Detection and characterization of B cell epitopes on β2-glycoprotein I

Clinical Immunology

Volumn 112, Issue 2, 2004, Pages 129-135

  Cockerill, Keith A ^a   Linnik, Matthew D ^a   Iverson, G Michael ^a  

^a La Jolla Pharmaceutical Company   (United States)

Author keywords

Antiphospholipid syndrome; Autoantibodies; Epitopes; Review; 2 glycoprotein I

Indexed keywords

ARGININE; AUTOANTIBODY; BETA2 GLYCOPROTEIN 1; EPITOPE; GLYCINE;

AMINO TERMINAL SEQUENCE; B LYMPHOCYTE; BINDING AFFINITY; IMMUNOREACTIVITY; LIQUID; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; REVIEW;

EID: 3042756326     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clim.2004.02.011     Document Type: Article

References (51)

1. McNeil H.P., Simpson R.J., Chesterman C.N., Krilis S.A. Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H). Proc. Natl. Acad. Sci. U. S. A. 87:1990;4120-4124
2. Galli M., Comfurius P., Maassen C., Hemker H.C., de Baets M.H., Breda-Vriesman P.J., Barbui T., Zwaal R.F., Bevers E.M. Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor. Lancet. 335:1990;1544-1547
3. Matsuura E., Igarashi Y., Fujimoto M., Ichikawa K., Koike T. Anticardiolipin cofactor(s) and differential diagnosis of autoimmune disease. Lancet. 336:1990;177-178
4. Bouma B., de Groot P.G., van den Elsen J.M., Ravelli R.B., Schouten A., Simmelink M.J., Derksen R.H., Kroon J., Gros P. Adhesion mechanism of human beta(2)-glycoprotein I to phospholipids based on its crystal structure. EMBO J. 18:1999;5166-5174
5. Schwarzenbacher R., Zeth K., Diederichs K., Gries A., Kostner G.M., Laggner P., Prassl R. Crystal structure of human beta2-glycoprotein I: implications for phospholipid binding and the antiphospholipid syndrome. EMBO J. 18:1999;6228-6239
6. Hammel M., Kriechbaum M., Gries A., Kostner G.M., Laggner P., Prassl R. Solution structure of human and bovine beta(2)-glycoprotein I revealed by small-angle X-ray scattering. J. Mol. Biol. 321:2002;85-97
7. Roubey R.A. Immunology of the antiphospholipid syndrome: antibodies, antigens, and autoimmune response. Thromb. Haemostasis. 82:1999;656-661
8. Matsuura E., Igarashi Y., Fujimoto M., Ichikawa K., Suzuki T., Sumida T., Yasuda T., Koike T. Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor. J. Immunol. 148:1992;3885-3891
9. Wagenknecht D.R., McIntyre J.A. Changes in beta 2-glycoprotein I antigenicity induced by phospholipid binding. Thromb. Haemostasis. 69:1993;361-365
10. Matsuura E., Igarashi Y., Yasuda T., Triplett D.A., Koike T. Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface. J. Exp. Med. 179:1994;457-462
11. Koike T., Tsutsumi A., Ichikawa K., Matsuura E. Antigenic specificity of the "anticardiolipin" antibodies. Blood. 85:1995;2277-2280
12. Ichikawa K., Khamashta M.A., Koike T., Matsuura E., Hughes G.R. Beta 2-glycoprotein I reactivity of monoclonal anticardiolipin antibodies from patients with the antiphospholipid syndrome. Arthritis Rheum. 37:1994;1453-1461
13. Pengo V., Biasiolo A., Fior M.G. Autoimmune antiphospholipid antibodies are directed against a cryptic epitope expressed when beta 2-glycoprotein I is bound to a suitable surface. Thromb. Haemostasis. 73:1995;29-34
14. Arvieux J., Roussel B., Jacob M.C., Colomb M.G. Measurement of anti-phospholipid antibodies by ELISA using beta 2-glycoprotein I as an antigen. J. Immunol. Methods. 143:1991;223-229
15. Cabral A.R., Cabiedes J., Alarcon-Segovia D. Antibodies to phospholipid-free beta 2-glycoprotein-I in patients with primary antiphospholipid syndrome. J. Rheumatol. 22:1995;1894-1898
16. Cabral A.R., Amigo M.C., Cabiedes J., Alarcon-Segovia D. The antiphospholipid/cofactor syndromes: a primary variant with antibodies to beta 2-glycoprotein-I but no antibodies detectable in standard antiphospholipid assays. Am. J. Med. 101:1996;472-481
17. Keeling D.M., Wilson A.J., Mackie I.J., Machin S.J., Isenberg D.A. Some 'antiphospholipid antibodies' bind to beta 2-glycoprotein I in the absence of phospholipid. Br. J. Haematol. 82:1992;571-574
18. Viard J.P., Amoura Z., Bach J.F. Association of anti-beta 2 glycoprotein I antibodies with lupus-type circulating anticoagulant and thrombosis in systemic lupus erythematosus. Am. J. Med. 93:1992;181-186
