Synthesis and evaluation of ether and halogenated derivatives of mannopeptimycin glycopeptide antibiotics

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 16, 2003, Pages 2805-2808

  Sum, Phaik Eng ^a   How, David ^a   Torres, Nancy ^a   Petersen, Peter J ^a   Ashcroft, Joseph ^a   Graziani, Edmund I ^a   Koehn, Frank E ^a   Mansour, Tarek S ^a  

^a WYETH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ETHER DERIVATIVE; GLYCOPEPTIDE; PIPERACILLIN; VANCOMYCIN;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BROMINATION; CARBON NUCLEAR MAGNETIC RESONANCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENTEROCOCCUS; GRAM POSITIVE BACTERIUM; HALOGENATION; LIPOPHILICITY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

POSIBACTERIA;

EID: 0038148996     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00542-0     Document Type: Article

References (9)

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2. (a) He, H.; Bernan, V.; Williamson, R. T.; Graziani, E. I.; Shen, B.; Greenstein, M.; Carter, G. T. In 41st Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, Dec 16-19, 2001; abstract F-1147.
3. (b) He H., Williamson R.T., Shen B., Graziani E.I., Yang H.Y., Sakya S.M., Petersen P.J., Carter G.T. J. Am. Chem. Soc. 124:2002;9729.
4. Sum P.-E., How D., Torres N., Petersen P.J., Lenoy E., Weiss W., Mansour T.S. Bioorg. Med. Chem. Lett. 13:2003;1151.
5. Sum P.-E., How D., Torres N., Petersen P.J., Newman H., Mansour T.S. Bioorg. Med. Chem. Lett. 13:2003;2607.
6. 2+.
7. 2+.
8. 2+ in about 1:1 ratio. All the reactions mentioned in this communication were monitored by ES/MS. All final products were purified by reverse-phase HPLC (acetnitrile-water-0.02% trifluoroacetic acid).
9. Cleeland, R.; and Squires, E. In Antibiotic in Laboratory Medicine; Lorian, V., Ed.; The Williams & Wilkins Co.: Baltimore, MD. 1991; p 752.