Synthesis and characterization of 9-[P-(N,N-dipropylsulfamide)] benzoylamino-1,2,3,4-4H-acridine - A potential prodrug for the CNS delivery of tacrine

Journal of Drug Targeting

Volumn 12, Issue 3, 2004, Pages 177-182

  Gong, Tao ^a   Huang, Yuan ^a   Zang, Zhi Rong ^a   Li, Li Li ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Biodistribution; Biopartition micellar chromatography; Prodrug; Tacrine hydrochloride

Indexed keywords

9 [4 (N,N DIPROPYLSULFAMIDE )]BENZOYLAMINO 1,2,3,4 4H ACRIDINE; ACETIC ACID ETHYL ESTER; ACRIDINE DERIVATIVE; AMINE; CARBOXYL GROUP; PROBENECID; PRODRUG; TACRINE; UNCLASSIFIED DRUG; WATER;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CHROMATOGRAPHY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG ACTIVATION; DRUG BRAIN LEVEL; DRUG EFFICACY; DRUG FORMULATION; DRUG LIVER LEVEL; DRUG PENETRATION; DRUG STABILITY; DRUG STRUCTURE; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; LIPOPHILICITY; LIVER TOXICITY; MASS SPECTROMETRY; NONHUMAN; PARTITION COEFFICIENT; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SYNTHESIS; TEMPERATURE DEPENDENCE; TIME; ULTRAVIOLET SPECTROSCOPY;

ACRIDINES; ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; BUFFERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; INJECTIONS, INTRAVENOUS; MICE; PRODRUGS; SOLUBILITY; SULFONAMIDES; TACRINE; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 3042725447     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.1080/1061186042000223653     Document Type: Article

References (11)

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