메뉴 건너뛰기




Volumn 5, Issue 6, 2004, Pages 1411-1422

Rosiglitazone plus metformin: Combination therapy for type 2 diabetes

Author keywords

Clinical efficacy; Rosiglitazone metformin combination therapy (Avandamet); Type 2 diabetes

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADENYLATE KINASE; ANTIRETROVIRUS AGENT; BIGUANIDE; C REACTIVE PROTEIN; CD40 LIGAND; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FATTY ACID; FIBRINOGEN; GLIBENCLAMIDE; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; ISOPHANE INSULIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; METFORMIN PLUS ROSIGLITAZONE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHENFORMIN; PIOGLITAZONE; PLACEBO; PROINSULIN; RAMIPRIL; ROSIGLITAZONE; SULFONYLUREA DERIVATIVE; TRIACYLGLYCEROL; TROGLITAZONE; UNINDEXED DRUG;

EID: 3042813607     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656566.5.6.1411     Document Type: Article
Times cited : (13)

References (96)
  • 1
    • 0035856920 scopus 로고    scopus 로고
    • Global and societal implications of the diabetes epidemic
    • ZIMMET P, ALBERTI KG, SHAW J: Global and societal implications of the diabetes epidemic. Nature (2001) 414:782-787.
    • (2001) Nature , vol.414 , pp. 782-787
    • Zimmet, P.1    Alberti, K.G.2    Shaw, J.3
  • 3
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylurea or insulin compared with conventional treatment and risk of complications in patients with Type 2 diabetes (UKPDS 33)
    • UK PROSPECTIVE DIABETES STUDY (UKPDS) GROUP
    • UK PROSPECTIVE DIABETES STUDY (UKPDS) GROUP: Intensive blood-glucose control with sulphonylurea or insulin compared with conventional treatment and risk of complications in patients with Type 2 diabetes (UKPDS 33). Lancet (1998) 352:837-853.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 4
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • THE DCCT REPORT
    • THE DCCT REPORT: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. (1993) 329:977-986.
    • (1993) N. Engl. J. Med. , vol.329 , pp. 977-986
  • 5
    • 0037126526 scopus 로고    scopus 로고
    • Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report
    • Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report. Circulation (2002) 106:3143-3421.
    • (2002) Circulation , vol.106 , pp. 3143-3421
  • 6
    • 0025963777 scopus 로고
    • The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus
    • GROOP LC, SALORANTA C, SHANK M, BONADONNA RC, FERRANNINI E, DEFRONZO RA: The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus. J. Clin. Endocrinol. Metab. (1991) 72:96-107.
    • (1991) J. Clin. Endocrinol. Metab. , vol.72 , pp. 96-107
    • Groop, L.C.1    Saloranta, C.2    Shank, M.3    Bonadonna, R.C.4    Ferrannini, E.5    Defronzo, R.A.6
  • 7
    • 0032511566 scopus 로고    scopus 로고
    • Intensive blood-glucose control with metformin on complications in overweight patients with Type 2 diabetes (UKPDS 34)
    • UK PROSPECTIVE DIABETES STUDY (UKPDS) GROUP
    • UK PROSPECTIVE DIABETES STUDY (UKPDS) GROUP: Intensive blood-glucose control with metformin on complications in overweight patients with Type 2 diabetes (UKPDS 34). Lancet (1998) 352:854-865.
    • (1998) Lancet , vol.352 , pp. 854-865
  • 8
    • 0038415951 scopus 로고    scopus 로고
    • Rationale and options for combination therapy in the treatment of Type 2 diabetes
    • VAN GAAL LF, DE LEEUW IH: Rationale and options for combination therapy in the treatment of Type 2 diabetes. Diabetologia (2003) 46(Suppl. 1):M44-M50.
    • (2003) Diabetologia , vol.46 , Issue.SUPPL. 1
    • Van Gaal, L.F.1    De Leeuw, I.H.2
  • 9
    • 0037116638 scopus 로고    scopus 로고
    • Oral antihyperglycemic therapy for type 2 diabetes: Scientific review
    • INZUCCHI SE: Oral antihyperglycemic therapy for type 2 diabetes: scientific review. JAMA (2002) 287:360-372.
    • (2002) JAMA , vol.287 , pp. 360-372
    • Inzucchi, S.E.1
  • 10
    • 0033578476 scopus 로고    scopus 로고
    • Pharmacologic therapy for type 2 diabetes mellitus
    • DEFRONZO RA: Pharmacologic therapy for type 2 diabetes mellitus. Ann. Intern. Med. (1999) 131:281-303.
    • (1999) Ann. Intern. Med. , vol.131 , pp. 281-303
    • Defronzo, R.A.1
  • 11
    • 0032568257 scopus 로고    scopus 로고
    • Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus
    • INZUCCHI SE, MAGGS DG, SPOLLETT GR et al.: Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus. N. Engl. J. Med. (1998) 338:867-872.
    • (1998) N. Engl. J. Med. , vol.338 , pp. 867-872
    • Inzucchi, S.E.1    Maggs, D.G.2    Spollett, G.R.3
  • 12
    • 0036343675 scopus 로고    scopus 로고
    • Rosiglitazone: A review of its use in the management of type 2 diabetes mellitus
    • WAGSTAFF AJ, GOA KL: Rosiglitazone: a review of its use in the management of type 2 diabetes mellitus. Drugs (2002) 62:1805-1837.
    • (2002) Drugs , vol.62 , pp. 1805-1837
    • Wagstaff, A.J.1    Goa, K.L.2
  • 13
    • 18144436363 scopus 로고    scopus 로고
    • Reducing insulin resistance with metformin: The evidence today
    • GIANNARELLI R, ARAGONA M, COPPELLI A, DEL PRATO S: Reducing insulin resistance with metformin: the evidence today. Diabetes Metab. (2003) 29(4 Pt 2):6S28-6S35.
