Novel ether derivatives of mannopeptimycin glycopeptide antibiotic

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 6, 2003, Pages 1151-1155

  Sum, Phaik Eng ^a   How, David ^a   Torres, Nancy ^a   Petersen, Peter J ^b   Lenoy, Eileen B ^b   Weiss, William J ^b   Mansour, Tarek S ^a  

^a PFIZER INC   (United States)

^b WYETH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAL DERIVATIVE; ANTIINFECTIVE AGENT; ETHER DERIVATIVE; GLYCOPEPTIDE; MANNOPEPTIMYCIN DERIVATIVE; METICILLIN; UNCLASSIFIED DRUG; VANCOMYCIN;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENTEROCOCCUS; ISOMER; NONHUMAN; REDUCTION; STAPHYLOCOCCUS; STREPTOCOCCUS;

EID: 0037463817     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00045-3     Document Type: Article

References (10)

1. Levy S.B. Scientific American, 278:1998;46.
2. De Voe, S. E.; Kunstmann, M. P. US Patent 3,495,004, 1970.
3. (a) He, H.; Bernan, V.; Williamson, T.; Graziani, E.; Shen, B.; Greenstein, M.; Carter, G. 41st Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, 16-19 December 2001; abstract F-1147. (b) He H., Williamson T., Shen B., Graziani E., Yang H.Y., Sakya S.M., Petersen P.J., Carter G. J. Am. Chem. Soc. 124:2002;9729.
4. (a) He, H.; Bernan, V.; Williamson, T.; Graziani, E.; Shen, B.; Greenstein, M.; Carter, G. 41st Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, 16-19 December 2001; abstract F-1147. (b) He H., Williamson T., Shen B., Graziani E., Yang H.Y., Sakya S.M., Petersen P.J., Carter G. J. Am. Chem. Soc. 124:2002;9729.
5. Singh, M. P.; Janso, J. E.; Luckman, S. W.; Greenstein, M. 41st Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, 16-19 December 2001; abstract F-1149.
6. Petersen, P. J.; Weiss, W. J.; Lenoy, E. B.; He, H.; Testa, R. T.; Bradford, P. A. 41st Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, 16-19 December 2001; abstract F-1148.
7. Johansson R., Samuelsson B. J. Chem. Soc., Perkin Trans. 1984;2371.
8. Jiang L., Chan T.-H. Tetrahedron Lett. 39:1998;355.
9. 2+. HPLC retention time (min.): 8a, 10.22; 8b, 10.64; 8c, 10.07; 8d, 9.72.
10. Cleeland, R.; Squires, E. In Antibiotic in Laboratory Medicine. Lorian, V., Ed.; The Williams & Wilkins Co., Baltimore, Md. 3rd. 1991; pp 752-783.