Effect of spinal cord transection on N-methyl-D-aspartate receptors in the cord

Journal of Neurotrauma

Volumn 15, Issue 12, 1998, Pages 1027-1036

  Krenz, Natalie R ^a   Weaver, Lynne C ^a  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

Autonomic dysreflexia; Chronic pain; Muscle spasticity; NMDA R1 immunocytochemistry; Spinal cord injury; 3H MK 801

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLADDER FUNCTION; BLOOD PRESSURE REGULATION; CHRONIC PAIN; CONTROLLED STUDY; DRUG RECEPTOR BINDING; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MUSCLE SPASM; NONHUMAN; PATHOLOGICAL REFLEX; RAT; RECEPTOR DENSITY; SPINAL CORD INJURY; SPINAL CORD TRANSSECTION; SYNAPTIC TRANSMISSION;

EID: 0031772617     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.1998.15.1027     Document Type: Article

References (50)

1. AANONSEN, L.M., and SEYBOLD, V.S. (1989). Phencyclidine and sigma receptors in rat spinal cord: binding characterization and quantitative autoradiography. Synapse 4, 1-10.
2. ANDERSON, D.K., PROCKOP, L.D., MEANS, E.D., and HARTLEY, L.E. (1976). Cerebrospinal fluid lactate and electrolyte levels following experimental spinal cord injury. J. Neurosurg. 44, 715-722.
3. BERNSTEIN, J.J., WACKER, W., and STANDLER, N. (1984). Spinal motoneuron dendritic alteration after spinal cord hemisection in rat. Exp. Neurol. 83, 548-554.
4. BURKE, D. (1988). Spasticity as an adaptation to pyramidal tract injury, in: Advances in Neurology Functional Recovery in Neurological Disease. S.G. Waxman (ed), Raven Press: New York, pps. 401-423.
5. CHRISTENSEN, M.D., EVERHART, A.W., PICKELMAN, J.T., and HULSEBOSCH, C.E. (1996). Mechanical and thermal allodynia in chronic central pain following spinal cord injury. Pain 68, 97-107.
6. CHRISTENSEN, M.D., and HULSEBOSCH, C.E. (1997). Spinal cord injury and anti-NGF treatment results in changes in CGRP density and distribution in the dorsal horn in the rat. Exp. Neurol. 147, 463-475.
7. CODERRE, T.J., KATZ, J., VACCARINO, A.L., and MELZACK, R. (1993). Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain 52, 259-285.
8. EIDE, P.K., STUBHAUG, A., and STENEHJAM, A.E. (1995). Central dysesthesia pain after traumatic spinal cord injury is dependent on N-methyl-D-aspartate receptor activation. Neurosurgery 37, 1080-1087.
9. EIDELBERG, E., NGUYEN, L.H., POLICH, R., and WALDEN, J.G. (1989). Transsynaptic degeneration of motoneurones caudal to spinal cord lesions. Brain Res. Bull. 22, 39-45.
10. FOSTER, A.C., and WONG, E.H.F. (1986). The novel anti-convulsant MK-801 binds to the activated state of the NMDA receptor in rat brain. Br. J. Pharmacol. 91, 403-409.
11. FURUYAMA, T., KIYAMA, H., SATO, K., et al. (1993). Region-specific expression of subunits of ionotropic glutamate 3 receptors (AMPA-type, KA-type and NMDA receptors) in the rat spinal cord with special reference to nociception. Mol. Brain. Res. 18, 141-151.
12. HALL, R.A., and SÖDERLING, T.R. (1997). Differential surface expression and phosphorylation of the N-methyl-D-aspartate receptor subunits NR1 and NR2 in cultured hippocampal neurons. J. Biol. Chem. 272, 4135-4140.
13. HAO, J.-X., and XU, X.-J. (1996). Treatment of chronic allodynia-like response in spinally injured rats: effects of sysis temically administered excitatory amino acid receptor antagonists. Pain 66, 279-285.