    • (2003) Diabetes Metab. , vol.29 , Issue.4 PART 2
    • Giannarelli, R.1    Aragona, M.2    Coppelli, A.3    Del Prato, S.4
  • 14
    • 23544439282 scopus 로고    scopus 로고
    • Avandamet® (rosiglitazone maleate and metformin hydrochloride) prescribing information
    • GlaxoSmithKline: GlaxoSmithKline, Research Triangle Park, NC 27709, USA
    • GlaxoSmithKline: Avandamet® (rosiglitazone maleate and metformin hydrochloride) prescribing information. GlaxoSmithKline, Research Triangle Park, NC 27709, USA (2003).
    • (2003)
  • 15
    • 23544465412 scopus 로고    scopus 로고
    • Glucophage® (metformin hydrochloride tablets 500 and 850 mg) prescribing information
    • Bristol-Myers Squibb: Bristol-Myers Squibb, Princeton, NJ, USA
    • Bristol-Myers Squibb: Glucophage® (metformin hydrochloride tablets 500 and 850 mg) prescribing information. Bristol-Myers Squibb, Princeton, NJ, USA (1997).
    • (1997)
  • 16
    • 0036250329 scopus 로고    scopus 로고
    • Differentiating members of the thiazolidinedione class: A focus on safety
    • LEBOVITZ HE: Differentiating members of the thiazolidinedione class: a focus on safety. Diabetes Metab. Res. Rev. (2002) 18(Suppl. 2):S23-S29.
    • (2002) Diabetes Metab. Res. Rev. , vol.18 , Issue.SUPPL. 2
    • Lebovitz, H.E.1
  • 17
    • 0035671770 scopus 로고    scopus 로고
    • Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients
    • MIYAZAKI Y, GLASS L, TRIPLITT C et al.: Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients. Diabetologia (2001) 44:2210-2219.
    • (2001) Diabetologia , vol.44 , pp. 2210-2219
    • Miyazaki, Y.1    Glass, L.2    Triplitt, C.3
  • 18
    • 0034496387 scopus 로고    scopus 로고
    • Pathophysiology and pharmacological treatment of insulin resistance
    • MATTHAEI S, STUMVOLL M, KELLERER M, HARING HU: Pathophysiology and pharmacological treatment of insulin resistance. Endocr. Rev. (2000) 21:585-618.
    • (2000) Endocr. Rev. , vol.21 , pp. 585-618
    • Matthaei, S.1    Stumvoll, M.2    Kellerer, M.3    Haring, H.U.4
  • 19
    • 0037768826 scopus 로고    scopus 로고
    • Thiazolidinediones - Some recent developments
    • STUMVOLL M: Thiazolidinediones - some recent developments. Expert Opin. Investig. Drugs. (2003) 12:1179-1187.
    • (2003) Expert Opin. Investig. Drugs , vol.12 , pp. 1179-1187
    • Stumvoll, M.1
  • 20
    • 14444281382 scopus 로고    scopus 로고
    • Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma
    • YOUNG PW, BUCKLE DR, CANTELLO BC et al.: Identification. of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma. J. Pharmacol. Exp. Ther. (1998) 284:751-759.
    • (1998) J. Pharmacol. Exp. Ther. , vol.284 , pp. 751-759
    • Young, P.W.1    Buckle, D.R.2    Cantello, B.C.3
  • 21
    • 0033659881 scopus 로고    scopus 로고
    • Unraveling the mechanism of action of thiazolidinediones
    • KAHN CR, CHEN L, COHEN SE: Unraveling the mechanism of action of thiazolidinediones. J. Clin. Invest. (2000) 106:1305-1307.
    • (2000) J. Clin. Invest. , vol.106 , pp. 1305-1307
    • Kahn, C.R.1    Chen, L.2    Cohen, S.E.3
  • 22
    • 0035992811 scopus 로고    scopus 로고
    • Glitazones: Clinical effects and molecular mechanisms
    • STUMVOLL M, HARING HU: Glitazones: clinical effects and molecular mechanisms. Ann. Med. (2002) 34:217-224.
    • (2002) Ann. Med. , vol.34 , pp. 217-224
    • Stumvoll, M.1    Haring, H.U.2
  • 23
    • 0037883037 scopus 로고    scopus 로고
    • Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients
    • MIYAZAKI Y, HE H, MANDARINO LJ, DEFRONZO RA: Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients. Diabetes (2003) 52:1943-1950.
    • (2003) Diabetes , vol.52 , pp. 1943-1950
    • Miyazaki, Y.1    He, H.2    Mandarino, L.J.3    Defronzo, R.A.4
  • 24
    • 0036895990 scopus 로고    scopus 로고
    • Rosiglitazone but not metformin enhances insulin- and exercise-stimulated skeletal muscle glucose uptake in patients with newly diagnosed type 2 diabetes
    • HALLSTEN K, VIRTANEN KA, LONNQVIST F et al.: Rosiglitazone but not metformin enhances insulin- and exercise-stimulated skeletal muscle glucose uptake in patients with newly diagnosed type 2 diabetes. Diabetes (2002) 51:3479-3485.
    • (2002) Diabetes , vol.51 , pp. 3479-3485
    • Hallsten, K.1    Virtanen, K.A.2    Lonnqvist, F.3
  • 25
    • 0036776903 scopus 로고    scopus 로고
    • Effect of rosiglitazone on insulin sensitivity and body composition in type 2 diabetic patients
    • CAREY DG, COWIN GJ, GALLOWAY GJ et al.: Effect of rosiglitazone on insulin sensitivity and body composition in type 2 diabetic patients. Obes. Res. (2002) 10:1008-1015.
    • (2002) Obes. Res. , vol.10 , pp. 1008-1015
    • Carey, D.G.1    Cowin, G.J.2    Galloway, G.J.3
  • 26
    • 0036310037 scopus 로고    scopus 로고
    • The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes
    • MAYERSON AB, HUNDAL RS, DUFOUR S et al.: The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. Diabetes (2002) 51:797-802.
