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Volumn 22, Issue 1-2, 1996, Pages 251-264

Reconstitution of the blood-brain barrier in cell culture for studies of drug transport and metabolism

Author keywords

anatomy; in vitro; inflammation; isolation; visualization

Indexed keywords

BLOOD; BRAIN; CELL CULTURE; CELLS; DRUG INTERACTIONS; METABOLISM; PHARMACOKINETICS; VISUALIZATION;

EID: 0030588582     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(96)00421-8     Document Type: Review
Times cited : (14)

References (107)
  • 1
    • 0011323348 scopus 로고
    • Pathophysiological aspects of acute EAE
    • [1] Juhler, M. (1988) Pathophysiological aspects of acute EAE. Acta Neurologica Scand. 78(Suppl. 119), 3-21.
    • (1988) Acta Neurologica Scand. , vol.78 , Issue.SUPPL. 119 , pp. 3-21
    • Juhler, M.1
  • 2
    • 0027070478 scopus 로고
    • Drug transport across the blood-brain barrier: II. Experimental techniques to study drug transport
    • [2] van Bree, J.B.M.M., de Boer, A.G., Danhof, M. and Breimer, D.D. (1992) Drug transport across the blood-brain barrier: II. Experimental techniques to study drug transport. Pharm. Weekblad Sci. Ed. 14, 338-348.
    • (1992) Pharm. Weekblad Sci. Ed. , vol.14 , pp. 338-348
    • Van Bree, J.B.M.M.1    De Boer, A.G.2    Danhof, M.3    Breimer, D.D.4
  • 3
    • 0021919062 scopus 로고
    • The blood-brain barrier in vitro: Ten years of research on microvessels isolated from the brain
    • [3] Joó, F. (1985) The blood-brain barrier in vitro: ten years of research on microvessels isolated from the brain. Neurochem. Int. 7, 1-25.
    • (1985) Neurochem. Int. , vol.7 , pp. 1-25
    • Joó, F.1
  • 4
    • 0026502638 scopus 로고
    • The cerebral microvessels in culture, an update
    • [4] Joó, F. (1992) The cerebral microvessels in culture, an update. J. Neurochem. 58, 1-17.
    • (1992) J. Neurochem. , vol.58 , pp. 1-17
    • Joó, F.1
  • 5
    • 0023022986 scopus 로고
    • Characterization of an in vitro blood-brain barrier model system for studying drug transport and metabolism
    • [5] Audus, K.L., Borchardt, R.T. (1986) Characterization of an in vitro blood-brain barrier model system for studying drug transport and metabolism. Pharm. Res. 3, 81-87.
    • (1986) Pharm. Res. , vol.3 , pp. 81-87
    • Audus, K.L.1    Borchardt, R.T.2
  • 6
    • 0022977590 scopus 로고
    • Cultivation of endothelial cells: Limitations and perspectives
    • [6] Balconi, G. and Dejana, E. (1986) Cultivation of endothelial cells: limitations and perspectives. Med. Biol. 64, 231-245.
    • (1986) Med. Biol. , vol.64 , pp. 231-245
    • Balconi, G.1    Dejana, E.2
  • 8
    • 0001220328 scopus 로고
    • Die aussere und innere sekretion des gesunden und kranken organismus im lichte der vitalen farbung
    • [8] Goldmann, E.E. (1909) Die aussere und innere sekretion des gesunden und kranken organismus im lichte der vitalen farbung. Beitr. Klin. Chirurg. 64, 192-265.
    • (1909) Beitr. Klin. Chirurg. , vol.64 , pp. 192-265
    • Goldmann, E.E.1
  • 10
    • 0001027257 scopus 로고
    • Die bedeutung der vitalen farbung fur die lehre vom stofaustausch zwischen dem zentralnervensystem und dem ubrigen korper
    • [10] Spatz, H. (1933) Die bedeutung der vitalen farbung fur die lehre vom stofaustausch zwischen dem zentralnervensystem und dem ubrigen korper. Arch. Psychiatr. Nervenkrank. 101, 267-358.
    • (1933) Arch. Psychiatr. Nervenkrank. , vol.101 , pp. 267-358
    • Spatz, H.1
  • 11
    • 0003173631 scopus 로고
    • Die allgemeinen grundlagen des stoffaustausches zwischen dem zentralnervensystem und dem ubrigen korper
    • [11] Walter, F.K. (1930) Die allgemeinen grundlagen des stoffaustausches zwischen dem zentralnervensystem und dem ubrigen korper. Arch. Psychiatr. Nervenkrank. 101, 195-230.
    • (1930) Arch. Psychiatr. Nervenkrank. , vol.101 , pp. 195-230
    • Walter, F.K.1
  • 12
    • 0014109002 scopus 로고
    • Fine structural localization of a blood-brain barrier to exogenous peroxidase
    • [12] Reese, T.S. and Karnovsky, M.J. (1967) Fine structural localization of a blood-brain barrier to exogenous peroxidase. J. Cell. Biol. 34, 207-217.
    • (1967) J. Cell. Biol. , vol.34 , pp. 207-217
    • Reese, T.S.1    Karnovsky, M.J.2
  • 13
    • 0014481056 scopus 로고
    • Junctions between intimately apposed cell membranes in the vertebrate brain
    • [13] Brightman, M.W. and Reese, T.S. (1969) Junctions between intimately apposed cell membranes in the vertebrate brain. J. Cell. Biol. 40, 648-677.
    • (1969) J. Cell. Biol. , vol.40 , pp. 648-677
    • Brightman, M.W.1    Reese, T.S.2
  • 14
    • 0025283118 scopus 로고
    • Leukocyte adhesion to endothelium in inflammation
    • [14] Osborn, L. (1990) Leukocyte adhesion to endothelium in inflammation. Cell 62, 3-6.
