CARBAMOYLMETHYL]TRIMETHYLAMMONIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; HYPERALGESIA; HYPERSENSITIVITY; LOCAL ANESTHESIA; MALE; MEDULLA OBLONGATA; MICROINJECTION; NERVE INJURY; NERVE LIGATION; NONHUMAN; RAT; SPINAL NERVE; TACTILE STIMULATION;

ANESTHETICS, LOCAL; ANIMALS; BRAIN; HEAT; HYPERALGESIA; MALE; PAIN MEASUREMENT; PHYSICAL STIMULATION; RATS; SPINAL NERVES;

EID: 3042831429     PISSN: 15265900     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpain.2004.05.002     Document Type: Article

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