Local anesthetics inhibit the g protein-mediated modulation of K+ and Ca++ currents in anterior pituitary cells

Molecular Pharmacology

Volumn 55, Issue 1, 1999, Pages 150-158

  Xiong, Zhiling ^a   Bukusoglu, Cuneyt ^a   Strichartz, Gary R ^a,b  

^a Pain Research Center   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOCAINE; CALCIUM ION; GUANINE NUCLEOTIDE BINDING PROTEIN; LIDOCAINE; LIDOCAINE ETHOBROMIDE; LOCAL ANESTHETIC AGENT; PHORBOL DIBUTYRATE; POTASSIUM ION; PROTIRELIN;

ADENOHYPOPHYSIS; AGONIST; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM CURRENT; CONCENTRATION RESPONSE; DEPOLARIZATION; DRUG MECHANISM; HISTAMINE RELEASE; HORMONE RECEPTOR INTERACTION; HYPOPHYSIS CELL; LOCAL ANESTHESIA; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

EID: 0032894292     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.55.1.150     Document Type: Article

References (28)

1. Bacaner MB, Clay JR, Shrier A and Brochu RM (1986) Potassium channel blockade: A mechanism for suppressing ventricular fibrillation. Proc Natl Acad Sci USA 83:2223-2227.
2. +-channels in arterial and intestinal smooth muscle cell membranes. Pflügers Arch 403:120-127.
3. Bernards CM and Hill HF (1992) Physical and chemical properties of drug molecules governing their diffusion through the spinal meninges. Anesthesiology 77:750.
4. 2+ levels in a pituitary cell line. Eur J Pharmacol 298:79-85.
5. Butterworth JF and Strichartz GR (1990) Molecular mechanisms of local anesthesia: A review. Anesthesiol 72:711-734.
6. + current but not the inward rectifier in rat ventricular myocytes. J Pharmacol Exp Ther 255:1038-1046.
7. o proteins in rat neuroendocrine cell lines. J Physiol (Lond) 502;2:321-333.
8. Dubinsky JM and Oxford GS (1984) Ionic currents in two strains of rat anterior pituitary tumor cells. J Gen Physiol 83:309-339.
9. Frazier DT, Narahashi T and Yamada M (1970) The site of action and active form of local anesthetics. II. Experiments with quaternary compounds. J Pharmacol Exp Thera 171:45-51.
10. 2+] indicators with greatly improved fluorescence properties. J Biol Chem 260:3440-3450.
11. Hamill OP, Marty A, Neher E, Sakmann B and Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 391:85-100.
12. Hille B (1977) Local anesthetics: Hydrophilic and hydrophobic pathways for the drug-receptor reaction. J Gen Physiol 69:497-515.
13. Josephson IR (1988) Lidocaine blocks Na, Ca, and K currents of chick ventricular myocytes. J Mol Cellu Cardiol 20:593-604.
14. (o) splice variant. Ciba Found Symp 190:171-182.
15. 2+. Anesthesiol 82:166-173.
16. 2+ conductances. Endocrinology 123:721-732.
17. + channel in rat hippocampal neurons. Br J Pharmacol 105:63-70.
18. 2+ release from isolated platelet membrane vesicles. Biochem Pharmacol 36:3331-3337.
19. Strichartz GR (1973) The inhibition of sodium currents in myelinated nerve by quternary derivatives of lidocaine. J Gen Physiol 62:37-57.
20. a values of clinically used drugs. Anesth Anal 71:158-170.
21. 6 resemble those of compound 48/80. Gen Pharmacol 26:1171-1178.
22. Voeikov VV and Lefkowitz RJ (1977) Effect of local anesthetics on guanyl nucleotide modulation of the catecholamine-sensitive adenylate cyclase system and β-adrenergic receptors. Biochem Biophys Acta 629:266-281.
23. Volpe P, Palade P, Costello B, Mitchell RD and Fleischer S (1983) Spontaneous calcium release from sarcoplasmic reticulum: Effect of local anesthetics. J Biol Chem 258:12434-12442.
24. 1 cells. Mol Cellu Endocrinol 74:185-190.
25. Wong BS, Lecar H and Adler M (1982) Single calcium-dependent potassium channels in clonal anterior pituitary cells. Biophys J 39:313-317.
26. Xiong ZL, Kitamura K and Kuriyama H (1991) ATP activates cationic currents and modulates the calcium current through GTP-binding protein in rabbit portal vein. J Physiol 440:143-165.
27. Xiong ZL and Strichartz GR (1995) Inhibition by local anesthetics of calcium channels in anterior pituitary cells. Biophys J 68:209.
28. + channels in Xenopus oocytes. Eur J Pharmacol 247:267-272.