    • (1990) Cell , vol.62 , pp. 3-6
    • Osborn, L.1
  • 16
    • 0022735176 scopus 로고
    • Blood-brain barrier transport of nutrients
    • [16] Pardridge, W.M. (1986) Blood-brain barrier transport of nutrients. Fed. Proc. 45, 2047-2049.
    • (1986) Fed. Proc. , vol.45 , pp. 2047-2049
    • Pardridge, W.M.1
  • 17
    • 0018846764 scopus 로고
    • Drug transport into the central nervous system
    • G.H. Glaser, J.K. Pentry and D.M. Woodbury (Eds.). Raven Press. New York
    • [17] Reed, D.J. (1980) Drug transport into the central nervous system. In: G.H. Glaser, J.K. Pentry and D.M. Woodbury (Eds.), Antiepileptic Drugs: Mechanisms of Action. Raven Press. New York, pp. 199-205.
    • (1980) Antiepileptic Drugs: Mechanisms of Action , pp. 199-205
    • Reed, D.J.1
  • 18
    • 0011323352 scopus 로고
    • Evolution in the concept of the blood-brain barrier phenomenon
    • H.M. Zimmermann (Ed.). Grune and Stratton, New York
    • [18] Lee, J.C. (1971) Evolution in the concept of the blood-brain barrier phenomenon. In: H.M. Zimmermann (Ed.), Progress in Neuropathology vol I. Grune and Stratton, New York, pp. 84-145.
    • (1971) Progress in Neuropathology , vol.1 , pp. 84-145
    • Lee, J.C.1
  • 19
    • 0011316663 scopus 로고
    • Electronmikroskopischen befund an den Capillaren der Hirnrinde
    • [19] Cervos-Navarro, J. (1963) Electronmikroskopischen befund an den Capillaren der Hirnrinde. Arch. Psychiatr. Nervenkrank. 204, 484-504.
    • (1963) Arch. Psychiatr. Nervenkrank. , vol.204 , pp. 484-504
    • Cervos-Navarro, J.1
  • 20
    • 0024292731 scopus 로고
    • Tight junction dynamics: Is paracellular transport regulated
    • [20] Madara, J.L. (1988) Tight junction dynamics: is paracellular transport regulated. Cell 53, 497-498.
    • (1988) Cell , vol.53 , pp. 497-498
    • Madara, J.L.1
  • 21
    • 0024267858 scopus 로고
    • Characterization of in vitro blood-brain barrier: Effects of molecular size and lipophilicity on cerebrovascular endothelial transport rates of drugs
    • [21] Van Bree, J.B.M.M., De Boer, A.G., Danhof, M., Ginsel, L.A. and Breimer, D.D. (1988) Characterization of in vitro blood-brain barrier: effects of molecular size and lipophilicity on cerebrovascular endothelial transport rates of drugs. J. Pharmacol. Exp. Ther. 247, 1233-1239.
    • (1988) J. Pharmacol. Exp. Ther. , vol.247 , pp. 1233-1239
    • Van Bree, J.B.M.M.1    De Boer, A.G.2    Danhof, M.3    Ginsel, L.A.4    Breimer, D.D.5
  • 24
    • 0023108382 scopus 로고
    • Astrocytes induce blood-brain barrier properties in endothelial cells
    • [24] Janzer, R.C. and Raff, M.C. (1987) Astrocytes induce blood-brain barrier properties in endothelial cells. Nature 325, 253-257.
    • (1987) Nature , vol.325 , pp. 253-257
    • Janzer, R.C.1    Raff, M.C.2
  • 25
    • 0023471290 scopus 로고
    • Astrocyte-mediated induction of tight junctions in brain capillary endothelium: An efficient in vitro model
    • [25] Arthur, F.E., Shivers, R.R. and Bowman, P.D. (1987) Astrocyte-mediated induction of tight junctions in brain capillary endothelium: an efficient in vitro model. Dev. Brain Res. 36, 155-159.
    • (1987) Dev. Brain Res. , vol.36 , pp. 155-159
    • Arthur, F.E.1    Shivers, R.R.2    Bowman, P.D.3
  • 26
    • 0023948101 scopus 로고
    • Development of membrane interactions between brain endothelial cells and astrocytes in vitro
    • [26] Tao Cheng, J.H. and Brightman, M.W. (1988) Development of membrane interactions between brain endothelial cells and astrocytes in vitro. Int. J. Dev. Neurosci. 6, 25-37.
    • (1988) Int. J. Dev. Neurosci. , vol.6 , pp. 25-37
    • Tao Cheng, J.H.1    Brightman, M.W.2
  • 27
    • 0025915770 scopus 로고
    • In vitro interaction of astrocyte and pericytes with capillary-like structures of brain microvessel endothelium
    • [27] Minakawa, T., Bready, J., Berliner, J., Fisher, M. and Cancilla, P.A. (1991) In vitro interaction of astrocyte and pericytes with capillary-like structures of brain microvessel endothelium. Lab. Invest. 65, 32-40.
    • (1991) Lab. Invest. , vol.65 , pp. 32-40
    • Minakawa, T.1    Bready, J.2    Berliner, J.3    Fisher, M.4    Cancilla, P.A.5
  • 29
    • 0022978771 scopus 로고
    • Differences in function and structure of the capillary endothelium in grey matter, white matter and a circumventricular organ of rat brain
    • [29] Gross, P.M., Sposito, N.M., Pettersen, S.E. and Fenstermacher, J.D. (1986) Differences in function and structure of the capillary endothelium in grey matter, white matter and a circumventricular organ of rat brain. Blood Vessels 23, 261-270.
