Involvement of the Major Histocompatibility Complex region in the regulation regulation of circulating CD8+ T-cell numbers in humans

Tissue Antigens

Volumn 64, Issue 1, 2004, Pages 25-34

  Cruz, E ^a,b,c   Vieira, J ^c   Goncalves R ^d   Alves, H ^d   Almeida, S ^c   Rodrigues, P ^c   Lacerda, R ^b   Porto, G ^a,b,c  

^a HOSPITAL DE SANTO ANTÓNIO   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c UNIVERSITY OF PORTO   (Portugal)

^d Ministerio da Saude Portuguese   (Portugal)

Author keywords

CD8+ T cells; HFE; HLA; Human genetics; MHC

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; HLA A ANTIGEN; HLA ANTIGEN CLASS 1;

ADULT; AGED; ALLELE; ARTICLE; CELL COUNT; CORRELATION ANALYSIS; FAMILY; FEMALE; GENE IDENTIFICATION; GENE MUTATION; GENETIC REGULATION; HAPLOTYPE; HEMOCHROMATOSIS; HUMAN; HYPOTHESIS; LYMPHOCYTE COUNT; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; NORMAL HUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALLELES; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; GENE FREQUENCY; GENOTYPE; HEMOCHROMATOSIS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA-A ANTIGENS; HLA-B ANTIGENS; HUMANS; LYMPHOCYTE COUNT; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MEMBRANE PROTEINS; MIDDLE AGED; PHENOTYPE;

ANIMALIA;

EID: 3042826686     PISSN: 00012815     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-0039.2004.00245.x     Document Type: Article

References (27)

1. Rocha B, Dautigny N, Pereira P. Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo. Eur J Immunol 1989: 19: 905-11.
2. Evans DM, Frazer IH, Martin NG. Genetic and environmental causes of variation in basal levels of blood cells. Twin Res 1999: 2: 250-7.
3. Kraal G, Weissman IL, Butcher EC. Genetic control of T-cell subset representation in inbred mice. Immunogenetics 1983: 18: 585-92.
4. van Meerwijk JP, Bianchi T, Marguerat S, MacDonald HR. Thymic lineage commitment rather than selection causes genetic variations in size of CD4 and CD8 compartments. J Immunol 1998: 160: 3649-54.
5. Sim BC, Aftahi N, Reilly C et al. Thymic skewing of the CD4/CD8 ratio maps with the T-cell receptor alpha-chain locus. Curr Biol 1998: 8: 701-4.
6. Damoiseaux JG, Cautain B, Bernard I et al. A dominant role for the thymus and MHC genes in determining the peripheral CD4/CD8 T cell ratio in the rat. J Immunol 1999: 163: 2983-9.
7. Amadori A, Zamarchi R, De Silvestro G et al. Genetic control of the CD4/CD8 T-cell ratio in humans. Nat Med 1995: 1: 1279-83.
8. Clementi M, Forabosco P, Amadori A et al. CD4 and CD8 T lymphocyte inheritance. Evidence for major autosomal recessive genes. Hum Genet 1999: 105: 337-42.
9. Hall MA, Ahmadi KR, Norman P et al. Genetic influence on peripheral blood T lymphocyte levels. Genes Immun 2000: 1: 423-7.
10. + T lymphocyte populations? Genes Immun 2001: 2: 381-7.
11. Hall MA, Norman PJ, Thiel B et al. Quantitative trait loci on chromosomes 1, 2, 3, 4, 8, 9, 11, 12 and 18 control variation in levels of T and B lymphocyte subpopulations. Am J Hum Genet 2002: 70: 1172-82.
12. Reimão R, Porto G, de Sousa M. Stability of CD4/CD8 ratios in man: new correlation between CD4/CD8 profiles and iron overload in idiopathic hemochromatosis patients. C R Acad Sci III 1991: 313: 481-7.
13. + lymphocytes and iron overload. Eur J Haematol 1994: 52: 283-90.
14. Porto G, Vicente C, Teixeira MA et al. Relative impact of HLA phenotype and CD4/CD8 ratios on the clinical expression of hemochromatosis. Hepatology 1997: 25: 397-402.
15. Fabio G, Zarantonello M, Mocellin C et al. Peripheral lymphocytes and intracellular cytokines in C282Y homozygous hemochromatosis patients. J Hepatol 2002: 37: 753-61.
16. de Sousa M, Porto G. The immunological system in hemochromatosis. J Hepatol 1998: 28: 1-7.
17. Feder JN, Gnirke A, Thomas W et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 1996: 13: 399-108.
18. Piperno A, Sampietro M, Pietrangelo A et al. Heterogeneity of hemochromatosis in Italy. Gastroenterology 1998: 114: 996-1002.
19. Adams PC, Chakrabarti S. Genotypic/phenotypic correlations in genetic hemochromatosis: evolution of diagnostic criteria. Gastroenterology 1998: 114: 319-23.
20. Barton JC, Shih WW, Sawada-Hirai R et al. Genetic and clinical description of hemochromatosis probands and heterozygotes: evidence that multiple genes linked to the major histocompatibility complex are responsible for hemochromatosis. Blood Cells Mol Dis 1997: 23: 135-45.
21. Porto G, Cardoso CS, Gordeuk V et al. Clinical and genetic heterogeneity in hereditary haemochromatosis: association between lymphocyte counts and expression of iron overload. Eur J Haematol 2001: 67: 110-8.
22. + cells in the liver lobuli. Eur J Clin Invest 2001: 31: 45-53.
23. Cardoso C, Porto G, Lacerda R et al. T-cell receptor repertoire in hereditary hemochromatosis: a study of 32 hemochromatosis patients and 274 healthy subjects. Hum Immunol 2001: 62: 488-99.
24. Cardoso CS, Oliveira P, Porto G et al. Comparative study of the two more frequent HFE mutations (C282Y and H63D): significant different allelic frequencies between the North and South of Portugal. Eur J Hum Genet 2001: 9: 843-8.
25. Alves H, Dias M, Mendes F et al. Allele and haplotype frequencies for HLA-A, B, C, DRB1 and DQB in random Portuguese families from the north population. Eur J Immunogenet 2001: 28: 282 [Abstract 169].
26. Yaouanq J. Human leucocyte antigen (HLA) association and typing in hemochomatosis. In: Barton JC, Edwards CQ, eds. Hemochromatosis: Genetics, Pathophysiology, Diagnosis and Treatment. Cambridge: Cambridge University Press, 2000: 63-74.
27. Jackson AU, Galecki AT, Burke DT, Miller RA. Genetic polymorphisms in mouse genes regulating age-sensitive and age-stable T cell subsets. Genes Immun 2003: 4: 30-9.