    • (2002) Diabetes , vol.51 , pp. 797-802
    • Mayerson, A.B.1    Hundal, R.S.2    Dufour, S.3
  • 27
    • 0041883085 scopus 로고    scopus 로고
    • Influence of rosiglitazone treatment on beta-cell function in type 2 diabetes: Evidence of an increased ability of glucose to entrain high-frequency insulin pulsatility
    • JUHL CB, HOLLINGDAL M, PORKSEN N, PRANGE A, LONNQVIST F, SCHMITZ O: Influence of rosiglitazone treatment on beta-cell function in type 2 diabetes: evidence of an increased ability of glucose to entrain high-frequency insulin pulsatility. J. Clin. Endocrinol. Metab. (2003) 88:3794-3800.
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 3794-3800
    • Juhl, C.B.1    Hollingdal, M.2    Porksen, N.3    Prange, A.4    Lonnqvist, F.5    Schmitz, O.6
  • 29
    • 0000875145 scopus 로고    scopus 로고
    • Rosiglitazone is superior to glyburide in reducing fasting plasma glucose after 1 yar of treatment in type 2 diabetic patients
    • CHARBONNEL B, LÖNNQVIST F, JONES NP, ABEL MG, PATWARDDHAN: Rosiglitazone is superior to glyburide in reducing fasting plasma glucose after 1 yar of treatment in type 2 diabetic patients. Diabetes (1999) 48(Suppl. 1):A114.
    • (1999) Diabetes , vol.48 , Issue.SUPPL. 1
    • Charbonnel, B.1    Lönnqvist, F.2    Jones, N.P.3    Abel, M.G.4    Patwarddhan, A.5
  • 30
    • 0000543685 scopus 로고    scopus 로고
    • Rosiglitazone reduces proinsulin/insulin ratio and improves β-cell function in type 2 diabetes
    • PORTER LE, FREED MI, JONES NP, BISWAS N: Rosiglitazone reduces proinsulin/insulin ratio and improves β-cell function in type 2 diabetes. Diabetologia (2000) 43(Suppl. 1):A192.
    • (2000) Diabetologia , vol.43 , Issue.SUPPL. 1
    • Porter, L.E.1    Freed, M.I.2    Jones, N.P.3    Biswas, N.4
  • 31
    • 1642414416 scopus 로고    scopus 로고
    • Rosiglitazone prevents the impairment of human islet function induced by fatty-acids. Evidence for a role PPAR-{gamma}2 in the modulation of insulin secretion
    • (Epub 2003 Nov 18)
    • LUPI R, DEL GUERRA S, MARSELLI L et al.: Rosiglitazone prevents the impairment of human islet function induced by fatty-acids. Evidence for a role PPAR-{gamma}2 in the modulation of insulin secretion. Am. J. Physiol. Endocrinol. Metab. (2004) 286(4):E560-E567 (Epub 2003 Nov 18).
    • (2004) Am. J. Physiol. Endocrinol. Metab. , vol.286 , Issue.4
    • Lupi, R.1    Del Guerra, S.2    Marselli, L.3
  • 32
    • 0032560545 scopus 로고    scopus 로고
    • Expression of the peroxime proliferators-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein
    • RICOTE M, HUANG J, FAJAS L et al.: Expression of the peroxime proliferators-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein. Natl. Acad. Sci. USA (1998) 95:7614-7619.
    • (1998) Natl. Acad. Sci. USA , vol.95 , pp. 7614-7619
    • Ricote, M.1    Huang, J.2    Fajas, L.3
  • 33
    • 0032587328 scopus 로고    scopus 로고
    • PPARγ activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression PPARγ as a potential mediator in vascular disease
    • MARX N, BOURCIER T, SURKHOVA GK, LIBBY P, PLUTZKY J: PPARγ activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression PPARγ as a potential mediator in vascular disease. Arterioscler. Thromb. Vasc. Biol. (1999) 19:546-551.
    • (1999) Arterioscler. Thromb. Vasc. Biol. , vol.19 , pp. 546-551
    • Marx, N.1    Bourcier, T.2    Surkhova, G.K.3    Libby, P.4    Plutzky, J.5
  • 34
    • 0034696412 scopus 로고    scopus 로고
    • Expression and function of PPARγ in rat and Human vascular smooth muscle cells
    • LAW RE, GOETZE S, XI XP et al.: Expression and function of PPARγ in rat and Human vascular smooth muscle cells. Circulation (2000) 101:1311-1318.
    • (2000) Circulation , vol.101 , pp. 1311-1318
    • Law, R.E.1    Goetze, S.2    Xi, X.P.3
  • 35
    • 0037221704 scopus 로고    scopus 로고
    • Differential regulation of lipogenesis and leptin production by independent signaling pathways and rosiglitazone during human adipocyte differentiation
    • PATEL NG, HOLDER JC, SMITH SA, KUMAR S, EGGO MC: Differential regulation of lipogenesis and leptin production by independent signaling pathways and rosiglitazone during human adipocyte differentiation. Diabetes (2003) 52:43-50.
    • (2003) Diabetes , vol.52 , pp. 43-50
    • Patel, N.G.1    Holder, J.C.2    Smith, S.A.3    Kumar, S.4    Eggo, M.C.5
  • 36
    • 0141532275 scopus 로고    scopus 로고
    • Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone
    • NEUSCHWANDER-TETRI BA, BRUNT EM, WEHMEIER KR, OLIVER D, BACON BR: Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone. Hepatology (2003) 38:1008-1017.
    • (2003) Hepatology , vol.38 , pp. 1008-1017
    • Neuschwander-Tetri, B.A.1    Brunt, E.M.2    Wehmeier, K.R.3    Oliver, D.4    Bacon, B.R.5
  • 38
    • 0842289940 scopus 로고    scopus 로고
    • In Type 2 diabetes, rosiglitazone therapy for insulin resistance ameliorates endothelial dysfunction independent of glucose control
    • PISTROSCH F, PASSAUER J, FISCHER S, FUECKER K, HANEFELD M, GROSS P: In Type 2 diabetes, rosiglitazone therapy for insulin resistance ameliorates endothelial dysfunction independent of glucose control. Diabetes Care (2004) 27:484-490.