    • (1986) Blood Vessels , vol.23 , pp. 261-270
    • Gross, P.M.1    Sposito, N.M.2    Pettersen, S.E.3    Fenstermacher, J.D.4
  • 31
    • 0023432176 scopus 로고
    • Simultaneous determination of regional cerebral blood flow, glucose metabolism, and ph in acute experimental allergic encephalomyelitis
    • [31] Juhler M. (1987) Simultaneous determination of regional cerebral blood flow, glucose metabolism, and pH in acute experimental allergic encephalomyelitis. J. Cereb. Blood Flow Metab. 7, 578-584.
    • (1987) J. Cereb. Blood Flow Metab. , vol.7 , pp. 578-584
    • Juhler, M.1
  • 33
    • 0019421989 scopus 로고
    • Microvessels isolated from rat brain: Localization of astrocyte processes by immunohistochemical techniques
    • [33] White, F.P., Dutton, G.R. and Norenberg, M.D. (1981) Microvessels isolated from rat brain: localization of astrocyte processes by immunohistochemical techniques. J. Neurochem. 36, 328-332.
    • (1981) J. Neurochem. , vol.36 , pp. 328-332
    • White, F.P.1    Dutton, G.R.2    Norenberg, M.D.3
  • 34
    • 0022253324 scopus 로고
    • The Blood-Brain Barrier. Transport across the cerebral endothelium
    • [34] Bradbury, M.W.B. (1985) The Blood-Brain Barrier. Transport across the cerebral endothelium. Circ. Res. 57, 213-222.
    • (1985) Circ. Res. , vol.57 , pp. 213-222
    • Bradbury, M.W.B.1
  • 35
    • 0021026190 scopus 로고
    • Characterization of the blood-brain barrier: Protein composition of the capillary endothelial cell membrane
    • [35] Lidinsky, W.A. and Drewes, L.R. (1983) Characterization of the blood-brain barrier: protein composition of the capillary endothelial cell membrane. J. Neurochem. 41, 1341-1348.
    • (1983) J. Neurochem. , vol.41 , pp. 1341-1348
    • Lidinsky, W.A.1    Drewes, L.R.2
  • 36
    • 0025295847 scopus 로고
    • Capillary depletion method for quantifying blood-brain barrier transcytosis of circulating peptides and plasma proteins
    • [36] Triguero, D., Buciak, J.L. and Pardridge, W.M. (1990) Capillary depletion method for quantifying blood-brain barrier transcytosis of circulating peptides and plasma proteins. J. Neurochem. 54, 1881-1888.
    • (1990) J. Neurochem. , vol.54 , pp. 1881-1888
    • Triguero, D.1    Buciak, J.L.2    Pardridge, W.M.3
  • 37
    • 0027423294 scopus 로고
    • The blood-brain barrier in vitro: The second decade
    • [37] Joo, F. (1993) The blood-brain barrier in vitro: the second decade. Neurochem. Int. 23, 499-521.
    • (1993) Neurochem. Int. , vol.23 , pp. 499-521
    • Joo, F.1
  • 38
    • 0026293045 scopus 로고
    • Blood-brain barrier: Transport studies in isolated brain capillaries and in cultured brain endothelial cells
    • Academic Press Inc., New York
    • [38] Takakura, Y., Audus, K.L. and Borchardt, R.T. (1991) Blood-brain Barrier: transport studies in isolated brain capillaries and in cultured brain endothelial cells. In: Advances in Pharmacology, Vol. 22, Academic Press Inc., New York.
    • (1991) Advances in Pharmacology , vol.22
    • Takakura, Y.1    Audus, K.L.2    Borchardt, R.T.3
  • 39
    • 0025787802 scopus 로고
    • The susceptibility of cerebral endothelial cells to astroglial induction of blood-brain barrier enzymes depends on their proliferative state
    • [39] Meyer, J., Rauh, J. and Galla, H.-J. (1991) The susceptibility of cerebral endothelial cells to astroglial induction of blood-brain barrier enzymes depends on their proliferative state. J. Neurochem. 57, 1971-1977.
    • (1991) J. Neurochem. , vol.57 , pp. 1971-1977
    • Meyer, J.1    Rauh, J.2    Galla, H.-J.3
  • 41
    • 0022610066 scopus 로고
    • Antibodies to blood-brain barrier bind selectively to brain capillary endothelial lateral membranes and to a 46K protein
    • [41] Pardridge, W.M., Yang, J., Eisenberg, J. and Mietus, L.J. (1986) Antibodies to blood-brain barrier bind selectively to brain capillary endothelial lateral membranes and to a 46K protein. J. Cereb. Blood Flow Metab. 6, 203-211.
    • (1986) J. Cereb. Blood Flow Metab. , vol.6 , pp. 203-211
    • Pardridge, W.M.1    Yang, J.2    Eisenberg, J.3    Mietus, L.J.4
  • 42
    • 0025265046 scopus 로고
    • An easier, reproducible, and mass-production method to study the blood-brain barrier in vitro
    • [42] Dehouck, M-P., Méresse, S., Delorme, P., Fruchart, J.-C. and Cecchelli, R. (1990) An easier, reproducible, and mass-production method to study the blood-brain barrier in vitro. J. Neurochem. 54, 1798-1801.
    • (1990) J. Neurochem. , vol.54 , pp. 1798-1801
    • Dehouck, M.-P.1    Méresse, S.2    Delorme, P.3    Fruchart, J.-C.4    Cecchelli, R.5
  • 43
    • 0025735082 scopus 로고
    • Culture and characterization of microvascular endothelial cells derived from human brain
    • [43] Dorovini-Zis, K., Prameya, R. and Bowman, P.D. (1991) Culture and characterization of microvascular endothelial cells derived from human brain. Lab. Invest. 64, 425-436.
