Transverse propagation of action potentials between parallel chains of cardiac muscle and smooth muscle cells in PSpice simulations

BioMedical Engineering Online

Volumn 3, Issue , 2004, Pages

  Sperelakis, Nicholas ^a   Kalloor, Bijoy ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Electric field in junctional cleft; Junctional cleft potential; PSpice simulations; Transverse propagation in cardiac muscle; Transverse propagation in smooth muscle

Indexed keywords

GAP JUNCTION PROTEIN;

ARTICLE; BIOLOGICAL MODEL; CELL JUNCTION; COMPUTER PROGRAM; COMPUTER SIMULATION; CONTROLLED STUDY; ELECTRIC FIELD; ELECTROSTIMULATION; HEART CONTRACTION; HEART DEPOLARIZATION; HEART EXCITATION; HEART MUSCLE FIBER MEMBRANE CONDUCTANCE; HEART MUSCLE FIBER MEMBRANE POTENTIAL; MATHEMATICAL COMPUTING; MUSCLE EXCITATION; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER MEMBRANE POTENTIAL; TIME; ACTION POTENTIAL; CARDIAC MUSCLE CELL; CELL COMMUNICATION; ELECTRICITY; EXTRACELLULAR SPACE; IMPEDANCE; PHYSIOLOGY; SMOOTH MUSCLE CELL;

ACTION POTENTIALS; CELL COMMUNICATION; COMPUTER SIMULATION; ELECTRIC IMPEDANCE; ELECTRICITY; EXTRACELLULAR SPACE; INTERCELLULAR JUNCTIONS; MODELS, BIOLOGICAL; MYOCYTES, CARDIAC; MYOCYTES, SMOOTH MUSCLE;

EID: 3042596872     PISSN: 1475925X     EISSN: None     Source Type: Journal    
DOI: 10.1186/14765-925X-3-5     Document Type: Article

References (33)

1. Sperelakis N, Mann JE: Evaluation of electric field changes in the cleft between excitable cells. J Theor Biol 1977, 64:71-96.
2. Sperelakis N, McConnell K: An electric field mechanism for transmission of excitation from cell to cell in cardiac muscle and smooth muscles. In: Research Advances in Biomedical Engineering Volume 2. Edited by: Mohan RM. Global Research Network; 2001:39-66.
3. Sperelakis N, McConnell K: Electric field interactions between closely-abutting excitable cells. IEEE-EMB 2002, 21:77-89.
4. Sperelakis N: Cable Properties and propagation of action potentials, ch. 18. In: Cell Physiology Source Book 1st edition. Academic Press Publishers; 1995:245-254.
5. Cohen SA: Immunocytochemical localization of rH1 sodium channel in adult rat heart atria and ventricle. Presence in terminal intercalated disks. Circulation 1996, 94:3083-3086.
6. Kucera JP, Rohr S, Rudy Y: Localization of sodium channels in intercalated disks modulates cardiac conduction. Circ Res 2002, 91:1176-1182.
7. Sperelakis N: Editorial: An electric field mechanism for transmission of excitation between myocardial cells. Circ Res 2002, 91:985-987.
8. Sperelakis N, