Synergistic anti-inflammatory activity of ω-3 lipid and rofecoxib pretreatment on macrophage proinflammatory cytokine production occurs via divergent NF-κB activation

Journal of Parenteral and Enteral Nutrition

Volumn 28, Issue 4, 2004, Pages 232-240

  Babcock, Tricia A ^a   Helton, W Scott ^a   Anwar, Khandaker N ^a   Zhao, You Yang ^a   Espat, N Joseph ^a   Flakoll, Paul ^b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b IOWA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; CYTOKINE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NUCLEAR PROTEIN; OMEGA 3 FATTY ACID; OMEGAVEN; PROSTAGLANDIN E2; ROFECOXIB; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL MOBILITY SHIFT ASSAY; LIPID METABOLISM; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ANIMALIA; ESCHERICHIA COLI;

EID: 3042682054     PISSN: 01486071     EISSN: None     Source Type: Journal    
DOI: 10.1177/0148607104028004232     Document Type: Article

References (53)

1. Siscovick DS, Raghunathan T, King I, et al. Dietary intake of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest. Am J Clin Nutr. 2000;71:208S-212S.
2. Barber MD, Ross JA, Preston T, Shenkin A, Fearon KC. Fish oil-enriched nutritional supplement attenuates progression of the acute-phase response in weight-losing patients with advanced pancreatic cancer. J Nutr. 1999;129:1120-1125.
3. De Vizia B, Raia V, Spano C, Pavlidis C, Coruzzo A, Alessio M. Effect of an 8-month treatment with ω-3 fatty acids (eicosapentaenoic and docosahexaenoic) in patients with cystic fibrosis. JPEN. 2003;27:52-57.
4. Booyens J, van der Merwe CF, Katzeff IE. Chronic arachidonic acid eicosanoid imbalance: a common feature in coronary artery disease, hypercholesterolemia, cancer and other important diseases: significance of desaturase enzyme inhibition and of the arachidonic acid desaturase-independent pathway. Med Hypotheses. 1985;18:53-60.
5. Kremer JM, Robinson DR. Studies of dietary supplementation with ω-3 fatty acids in patients with rheumatoid arthritis. World Rev Nutr Diet. 1991;66:367-382.
6. Espat NJ, Moldawer LL, Copeland EM. Cytokine-mediated alterations in host metabolism prevent nutritional repletion in cachectic cancer-patients. J Surg Oncol. 1995;58:77-82.
7. Vane JR, Mitchell JA, Appleton I, et al. Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. Proc Natl Acad Sci USA. 1994;91:2046-2050.
8. Herschman HR, Xie W, Reddy S. Inflammation, reproduction, cancer and all that: the regulation and role of the inducible prostaglandin synthase. Bioessays. 1995;17:1031-1037.
9. Dennis EA, Rhee SG, Billah MM, Hannun YA. Role of phospholipase in generating lipid second messengers in signal transduction. FASEB J. 1991;5:2068-2077.
10. Mack SV, Mackrell PJ, Concannon EM, et al. NS-398 treatment after trauma modifies NF-κB activation and improves survival. J Surg Res. 2001;98:40-46.
11. O'Neill GP, Ford-Hutchinson AW. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. FEBS Lett. 1993;330:156-160.
12. Feuerstein G, Hallenbeck JM. Prostaglandins, leukotrienes, and platelet-activating factor in shock. Annu Rev Pharmacol Toxicol. 1987;27:301-313.
13. Schonbeck U, Sukhova GK, Graber P, Coulter S, Libby P. Augmented expression of cyclooxygenase-2 in human atherosclerotic lesions. Am J Pathol. 1999;155:1281-1291.
14. Jones DA, Carlton DP, McIntyre TM, Zimmerman GA, Prescott SM. Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines. J Biol Chem. 1993;268:9049-9054.
15. Hambleton J, Weinstein SL, Lem L, DeFranco AL. Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. Proc Natl Acad Sci USA. 1996;93:2774-2778.
16. Hwang D, Rhee SH. Receptor-mediated signaling pathways: potential targets of modulation by dietary fatty acids. Am J Clin Nutr. 1999;70:545-556.
17. Beutler B. Endotoxin, toll-like receptor 4, and the afferent limb of innate immunity. Curr Opin Microbiol. 2000;3:23-28.
18. Beutler B. Tlr4: central component of the sole mammalian LPS sensor. Curr Opin Immunol. 2000;12:20-26.
19. Lo CJ, Chiu KC, Fu M, Lo R, Helton S. Fish oil decreases macrophage tumor necrosis factor gene transcription by altering the NFκB activity. J Surg Res. 1999;82:216-221.
20. Lo CJ, Chiu KC, Fu M, Lo R, Helton S. Fish oil augments macrophage cyclooxygenase II (COX-2) gene expression induced by endotoxin. J Surg Res. 1999;86:103-107.
21. Babcock TA, Novak T, Ong E, Jho DH, Helton WS, Espat NJ. Modulation of lipopolysaccharide-stimulated macrophage tumor necrosis factor-α production by ω-3 fatty acid is associated with differential cyclooxygenase-2 protein expression and is independent of interleukin-10. J Surg Res. 2002;107:135-139.
22. Babcock TA, Helton WS, Hong D, Espat NJ. Omega-3 fatty acid lipid emulsion reduces LPS-stimulated macrophage TNF-α production. Surg Infect (Larchmt). 2002;3:145-149.
23. Bagga D, Wang L, Farias-Eisner R, Glaspy JA, Reddy ST. Differential effects of prostaglandin derived from ω-6 and ω-3 poly-unsaturated fatty acids on COX-2 expression and IL-6 secretion. Proc Natl Acad Sci USA. 2003;100:1751-1756.
24. Babcock TA, Kurland A, Helton WS, Rahman A, Anwar KN, Espat NJ. Inhibition of activator protein-1 transcription factor activation by ω-3 fatty acid modulation of mitogen-activated protein kinase signaling kinases. JPEN. 2003;27:176-180.
25. Novak TE, Babcock TA, Jho DH, Helton WS, Espat NJ. NF-κB inhibition by ω-3 fatty acids modulates LPS-stimulated macrophage TNF-α transcription. Am J Physiol Lung Cell Mol Physiol. 2003;284:L84-L89.
26. 2 production by lipopolysaccharide-stimulated macrophages is not dependent on nuclear factor κB. J Surg Res. 2003;113:189-194.
27. 2 production by endotoxin-stimulated alveolar macrophages is regulated by phospholipase C pathways. J Trauma. 1996;40:557-562.
28. Calder PC. Polyunsaturated fatty acids, inflammation, and immunity. Lipids. 2001;36:1007-1024.
29. Connor WE. Importance of n-3 fatty acids in health and disease. Am J Clin Nutr 2000;71:171S-175S.
30. 2. Biochem Biophys Res Commun. 1986;137:404-410.
31. Cao Y, Prescott SM. Many actions of cyclooxygenase-2 in cellular dynamics and in cancer. J Cell Physiol. 2002;190:279-286.
32. 2 generation in mouse osteoblastic cells: enhancement by secretory phospholipase A2. J Biol Chem. 1997;272:19891-19897.
33. 2 in a murine model of inflammation: possible role of cyclooxygenase-2. Proc Natl Acad Sci USA. 1996; 93:4885-4890.
34. 2: distinct roles of cyclooxygenase-1 and -2. J Biol Chem. 1997;272:25693-25699.
35. Karmali RA. Historical perspective and potential use of n-3 fatty acids in therapy of cancer cachexia. Nutrition. 1996;12: S2-S4.
36. Hwang D, Jang BC, Yu G, Boudreau M. Expression of mitogen-inducible cyclooxygenase induced by lipopolysaccharide: mediation through both mitogen-activated protein kinase and NF-κB signaling pathways in macrophages. Biochem Pharmacol. 1997; 54:87-96.
37. Jordan A, Stein J. Modulation of epidermal growth factor-induced cell proliferation by an ω-3 fatty-acid-containing lipid emulsion on human pancreatic cancer cell line Mia Paca-2. Nutrition. 2001;17:474-475.
38. Lands WE, Libelt B, Morris A, et al. Maintenance of lower proportions of (n-6) eicosanoid precursors in phospholipids of human plasma in response to added dietary (n-3) fatty acids. Biochim Biophys Acta. 1992;1180:147-162.
39. Culp BR, Titus BG, Lands WE. Inhibition of prostaglandin biosynthesis by eicosapentaenoic acid. Prostaglandins Med. 1979; 3:269-278.
40. Herschman HR. Prostaglandin synthase 2. Biochim Biophys Acta. 1996;1299:125-140.
41. Niederberger E, Tegeder I, Vetter G, et al. Celecoxib loses its anti-inflammatory efficacy at high doses through activation of NF-κB. FASEB J. 2001;15:1622-1624.
42. Lo CJ, Cryer HG, Fu M, Lo FR. Regulation of macrophage eicosanoid generation is dependent on nuclear factor κB. J Trauma. 1998;45:19-23.
43. Bone RC. Toward an epidemiology and natural history of SIRS (systemic inflammatory response syndrome). JAMA. 1992;268: 3452-3455.
44. Jiang C, Ting AT, Seed B. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines. Nature. 1998;391:82-86.
45. Surh YJ, Chun KS, Cha HH, et al. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB activation. Mutat Res. 2001;480-481:243-268.
46. Faisst S, Meyer S. Compilation of vertebrate-encoded transcription factors. Nucleic Acids Res. 1992;20:3-26.
47. Tegeder I, Pfeilschifter J, Geisslinger G. Cyclooxygenase-independent actions of cyclooxygenase inhibitors. FASEB J. 2001;15: 2057-2072.
48. Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature. 1998;391:79-82.
49. Sugiyama H, Nonaka T, Kishimoto T, Komoriya K, Tsuji K, Nakahata T. Peroxisome proliferator-activated receptors are expressed in mouse bone marrow-derived mast cells. FEBS Lett. 2000;467:259-262.
50. Paik JH, Ju JH, Lee JY, Boudreau MD, Hwang DH. Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase: mediation through different signaling pathways. J Biol Chem. 2000;275:28173-28179.
51. Libby P, Warner SJ, Friedman GB. Interleukin 1: a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids. J Clin Invest. 1988; 81:487-498.
52. Hwang D. Fatty acids and immune responses: a new perspective in searching for clues to mechanism. Annu Rev Nutr. 2000;20: 431-456.
53. 2 that regulate cellular immune responses in the mouse. J Clin Invest. 2001;108:1229-1235.