    • (1991) Lab. Invest. , vol.64 , pp. 425-436
    • Dorovini-Zis, K.1    Prameya, R.2    Bowman, P.D.3
  • 44
    • 0000953843 scopus 로고
    • Application of cultured endothelial cells of the brain microvasculature in the study of the blood-brain barrier
    • [44] Miller, D.W., Audus, K.L. and Borchardt, R.T. (1992) Application of cultured endothelial cells of the brain microvasculature in the study of the blood-brain barrier. J. Tissue Culture Methods 14, 217-224.
    • (1992) J. Tissue Culture Methods , vol.14 , pp. 217-224
    • Miller, D.W.1    Audus, K.L.2    Borchardt, R.T.3
  • 45
    • 0024583969 scopus 로고
    • Characterization of gamma-glutamyl transpeptidase activity of cultured endothelial cells from porcine brain capillaries
    • [45] Mischeck, U., Meyer, J. and Galla, H.J. (1989) Characterization of gamma-glutamyl transpeptidase activity of cultured endothelial cells from porcine brain capillaries. Cell. Tissue Res. 256, 221-226.
    • (1989) Cell. Tissue Res. , vol.256 , pp. 221-226
    • Mischeck, U.1    Meyer, J.2    Galla, H.J.3
  • 46
    • 0025762272 scopus 로고
    • Endothelial cell seeding
    • [46] Mosquera, D.A. and Goldman, M. (1991) Endothelial cell seeding. Br. J. Surg. 87, 655-660.
    • (1991) Br. J. Surg. , vol.87 , pp. 655-660
    • Mosquera, D.A.1    Goldman, M.2
  • 47
    • 0024427658 scopus 로고
    • Reduced reproductive capacity of freshly harvested endothelial cells in smokers: A possible shortcoming in the success of seeding?
    • [47] Zilla, P., Siedler S., Fasol, R. and Sharelkin, J.B. (1989) Reduced reproductive capacity of freshly harvested endothelial cells in smokers: a possible shortcoming in the success of seeding? J. Vasc. Surg. 10, 143-148.
    • (1989) J. Vasc. Surg. , vol.10 , pp. 143-148
    • Zilla, P.1    Siedler, S.2    Fasol, R.3    Sharelkin, J.B.4
  • 48
    • 0011323354 scopus 로고
    • Heterogeneity in endothelial cells with special reference to their growth related proteins
    • Plenum Press, New York
    • [48] Kumar, S., Kumar, P., Pey, D., Sattar, A., Wang, M. and Ponting, J. (1994) Heterogeneity in endothelial cells with special reference to their growth related proteins. In: Angiogenesis in Health and Diseases. Plenum Press, New York, pp. 63-78.
    • (1994) Angiogenesis in Health and Diseases , pp. 63-78
    • Kumar, S.1    Kumar, P.2    Pey, D.3    Sattar, A.4    Wang, M.5    Ponting, J.6
  • 50
    • 0026130593 scopus 로고
    • Endothelial and epithelial cell adhesion molecules
    • [50] Albelda, S.M. (1991) Endothelial and epithelial cell adhesion molecules. Am. J. Respir. Cell. Mol. Biol. 4, 195-203.
    • (1991) Am. J. Respir. Cell. Mol. Biol. , vol.4 , pp. 195-203
    • Albelda, S.M.1
  • 51
    • 0026502282 scopus 로고
    • Blood-brain barrier pericytes are the main source of γ-glutamyl transpeptidase activity in brain capillaries
    • [51] Risau, W., Dingler, A., Albrecht, U., Dehouck, M.-P. and Cechelli, R. (1992) Blood-brain barrier pericytes are the main source of γ-glutamyl transpeptidase activity in brain capillaries. J. Neurochem. 58, 667-672.
    • (1992) J. Neurochem. , vol.58 , pp. 667-672
    • Risau, W.1    Dingler, A.2    Albrecht, U.3    Dehouck, M.-P.4    Cechelli, R.5
  • 52
    • 0027491351 scopus 로고
    • Characterization of the scavenger receptor on bovine cerebral endothelial cells in vitro
    • [52] de Vries, H.E., Kuiper, J., de Boer, A.C., van Berkel, Th.J.C. and Breimer, D.D. (1993) Characterization of the scavenger receptor on bovine cerebral endothelial cells in vitro. J. Neurochem. 61, 1813-1821.
    • (1993) J. Neurochem. , vol.61 , pp. 1813-1821
    • De Vries, H.E.1    Kuiper, J.2    De Boer, A.C.3    Van Berkel, Th.J.C.4    Breimer, D.D.5
  • 53
    • 0024074965 scopus 로고
    • Fibronectin and vitronectin regulate the organization of their respective ARG-Gly-Asp adhesion receptors in cultured human endothelial cells
    • [53] Dejana, E., Colella, S., Conforti, G., Abbadini, M., Gaboli, M. and Marchisio, P.C. (1988) Fibronectin and vitronectin regulate the organization of their respective ARG-Gly-Asp adhesion receptors in cultured human endothelial cells. J. Cell. Biol. 107, 1215-1223.
    • (1988) J. Cell. Biol. , vol.107 , pp. 1215-1223
    • Dejana, E.1    Colella, S.2    Conforti, G.3    Abbadini, M.4    Gaboli, M.5    Marchisio, P.C.6
  • 56
    • 0025951892 scopus 로고
    • Glutamine stimulates growth in rat cerebral endothelial cell culture
    • [56] Dux, E., Noble, L. and Chan, RH. (1991) Glutamine stimulates growth in rat cerebral endothelial cell culture. J. Neurosci. Res. 29, 355-361.
