Phosphoinositide-3-OH-kinase inhibitor LY294002 prevents activation of Ancylostoma caninum and Ancylostoma ceylanicum third-stage infective larvae

International Journal for Parasitology

Volumn 34, Issue 8, 2004, Pages 909-914

  Brand, Andrea ^a   Hawdon, John M ^a  

^a GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Ancylostoma; Dauer; Insulin signaling; LY294002; PI3 kinase; Transition to parasitism

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 8 BROMO CYCLIC GMP; ARECOLINE; CYCLIC GMP; INSULIN; MUSCARINIC AGENT; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR;

PARASITOLOGY;

ANCYLOSTOMA CANINUM; ANCYLOSTOMA CEYLANICUM; ARTICLE; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; ENZYME ACTIVITY; FEEDING; HOOKWORM; LARVA; NONHUMAN; PARASITE DEVELOPMENT; PARASITISM;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANCYLOSTOMA; ANIMALS; ARECOLINE; BLOTTING, WESTERN; CHROMONES; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; ENZYME INHIBITORS; INSULIN; LARVA; MORPHOLINES; MUSCARINIC AGONISTS; SIGNAL TRANSDUCTION;

ANCYLOSTOMA; ANCYLOSTOMA CANINUM; ANCYLOSTOMA CEYLANICUM; ANCYLOSTOMATOIDEA; CAENORHABDITIS; CAENORHABDITIS ELEGANS;

EID: 3042611978     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpara.2004.04.003     Document Type: Article

References (25)

1. Babar P., Adamson C., Walker G.A., Walker D.W., Lithgow G.J. P13-kinase inhibition induces dauer formation, thermotolerance and longevity in C. elegans. Neurobiol. Aging. 20:1999;513-519
2. Birnby D.A., Link E.M., Vowels J.J., Tian H., Colacurcio P.L., Thomas J.H. A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in Caenorhabditis elegans. Genetics. 155:2000;85-104
3. Cassada R.C., Russell R.L. The dauer larva, a post-embryonic developmental variant of the nematode Caenorhabditis elegans. Dev. Biol. 46:1975;326-342
4. Chowdhury A.B., Schad G.A. Ancylostoma ceylanicum: a parasite of man in Calcutta and environs. Am. J. Trop. Med. Hyg. 21:1972;300-301
5. Garside P., Behnke J.M. Ancylostoma ceylanicum in the hamster: observations on the host-parasite relationship during primary infection. Parasitology. 98:1989;283-289
6. Hanna-Rose W., Han M. Getting signals crossed in C. elegans. Curr. Opin. Gen. Dev. 10:2000;523-528
7. Hawdon J.M., Schad G.A. Serum stimulated feeding in vitro by third stage infective larvae of the canine hookworm Ancylostoma caninum. J. Parasitol. 76:1990;394-398
8. Hawdon J.M., Schad G.A. Long-term storage of hookworm infective larvae in buffered saline solution maintains larval responsiveness to host signals. J. Helm. Soc. Wash. 58:1991;140-142
9. Hawdon J.M., Schad G.A. Ancylostoma caninum: glutathione stimulates feeding in third-stage larvae by a sulfhydryl-independent mechanism. Exp. Parasitol. 77:1993;489-491
10. Hawdon J.M., Hotez P.J. Hookworm: developmental biology of the infectious process. Curr. Opin. Gen. Dev. 6:1996;618-623
11. Hawdon J.M., Datu B. The second messenger cyclic GMP mediates activation in Ancylostoma caninum infective larvae. Int. J. Parasitol. 33:2003;787-793
12. Hawdon J.M., Jones B.F., Perregaux M.A., Hotez P.J. Ancylostoma caninum: metalloprotease release coincides with activation of infective larvae in vitro. Exp. Parasitol. 80:1995;205-211
13. Hawdon J.M., Jones B.F., Hoffman D.R., Hotez P.J. Cloning and characterization of Ancylostoma secreted protein: a novel protein associated with the transition to parasitism by infective hookworm larvae. J. Biol. Chem. 271:1996;6672-6678
14. Hawdon J.M., Narasimhan S., Hotez P.J. Ancylostoma secreted protein 2: cloning and characterization of a second member of a family of nematode secreted proteins from Ancylostoma caninum. Mol. Biochem. Parasitol. 99:1999;149-165
15. Hotez P.J., Hawdon J.M., Schad G.A. Hookworm larval infectivity, arrest, and amphiparatenesis: the Caenorhabditis elegans daf-c paradigm. Parasitol. Today. 9:1993;23-26
16. Kimura K.D., Tissenbaum H.A., Liu Y., Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science. 277:1997;942-946
17. Morris J.Z., Tissenbaum H.A., Ruvkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature. 382:1996;536-539
18. Nelson D.W., Padgett R.W. Insulin worms its way into the spotlight. Genes Dev. 17:2003;813-818
19. Paradis S., Ruvkun G. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev. 12:1998;2488-2498
20. Riddle D.L., Albert P.S. Genetic and Environmental Regulation of Dauer Larva Development. Riddle D.L., Blumenthal T., Meyer B.J., Priess J.R. C. elegans II. 1997;739-768 Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
21. Rogers W.P., Sommerville R.I. The infective stage of nematode parasites and its significance in parasitism. Adv. Parasitol. 1:1963;109-177
22. Schad G.A., Page M.R. Ancylostoma caninum: adult worm removal, corticosteroid treatment, and resumed development of arrested larvae in dogs. Exp. Parasitol. 54:1982;303-309
23. Tissenbaum H.A., Hawdon J., Perregaux M., Hotez P., Guarente L., Ruvkun G. A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum. Proc. Natl Acad. Sci. USA. 97:2000;460-465
24. Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl Acad. Sci. USA. 76:1979;4350
25. Zhan B., Hotez P.J., Wang Y., Hawdon J.M. A developmentally regulated metalloprotease secreted by host-stimulated Ancylostoma caninum third-stage infective larvae is a member of the astacin family of proteases. Mol. Biochem. Parasitol. 120:2002;291-296