Promoter-binding and repression on PDGFRB by c-Myc are separable activities

Nucleic Acids Research

Volumn 32, Issue 11, 2004, Pages 3462-3468

  Mao, Danile Y L ^a,b   Barsyte Lovejoy, Dalia ^b   Ho, Cynthia S W ^a,b,c   Watson, John D ^b   Stojanova, Angelina ^a,b   Penn, Linda Z ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MUTANT PROTEIN; MYC PROTEIN; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRICHOSTATIN A; DNA BINDING PROTEIN; HYDROXAMIC ACID; REPRESSOR PROTEIN; RNA POLYMERASE II;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CHROMATIN; CONTROLLED STUDY; FIBROBLAST; GENE ACTIVITY; GENE REPRESSION; HYPOTHESIS; IMMUNOPRECIPITATION; IN VIVO STUDY; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; BINDING SITE; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM;

ANIMALS; BINDING SITES; DNA-BINDING PROTEINS; FIBROBLASTS; GENE EXPRESSION REGULATION; HYDROXAMIC ACIDS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-MYC; RATS; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; REPRESSOR PROTEINS; RNA POLYMERASE II; TRANS-ACTIVATORS;

EID: 3042737686     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkh669     Document Type: Article

References (34)

1. Takehara,K. (2000) Growth regulation of skin fibroblasts. J. Dermatol. Sci., 24 (Suppl 1), S70-S77.
2. Kelly,K., Cochran,B.H., Stiles,C.D. and Leder,P. (1983) Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell, 35, 603-610.
3. Oster,S.K., Ho,C.S., Soucie,E.L. and Penn,L.Z. (2002) The myc oncogene: MarvelouslY Complex. Adv. Cancer Res., 84, 81-154.
4. Felsher,D.W. and Bishop,J.M. (1999) Reversible tumorigenesis by MYC in hematopoietic lineages. Mol. Cell, 4, 199-207.
5. Pelengaris,S., Khan,M. and Evan,G.I. (2002) Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell, 109, 321-334.
6. Penn,L.J., Brooks,M.W., Laufer,E.M. and Land,H. (1990) Negative autoregulation of c-myc transcription. EMBO J., 9, 1113-1121.
7. Oster,S.K., Marhin,W.W., Aker,C., Facchini,L.M., Dion,P.A., Funa,K., Post,M., Sedivy,J.M. and Penn,L.Z. (2000) Myc is an essential negative regulator of platelet-derived growth factor beta receptor expression. Mol. Cell. Biol., 20, 6768-6778.
8. Chen,C.R., Kang,Y. and Massague,J. (2001) Defective repression of c-myc in breast cancer cells: a loss at the core of the transforming growth factor beta growth arrest program. Proc. Natl Acad. Sci. USA, 98, 992-999.
9. Zeller,K.I., Jegga,A.G., Aronow,B.J., O'Donnell,K.A. and Dang,C.V. (2003) An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets. Genome Biol., 4, R69.
10. Blackwell,T.K., Kretzner,L., Blackwood,E.M., Eisenman,R.N. and Weintraub,H. (1990) Sequence-specific DNA binding by the c-Myc protein. Science, 250, 1149-1151.
11. Blackwood,E.M. and Eienman,R.N. (1991) Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science, 251, 1211-1217.
12. Bouchard,C., Dittrich,O., Kiermaier,A., Dohmann,K., Menkel,A., Eilers,M. and Luscher,B. (2001) Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter. Genes Dev., 15, 2042-2047.
13. McMahon,S.B., Wood,M.A. and Cole,M.D. (2000) The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. Mol. Cell. Biol., 20, 556-562.
14. Frank,S.R., Schroeder,M., Fernandez,P., Taubert,S. and Amati,B. (2001) Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Genes Dev., 15, 2069-2082.
15. Eberhardy,S.R. and Farnham,P.J. (2002) Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter. J. Biol. Chem., 277, 40156-40162.