    • (1991) J. Neurosci. Res. , vol.29 , pp. 355-361
    • Dux, E.1    Noble, L.2    Chan, R.H.3
  • 57
    • 0027617030 scopus 로고
    • Extracellular matrix modulates the proliferation of rat astrocytes in serum-free culture
    • [57] Nagano, N., Aoyagi, M. and Hirakawa, K. (1993) Extracellular matrix modulates the proliferation of rat astrocytes in serum-free culture. Glia 8, 71-76.
    • (1993) Glia , vol.8 , pp. 71-76
    • Nagano, N.1    Aoyagi, M.2    Hirakawa, K.3
  • 58
    • 0024518641 scopus 로고
    • Culture of human vascular endothelial cells on a positively charged polystyrene surface, Primaria: Comparison with fibronectin-coated tissue culture grade polystyrene
    • [58] Klein-Soyer, C., Hemmindinger, S. and Cazenave, J.-P. (1989) Culture of human vascular endothelial cells on a positively charged polystyrene surface, Primaria: comparison with fibronectin-coated tissue culture grade polystyrene. Biomaterials 10, 85-90.
    • (1989) Biomaterials , vol.10 , pp. 85-90
    • Klein-Soyer, C.1    Hemmindinger, S.2    Cazenave, J.-P.3
  • 59
    • 0000963476 scopus 로고
    • Endothelial cells grown on permeable membrane supports
    • [59] Shasby, S.S. (1992) Endothelial cells grown on permeable membrane supports. J. Tissue Culture Methods 14, 247-252.
    • (1992) J. Tissue Culture Methods , vol.14 , pp. 247-252
    • Shasby, S.S.1
  • 60
    • 0027408642 scopus 로고
    • Endothelial cell culture, evaluation of biomaterials
    • [60] Ziats, N.R and Amserson, J.M. (1993) Endothelial cell culture, evaluation of biomaterials. S.T.P. Pharma Sci. 3, 23-30.
    • (1993) S.T.P. Pharma Sci. , vol.3 , pp. 23-30
    • Ziats, N.R.1    Amserson, J.M.2
  • 61
    • 0025996979 scopus 로고
    • Culture of human adult endothelial cells on liquid-liquid interfaces: A new approach to the study of cell-matrix interactions
    • [61] Ando, J., Albeda, S.M. and Levine, E.M. (1991) Culture of human adult endothelial cells on liquid-liquid interfaces: a new approach to the study of cell-matrix interactions. In Vitro Cell. Dev. Biol. 27A, 525-532.
    • (1991) In Vitro Cell. Dev. Biol. , vol.27 A , pp. 525-532
    • Ando, J.1    Albeda, S.M.2    Levine, E.M.3
  • 62
    • 0028015618 scopus 로고
    • Growth of brain microvessel endothelial cells on collagen gels: Applications to the study of blood-brain barrier physiology and CNS inflammation
    • [62] Biegel, D. and Pachter, J.S. (1994) Growth of brain microvessel endothelial cells on collagen gels: applications to the study of blood-brain barrier physiology and CNS inflammation. In Vitro Cell. Dev. Biol. 30A, 581-588.
    • (1994) In Vitro Cell. Dev. Biol. , vol.30 A , pp. 581-588
    • Biegel, D.1    Pachter, J.S.2
  • 64
    • 0024499329 scopus 로고
    • Effect of trypsinization in cell culture on bradykinin receptors in vascular endothelial cells
    • [64] Sung, C.-P., Arleth, A., Shikano, K., Zarbo-Potapovich, B. and Berkowitz, B.A. (1989) Effect of trypsinization in cell culture on bradykinin receptors in vascular endothelial cells. Biochem. Pharmacol. 38, 696-699.
    • (1989) Biochem. Pharmacol. , vol.38 , pp. 696-699
    • Sung, C.-P.1    Arleth, A.2    Shikano, K.3    Zarbo-Potapovich, B.4    Berkowitz, B.A.5
  • 65
    • 0026558235 scopus 로고
    • Organ derived microvessel endothelial cells exhibit differential responsiveness to thrombin and other growth factors
    • [65] Belloni, P.N., Darrell, H.J.C. and Nicolson, G.L. (1992) Organ derived microvessel endothelial cells exhibit differential responsiveness to thrombin and other growth factors. Microvascular Res. 43, 20-45.
    • (1992) Microvascular Res. , vol.43 , pp. 20-45
    • Belloni, P.N.1    Darrell, H.J.C.2    Nicolson, G.L.3
  • 66
    • 0025182058 scopus 로고
    • Serial subculture and relative transport of human endothelial cells in serum-free, defined conditions
    • [66] Weiss, R.L., Selleck, S.E., Reusch, M. and Wintroub, B.U. (1990) Serial subculture and relative transport of human endothelial cells in serum-free, defined conditions. In Vitro Cell Dev. Biol. 26, 759-768.
    • (1990) In Vitro Cell Dev. Biol. , vol.26 , pp. 759-768
    • Weiss, R.L.1    Selleck, S.E.2    Reusch, M.3    Wintroub, B.U.4
  • 67
    • 0025329190 scopus 로고
    • Comparison of in vitro and in vivo models of drug transcytosis through the blood-brain barrier
    • [67] Pardridge, W.M., Triguero, D., Yang, J. and Cancilla, P.A. (1990) Comparison of in vitro and in vivo models of drug transcytosis through the blood-brain barrier. J. Pharmacol. Exp. Ther. 253, 884-891.
