Hydrophobic acetal and ketal derivatives of mannopeptimycin-α and desmethylhexahydromannopeptimycin-α: Semisynthetic glycopeptides with potent activity against Gram-positive bacteria

Journal of Medicinal Chemistry

Volumn 47, Issue 14, 2004, Pages 3487-3490

  Dushin, Russell G ^a   Wang, Ting Zhong ^a   Sum, Phaik Eng ^a   He, Haiyin ^a   Sutherland, Alan G ^a   Ashcroft, Joseph S ^a   Graziani, Edmund I ^a   Koehn, Frank E ^a   Bradford, Patricia A ^a   Petersen, Peter J ^a   Wheless, Karen L ^a   How, David ^a   Torres, Nancy ^a   Lenoy, Eileen B ^a   Weiss, William J ^a   Lang, Stanley A ^a   Projan, Steven J ^a   Shlaes, David M ^a   Mansour, Tarek S ^a  

^a WYETH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AC 986446; ACETAL; ANTIINFECTIVE AGENT; DESMETHYLHEXAHYDROMANNOPEPTIMYCIN ALPHA DERIVATIVE; DIMETHYL ACETAL; DISACCHARIDE; MANNOPEPTIMYCIN; MANNOPEPTIMYCIN ALPHA DERIVATIVE; MANNOSE; UNCLASSIFIED DRUG; VANCOMYCIN;

ACIDITY; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; GRAM POSITIVE BACTERIUM; HYDROPHOBICITY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PENICILLIN RESISTANCE; REACTION ANALYSIS; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION;

ACETALS; ANTI-BACTERIAL AGENTS; GLYCOPEPTIDES; GRAM-POSITIVE BACTERIA; HYDROPHOBICITY; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 3042691790     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049765y     Document Type: Article

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