Mannopeptimycins, new cyclic glycopeptide antibiotics produced by Streptomyces hygroscopicus LL-AC98: Antibacterial and mechanistic activities

Antimicrobial Agents and Chemotherapy

Volumn 47, Issue 1, 2003, Pages 62-69

  Singh, M P ^a   Petersen, P J ^a   Weiss, W J ^a   Janso, J E ^a   Luckman, S W ^a   Lenoy, E B ^a   Bradford, P A ^a   Testa, R T ^a   Greenstein, M ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; AMPHOTERICIN B; AMPICILLIN; ANTIBIOTIC AGENT; BACITRACIN; CIPROFLOXACIN; DISACCHARIDE; ERYTHROMYCIN; GENTAMICIN; GLYCOPEPTIDE; ISOVALERIC ACID; MANNOPEPTIMYCIN ALPHA; MANNOPEPTIMYCIN BETA; MANNOPEPTIMYCIN DELTA; MANNOPEPTIMYCIN EPSILON; MANNOPEPTIMYCIN GAMMA; MANNOSE; N ACETYLGLUCOSAMINE; PENICILLIN G; PEPTIDOGLYCAN; PIPERACILLIN; POLYMYXIN; POLYMYXIN B; POTASSIUM ION; RAMOPLANIN; RIFAMPICIN; TEICOPLANIN; TIGECYCLINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANCOMYCIN;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL CELL WALL; CANDIDA ALBICANS; CONTROLLED STUDY; DNA SYNTHESIS; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; ENTEROCOCCUS; ESCHERICHIA COLI; EUKARYOTE; FEMALE; HEMOLYSIS; HUMAN; HUMAN CELL; MEMBRANE DAMAGE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROKARYOTE; PROTEIN SYNTHESIS; RNA SYNTHESIS; STAPHYLOCOCCUS AUREUS; STREPTOMYCES HYGROSCOPICUS; STRUCTURE ACTIVITY RELATION;

EID: 0037227867     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.47.1.62-69.2003     Document Type: Article

References (16)

1. Barbosa, M. D. F. S., G. Yang, J. Fang, M. G. Kurilla, and D. L. Pompliano. 2002. Development of a whole-cell assay for peptidoglycan biosynthesis inhibitor. Antimicrob. Agents Chemother. 40:943-946.
2. Bonomo, R. A. 2000. Multiple antibiotic-resistant bacteria in long-term-care facilities: an emerging problem in the practice of infectious diseases. Clin. Infect. Dis. 31:1414-1422.
3. Cetinkaya, Y., P. Falk, and C. G. Mayhall. Vancomycin-resistant enterococci. Clin. Microbiol. Rev. 13: 686-707.
4. Chopra, I., J. Hodgson, B. Metcalf, and G. Poste. 1997. The search for antibacterial agents effective against bacteria resistant to multiple antibiotics. Antimicrob. Agents Chemother. 41:497-503.
5. Gerberding, J. L. 2000. CDC semiannual report: aggregate data from the national infection surveillance (NNIS) system. U.S. Department of Health and Human Services, Atlanta, Ga.
6. Hageman, J. C., D. A. Pegues, C. Jepson, R. L. Bell, M. Guinan, K. W. Ward, M. D. Cohen, J. A. Hindler, F. C. Tenover, S. K. McAllister, M. E. Kellum, and S. K. Fridkin. 2001. Vancomycin-intermediate Staphylococcus aureus in a home health-care patient. Emerg. Infect. Dis. 7:1023-1025.
7. He, H., R. T. Williamson, B. Shen, E. I. Graziani, H. Y. Yang, S. M. Sakya, P. J. Petersen, and G. T. Carter. 2002. Mannopeptimycins, novel antibacterial glycopeptides from Streptomyces hygroscopicus LL-AC98. J. Am. Chem. Soc. 124:9727-9736.
8. Hsueh, P., C. Liu, and K. Luh. 2002. Current status of antimicrobial resistance in Taiwan, Emerg. Infect. Dis. 8:132-137.
9. Huang, S. S., B. J. Labus, M. C. Samuel, D. T. Wan, and A. L. Reingld. 2002. Antibiotic resistance patterns of bacterial isolates from blood in San Francisco County, California, 1996-1999. Emerg. Infect. Dis. 8:195-201.
10. National Committee for Clinical Laboratory Standards. 2000. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M7-A5. National Committee for Clinical Laboratory Standards, Wayne, Pa.
11. Novak, R., B. Henriques, E. Charpentier, S. Normark, and E. Tuomanen. 1999. Emergence of vancomycin tolerance in Streptococcus pneumoniae. Nature (London) 399:590-593.
12. Payne, D. J., N. G. Wallis, D. R. Gentry, and M. Rosenberg. 2000. The impact of genomics on novel antibacterial targets. Curr. Opin. Drug Discov. Dev. 3:177-190.
13. Perl, T. M. 1999. The threat of vancomycin resistance. Am. J. Med. 106:26S-37S.
14. Sampson, B. A., R. Misra, and S. A. Benson. 1989. Identification and characterization of a new gene of Escherichia coli K-12 involved in outer membrane permeability. Genetics 122:491-501.
15. Singh, M. P., and M. Greenstein. 2000. Antimicrobial leads from microbial natural products discovery. Curr. Opin. Drug Discov. Dev. 3:167-176.
16. Singh, M. P., P. J. Petersen, W. J. Weiss, F. Kong, and M. Greenstein. 2000. Saccharomicins, novel heptadecaglycoside antibiotics produced by Saccharothrix espanaensis: antibacterial and mechanistic activities. Antimicrob. Agents Chemother. 44:2154-2159.