Inhibitory effects of halothane on the thermogenic pathway in brown adipocytes: Localization to adenylyl cyclase and mitochondrial fatty acid oxidation

Biochemical Pharmacology

Volumn 68, Issue 3, 2004, Pages 463-477

  Ohlson, Kerstin B E ^a,b   Shabalina, Irina G ^a   Lennström, Katarina ^a   Backlund, Emma C ^a   Mohell, Nina ^a,d   Bronnikov, Gennady E ^a,e   Lindahl, Sten G E ^c   Cannon, Barbara ^a   Nedergaard, Jan ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d BIOVITRUM AB   (Sweden)

^e INSTITUTE OF CELL BIOPHYSICS   (Russian Federation)

Author keywords

Adenylyl cyclase; Brown adipose tissue; carbonyl cyanide p (trifluoromethoxy)phenylhydrazone; Fatty acid oxidation; FCCP; Halothane; Thermogenesis; UCP1; uncoupling protein 1; Volatile anesthetics

Indexed keywords

ADENYLATE CYCLASE; FATTY ACID; HALOTHANE; INHALATION ANESTHETIC AGENT;

ANESTHESIA MECHANISM; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG TARGETING; ENZYME INHIBITION; ENZYME LOCALIZATION; FATTY ACID OXIDATION; FEMALE; GENE INDUCTION; LIPOLYSIS; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; NONSHIVERING THERMOGENESIS; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; ADIPOCYTES; ADIPOSE TISSUE, BROWN; ANESTHETICS, INHALATION; ANIMALS; BIOLOGICAL TRANSPORT; CARNITINE; CARRIER PROTEINS; CELLS, CULTURED; CRICETINAE; CYCLIC AMP; DRUG INTERACTIONS; FATTY ACIDS; FEMALE; HALOTHANE; ION CHANNELS; MALE; MEMBRANE PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NOREPINEPHRINE; OXIDATION-REDUCTION; RECEPTORS, ADRENERGIC, ALPHA; THERMOGENESIS;

EID: 3042701185     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.03.028     Document Type: Article

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