    • (1990) J. Pharmacol. Exp. Ther. , vol.253 , pp. 884-891
    • Pardridge, W.M.1    Triguero, D.2    Yang, J.3    Cancilla, P.A.4
  • 68
    • 0025107709 scopus 로고
    • Astrocyte-mediated induction of alkaline phosphatase activity in human umbilical cord vein endothelium: An in vitro model
    • [68] Tio, S., Deenen, M. and Marani, E. (1990) Astrocyte-mediated induction of alkaline phosphatase activity in human umbilical cord vein endothelium: an in vitro model. Eur. J. Morphol. 28, 289-300.
    • (1990) Eur. J. Morphol. , vol.28 , pp. 289-300
    • Tio, S.1    Deenen, M.2    Marani, E.3
  • 69
    • 0003152037 scopus 로고
    • Preparation of astrocyte and oligodendrocyte cultures from primary rat glial cultures
    • Alan R. Liss Inc.
    • [69] Cole, R. and de Vellis, J. (1989) Preparation of astrocyte and oligodendrocyte cultures from primary rat glial cultures. In: A Dissection and Tissue Culture, Manual of the Nervous System. Alan R. Liss Inc., pp. 121-133.
    • (1989) A Dissection and Tissue Culture, Manual of the Nervous System , pp. 121-133
    • Cole, R.1    De Vellis, J.2
  • 70
    • 0019313317 scopus 로고
    • Preparation of separate astroglial and oligodendroglial cultures from rat cerebral tissue
    • [70] McCarthy, K.D. and De Vellis, J. (1980) Preparation of separate astroglial and oligodendroglial cultures from rat cerebral tissue. J. Cell Biol. 85, 890-902.
    • (1980) J. Cell Biol. , vol.85 , pp. 890-902
    • McCarthy, K.D.1    De Vellis, J.2
  • 71
    • 0023108382 scopus 로고
    • Astrocytes induce blood-brain barrier properties in endothelial cells
    • [71] Janzer, R.C. and Raff, M.C. (1987) Astrocytes induce blood-brain barrier properties in endothelial cells. Nature 325, 253-257.
    • (1987) Nature , vol.325 , pp. 253-257
    • Janzer, R.C.1    Raff, M.C.2
  • 72
    • 0027373799 scopus 로고
    • Human fetal astrocytes induce the expression of blood-brain barrier specific proteins by autologous endothelial cells
    • [72] Hurwitz, A.A., Berman, J.W., Rashbaum, W.K. and Lyman, W.D. (1993) Human fetal astrocytes induce the expression of blood-brain barrier specific proteins by autologous endothelial cells. Brain Res. 625, 238-243.
    • (1993) Brain Res. , vol.625 , pp. 238-243
    • Hurwitz, A.A.1    Berman, J.W.2    Rashbaum, W.K.3    Lyman, W.D.4
  • 74
    • 0025951892 scopus 로고
    • Glutamine stimulates growth in rat cerebral endothelial cell culture
    • [74] Dux, E., Noble, L. and Chan, P.H. (1991) Glutamine stimulates growth in rat cerebral endothelial cell culture. J. Neurosci. Res. 29, 355-361.
    • (1991) J. Neurosci. Res. , vol.29 , pp. 355-361
    • Dux, E.1    Noble, L.2    Chan, P.H.3
  • 75
    • 0026347011 scopus 로고
    • Stimulation of endothelial cell migration by thrombin
    • [75] Pankonin, G. and Teuscher, E. (1991) Stimulation of endothelial cell migration by thrombin. Biomed. Biochim. Acta 50, 1073-1078.
    • (1991) Biomed. Biochim. Acta , vol.50 , pp. 1073-1078
    • Pankonin, G.1    Teuscher, E.2
  • 77
    • 0026473365 scopus 로고
    • Mechanisms of endothelial growth control
    • [77] D'Amore, P.A. (1992) Mechanisms of endothelial growth control. Am. J. Respir. Cell. Mol. Biol. 6, 1-8.
    • (1992) Am. J. Respir. Cell. Mol. Biol. , vol.6 , pp. 1-8
    • D'Amore, P.A.1
  • 78
    • 0022820359 scopus 로고
    • An apparatus to study the response of cultured endothelium to shear stress
    • [78] Viggers, R.R., Wechezak, A.R. and Sauvage, L.R. (1986) An apparatus to study the response of cultured endothelium to shear stress. J. Biomech. Eng. 108, 332-337.
    • (1986) J. Biomech. Eng. , vol.108 , pp. 332-337
    • Viggers, R.R.1    Wechezak, A.R.2    Sauvage, L.R.3
  • 79
    • 0024371272 scopus 로고
    • Response of cultured endothelial cells to mechanical stimulation
    • [79] Dartsch, P.C. and Betz, E. (1989) Response of cultured endothelial cells to mechanical stimulation. Basic Res. Cardiol. 84, 268-281.
    • (1989) Basic Res. Cardiol. , vol.84 , pp. 268-281
    • Dartsch, P.C.1    Betz, E.2
  • 80
    • 0027499490 scopus 로고
    • Applications of primary cultures of brain microvessel endothelial cell monolayers in the study of vasoactive peptide interaction with the blood/brain barrier
    • [80] Reardon, P.M. and Audus, K.L. (1993) Applications of primary cultures of brain microvessel endothelial cell monolayers in the study of vasoactive peptide interaction with the blood/brain barrier. S.T.P. Pharma Sci. 3, 63-68.
    • (1993) S.T.P. Pharma Sci. , vol.3 , pp. 63-68
    • Reardon, P.M.1    Audus, K.L.2
  • 81
    • 0028024646 scopus 로고
    • Regulation of gamma-glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells
    • [81] Roux, F., Durieu-Trautmann, O., Chaverot, N., Claire, M., Mailly, P., Bourre, J.-M., Strosberg, A.D. and Couraud, P.-O. (1994) Regulation of gamma-glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells. J. Cell. Physiol. 159, 101-113.
