A dominant role for the thymus and MHC genes in determining the peripheral CD4/CD8 T cell ratio in the rat

Journal of Immunology

Volumn 163, Issue 6, 1999, Pages 2983-2989

  Damoiseaux, Jan G M C ^a   Cautain, Bastien ^b   Bernard, Isabelle ^b   Mas, Magali ^b   Van Breda Vriesman, Peter J C ^a   Druet, Philippe ^b   Fournié, Gilbert ^b   Saoudi, Abdelhadi ^b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b CHU PURPAN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; IMMUNOREGULATION; LYMPHOCYTE COUNT; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE SUBPOPULATION; THYMUS;

EID: 0033567997     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Kraal, G., I. L. Weissman, and E. Butcher. 1983. Genetic control of T-cell subset representation in inbred mice. Immunogenetics 18:585.
2. Amadori, A., R. Zamarchi, G. De Silvestro, G. Forza, G. Cavatton, G. A. Danieli, M. Clementi, and L. Chieco-Bianchi. 1995. Genetic control of the CD4/CD8 T-cell ratio in humans. Nat. Med. 1:1279.
3. Nossal, G. J. V. 1994. Negative selection of lymphocytes. Cell 76:229.
4. Jameson, S. C., K. A. Hogquist, and M. J. Bevan. 1995. Positive selection of thymocytes. Anna. Rev. Immunol. 13:93.
5. + T cells. Curr. Opin. Immunol. 8:225.
6. Surh, C. D., and J. Sprent. 1994. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372:100.
7. Speiser, D. E., H. Pircher, P. S. Ohashi, D. Kyburz, H. Hengartner, and R. M. Zinkernagel. 1992. Clonal deletion induced by either radioresistant thymic host cells or lymphohemopoietic donor cells at different stages of class I-restricted T cell ontogeny. J. Exp. Med. 175:1277.
8. Davis, C. B., N. Killeen, M. E. C. Crooks, D. Raulet, and D. R. Littman. 1993. Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes. Cell 73:237.
9. + thymocytes: selection rather than instruction? Science 261:911.
10. Boehmer, H. von. 1996. CD4/CD8 lineage commitment: back to instruction? J. Exp. Med. 183:713.
11. Gabor, M. J., R. Scollay, and D. I. Godfrey. 1997. Thymic T cell export is not influenced by the peripheral T cell pool. Eur. J. Immunol. 27:2986.
12. + thymic emigrants. J. Immunol. 160:3705.
13. + T cells, but affect their long-term life span. Immunity 5:217.
14. Damoiseaux, J. G. M. C., L. J. J. Beijleveld, and P. J. C. van Breda Vriesman. 1998. A dominant role for non-MHC gene effects in susceptibility to cyclosporin A (CsA)-induced autoimmunity. Clin. Exp. Immunol. 113:333.
15. Hünig, T., H.-J. Wallny, J. K. Hartley, A. Lawetzky, and G. Tiefenthaler. 1989. A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. J. Exp. Med. 169:73.
16. Torres-Nagel, N., E. Kraus, M. H. Brown, G. Tiefenthaler, R. Mitnacht, A. F. Williams, and T. Hünig. 1992. Differential thymus dependence of rat CD8 isoform expression. Eur. J. Immunol. 22:2841.
17. Williams, A. F., G. Galfre, and C. Milstein. 1977. Analysis of cell surfaces by xenogeneic myeloma-hybrid antibodies: differentiation antigens of rat lymphocytes. Cell 12:663.
18. McMaster, W. R., and A. F. Williams. 1979. Identification of Ia glycoproteins in rat thymus and purification from rat spleen. Eur. J. Immunol. 9:426.
19. Brideau, R. J., P. B. Carter, W. R. McMaster, D. W. Mason, and A. F. Williams. 1980. Two subsets of rat T lymphocytes defined with monoclonal antibodies. Eur. J. Immunol. 10:609.
20. Hunt, S. V., and M. H. Fowler. 1981. A repopulation assay for B and T lymphocyte stem cells employing radiation chimaeras. Cell Tissue Kinet. 14:445.
21. Boitard, C., S. Michie, P. Serrurier, G. W. Butcher, A. P. Larkins, and H. O. McDewitt. 1985. In vivo prevention of thyroid and pancreatic autoimmunity in the BB rat by antibody to class II major histocompatibility complex gene products. Proc. Natl. Acad. Sci. USA 82:6627.
22. Beijleveld, L. J. J., H. Groen, C. P. M. Broeren, F. Klatter, J. Kampinga, J. G. M. C. Damoiseaux, and P. J. C. van Breda Vriesman. 1996. Susceptibility to clinically manifest cyclosporine A (CsA)-induced autoimmune disease is associated with interferon-γ (IFN-γ) producing CD45RC+RT6-T helper cells. Clin. Exp. Immunol. 105:486.
