Ultrastructural analysis of hippocampal pyramidal neurons from apolipoprotein E-deficient mice treated with a cathepsin inhibitor

Journal of Neurocytology

Volumn 33, Issue 1 SPEC. ISS., 2004, Pages 37-48

  Díaz Cintra, Sofia ^a   Yong, Alex ^b   Aguilar, Azucena ^a   Bi, Xiaoning ^b   Lynch, Gary ^b   Ribak, Charles E ^b  

^a INSTITUTO DE NEUROBIOLOGÍA   (Mexico)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; CATHEPSIN; CATHEPSIN B; CATHEPSIN L;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CELL COUNT; CELL NUCLEUS; DENDRITE; ELECTRON MICROSCOPY; GOLGI COMPLEX; HIPPOCAMPUS; LYSOSOME; MICROTUBULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SYNAPSE; ULTRASTRUCTURE;

ANIMALS; APOLIPOPROTEINS E; CATHEPSINS; DIAZOMETHANE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEASE INHIBITORS; PYRAMIDAL CELLS;

ANIMALIA; HIPPOCAMPUS HIPPOCAMPUS;

EID: 3042703209     PISSN: 03004864     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:NEUR.0000029647.41374.98     Document Type: Article

References (28)

1. BEDNARSKI, E. & LYNCH, G. (1996) Cytosolic proteolysis of tau by cathepsin D in hippocampus following suppression of cathepsins B and L. Journal of Neurochemistry 67, 1846-1855.
2. BEDNARSKI, E., RIBAK, C. E. & LYNCH, G. (1997) Suppression of cathepsins B and L causes a proliferation of lysosomes and the formation of meganeurites in hippocampus. Journal of Neuroscience 17, 4006-4021.
3. BI, X., YONG, A. P., ZHOU, J., RIBAK, C. E. & LYNCH, G. (2001) Rapid induction of intraneuronal neurofibrillary tangles in apolipoprotein E-deficient mice. Proceedings of the National Academy of Science, USA 98, 8832-8837.
4. BI, X., ZHOU, J. & LYNCH, G. (1999) Lysosomal protease inhibitors induce meganeurites and tangle-like structures in entorhinohippocampal regions vulnerable to Alzheimer's disease. Experimental Neurology 158, 312-327.
5. BRAAK, H. (1979) Spindle-shaped appendages of IIIab-pyramids filled with lipofuscin: A striking pathological change of senescent human isocortex. Acta Neuropathologica (Berlin) 46, 197-202.
6. BRIZZEE, K. R., CANCILLA, P. A., SHERWOOD, N. & TIMIRAS, P. S. (1969) The amount and distribution of pigments in neurons and glia of the cerebral cortex. Autofluorescent and ultrastructural studies. Journal of Gerontology 24, 127-135.
7. BRUNK, U. & ERICSSON, J. L. (1972) Electron microscopical studies on rat brain neurons. Localization of acid phosphatase and mode of formation of lipofuscin bodies. Journal of Ultrastructural Research 38, 1-15.
8. CATALDO, A. M. & NIXON, R. A. (1990) Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain. Proceedings of the National Academy of Sciences, USA 87, 3861-3865.
9. CATALDO, A. M., HAMILTON, D. J., BARNETT, J. L., PASKEVICH, P. A. & NIXON, R. A. (1996) Properties of the endosomal-lysosomal system in the human central nervous system: Disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease. Journal of Neuroscience 16, 186-199.
10. DAVIES, C. A., MANN, D. M., SUMPTER, P. Q. & YATES, P. O. (1987) A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease. Journal of Neurological Sciences 78, 151-164.
11. FREUND, T. L. & BUZSAKI, G. (1996) Interneurons of the hippocampus. Hippocampus 6, 347-470.