    • (2004) Diabetes Care , vol.27 , pp. 484-490
    • Pistrosch, F.1    Passauer, J.2    Fischer, S.3    Fuecker, K.4    Hanefeld, M.5    Gross, P.6
  • 39
    • 0043273978 scopus 로고    scopus 로고
    • Preventing effects of rosiglitazone on restenosis after coronary stenting in patients with type 2 diabetes
    • CHOI SH, CHOI DH, KO YK et al.: Preventing effects of rosiglitazone on restenosis after coronary stenting in patients with type 2 diabetes. Diabetes (2003) 52(Suppl.1):A19.
    • (2003) Diabetes , vol.52 , Issue.SUPPL. 1
    • Choi, S.H.1    Choi, D.H.2    Ko, Y.K.3
  • 40
    • 1442288375 scopus 로고    scopus 로고
    • PPAR{gamma} agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice
    • RYAN MJ, DIDION SP MATHUR S, FARACI FM, SIGMUND CD: PPAR{gamma} agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice. Hypertension (2004) 43(3):661-666.
    • (2004) Hypertension , vol.43 , Issue.3 , pp. 661-666
    • Ryan, M.J.1    Didion, S.P.2    Mathur, S.3    Faraci, F.M.4    Sigmund, C.D.5
  • 41
    • 0041366838 scopus 로고    scopus 로고
    • Treatment with rosiglitazone reduces hyperinsulinemia and improves arterial elasticity in patients with type 2 diabetes mellitus
    • SHARGORODSKY M, WAINSTEIN G, GAVISH E, LEIBOVITZ Z, MATAS D, ZIMLICHMAN R: Treatment with rosiglitazone reduces hyperinsulinemia and improves arterial elasticity in patients with type 2 diabetes mellitus. Am. J. Hypertens. (2003) 16:617-622.
    • (2003) Am. J. Hypertens. , vol.16 , pp. 617-622
    • Shargorodsky, M.1    Wainstein, G.2    Gavish, E.3    Leibovitz, Z.4    Matas, D.5    Zimlichman, R.6
  • 42
    • 0038220757 scopus 로고    scopus 로고
    • Rosiglitazone improves insulin sensitivity and lowers blood pressure in hypertensive patients
    • RAJI A, SEELY EW, BEKINS SA, WILLIAMS GH, SIMONSON DC: Rosiglitazone improves insulin sensitivity and lowers blood pressure in hypertensive patients. Diabetes Care (2003) 26:172-178.
    • (2003) Diabetes Care , vol.26 , pp. 172-178
    • Raji, A.1    Seely, E.W.2    Bekins, S.A.3    Williams, G.H.4    Simonson, D.C.5
  • 43
    • 0141540455 scopus 로고    scopus 로고
    • Rosiglitazone inhibits the insulin-mediated increase in PAI-1 secretion in human abdominal subcutaneous adipocytes
    • HARTE AL, MCTERNAN PG, MCTERNAN CL, SMITH SA, BARNETT AH, KUMAR S: Rosiglitazone inhibits the insulin-mediated increase in PAI-1 secretion in human abdominal subcutaneous adipocytes. Diabetes Obes. Metab. (2003) 5:302-310.
    • (2003) Diabetes Obes. Metab. , vol.5 , pp. 302-310
    • Harte, A.L.1    McTernan, P.G.2    McTernan, C.L.3    Smith, S.A.4    Barnett, A.H.5    Kumar, S.6
  • 44
    • 0037390373 scopus 로고    scopus 로고
    • Regulation of plasma PAI-1 concentrations in HAART-associated lipodystrophy during rosiglitazone therapy
    • YKI-JARVINEN H, SUTINEN J, SILVEIRA A et al.: Regulation of plasma PAI-1 concentrations in HAART-associated lipodystrophy during rosiglitazone therapy. Arterioscler. Thromb. Vasc. Biol. (2003) 23:688-694.
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , pp. 688-694
    • Yki-Jarvinen, H.1    Sutinen, J.2    Silveira, A.3
  • 45
    • 0037031267 scopus 로고    scopus 로고
    • Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus
    • HAFFNER SM, GREENBERG AS, WESTON WM, CHEN H, WILLIAMS K, FREED MI: Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus. Circulation (2002) 106:679-684.
    • (2002) Circulation , vol.106 , pp. 679-684
    • Haffner, S.M.1    Greenberg, A.S.2    Weston, W.M.3    Chen, H.4    Williams, K.5    Freed, M.I.6
  • 46
    • 0242543997 scopus 로고    scopus 로고
    • The effects of rosiglitazone, a peroxisome proliferator-activated receptor-gamma agonist, on markers of endothelial cell activation, C-reactive protein, and fibrinogen levels in non-diabetic coronary artery disease patients
    • SIDHU JS, COWAN D, KASKI JC: The effects of rosiglitazone, a peroxisome proliferator-activated receptor-gamma agonist, on markers of endothelial cell activation, C-reactive protein, and fibrinogen levels in non-diabetic coronary artery disease patients. J. Am. Coll. Cardiol. (2003) 42:1757-1763.
    • (2003) J. Am. Coll. Cardiol. , vol.42 , pp. 1757-1763
    • Sidhu, J.S.1    Cowan, D.2    Kaski, J.C.3
  • 47
    • 0037461106 scopus 로고    scopus 로고
    • Effect of rosiglitazone treatment on soluble CD40L in patients with Type 2 diabetes and coronary artery disease
    • MARX N, IMHOF A, FROEHLICH J et al.: Effect of rosiglitazone treatment on soluble CD40L in patients with Type 2 diabetes and coronary artery disease. Circulation (2003) 107:1954-1957.