14. HEADLEY, P.M., and GRILLNER, S. (1990). Excitatory amino acids and synaptic transmission: the evidence for a physiological function. Trends Pharmacol. Sci. 11, 205-211.
15. JANSEN, K.L.R., FAULL, R.L.M., DRAGUNOW, M., and WALDVOGEL, H. (1990). Autoradiographic localization of NMDA, quisqualate, and kainic acid receptors in human spinal cord. Neurosci. Lett. 108, 53-57.
16. KITAMURA, Y., MIYAZAKI, A., YAMANAKA, Y., and NONAKA, S. (1993). Stimulatory effects of protein kinase C and calmodulin kinase II on N-methyl-D-aspartate receptor/channels in the postsynaptic density of rat brain. J. Neurochem. 61, 100-109.
17. KRASSIOUKOV, A.V., and WEAVER, L.C. (1995). Episodic hypertension due to autonomic dysreflexia in acute and chronic spinal cord-injured rats. Am. J. Physiol. 268, H2077-H2083.
18. KRASSIOUKOV, A.V., and WEAVER, L.C. (1996). Morphological changes in sympathetic preganglionic neurons after spinal cord injury in rats. Neuroscience 70, 211-226.
19. KRENZ, N.R., and WEAVER, L.C. (1998a). Changes in the morphology of sympathetic preganglionic neurons parallel the development of autonomic dysreflexia after spinal cord injury in rats. Neurosci. Lett. 243, 61-64.
20. KRENZ, N.R., and WEAVER, L.C. (1998b). Sprouting of primary afferent fibers after spinal cord transection in the rat. Neuroscience 85, 443-458.
21. KRUMINS, S.A., and FADEN, A.I. (1986). Traumatic injury alters opiate receptor binding in rat spinal cord. Ann. Neurol. 19, 498-501.
22. KRUSE, M.N., and DE GROAT, W.C. (1993). Changes in lower urinary tract function following spinal cord injury. J. Restor. Neurol. Neurosci. 5, 79-80.
23. LAURIE, D.J., and SEEBURG, P.H. (1994). Ligand affinities at recombinant N-methyl-D-aspartate receptors depend on subunit composition. Eur. J. Pharmacol. 268, 335-345.
24. 2+-dependent phosphatase. Nature 369, 235-239.
25. LIU, D., THANGNIPON, W., and MCADOO, D.J. (1991). Excitatory amino acids rise to toxic levels upon impact injury to the rat spinal cord. Brain Res. 547, 344-348.
26. MAIOROV, D.N., KRENZ, N.R., KRASSIOUKOV, A.V., and WEAVER, L.C. (1997a). Role of spinal NMDA and AMPA receptors in episodic hypertension in conscious spinal rats. Am. J. Physiol. 273, H1266-H1274.
27. MAIOROV, D.N., WEAVER, L.C., and KRASSIOUKOV, A.V. (1997b). Relationship between sympathetic activity and arterial pressure in conscious spinal rats. Am. J. Physiol. 272, H625-H631.
28. MATHIAS, C.J., and FRANKEL, H.L. (1988). Cardiovascular control in spinal man. Annu. Rev. Physiol. 50, 577-592.
29. MILLS, E.H., MINSON, J.B., PILOWSKY, P.M., and CHALMERS, J.P. (1988). N-methyl-D-aspartate receptors in the spinal cord mediate pressor responses to stimulation of the rostral ventrolateral medulla in the rat. Clin. Exp. Pharmacol. Physiol. 15, 147-155.
30. MO, N., and DUN, N.J. (1987). Excitatory postsynaptic potentials in neonatal rat sympathetic preganglionic neurons: possible mediation by NMDA receptors. Neurosci. Lett. 77, 327-332.
31. MONYER, H., SPRENGEL, R., SCHOEPFER, R., et al. (1992) Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 256, 1217-1221.
32. MORIYOSHI, K., MASU, M., ISHII, T., SHIGEMOTO, R., MIZUNO, N., and NAKANISHI, S. (1991). Molecular cloning and characterization of the rat NMDA receptor. Nature 354, 31-37.