23. Yang, C., and E. B. Bell. 1992. Functional maturation of recent thymic emigrants in the periphery: development of alloreactivity correlates with the cyclic expression of CD45RC isoforms. Eur. J. Immunol. 22:2261.
24. Hosseinzadeh, H., and I, Goldschneider. 1993. Recent thymic emigrants in the rat express a unique antigenic phenotype and undergo post-thymic maturation in peripheral lymphoid tissues. J. Immunol. 150:1670.
25. Meerwijk, J. P. M. van, T. Bianchi, S. Marguerat, and H. R. MacDonald. 1998. Thymic lineage commitment rather than selection causes genetic variations in size of CD4 and CD8 compartments. J. Immunol. 160:3649.
26. Berzins, S. P., R. L. Boyd, and J. F. A. P. Miller. 1998. The role of the thymus and recent thymic migrants in the maintenance of the adult peripheral lymphocyte pool. J. Exp. Med. 187:1839.
27. + mouse and rat thymocytes to equivalent triggering signals: correlation with thymic expression of a truncated CD8α chain in mice but not rats. J. Immunol. 160:700.
28. Delaney, J. R., Y. Sykulev, H. N. Eisen, and S. Tonegawa. 1998. Differences in the level of expression of class I major histocompatibility complex proteins on thymic epithelial and dendritic cells influence the decision of immature thymocytes between positive and negative selection. Proc. Natl. Acad. Sci. USA 95:5235.
29. Joly, E., and G. W. Butcher. 1998. Why are there two rat TAPs? Immunol. Today 19:580.
30. Salter, R. D., R. J. Benjamin, P. K. Wesley, S. E. Buxton, T. P. Garrett, C. Clayberger, A. M. Krensky, A. M. Norment, D. R. Littman, and P. Parham. 1990. A binding site for the T cell coreceptor CD8 on the α3 domain of HLA-A2. Nature 345:41.
31. Aldrich, C. J., R. E. Hammer, S. Jones-Youngblood, U. Koszinowski, L. Hood, I. Stroynowski, and J. Forman. 1991. Negative and positive selection of antigen-specific cytotoxic T lymphocytes affected by the α3 domain of MHC I molecules. Nature 352:718.
32. Salter, R. D., A. M. Norment, B. P. Chen, C. Clayberger, A. M. Krensky, D. R. Littman, and P. Parham. 1989. Polymorphism in the α3 domain of HLA-A molecules affects binding to CD8. Nature 338:345.
33. Joly, E., A.-F. Le Rolle, A. L. Gonzalez, B. Mehling, J. Stevens, W. J. Coadwell, T. Hünig, J. C. Howard, and G. W. Butcher. 1998. Co-evolution of rat TAP transporters and MHC class I RT1-A molecules. Curr. Biol. 8:169.
34. Happ, M. P., P. Wettstein, B. Dietzschold, and E. Heber-Katz. 1988. Genetic control of the development of experimental allergic encephalomyelitis in rats. Separation of MHC and non-MHC gene effects. J. Immunol. 141:1489.
35. Wodzig, K. W. H., G. D. Majoor, and P. J. C. van Breda Vriesman. 1993. Susceptibility and resistance to cyclosporin A-induced autoimmunity in rats. Autoimmunity 16:29.
36. Druet, P., S. Ramanathan, and L. Pelletier. 1996. Th1 and Th2 lymphocytes in autoimmunity. Adv. Nephrol. 25:217.
37. Goldman, M., P. Druet, and E. Gleichmann. 1991. Th2 cells in systemic autoimmunity: insights from allogeneic diseases and chemically-induced autoimmunity. Immunol. Today 12:223.
38. Croft, M., L. Carter, S. L. Swain, and R. W. Dutton. 1994. Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J. Exp. Med. 180:1715.
39. + T cells into subpopulations with distinct cytokine profiles. J. Immunol. 155:2928.
40. + T cells secreting Th1 or Th2 cytokines. Immunity 2:271.
41. + T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production. J. Exp. Med. 178:889.
42. + T cells. Eur. J. Immunol. 27:2657.
43. + T cells control Th2-driven pathology during pulmonary respiratory syncytial virus infection. Eur. J. Immunol. 27:3341.
44. + T lymphocytes down regulate T helper cell type cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infection. J. Exp. Med. 186:421.
45. Castedo, M., L. Pelletier, R. Pasquier, and P. Druet. 1994. Improvement of Th1 functions during the regulation phase of mercury disease in Brown Norway rats. Scand. J. Immunol. 39:144.