16. Staller,P., Peukert,K., Kiermaier,A., Seoane,J., Lukas,J., Karsunky,H., Moroy,T., Bartek,J., Massague,J., Hanel,F. and Eilers,M. (2001) Repression of p15INK4b expression by Myc through association with Miz-1. Nature Cell Biol., 3, 392-399.
17. Seoane,J., Le,H.V. and Massague,J. (2002) Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature, 419, 729-734.
18. Mao,D.Y.L., Watson,J.D., Yan,P.S., Barsyte-Lovejoy,D., Khosravi,F., Wong,W.W., Farnham,P.J., Huang,T.H. and Penn,L.Z. (2003) Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression. Curr. Biol., 13, 882-986.
19. Izumi,H., Molander,C., Penn,L.Z., Ishisaki,A., Kohno,K. and Funa,K. (2001) Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor. J. Cell Sci., 114, 1533-1544.
20. Gartel,A.L., Ye,X., Goufman,E., Shianov,P., Hay,N., Najmabadi,F. and Tyner,A.L. (2001) Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3. Proc. Natl Acad. Sci. USA, 98, 4510-4515.
21. Herold,S., Wanzel,M., Beuger,V., Frohme,C., Beul,D., Hillukkala,T., Syvaoja,J., Saluz,H.P., Haenel,F. and Eilers,M. (2002) Negative regulation of the mammalian UV response by Myc through association with Miz-1. Mol. Cell, 10, 509-521.
22. Wanzel,M., Herold,S. and Eilers,M. (2003) Transcriptional repression by Myc. Trends Cell Biol., 13, 146-150.
23. Mateyak,M.K., Obaya,A.J., Adachi,S. and Sedivy,J.M. (1997) Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination. Cell Growth Differ., 8, 1039-1048.
24. Oster,S.K., Mao,D.Y.L., Kennedy,J. and Penn,L.Z. (2003) Functional analysis of the N-terminal domain of the Myc oncoprotein. Oncogene, 22, 1998-2010.
25. Ballagi,A.E., Ishizaki,A., Nehlin,J.O. and Funa,K. (1995) Isolation and characterization of the mouse PDGF beta-receptor promoter. Biochem. Biophys. Res. Commun., 210, 165-173.
26. Ferre-D'Amare,A.R., Prendergast,G.C., Ziff,E.B. and Burley,S.K. (1993) Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain. Nature, 363, 38-45.
27. Stone,J., de Lange,T., Ramsay,G., Jakobovits,E., Bishop,J.M., Varmus,H. and Lee,W. (1987) Definition of regions in human c-myc that are involved in transformation and nuclear localization. Mol. Cell. Biol., 7, 1697-1709.
28. Gaubatz,S., Imhof,A., Dosch,R., Werner,O., Mitchell,P., Buettner,R. and Eilers,M. (1995) Transcriptional activation by Myc is under negative control by the transcription factor AP-2. EMBO J., 14, 1508-1519.
29. Taira,T., Sawai,M., Ikeda,M., Tamai,K., Iguchi-Ariga,S.M. and Ariga,H. (1999) Cell cycle-dependent switch of up-and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y. J. Biol. Chem., 274, 24270-24279.
30. Eberhardy,S.R. and Farnham,P.J. (2001) c-Myc mediates activation of the cad promoter via a post-RNA polymerase II recruitment mechanism. J. Biol. Chem., 276, 48562-48571.
31. Watson,J.D., Oster,S.K., Shago,M., Khosravi,F. and Penn,L.Z. (2002) Identifying genes regulated in a Myc-dependent manner. J. Biol. Chem., 277, 36921-36930.
32. Wilson,M.A., Ricci,A.R., Deroo,B.J. and Archer,T.K. (2002) The histone deacetylase inhibitor trichostatin A blocks progesterone receptor-mediated transactivation of the mouse mammary tumor virus promoter in vivo. J. Biol. Chem., 277, 15171-15181.
33. Wu,S., Cetinkaya,C., Munoz-Alonso,M.J., von der Lehr,N., Bahram,F., Beuger,V., Eilers,M., Leon,J. and Larsson,L.G. (2003) Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter. Oncogene, 22, 351-360.
34. Barsyte-Lovejoy,D. Mao,D.Y.L. and Penn,L.Z. (2004) c-Myc represses the proximal promoters of GADD45a and GADD153 by a post-RNA polymerase II recruitment mechanism. Oncogene, 23, 3481-3486.