Gd3+-loaded polyion complex for pH depiction with magnetic resonance imaging

Journal of Biomedical Materials Research

Volumn 49, Issue 3, 2000, Pages 390-395

  Mikawa, Masahito ^a,b   Miwa, Naoto ^b   Bräutigam, Matthias ^c   Akaike, Toshihiro ^a   Maruyama, Atsushi ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b Nagoya University   (Japan)

^c Research and Development   (Japan)

Author keywords

Contrast agent; MRI; PH; Polyion complex; T1 proton relaxation

Indexed keywords

AMINES; CONTRAST MEDIA; GADOLINIUM; MAGNETIC RESONANCE IMAGING; PH EFFECTS; PROTONS; RELAXATION PROCESSES; STOICHIOMETRY; SWELLING;

POLYION COMPLEX; PROTON RELAXATION;

BIOMATERIALS;

1,3 PROPANEDIAMINE; CHELATING AGENT; GADOLINIUM; GADOLINIUM PENTETATE; N,N DIMETHYLFORMAMIDE; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; POLY(ETHYL METHACRYLATE); POLYANION; POLYCATION; TRIETHYLAMINE;

ARTICLE; CHELATION; COMPLEX FORMATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PH; PHANTOM; STOICHIOMETRY; TITRIMETRY;

CATIONS; CONTRAST MEDIA; GADOLINIUM DTPA; HUMANS; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE IMAGING; PHANTOMS, IMAGING;

EID: 0034607168     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4636(20000305)49:3<390::AID-JBM12>3.0.CO;2-Q     Document Type: Article

References (25)

1. Degani H, Gusis V, Weinstein D, Fields S, Strano S. Mapping pathophysiological features of breast tumors by MRI at high spatial resolution. Nature Med 1997;3:780-782.
2. Unger EC, Ugurbil K, Latchaw RE. Contrast agents for cerebral perfusion MR imaging. J Magn Reson Imag 1994;4:235-242.
3. Schuhmann-Giampieri G. Liver contrast media for magnetic resonance imaging interrelations between pharmacokinetics and imaging. Invest Radiol 1993;28:753-761.
4. Weissleder R, Bogdanov A, Papisov M. Drug targeting in magnetic resonance imaging. Magn Reson Quarterly 1992;8:55-63.
5. 3+-diethylene triaminepentaacetic acid and dextran. II. Influence of spacer arm length and conjugate molecular mass on paramagnetic properties and some biological parameters. Bioconjugate Chem 1998;9:94-99.
6. Marecos E, Weissleder R, Bogdanov Jr A. Antibody-mediated versus nontargeted delivery in a human small cell lung carcinoma model. Bioconjugate Chem 1998;9:184-191.
7. Bogdanov Jr A, Weissleder R, Brady TJ. Long-circulating blood pool imaging agents. Adv Drug Del Rev 1995;16:335-348.
8. Brasch RC. Rationale and application for macromolecular Gd-based contrast agents. Magn Reson Med 1991;22:282-287.
9. Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 1989;49:6449.
10. Gerweck LE, Seetharaman K. Cellular pH gradient in tumor versus normal tissue: Potential exploitation for the treatment of cancer. Cancer Res 1996;56:1194-1198.
11. Lauffer RB. Paramagnetic metal complexes as water proton relaxation agents for NMR imaging: Theory and design. Chem Rev 1987;87:901-927.
12. Kowalewski J, Nordenkioeld L, Benetis N, Westlund PO. Theory of nuclear spin relaxation in paramagnetic system in solution. Prog NMR Spectrosc 1985;17:141-185.
13. Brasch RC. Introduction to the gadolinium class. J Comput Assist Tomogr 1993;17:S14-S18.
14. Koenig SH. The need for electron paramagnetic resonance and water exchange-rate data for understanding small magnetic resonance imaging contrast agents and their macromolecular complexes. Invest Radiol 1994;29:S127-S130.
15. Wiener EC, Auteri FP, Chen JW, Brechbiel MW, Gansow OA, Schnider DS, Belford RL, Clarkson RB, Lauterbur PC. Molecular dynamics of ion-chelate complexes attached to dendrimers. J Am Chem Soc 1996;118:7774-7782.
16. Abe K, Ohno H, Tsuchida E. Phase changes of polyion complex between poly(methacrylic acid) and a polycation carrying charges in the chain backbone. Makromol Chem 1977;178: 2285-2293.
17. Burgess DJ, Carless JE. Microelectrophoretic studies of gelatin and acacia for the prediction of complex coacervation. J Colloid Interface Sci 1984;98:1.
18. Tsung M, Burgess DJ. Preparation and stabilization of heparin/gelatin complex coacervate microcapsules. J Pharm Sci 1997;86:603-607.
19. Ohno H, Tsuchida E. Fluorescence study of the formation of polyelectrolyte complex in aqueous medium. Makromol Chim: Rapid Comm 1980;1:585-589.
20. Burgess DJ. Practical analysis of complex coacervate systems. J Colloid Interface Sci 1990;140:227-238.
21. Mikawa M, Miwa N, Bräutigam M, Akaike T, Maruyama A. A pH-sensitive contrast agent for functional magnetic resonance imaging (MRI). Chem Lett 1998;7:693-694.
22. Love DB. Polychelant compounds. US patent no. 5446145; 1995.
23. Asayama S, Maruyama A, Cho CS, Akaike T. Design of combtype polyamine copolymers for a novel pH-sensitive DNA carrier. Bioconjugate Chem 1997;8:833-838.
24. Brasch RC, Weinmann H-J, Wesbey GE. Contrast-enhanced NMR imaging: Animal studies using gadolinium-DTPA complex. Am J Radiol 1984;142:625-630.
25. Moats RA, Fraser SE, Meade TJ. A "Smart" magnetic resonance imaging agent that reports on specific enzymatic activity. Angew Chem Int Ed Engl 1997;36:726-728.