    • (1994) J. Cell. Physiol. , vol.159 , pp. 101-113
    • Roux, F.1    Durieu-Trautmann, O.2    Chaverot, N.3    Claire, M.4    Mailly, P.5    Bourre, J.-M.6    Strosberg, A.D.7    Couraud, P.-O.8
  • 82
    • 0028267532 scopus 로고
    • Quantification and visualization of the transport of octreotide, a somatostatin analogue, across monolayers of cerebrovascular endothelial cells
    • [82] Jaehde, U., Masereeuw, R., de Boer, A.G., Fricker, G., Nagelkerke, J.F., Vonderscher, J. and Breimer, D.D. (1994) Quantification and visualization of the transport of octreotide, a somatostatin analogue, across monolayers of cerebrovascular endothelial cells. Pharm. Res. 11, 442-448.
    • (1994) Pharm. Res. , vol.11 , pp. 442-448
    • Jaehde, U.1    Masereeuw, R.2    De Boer, A.G.3    Fricker, G.4    Nagelkerke, J.F.5    Vonderscher, J.6    Breimer, D.D.7
  • 83
    • 0023752149 scopus 로고
    • Carrier-mediated transport of baclofen across monolayers of bovine brain endothelial cells in primary culture
    • [83] van Bree, J.B.M.M., Audus, K.L. and Borchardt, R.T. (1988) Carrier-mediated transport of baclofen across monolayers of bovine brain endothelial cells in primary culture. Pharm. Res. 5, 369-371.
    • (1988) Pharm. Res. , vol.5 , pp. 369-371
    • Van Bree, J.B.M.M.1    Audus, K.L.2    Borchardt, R.T.3
  • 84
    • 0028299612 scopus 로고
    • In vitro and in vivo transport of zidivudine (AZT) across the blood-brain barrier and the effect of transport inhibitors
    • [84] Masereeuw, R., Jaehde, U., Langemeijer, M.W.E., de Boer, A.G. and Breimer, D.D. (1994) In vitro and in vivo transport of Zidivudine (AZT) across the blood-brain barrier and the effect of transport inhibitors. Pharm. Res. 11, 324-330.
    • (1994) Pharm. Res. , vol.11 , pp. 324-330
    • Masereeuw, R.1    Jaehde, U.2    Langemeijer, M.W.E.3    De Boer, A.G.4    Breimer, D.D.5
  • 85
    • 0025329190 scopus 로고
    • Comparison of in vitro and in vivo models of drug transcytosis through the blood-brain barrier
    • [85] Pardridge, W.M., Triguero, D., Yang, J. and Cancilla, P.A. (1990) Comparison of in vitro and in vivo models of drug transcytosis through the blood-brain barrier. J. Pharmacol. Exp. Ther. 253, 884-891.
    • (1990) J. Pharmacol. Exp. Ther. , vol.253 , pp. 884-891
    • Pardridge, W.M.1    Triguero, D.2    Yang, J.3    Cancilla, P.A.4
  • 87
    • 0011274617 scopus 로고
    • The role of P-glycoprotein in regulating the blood-brain barrier permeability of peptides
    • Amsterdam, The Netherlands
    • [87] Chikhale, E.G. and Borchardt, R.T. (1995) The role of P-glycoprotein in regulating the blood-brain barrier permeability of peptides, 2nd. Int. Symp. on Drug Transport to the Brain. Amsterdam, The Netherlands.
    • (1995) 2nd. Int. Symp. on Drug Transport to the Brain
    • Chikhale, E.G.1    Borchardt, R.T.2
  • 88
    • 0027474456 scopus 로고
    • How cancer cells evade chemotherapy: Sixteenth Richard and Hinda Rosenthal Foundation Award Lecture
    • [88] Gottesman, M.M. (1993) How cancer cells evade chemotherapy: sixteenth Richard and Hinda Rosenthal Foundation Award Lecture, Cancer Res. 53, 747-754.
    • (1993) Cancer Res. , vol.53 , pp. 747-754
    • Gottesman, M.M.1
  • 89
    • 0026073186 scopus 로고
    • Genetic mechanisms of drug resistance. A review
    • [89] Borst, P. (1991) Genetic mechanisms of drug resistance. A review. Acta Oncol. 30, 87-105.
    • (1991) Acta Oncol. , vol.30 , pp. 87-105
    • Borst, P.1
  • 90
    • 0026210867 scopus 로고
    • Multidrug resistance mediated by P-glycoproteins
    • [90] Schinkel, A.H. and Borst, P. (1991) Multidrug resistance mediated by P-glycoproteins. Semin. Cancer Biol. 2, 213-226.
    • (1991) Semin. Cancer Biol. , vol.2 , pp. 213-226
    • Schinkel, A.H.1    Borst, P.2
  • 91
    • 0024409543 scopus 로고
    • Low-density lipoprotein receptor on endothelium of brain capillaries
    • [91] Méresse, S., Delbart, C., Fruchart, J.-C. and Cecchelli, R. (1989) Low-density lipoprotein receptor on endothelium of brain capillaries. J. Neurochem. 53, 340-345.
    • (1989) J. Neurochem. , vol.53 , pp. 340-345
    • Méresse, S.1    Delbart, C.2    Fruchart, J.-C.3    Cecchelli, R.4
  • 92
    • 0021058742 scopus 로고
    • In vivo and in vitro uptake and degradation of acetylated low density lipoprotein by rat liver endothelial, kupffer, and parenchymal cells
    • [92] Nagelkerke, J.F., Barto, K.P. and van Berkel, Th.J.C. (1983) In vivo and in vitro uptake and degradation of acetylated low density lipoprotein by rat liver endothelial, Kupffer, and parenchymal cells. J. Biol. Chem. 258, 12221-12227.