19. Cabiedes J., Cabral A.R., Alarcon-Segovia D. Clinical manifestations of the antiphospholipid syndrome in patients with systemic lupus erythematosus associate more strongly with anti-beta 2-glycoprotein-I than with antiphospholipid antibodies. J. Rheumatol. 22:1995;1899-1906
20. Alarcon-Segovia D., Mestanza M., Cabiedes J., Cabral A.R. The antiphospholipid/cofactor syndromes: II. A variant in patients with systemic lupus erythematosus with antibodies to beta 2-glycoprotein I but no antibodies detectable in standard antiphospholipid assays. J. Rheumatol. 24:1997;1545-1551
21. Arvieux J., Regnault V., Hachulla E., Darnige L., Roussel B., Bensa J.C. Heterogeneity and immunochemical properties of anti-beta2-glycoprotein I autoantibodies. Thromb. Haemostasis. 80:1998;393-398
22. Balestrieri G., Tincani A., Spatola L., Allegri F., Prati E., Cattaneo R., Valesini G., Del Papa N., Meroni P. Anti-beta 2-glycoprotein I antibodies: a marker of antiphospholipid syndrome? Lupus. 4:1995;122-130
23. Hunt J.E., Simpson R.J., Krilis S.A. Identification of a region of beta 2-glycoprotein I critical for lipid binding and anti-cardiolipin antibody cofactor activity. Proc. Natl. Acad. Sci. U. S. A. 90:1993;2141-2145
24. Steinkasserer A., Barlow P.N., Willis A.C., Kertesz Z., Campbell I.D., Sim R.B., Norman D.G. Activity, disulphide mapping and structural modelling of the fifth domain of human beta 2-glycoprotein I. FEBS Lett. 313:1992;193-197
25. Hunt J., Krilis S. The fifth domain of beta 2-glycoprotein I contains a phospholipid binding site (Cys281-Cys288) and a region recognized by anticardiolipin antibodies. J. Immunol. 152:1994;653-659
26. Sheng Y., Sali A., Herzog H., Lahnstein J., Krilis S.A. Site-directed mutagenesis of recombinant human beta 2-glycoprotein I identifies a cluster of lysine residues that are critical for phospholipid binding and anti-cardiolipin antibody activity. J. Immunol. 157:1996;3744-3751
27. Matsuura E., Inagaki J., Kasahara H., Yamamoto D., Atsumi T., Kobayashi K., Kaihara K., Zhao D., Ichikawa K., Tsutsumi A., Yasuda T., Triplett D.A., Koike T. Proteolytic cleavage of beta(2)-glycoprotein I: reduction of antigenicity and the structural relationship. Int. Immunol. 12:2000;1183-1192
28. Hagihara Y., Enjyoji K., Omasa T., Katakura Y., Suga K., Igarashi M., Matsuura E., Kato H., Yoshimura T., Goto Y. Structure and function of the recombinant fifth domain of human beta 2-glycoprotein I: effects of specific cleavage between Lys77 and Thr78. J. Biochem. (Tokyo). 121:1997;128-137
29. Ohkura N., Hagihara Y., Yoshimura T., Goto Y., Kato H. Plasmin can reduce the function of human beta2 glycoprotein I by cleaving domain V into a nicked form. Blood. 91:1998;4173-4179
30. Horbach D.A., van Oort E., Lisman T., Meijers J.C., Derksen R.H., de Groot P.G. Beta2-glycoprotein I is proteolytically cleaved in vivo upon activation of fibrinolysis. Thromb. Haemostasis. 81:1999;87-95
31. Chamley L.W., Duncalf A.M., Konarkowska B., Mitchell M.D., Johnson P.M. Conformationally altered beta 2-glycoprotein I is the antigen for anti-cardiolipin autoantibodies. Clin. Exp. Immunol. 115:1999;571-576
32. Tincani A., Spatola L., Prati E., Allegri F., Ferremi P., Cattaneo R., Meroni P., Balestrieri G. The anti-beta2-glycoprotein I activity in human anti-phospholipid syndrome sera is due to monoreactive low-affinity autoantibodies directed to epitopes located on native beta2-glycoprotein I and preserved during species' evolution. J. Immunol. 157:1996;5732-5738
33. Forastiero R.R., Martinuzzo M.E., Kordich L.C., Carreras L.O. Reactivity to beta 2 glycoprotein I clearly differentiates anticardiolipin antibodies from antiphospholipid syndrome and syphilis. Thromb. Haemostasis. 75:1996;717-720
34. Iverson G.M., Victoria E.J., Marquis D.M. Anti-beta2 glycoprotein I (beta2GPI) autoantibodies recognize an epitope on the first domain of beta2GPI. Proc. Natl. Acad. Sci. U. S. A. 95:1998;15542-15546
