Rat tyrosine hydroxylase promoter directs tetracycline-inducible foreign gene expression in dopaminergic cell types

Molecular Brain Research

Volumn 126, Issue 2, 2004, Pages 173-180

  Gardaneh, Mossa ^a,b   O'Malley, Karen L ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Bcl 2; Cellular and molecular biology; Dopaminergic; Gene structure and function: general; Inducible; Parkinson's disease; Transactivator; Tyrosine hydroxylase

Indexed keywords

NEUROTOXIN; PROTEIN BCL 2; TETRACYCLINE; TRANSACTIVATOR PROTEIN; TYROSINE 3 MONOOXYGENASE;

ARTICLE; CELL DEATH; CELL TYPE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; EMBRYO; FEASIBILITY STUDY; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE EXPRESSION SYSTEM; HUMAN; HUMAN CELL; KIDNEY CELL; NEUROTOXICITY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPORTER GENE;

ANIMALS; CELL LINE; CELL SURVIVAL; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO; GENE EXPRESSION REGULATION; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY; LUMINESCENT PROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN SYNTHESIS INHIBITORS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RECOMBINANT FUSION PROTEINS; TETRACYCLINE; TIME FACTORS; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSFECTION; TYROSINE 3-MONOOXYGENASE;

ANIMALIA; CUCUMBER MOSAIC VIRUS;

EID: 3042714336     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbrainres.2004.04.008     Document Type: Article

References (23)

1. Banerjee S.A., Hoppe P., Brilliant M., Chikaraishi D.M. 5′ flanking sequences of the rat tyrosine hydroxylase gene target accurate tissue-specific, developmental, and transsynaptic expression in transgenic mice. J. Neurosci. 12:1992;4460-4467
2. Banerjee S.A., Roffler-Tarlov S., Szabo M., Frohman L., Chikaraishi D.M. DNA regulatory sequences of the rat tyrosine hydroxylase gene direct correct catecholaminergic cell-type specificity of a human growth hormone reporter in the CNS of transgenic mice causing a dwarf phenotype. Mol. Brain Res. 24:1994;89-106
3. Baron U., Freundlieb S., Gossen M., Bujard H. Co-regulation of two gene activities by tetracycline via a bidirectional promoter. Nucleic Acids Res. 23:1995;3605-3606
4. Choi H.K., Won L.A., Kontur P.J., Hammond D.N., Fox A.P., Wainer B.H., Hoffmann P.C., Heller A. Immortalization of embryonic mesencephalic dopaminergic neurons by somatic cell fusion. Brain Res. 552:1991;67-76
5. Forster K., Helbl V., Lederer T., Urlinger S., Wittenburg N., Hillen W. Tetracycline-inducible expression systems with reduced basal activity in mammalian cells. Nucleic Acids Res. 27:1999;708-710
6. Freundlieb S., Schirra-Muller C., Bujard H. A tetracycline controlled activation/repression system with increased potential for gene transfer into mammalian cells. J. Gene Med. 1:1999;4-12
7. Gossen M., Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. U. S. A. 89:1992;5547-5551
8. Gossen M., Freundlieb S., Bender G., Muller G., Hillen W., Bujard H. Transcriptional activation by tetracyclines in mammalian cells. Science. 268:1995;1766-1769
9. Lamartina S., Roscilli G., Rinaudo C.D., Sporeno E., Silvi L., Hillen W., Bujard H., Cortese R., Ciliberto G., Toniatti C. Stringent control of gene expression in vivo by using novel doxycycline-dependent trans-activators. Hum. Gene Ther. 13:2002;199-210
10. Lewandoski M. Conditional control of gene expression in the mouse. Nat. Rev., Genet. 2:2001;743-755
11. Liu J., Merlie J.P., Todd R.D., O'Malley K.L. Identification of cell type-specific promoter elements associated with the rat tyrosine hydroxylase gene using transgenic founder analysis. Mol. Brain Res. 50:1997;33-42
12. Lotharius J., Dugan L.L., O'Malley K.L. Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons. J. Neurosci. 19:1999;1284-1293
13. Min N., Joh T.H., Kim K.S., Peng C., Son J.H. 5′ upstream DNA sequence of the rat tyrosine hydroxylase gene directs high-level and tissue-specific expression to catecholaminergic neurons in the central nervous system of transgenic mice. Mol. Brain Res. 27:1994;281-289
14. +, but not 6-ODHA, induced cell death in a dopaminergic neuronal cell line. Neurobiol. Dis. 2:1995;157-167
15. + but not 6-OHDA-induced cell death in dopaminergic neurons. Neurobiol. Dis. 14:2003;43-51
16. Qu Z., Thottassery J.V., Van Ginkel S., Manuvakhova M., Westbrook L., Roland-Lazenby C., Hays S., Kern F.G. Homogeneity and long-term stability of tetracycline-regulated gene expression with low basal activity by using the rtTA2S-M2 transactivator and insulator-flanked reporter vectors. Gene. 327:2004;61-73
17. Robertson A., Perea J., Tolmachova T., Thomas P.K., Huxley C. Effects of mouse strain, position of integration and tetracycline analogue on the tetracycline conditional system in transgenic mice. Gene. 282:2002;65-74
18. Salucci V., Scarito A., Aurisicchio L., Lamartina S., Nicolaus G., Giampaoli S., Gonzalez-Paz O., Toniatti C., Bujard H., Hillen W., Ciliberto G., Palombo F. Tight control of gene expression by a helper-dependent adenovirus vector carrying the rtTA2(s)-M2 tetracycline transactivator and repressor system. Gene Ther. 9:2002;1415-1421
19. Song S., Wang Y., Bak S.Y., Lang P., Ullrey D., Neve R.L., O'Malley K.L., Geller A.I. An HSV-1 vector containing the rat tyrosine hydroxylase promoter enhances both long-term and cell type-specific expression in the midbrain. J. Neurochem. 68:1997;1792-1803
20. Song S., Wang Y., Bak S.Y., During M.J., Bryan J., Ashe O., Ullrey D.B., Trask L.E., Grant F.D., O'Malley K.L., Riedel H., Goldstein D.S., Neve K.A., LaHoste G.J., Marshall J.F., Haycock J.W., Neve R.L., Geller A.I. Modulation of rat rotational behavior by direct gene transfer of constitutively active protein kinase C into nigrostriatal neurons. J. Neurosci. 18:1998;4119-4132
21. Urlinger S., Baron U., Thellmann M., Hasan M.T., Bujard H., Hillen W. Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity. Proc. Natl. Acad. Sci. U. S. A. 97:2000;7963-7968
22. Zhu Z., Ma B., Homer R.J., Zheng T., Elias J.A. Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice. J. Biol. Chem. 276:2001;25222-25229
23. Zhu Z., Zheng T., Lee C.G., Homer R.J., Elias J.A. Tetracycline- controlled transcriptional regulation systems: advances and application in transgenic animal modeling. Semin. Cell Dev. Biol. 13:2002;121-128