The retinal degeneration (rd) gene seriously impairs spatial cognitive performance in normal and Alzheimer's transgenic mice

NeuroReport

Volumn 15, Issue 1, 2004, Pages 73-77

  Garcia, M F ^a   Gordon, M N ^a   Hutton, M ^b   Lewis, J ^b   McGowan, E ^b   Dickey, C A ^a   Morgan, D ^a   Arendash, G W ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Anxiety level; APP transgenics; Cognitive performance; rd gene; Retinal degeneration; Sensorimotor function; Tau transgenics

Indexed keywords

ALZHEIMER DISEASE; ARTICLE; COGNITION; GENOTYPE; HOMOZYGOSITY; MAZE TEST; MOUSE; NONHUMAN; PERFORMANCE; PRIORITY JOURNAL; RECOGNITION; RETINA DEGENERATION; TRANSGENIC MOUSE; VISUAL ACUITY; ANIMAL; BEHAVIOR; C57BL MOUSE; COGNITIVE DEFECT; COMPARATIVE STUDY; DBA MOUSE; GENETICS; HUMAN; PHYSIOLOGY; REACTION TIME;

TAU PROTEIN;

ALZHEIMER DISEASE; ANIMALS; COGNITION; COGNITION DISORDERS; HUMANS; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, TRANSGENIC; REACTION TIME; RETINAL DEGENERATION; SPATIAL BEHAVIOR; TAU PROTEINS;

EID: 3042825512     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001756-200401190-00015     Document Type: Article

References (18)

1. Ogilvie J and Speck J. Dopamine has a critical role in photoreceptor degeneration in the rd mouse. Neurobiol Dis 10, 33-40 (2002).
2. Jimenez A, Garcia-Fernandez J, Gonzalez B and Foster R. The spatiotemporal pattern of photoreceptor degeneration in the aged rd/rd mouse retina. Cell Tissue Res 284, 193-202 (1996).
3. Portero-Cailliau C, Suno C, Nathans J and Adler R. Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa. Proc Natl Acad Sci USA 91, 974-978 (1994).
4. Sidman R and Green M. Retinal degeneration in the mouse location of the rd locus in linkage group XVII. J Hered 56, 23-29 (1965).
5. Zhou G and Williams R. Mouse models for the analysis of myopia: An analysis of variation in eye size of adult mice. Optom Vis Sci 76, 408-418 (1996).
6. Spencer R, O-Steen K and McEwen B. Water maze performance of aged Sprague-Dawley rats in relation to retinal morphologic measures. Behav Brain Res 68, 139-150 (1995).
7. Wahsten D. Contributions of the genes albinism (c) and retinal degeneration (rd) to a strain-by-training procedure interaction in avoidance learning. Behav Genet 3, 303-316 (1973).
8. Fuller J, Brady-wood S and Elias M. Effects of retinal degeneration and brain size upon spatial reversal learning in mice. Percept Motor Skills 36, 947-950 (1973).
9. Cook M, Williams R and Flaherty L. Anxiety-related behaviors in the elevated zero-maze are affected by genetic factors and retinal degeneration. Behav Neurosci 115, 468-476 (2001).
10. Hsiao K, Chapman P, Nilsen S, Eckan C, Harigaya Y and Younkin S et al. Correlative memory deficits, Aβ elevation, & amyloid plaques in transgenic mice. Science 274, 99-102 (1996).
11. Frautchy S, Yang F, Irrizarry M, Hyman B, Saido T, Hsiao K and Cole G. Microglial response to amyloid plaques in APPsw transgenic mice. Am J Pathol 152, 307-317 (1998).
12. Lewis J, McGowan E, Rockwood J, Melrose H, Nacharaju P, Van Slegtenhorst M et al. Neurofibrillary tangles, amytophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nature Genet 25, 402-405 (2000).
13. Lewis J, Dickson D, Lin W-L, Chisholm L, Corral A, Jones G et al. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 293, 1487-1491 (2001).
14. Arendash GW, King DL, Gordon MN, Morgan D, Hatcher JM, Hope CE et al. Progressive-age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes. Brain Res 891, 42-53 (2001).
15. De Bruin J, Sanchez-Santed F, Heinsbrock R, Donker A and Postmes P. A behavioural analysis of rats with damage to the medial prefrontal cortex using the Morris water maze: evidence for behavioural flexibility, but not for impaired spatial navigation. Brain Res 652, 323-333 (1994).
16. Arendash GW and King D. Intra- and inter-task relationships in a behavioral test battery given to Tg2576 transgenic mice and controls. Physiol Behav 75, 643-652 (2002).
17. King DL and Arendash GW. Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months. Physiol Behav 75, 627-642 (2002).
18. Trullas R and Skolnick P. Differences in fear motivated behaviors among inbred mouse strains. Psychopharmacology 111, 323-331 (1993).