35. Iverson G.M., Reddel S., Victoria E.J., Cockerill K.A., Wang Y.X., Marti-Renom M.A., Sali A., Marquis D.M., Krilis S.A., Linnik M.D. Use of single point mutations in domain I of beta 2-glycoprotein I to determine fine antigenic specificity of antiphospholipid autoantibodies. J. Immunol. 169:2002;7097-7103
36. Roubey R.A., Eisenberg R.A., Harper M.F., Winfield J.B. "Anticardiolipin" autoantibodies recognize beta 2-glycoprotein I in the absence of phospholipid. Importance of Ag density and bivalent binding. J. Immunol. 154:1995;954-960
37. Friguet B., Chaffotte A.F., Djavadi-Ohaniance L., Goldberg M.E. Measurements of the true affinity constant in solution of antigen-antibody complexes by enzyme-linked immunosorbent assay. J. Immunol. Methods. 77:1985;305-319
38. Sheng Y., Kandiah D.A., Krilis S.A. Anti-beta 2-glycoprotein I autoantibodies from patients with the "antiphospholipid" syndrome bind to beta 2-glycoprotein I with low affinity: dimerization of beta 2-glycoprotein I induces a significant increase in anti-beta 2-glycoprotein I antibody affinity. J. Immunol. 161:1998;2038-2043
39. Galazka M., Tang M., DeBari V.A., Kohles J.D., Lee J.K., Keil L.B., Petersheim M. Modification of beta 2glycoprotein I by glutardialdehyde. Conformational changes and aggregation accompany exposure of the cryptic autoepitope. Appl. Biochem. Biotechnol. 76:1999;1-13
40. Regnault V., De Maistre E., Wahl D., Lecompte T. Monovalent binding of autoantibodies to beta2-glycoprotein I, detected using surface plasmon resonance at low antigen density. Br. J. Haematol. 109:2000;187-194
41. Takeya H., Mori T., Gabazza E.C., Kuroda K., Deguchi H., Matsuura E., Ichikawa K., Koike T., Suzuki K. Anti-beta2-glycoprotein I (beta2GPI) monoclonal antibodies with lupus anticoagulant-like activity enhance the beta2GPI binding to phospholipids. J. Clin. Invest. 99:1997;2260-2268
42. Arnout J., Wittevrongel C., Vanrusselt M., Hoylaerts M., Vermylen J. Beta-2-glycoprotein I dependent lupus anticoagulants form stable bivalent antibody beta-2-glycoprotein I complexes on phospholipid surfaces. Thromb. Haemostasis. 79:1998;79-86
43. Gharavi A.E., Cucurull E., Tang H., Silver R.M., Branch D.W. Effect of antiphospholipid antibodies on beta(2) glycoprotein I-phospholipid interaction. Am. J. Reprod. Immunol. 39:1998;310-315
44. Lutters B.C., Meijers J.C., Derksen R.H., Arnout J., de Groot P.G. Dimers of beta 2-glycoprotein I mimic the in vitro effects of beta 2-glycoprotein I-anti-beta 2-glycoprotein I antibody complexes. J. Biol. Chem. 276:2001;3060-3067
45. Igarashi M., Matsuura E., Igarashi Y., Nagae H., Ichikawa K., Triplett D.A., Koike T. Human beta2-glycoprotein I as an anticardiolipin cofactor determined using mutants expressed by a baculovirus system. Blood. 87:1996;3262-3270
46. McNeeley P.A., Dlott J.S., Furie R.A., Jack R.M., Ortel T.L., Triplett D.A., Victoria E.J., Linnik M.D. Beta2-glycoprotein I-dependent anticardiolipin antibodies preferentially bind the amino terminal domain of beta2-glycoprotein I. Thromb. Haemostasis. 86:2001;590-595
47. George J., Gilburd B., Hojnik M., Levy Y., Langevitz P., Matsuura E., Koike T., Shoenfeld Y. Target recognition of beta2-glycoprotein I (beta2GPI)-dependent anticardiolipin antibodies: evidence for involvement of the fourth domain of beta2GPI in antibody binding. J. Immunol. 160:1998;3917-3923
48. Koike T., Ichikawa K., Kasahara H., Atsumi T., Tsutsumi A., Matsuura E. Epitopes on beta2-GPI recognized by anticardiolipin antibodies. Lupus. 7(Suppl 2):1998;S14-S17
49. Iverson G.M., Matsuura E., Victoria E.J., Cockerill K.A., Linnik M.D. The orientation of beta2GPI on the plate is important for the binding of anti-beta2GPI autoantibodies by ELISA. J. Autoimmun. 18:2002;289-297
50. Chen S., Yang C., Shen N., Xue F. Cloning and expression of beta 2-glycoprotein 1 recognized by antiphospholipid antibodies and its clinical investigation. Chin. Med. J. (Engl.). 112:1999;67-71
51. Levy Y., Sherer Y., Mathieu A., Cauli A., Passiu G., Sanna G., Janackovic Z., Blank M., Shoenfeld Y. Anti-cardiolipin antibody from a patient with antiphospholipid syndrome (APS) recognizes only an epitope expressed by cardiolipin/beta 2-glycoprotein-I (beta 2GPI) complex and induces APS. Clin. Exp. Rheumatol. 18:2000;479-484