    • (2003) Circulation , vol.107 , pp. 1954-1957
    • Marx, N.1    Imhof, A.2    Froehlich, J.3
  • 48
    • 0036481709 scopus 로고    scopus 로고
    • Syntetic perxisome proliferator-activated. receptor-γ agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients
    • YANG W-S, JENG CY, WU TJ et al.: Syntetic perxisome proliferator-activated. receptor-γ agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients. Diabetes Care (2002) 25:376-380.
    • (2002) Diabetes Care , vol.25 , pp. 376-380
    • Yang, W.-S.1    Jeng, C.Y.2    Wu, T.J.3
  • 49
    • 0036830104 scopus 로고    scopus 로고
    • Effects of rosiglitazone alone and in combination with atorvastatin on metabolic abnormalities in type 2 diabetes mellitus
    • FREED MI, RATNER R, MARCOVINA SM et al.: Effects of rosiglitazone alone and in combination with atorvastatin on metabolic abnormalities in type 2 diabetes mellitus. Am. J. Cardiol. (2002) 90:947-952.
    • (2002) Am. J. Cardiol. , vol.90 , pp. 947-952
    • Freed, M.I.1    Ratner, R.2    Marcovina, S.M.3
  • 50
    • 0038142254 scopus 로고    scopus 로고
    • The effect of rosiglitazone on serum lipoprotein(a) levels in Korean patients with type 2 diabetes mellitus
    • KO SH, SONG KH, AHN YB et al.: The effect of rosiglitazone on serum lipoprotein(a) levels in Korean patients with type 2 diabetes mellitus. Metabolism (2003) 52:731-734.
    • (2003) Metabolism , vol.52 , pp. 731-734
    • Ko, S.H.1    Song, K.H.2    Ahn, Y.B.3
  • 51
    • 3042711461 scopus 로고    scopus 로고
    • Rosiglitazone in treatment of HAART-associated lipodystrophy - A randomized double-blind placebo-controlled study
    • SUTINEN J, HAKKINEN AM, WESTERBACKA J et al.: Rosiglitazone in treatment of HAART-associated lipodystrophy - a randomized double-blind placebo-controlled study. Antivir. Ther. (2003)52:731-734.
    • (2003) Antivir. Ther. , vol.52 , pp. 731-734
    • Sutinen, J.1    Hakkinen, A.M.2    Westerbacka, J.3
  • 52
    • 0037347859 scopus 로고    scopus 로고
    • Rosiglitazone: Potential beneficial impact on cardiovascular disease
    • VIBERTI GC: Rosiglitazone: potential beneficial impact on cardiovascular disease. Int. J. Clin. Pract. (2003) 57:128-134.
    • (2003) Int. J. Clin. Pract. , vol.57 , pp. 128-134
    • Viberti, G.C.1
  • 53
    • 0031762953 scopus 로고    scopus 로고
    • Metformin: A review of its metabolic effects
    • CUSI K, DEFRONZO RA: Metformin: a review of its metabolic effects. Diabetes Rev. (1998) 6:89-131.
    • (1998) Diabetes Rev. , vol.6 , pp. 89-131
    • Cusi, K.1    Defronzo, R.A.2
  • 54
    • 0041736553 scopus 로고    scopus 로고
    • Metformin: New understandings, new uses
    • HUNDAL RS, INZUCCHI SE: Metformin: new understandings, new uses. Drugs (2003) 63:1879-1894.
    • (2003) Drugs , vol.63 , pp. 1879-1894
    • Hundal, R.S.1    Inzucchi, S.E.2
  • 56
    • 0031046921 scopus 로고    scopus 로고
    • Effects of metformin on the pathways of glucose utilization after oral glucose in non-insulin-dependent diabetes mellitus patients
    • FERY F, PLAT L, BALASSE EO: Effects of metformin on the pathways of glucose utilization after oral glucose in non-insulin-dependent diabetes mellitus patients. Metabolism (1997) 46:227-233.
    • (1997) Metabolism , vol.46 , pp. 227-233
    • Fery, F.1    Plat, L.2    Balasse, E.O.3
  • 57
    • 18144453903 scopus 로고    scopus 로고
    • Mitochondrial metabolism and type-2 diabetes: A specific target of metformin
    • LEVERVE XM, GUIGAS B, DETAILLE D et al.: Mitochondrial metabolism and type-2 diabetes: a specific target of metformin. Diabetes Metab. (2003) 29(4 Pt 2):6S88-6S94.
    • (2003) Diabetes Metab. , vol.29 , Issue.4 PART 2
    • Leverve, X.M.1    Guigas, B.2    Detaille, D.3
  • 58
    • 0033390614 scopus 로고    scopus 로고
    • Metformin inhibits catecholamine-stimulated lipolysis in obese, hyperinsulinemic, hypertensive subjects in subcutaneous adipose tissue: An in situ microdialysis study
    • FLECHTNER-MORS M, DITSCHUNEIT HH, JENKINSON CP, ALT A, ADLER G: Metformin inhibits catecholamine-stimulated lipolysis in obese, hyperinsulinemic, hypertensive subjects in subcutaneous adipose tissue: an in situ microdialysis study. Diabetes Med. (1999) 16(12):1000-1006.
    • (1999) Diabetes Med. , vol.16 , Issue.12 , pp. 1000-1006
    • Flechtner-Mors, M.1    Ditschuneit, H.H.2    Jenkinson, C.P.3    Alt, A.4    Adler, G.5
  • 59
    • 0025907205 scopus 로고
    • Glucose and lipid metabolism in non-insulin-dependent diabetes. Effect of metformin
    • RICCIO A, DEL PRATO S, VIGILI DE KREUTZENBERG S, TIENGO A: Glucose and lipid metabolism in non-insulin-dependent diabetes. Effect of metformin. Diabetes Metab. (1991) 17(1 Pt 2):180-184.