33. PANTER, S.S., YUM, S.W., and FADEN, A.I. (1990). Alterations in extracellular amino acids after traumatic spinal cord injury. Ann. Neurol. 27, 96-99.
34. PETRALIA, R.S., YOKOTANI, N., and WENTHOLD, R.J. (1994). Light and electron microscope distribution of the NMDA receptor subunit NMDA-R1 in the rat nervous system using a selective anti-peptide antibody. J. Neurosci. 14, 667-696.
35. PIERROT-DESEILLIGNY, E., and MAZIERES, L. (1985). Spinal mechanisms underlying spasticity, in: Clinical Neurophysiology in Spasticity. P.J. Delwaide and R.R. Young (eds), Elsevier Science Publishers BV: Amsterdam, pps. 63-76.
36. 3H]MK-801 binding to the N-methyl-D-aspartate receptor-ion channel complex by L-glutamate, glycine, and polyamines. J. Neurochem. 51, 830-836.
37. RESINK, A., VILLA, M., BENKE, D., HIDAKA, H., MÖHLER, H., and BALÁZS, R. (1996). Characterization of agonist-induced down-regulation of NMDA receptors in cerebellar granule cell cultures. J. Neurochem. 66, 369-377.
38. ROCHFORD, J., YASHPAL, K., and HENRY, J.L. (1990). Intrathecal administration of calcitonin gene-related peptide (CGRP) increases heart rate and decreases arterial pressure in the urethane anesthetized rat. Brain Res. Bull. 25, 809-816.
39. ROSENMUND, C., and WESTBROOK, G.L. (1993). Calcium-induced actin depolymerization reduces NMDA channel activity. Neuron 10, 805-814.
40. 3H]MK-801 binding sites in the normal human spinal cord. Brain Res. 539, 164-168.
41. SHENG, M., CUMMINGS, J., ROLDAN, L.A., JAN, Y.N., and JAN, L.Y. (1994). Changing subunit composition of heteromeric NMDA receptors during development of rat cortex. Nature 368, 144-147.
42. SOKOL, R.R., and ROHLF, F.J. (1981). Biometry: The Principles and Practice of Statistics in Biological Research. W.H. Freeman: San Francisco.
43. SPANSWICK, D., and LOGAN, S.D. (1990). Sympathetic preganglionic neurones in neonatal rat spinal cord in vitro: electrophysiological characteristics and the effects of selective excitatory amino acid receptor agonists. Brain Res. 525, 181-188.
44. SUN, F.-Y., and FADEN, A.I. (1994). High- and low-affinity NMDA receptor-binding sites in rat spinal cord: effects of traumatic injury. Brain Res. 666, 88-92.
45. SUNDARAM, K., and SAPRU, H. (1991). NMDA receptors in the intermediolateral column of the spinal cord mediate sympathoexcitatory cardiac responses elicited from the ventrolateral medullary presser area. Brain Res. 544, 33-41.
46. TOLLE, T.R., BERTHELE, A., ZIEGLGANSBERGER, W., SEEBURG, P.H., and WISDEN, W. (1993). The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray. J. Neurosci. 13, 5009-5028.
47. VITA, G., HAWKINS, E.F., and ENGEL, W.K. (1990). Effects of experimental spinal cord transection on substance P receptors: a quantitative autoradiography study. Neuropeptides 17, 147-153.
48. WEST, M., and HUANG, W. (1994). Spinal cord excitatory amino acids and cardiovascular autonomic responses. Am. J. Physiol. 267, H865-H873.
49. WYSZYNSKI, M., LIN, J., RAO, A., et al. (1997). Competitive binding of alpha-actinin and calmodulin to the NMDA receptor. Nature 385, 439-442.
50. YOSHIMURA, M., SHIMIZU, T., YAJIRI, Y., INOKUCHI, H., and NISHI, S. (1993). Primary afferent-evoked slow EPSPs and responses to substance P of dorsal horn neurons in the adult rat spinal cord slices. Regul. Pept. 46, 407-409.