    • (1983) J. Biol. Chem. , vol.258 , pp. 12221-12227
    • Nagelkerke, J.F.1    Barto, K.P.2    Van Berkel, Th.J.C.3
  • 96
    • 0002037734 scopus 로고
    • Xenobiotic metabolism by brain mono-oxygenases and other cerebral enzymes
    • [96] Mesnel, M., Testa, B. and Jenner, P. (1984) Xenobiotic metabolism by brain mono-oxygenases and other cerebral enzymes. Adv. Drug Res. 13, 95-207.
    • (1984) Adv. Drug Res. , vol.13 , pp. 95-207
    • Mesnel, M.1    Testa, B.2    Jenner, P.3
  • 97
    • 0024212094 scopus 로고
    • Inhibition of adsorptive endocytosis and transcytosis in pulmonary microvessels
    • [97] Pietra, G.G., Johns, L., Byrnes, W. and Villaschi, S. (1988) Inhibition of adsorptive endocytosis and transcytosis in pulmonary microvessels. Lab. Invest. 59, 683-691.
    • (1988) Lab. Invest. , vol.59 , pp. 683-691
    • Pietra, G.G.1    Johns, L.2    Byrnes, W.3    Villaschi, S.4
  • 98
    • 0018872030 scopus 로고
    • Cloroquine and ammonium ion inhibit receptor-mediated endocytosis of mannose-glycoconjugates by macrophages: Apparent inhibition of receptor recycling
    • [98] Tietze, C., Schlesinger, P. and Stahl, P. (1980) Cloroquine and ammonium ion inhibit receptor-mediated endocytosis of mannose-glycoconjugates by macrophages: apparent inhibition of receptor recycling. Biochem. Biophys. Res. Commun. 93, 1-8.
    • (1980) Biochem. Biophys. Res. Commun. , vol.93 , pp. 1-8
    • Tietze, C.1    Schlesinger, P.2    Stahl, P.3
  • 99
    • 0024379547 scopus 로고
    • Transport of vasopressin fragments across the blood-brain-barrier: In vitro studies using monolayers cultures of bovine brain endothelial cells
    • [99] van Bree, J.B.M.M., de Boer, A.G., Verhoef, J.C., Danhof, M. and Breimer, D.D. (1989) Transport of vasopressin fragments across the blood-brain-barrier: in vitro studies using monolayers cultures of bovine brain endothelial cells. J. Pharmacol. Exp. Ther. 249, 1836-1840.
    • (1989) J. Pharmacol. Exp. Ther. , vol.249 , pp. 1836-1840
    • Van Bree, J.B.M.M.1    De Boer, A.G.2    Verhoef, J.C.3    Danhof, M.4    Breimer, D.D.5
  • 100
    • 0027427996 scopus 로고
    • Permeability enhancement in Caco-2 cell monolayers by sodium salicylate and sodium taurodihydrofusidate: Assessment of effect-reversibility and imaging of transepithelial transport routes by confocal laser scanning microscopy
    • [100] Hurni, M.A., Noach, A.B.J., Blom-Roosemalen, M.C.M., de Boer, A.G., Nagelkerke, J.F. and Breimer, D.D. (1993) Permeability enhancement in Caco-2 cell monolayers by sodium salicylate and sodium taurodihydrofusidate: assessment of effect-reversibility and imaging of transepithelial transport routes by confocal laser scanning microscopy. J. Pharmacol. Exp. Ther. 267, 942-950.
    • (1993) J. Pharmacol. Exp. Ther. , vol.267 , pp. 942-950
    • Hurni, M.A.1    Noach, A.B.J.2    Blom-Roosemalen, M.C.M.3    De Boer, A.G.4    Nagelkerke, J.F.5    Breimer, D.D.6
  • 103
    • 0024363682 scopus 로고
    • The role of endothelium in chronic inflammation
    • [103] Ziff, M. (1989) The role of endothelium in chronic inflammation. Springer Semin Immunopathol 11, 199-214.
    • (1989) Springer Semin Immunopathol , vol.11 , pp. 199-214
    • Ziff, M.1
  • 104
    • 0025285170 scopus 로고
    • Immune function of the blood-brain barrier: Incomplete presentation of protein (auto-)antigens by rat brain microvascular endothelium in vitro
    • [104] Risau, W., Engelhardt, B. and Wekerle, H. (1990) Immune function of the blood-brain barrier: incomplete presentation of protein (auto-)antigens by rat brain microvascular endothelium in vitro. J. Cell Biol. 110, 1757-1766.
    • (1990) J. Cell Biol. , vol.110 , pp. 1757-1766
    • Risau, W.1    Engelhardt, B.2    Wekerle, H.3
  • 105
    • 0027549155 scopus 로고
    • Breaching the blood-brain barrier
    • [105] Tuomanen, E. (1993) Breaching the blood-brain barrier. Sci. Am. 56-60.
    • (1993) Sci. Am. , pp. 56-60
    • Tuomanen, E.1
  • 107
    • 0026662561 scopus 로고
    • Diminished leukocyte-endothelium interaction in tumor microvessels
    • [107] Wu, N.Z., Klitzman, B., Dodge, R. and Dewhirst, M.W. (1992) Diminished leukocyte-endothelium interaction in tumor microvessels. Cancer Res. 52, 4265-4268.
    • (1992) Cancer Res. , vol.52 , pp. 4265-4268
    • Wu, N.Z.1    Klitzman, B.2    Dodge, R.3    Dewhirst, M.W.4


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