    • (1991) Diabetes Metab. , vol.17 , Issue.1 PART 2 , pp. 180-184
    • Riccio, A.1    Del Prato, S.2    Vigili, D.E.3    Kreutzenberg, S.4    Tiengo, A.5
  • 60
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • ZHOU G, MYERS R, LI Y et al.: Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. (2001) 108:1167-1174.
    • (2001) J. Clin. Invest. , vol.108 , pp. 1167-1174
    • Zhou, G.1    Myers, R.2    Li, Y.3
  • 61
    • 85047689953 scopus 로고
    • 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?
    • CORTON JM, GILLESPIE JG, HAWLEY SA, HARDIE DG: 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? Eur. J. Biochem. (1995) 229:558-565.
    • (1995) Eur. J. Biochem. , vol.229 , pp. 558-565
    • Corton, J.M.1    Gillespie, J.G.2    Hawley, S.A.3    Hardie, D.G.4
  • 62
    • 0034783579 scopus 로고    scopus 로고
    • The blooming of the French lilac
    • WITTERS LA: The blooming of the French lilac. J. Clin. Invest. (2001) 108:1105-1057.
    • (2001) J. Clin. Invest. , vol.108 , pp. 1057-1105
    • Witters, L.A.1
  • 63
    • 0032921702 scopus 로고    scopus 로고
    • The biguanide compound metformin prevents desensitization of human pancreatic islets induced by high glucose
    • LUPI R, DEL GUERRA S, TELLINI C et al.: The biguanide compound metformin prevents desensitization of human pancreatic islets induced by high glucose. Eur. J. Pharmacol. (1999) 364:205-209.
    • (1999) Eur. J. Pharmacol. , vol.364 , pp. 205-209
    • Lupi, R.1    Del Guerra, S.2    Tellini, C.3
  • 64
    • 0036318319 scopus 로고    scopus 로고
    • Lipotoxicity in human pancreatic islets and the protective effect of metformin
    • LUPI R, DEL GUERRA S, FIERABRACCI V et al.: Lipotoxicity in human pancreatic islets and the protective effect of metformin. Diabetes (2002) 51(Suppl. 1):S134-S137.
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 1
    • Lupi, R.1    Del Guerra, S.2    Fierabracci, V.3
  • 65
    • 0842306338 scopus 로고    scopus 로고
    • Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitus
    • ABBASI F, CHU JW, MCLAUGHLIN T, LAMENDOLA C, LEARY ET, REAVEN GM: Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitus. Metabolism (2004) 53:159-164.
    • (2004) Metabolism , vol.53 , pp. 159-164
    • Abbasi, F.1    Chu, J.W.2    Mclaughlin, T.3    Lamendola, C.4    Leary, E.T.5    Reaven, G.M.6
  • 66
    • 18144447850 scopus 로고    scopus 로고
    • Antiatherogenic properties of metformin: The experimental evidence
    • MAMPUTU JC, WIERNSPERGER NF, RENIER G: Antiatherogenic properties of metformin: the experimental evidence. Diabetes Metab. (2003) 29(4 Pt 2):6S71-6S76.
    • (2003) Diabetes Metab. , vol.29 , Issue.4 PART 2
    • Mamputu, J.C.1    Wiernsperger, N.F.2    Renier, G.3
  • 67
    • 18144442252 scopus 로고    scopus 로고
    • Potential contribution of metformin to the management of cardiovascular disease risk in patients with abdominal obesity, the metabolic syndrome and type 2 diabetes
    • DESPRES JP: Potential contribution of metformin to the management of cardiovascular disease risk in patients with abdominal obesity, the metabolic syndrome and type 2 diabetes. Diabetes Metab. (2003) 29(4 Pt 2):6S53-6S61.
    • (2003) Diabetes Metab. , vol.29 , Issue.4 PART 2
    • Despres, J.P.1
  • 68
    • 17944398255 scopus 로고    scopus 로고
    • Metformin inhibition of glycation processes
    • BEISSWENGER P, RUGGIERO-LOPEZ D: Metformin inhibition of glycation processes. Diabetes Metab. (2003) 29(4 Pt 2):6S95-6S103.
    • (2003) Diabetes Metab. , vol.29 , Issue.4 PART 2
    • Beisswenger, P.1    Ruggiero-Lopez, D.2
  • 69
    • 0027418996 scopus 로고
    • Drugs controlling triglyceride metabolism
    • FRANCESCHINI G, PAOLETTI R: Drugs controlling triglyceride metabolism. Med. Res. Rev. (1993) 13:125-138.
    • (1993) Med. Res. Rev. , vol.13 , pp. 125-138
    • Franceschini, G.1    Paoletti, R.2
  • 70
    • 18144451494 scopus 로고    scopus 로고
    • Beneficial effects of metformin on haemostasis and vascular function in man
    • GRANT P: Beneficial effects of metformin on haemostasis and vascular function in man. Diabetes Metab. (2003) 29(4 Pt 2):6S44-6S52.
    • (2003) Diabetes Metab. , vol.29 , Issue.4 PART 2
    • Grant, P.1
  • 71
    • 0027494134 scopus 로고
    • Metformin improves glucose, lipid metabolism, and reduces blood pressure in hypertensive, obese women
    • GIUGLIANO D, DE ROSA N, DI MARO G et al.: Metformin improves glucose, lipid metabolism, and reduces blood pressure in hypertensive, obese women. Diabetes Care (1993) 16:1387-1390.
    • (1993) Diabetes Care , vol.16 , pp. 1387-1390
    • Giugliano, D.1    De Rosa, N.2    Di Maro, G.3
  • 72
    • 9244227632 scopus 로고    scopus 로고
    • Improvement of insulin sensitività by metformin treatment does not lower blood pressure of nonobese insulin-resistant hypertensive patients with normal glucose tolerance
    • DORELLA M, GIUSTO M, DA TOS V et al.: Improvement of insulin sensitività by metformin treatment does not lower blood pressure of nonobese insulin-resistant hypertensive patients with normal glucose tolerance. Clin. Endocrinol. Metab. (1996) 81:1568-1574.
