Hepatic damage in C282Y homozygotes relates to low numbers of CD8+ cells in the liver lobuli

European Journal of Clinical Investigation

Volumn 31, Issue 1, 2001, Pages 45-53

  Cardoso, E M P ^a   Hagen, K ^a   De Sousa, M ^a,b   Hultcrantz, R ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

CD8+ T lymphocytes; Haemochromatosis gene (HFE); Iron; Liver cirrhosis

Indexed keywords

CD8 ANTIGEN; FERRITIN; IRON; TRANSFERRIN;

ADULT; AGED; ARTICLE; CELL SELECTION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE; GENE MUTATION; HEMOCHROMATOSIS; HOMOZYGOTE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER BIOPSY; LIVER CIRRHOSIS; LIVER INJURY; MALE; PHLEBOTOMY; PRIORITY JOURNAL; T LYMPHOCYTE;

ADULT; AGE FACTORS; AGED; AMINO ACID SUBSTITUTION; BIOPSY; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; FERRITINS; HEMOCHROMATOSIS; HEMOSIDERIN; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HOMOZYGOTE; HUMANS; IRON; JEJUNUM; LIVER; LIVER CIRRHOSIS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; POLY(A)-BINDING PROTEINS; PROTEINS; RNA-BINDING PROTEINS;

EID: 0035130677     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.2001.00744.x     Document Type: Article

References (36)

1. Hemochromatosis: Genetics and pathogenesis
2. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
3. Mutation analysis in hereditary hemochromatosis
4. Haemochromatosis and HLA-H
5. Haemochromatosis and HLA-H
6. HFE mutations in patients with hereditary haemochromatosis in Sweden
7. Clinical and family studies in genetic hemochromatosis and HFE studies in five atypical families
8. Homozygosity for the predominant Cys282Tyr mutation and absence of disease expression in hereditary haemochromatosis
9. Stability of CD4/CD8 ratios in man: New correlation between CD4/CD8 profiles and iron overload in idiopathic haemochromatosis patients
10. Haemochromatosis as a window into the study of the immunological system: A novel correlation between CD8+ lymphocytes and iron overload
11. Decreased CD8-p561ck activity in peripheral blood T-lymphocytes from patients with hereditary haemochromatosis
12. Relative impact of HLA phenotype and CD4-CD8 ratios on the clinical expression of hemochromatosis
13. Anomalies of the CD8+ T cell pool in haemochromatosis: HLA-A3-linked expansions of CD8+CD28- T cells
14. HFE gene knockout produces mouse model of hereditary hemochromatosis
15. Iron overload in beta 2-microglobulin-deficient mice
16. Beta2 knockout mice develop parenchymal iron overload: A putative role for class I genes of the major histocompatibility complex in iron metabolism
17. Defective iron homeostasis in beta 2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man
18. Iron overload and heart fibrosis in b-microglobulin and RAG-deficient mice
19. gd Intraepithelial drive tumor necrosis factor-a responsiveness to intestinal iron challenge: Relevance to hemochromatosis
20. The immunological system in hemochromatosis
21. Kupffer cell iron overload induces intercellular adhesion molecule-1 expression on hepatocytes in genetic hemochromatosis
22. Lymphocyte and macrophage phenotypes in chronic hepatitis C infection. Correlation with disease activity
23. Dynamics of intra-hepatic lymphocytes in chronic hepatitis C. enrichment for Valpha24+ T cells and rapid elimination of effector cells by apoptosis
24. A monoclonal antibody reactive with a 15-kDa cytoplasmic granule-associated protein defines a subpopulation of CD8+ T lymphocytes
25. A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells
26. Hepatic pathology in relatives of patients with hemochromatosis
27. Classification of chronic hepatitis: Diagnosis, grading and staging
28. Hereditary hemochromatosis in adults without pathogenic mutations in the hemochromatosis gene
29. The relationship between iron overload, clinical symptoms, and age in 410 patients with genetic hemochromatosis
30. Primary iron overload
31. Liver pathology in genetic hemochromatosis: A review of 135 homozygous cases and their bioclinical correlations
32. Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition
33. Genes, immunity, and senescence: Looking for a link
34. Experimental hemochromatossis due to MHC class I HFE deficiency: Immune status and iron metabolism