12. GOTZ, J., CHEN, F., VAN DORPE, J. & NITSCH, R. M. (2001) Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Aβ42 fibrils. Science 293, 1491-1495.
13. GREEN, G. D. & SHAW, L. (1981) Peptidyl diazomethylketones are specific inactivators of thiol proteinases. Journal of Biological Chemistry 256, 1923-1928.
14. HINDS, J. W. & McNELLY, N. A. (1979) Aging in the rat olfactory bulb: Quantitative changes in mitral cell organelles and somato-dendritic synapses. Journal of Comparative Neurology 184, 811-820.
15. LE, R., CRUZ, L., URBANC, B., KNOWLES, R. B., HSIAO-ASHE, K., DUFF, K., IRIZARRY, M. C., STANLEY, H. E. & HYMAN, B. T. (2001) Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: Implications for neural system disruption. Journal of Neuropathology and Experimental Neurology 60, 753-758.
16. LEWIS, J., DICKSON, D. W., LIN, W. L., CHISHOLM, L., CORRAL, A., JONES, G., YEN, S. H., SAHARA, N., SKIPPER, L., YAGER, D., ECKMAN, C., HARDY, J., HUTTON, M. & MCGOWAN, L. (2001) Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 293, 1446-1447.
17. MASLIAH, L., MALLORY, M., ALLORD, M., DETERESA, R., HANSEN, L. A., MCKEEL, D. W., JR. & MORRIS, J. C. (2001) Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease. Neurology 56, 127-129.
18. NAKANISHI, H., TOMINAGA, K., AMANO, T., HIROTSU, I., INOUE, T. & YAMAMOTO, K. (1994) Age-related changes in activities and localizations of cathepsins D, E, B, and L in the rat brain tissues. Experimental Neurology 126, 119-128.
19. PETERS, A., PALAY, S. L. & WEBSTER, H. DE F. (1991) The Fine Structure of the Nervous System. New York: Oxford University Press.
20. SELKOE, D. J. (2002) Alzheimer's disease is a synaptic failure. Science 298, 789-791.
21. SHAMBOUL, K. M. (1979) Retrograde axon reaction in the lateral vestibular nucleus of neonatal and adult rats. Journal of Anatomy 129, 225-233.
22. SORICELLI, A., POSTIGLIONE, A., GRIVET-FOJAJA, M. R., MAINENTI, P. P., DISCEPOLO, A., VARRONE, A., SALVATORE, M. & LASSEN, N. A. (1996) Reduced cortical distribution volume of iodine-123 iomazenil in Alzheimer's disease as a measure of loss of synapses. European Journal of Nuclear Medicine 23, 1323-1328.
23. STOPPINI, L., BUCHS, P. A. & MULLER, D. (1991) A simple method for organotypic cultures of nervous tissue. Journal of Neuroscience Methods 37, 173-182.
24. STRITTMATTER, W. J. & ROSES, A. D. (1996) Apolipoprotein E and Alzheimer's disease. Annual Review of Neuroscience 19, 53-77.
25. SZE, C. I., TRONCOSO, J. C., KAWAS, C., MOUTON, P., PRICE, D. L. & MARTIN, L. J. (1997) Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease. Journal of Neuropathology and Experimental Neurology 56, 933-944.
26. TERAI, K., IWAI, A., KAWABATA, S., TASAKI, Y., WATANABE, T., MIYATA, K. & YAMAGUCHI, T. (2001) beta-amyloid deposits in transgenic mice expressing human Beta-amyloid precursor protein have the same characteristics as those in Alzheimer's disease. Neuroscience 104, 299-310.
27. TERRY, R. D., GONATAS, N. K. & WEISS, M. (1964) The ultrastructure of the cerebral cortex in Alzheimer's disease. Transactions of the American Neurology Association 89, 12.
28. YONG, A. P., BEDNARSKI, E., GALL, C. M., LYNCH, G. & RIBAK, C. E. (1999) Lysosomal dysfunction results in lamina-specific meganeurite formation but not apoptosis in frontal cortex. Experimental Neurology 157, 150-160.