    • (1996) Clin. Endocrinol. Metab. , vol.81 , pp. 1568-1574
    • Dorella, M.1    Giusto, M.2    Da Tos, V.3
  • 73
    • 0033911580 scopus 로고    scopus 로고
    • Absorption, disposition, and metabolism of rosiglitazone, a potent thiazolidinedione insulin sensitizer, in humans
    • COX PJ, RYAN DA, HOLLIS FJ et al.: Absorption, disposition, and metabolism of rosiglitazone, a potent thiazolidinedione insulin sensitizer, in humans. Drug Metab. Dispos. (2000) 28:772-780.
    • (2000) Drug Metab. Dispos. , vol.28 , pp. 772-780
    • Cox, P.J.1    Ryan, D.A.2    Hollis, F.J.3
  • 76
    • 0032818309 scopus 로고    scopus 로고
    • Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone
    • BALDWIN SJ, CLARKE SE, CHENERY RJ: Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone. Br. J. Clin. Pharmacol. (1999) 48:424-432.
    • (1999) Br. J. Clin. Pharmacol. , vol.48 , pp. 424-432
    • Baldwin, S.J.1    Clarke, S.E.2    Chenery, R.J.3
  • 77
    • 0009992195 scopus 로고    scopus 로고
    • Population pharmacokinetics of rosiglitazone in phase III clinical trials
    • (Abstract PII-33)
    • PATERL BR, DIRINGER K, CONRAD J et al.: Population pharmacokinetics of rosiglitazone in phase III clinical trials. Clin. Pharmacol. Ther. (2000) 67:123 (Abstract PII-33).
    • (2000) Clin. Pharmacol. Ther. , vol.67 , pp. 123
    • Paterl, B.R.1    Diringer, K.2    Conrad, J.3
  • 78
    • 0028856712 scopus 로고
    • Kidney function and age are both predictors of pharmacokinetics of metformin
    • SAMBOL NC, CHIANG J, LIN ET et al.: Kidney function and age are both predictors of pharmacokinetics of metformin. J. Clin. Pharmacol. (1995) 35:1094-1102.
    • (1995) J. Clin. Pharmacol. , vol.35 , pp. 1094-1102
    • Sambol, N.C.1    Chiang, J.2    Lin, E.T.3
  • 79
    • 0034607438 scopus 로고    scopus 로고
    • Effect of metformin and rosiglitazone combination therapy in patients with Type 2 diabetes mellitus: A randomized controlled trial
    • FONSECA V, ROSENSTOCK J, PATWARDHAN R, SALZMAN A: Effect of metformin and rosiglitazone combination therapy in patients with Type 2 diabetes mellitus: a randomized controlled trial. JAMA (2000) 283:1695-1702.
    • (2000) JAMA , vol.283 , pp. 1695-1702
    • Fonseca, V.1    Rosenstock, J.2    Patwardhan, R.3    Salzman, A.4
  • 80
    • 0036244970 scopus 로고    scopus 로고
    • Efficacy and safety of rosiglitazone plus metformin in Mexicans with type 2 diabetes
    • GOMEZ-PEREZ FJ, FANGHÄNEL-SALMON G, BARBOSA JA et al.: Efficacy and safety of rosiglitazone plus metformin in Mexicans with type 2 diabetes. Diabetes Metab. Res. Rev. (2002) 18:127-134.
    • (2002) Diabetes Metab. Res. Rev. , vol.18 , pp. 127-134
    • Gomez-Perez, F.J.1    Fanghänel-Salmon, G.2    Barbosa, J.A.3
  • 81
    • 0344061039 scopus 로고    scopus 로고
    • Adddition of rosiglitazone to metformin is most effective in obese, insulin-resistant patients with type 2 diabetes
    • JONES TA, SUTTER M, VAN GAAL LF, JONES NP: Adddition of rosiglitazone to metformin is most effective in obese, insulin-resistant patients with type 2 diabetes. Diabetes Obes. Metab. (2003) 5:163-170.
    • (2003) Diabetes Obes. Metab. , vol.5 , pp. 163-170
    • Jones, T.A.1    Sutter, M.2    Van Gaal, L.F.3    Jones, N.P.4
  • 82
    • 3042797764 scopus 로고    scopus 로고
    • Drug trial report: Efficacy and safety of combination of metformin and rosiglitazone in patients with Type 2 diabetes mellitus. A postmarketing study
    • BALLARY C, DESAI A: Drug trial report: efficacy and safety of combination of metformin and rosiglitazone in patients with Type 2 diabetes mellitus. A postmarketing study. JAMA (2003) 101:1-5.
    • (2003) JAMA , vol.101 , pp. 1-5
    • Ballary, C.1    Desai, A.2
  • 83
    • 0344412851 scopus 로고    scopus 로고
    • The combined effect of triple therapy with rosiglitazone, metformin, and insulin aspart in type 2 diabetic patients
    • POULSEN MK, HENRIKSEN JE, HOTHER-NIELSEN O, BECK-NIELSEN H: The combined effect of triple therapy with rosiglitazone, metformin, and insulin aspart in type 2 diabetic patients. Diabetes Care (2003) 26:3273-3279.
    • (2003) Diabetes Care , vol.26 , pp. 3273-3279
    • Poulsen, M.K.1    Henriksen, J.E.2    Hother-Nielsen, O.3    Beck-Nielsen, H.4
  • 84
    • 3042711308 scopus 로고    scopus 로고
    • Study 284 (EMPIRE) Greater benefits of rosiglitazone (RSG) added to submaximal dose of metformin (MET) compared to maximizing metformin dose in type 2 diabetes mellitus (T2DM) patients
    • A
    • ROSNSTOCK J, GOLDSTEIN B, WOODDEL M, STROW LJ, WATERHOUSE R, COBITZ AR: Study 284 (EMPIRE) Greater benefits of rosiglitazone (RSG) added to submaximal dose of metformin (MET) compared to maximizing metformin dose in type 2 diabetes mellitus (T2DM) patients. Diabetes (2004) 53:A.
    • (2004) Diabetes , vol.53
    • Rosnstock, J.1    Goldstein, B.2    Wooddel, M.3    Strow, L.J.4    Waterhouse, R.5    Cobitz, A.R.6
  • 85
    • 0033975057 scopus 로고    scopus 로고
    • Addition of low-dose rosiglitazone to sulphanylurea therapy improve glycemic control in Type 2 diabetic patients
    • WOLFFENBUTTEL BH, GOMIS R, SQUATRITO S, JONES NP, PATWARDHAN RN: Addition of low-dose rosiglitazone to sulphanylurea therapy improve glycemic control in Type 2 diabetic patients. Diabet Med. (2000) 17(1):40-47.
    • (2000) Diabet. Med. , vol.17 , Issue.1 , pp. 40-47
    • Wolffenbuttel, B.H.1    Gomis, R.2    Squatrito, S.3    Jones, N.P.4    Patwardhan, R.N.5
  • 86
    • 12344249130 scopus 로고    scopus 로고
    • Type 2 diabetes in the elderly: Reaching durable glycemic goals with combination sulfonalnylurea and rosiglitazone
    • THE ROSIGLITAZONE 135 STUDY GROUP
    • ROSENSTOCK J, PORTER MA, HEISE, O'NEILL MC, KRAVITZ B, FREED MI, THE ROSIGLITAZONE 135 STUDY GROUP: Type 2 diabetes in the elderly: reaching durable glycemic goals with combination sulfonalnylurea and rosiglitazone. Diabetes Metab. (2003) 29:S247-S248.
    • (2003) Diabetes Metab. , vol.29
    • Rosenstock, J.1    Porter, M.A.2    Heise, A.3    O'Neill, M.C.4    Kravitz, B.5    Freed, M.I.6
  • 87
    • 23544454312 scopus 로고    scopus 로고
    • Efficacy and safety of rosiglitazone in combination with glimperide
    • HAMMAN A, MATTHAEL S, MAUERSBERGER H et al.: Efficacy and safety of rosiglitazone in combination with glimperide. Diabetes Metab. (2003) 29:4S249.
    • (2003) Diabetes Metab. , vol.29
    • Hamman, A.1    Matthael, S.2    Mauersberger, H.3
  • 88
    • 10744221639 scopus 로고    scopus 로고
    • Thiazolidinedione use, fluid retention, and congestive heart failure: A consensus statement from American Heart Association and American Diabetes Association
    • NESTO RW, BELL D, BONOW RO et al.: Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from American Heart Association and American Diabetes Association. Diabetes Care (2004) 27:256-263.
    • (2004) Diabetes Care , vol.27 , pp. 256-263
    • Nesto, R.W.1    Bell, D.2    Bonow, R.O.3
  • 89
    • 0042053851 scopus 로고    scopus 로고
    • Avandia® (rosiglitazone maleate) package insert
    • GlaxoSmithKline: GlaxoSmithKline, Philadelphia, PA, USA
    • GlaxoSmithKline: Avandia® (rosiglitazone maleate) package insert. GlaxoSmithKline, Philadelphia, PA, USA 2000.
    • (2000)
  • 92
    • 0036211463 scopus 로고    scopus 로고
    • Adherence to oral antidiabetic therapy in a managed care organization: A comparison of monotherapy, combination therapy, and fixed-dose combination therapy
    • MELIKIAN C, WHITE TJ, VANDERPLAS A, DEZII CM, CHANG E: Adherence to oral antidiabetic therapy in a managed care organization: a comparison of monotherapy, combination therapy, and fixed-dose combination therapy. Clin. Ther. (2002) 24:460-467.
    • (2002) Clin. Ther. , vol.24 , pp. 460-467
    • Melikian, C.1    White, T.J.2    Vanderplas, A.3    Dezii, C.M.4    Chang, E.5
  • 93
    • 0032983666 scopus 로고    scopus 로고
    • Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: Progressive requirement for multiple therapies (UKPDS 49)
    • UK Prospective Diabetes Study (UKPDS) Group
    • TURNER RC, CULL CA, FRIGHI V, HOLMAN RR: Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. JAMA (1999) 281:2005-2012.
    • (1999) JAMA , vol.281 , pp. 2005-2012
    • Turner, R.C.1    Cull, C.A.2    Frighi, V.3    Holman, R.R.4
  • 94
    • 23544448874 scopus 로고    scopus 로고
    • Metformin ameliorates function and survival of pancreatic islets isolated from Type 2 diabetic patients
    • DEL GUERRA S, LUPI R, MARSELLI L et al.: Metformin ameliorates function and survival of pancreatic islets isolated from Type 2 diabetic patients. Diabetologia (2003) 46(Suppl 2):A169.
    • (2003) Diabetologia , vol.46 , Issue.SUPPL. 2
    • Del Guerra, S.1    Lupi, R.2    Marselli, L.3
  • 95
    • 0035042679 scopus 로고    scopus 로고
    • Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death
    • FINEGOOD DT, MCARTHUR MD, KOJWANG D et al.: Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death. Diabetes (2001) 50:1021-1029.
    • (2001) Diabetes , vol.50 , pp. 1021-1029
    • Finegood, D.T.1    Mcarthur, M.D.2    Kojwang, D.3
  • 96
    • 0346219298 scopus 로고    scopus 로고
    • Beta-cell rejuvenation with thiazolidinediones
    • BELL DS: Beta-cell rejuvenation with thiazolidinediones. Am. J. Med. (2003) 115(Suppl 8A):20S-23S.
    • (2003) Am. J. Med. , vol.115 , Issue.SUPPL. 8A
    • Bell, D.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.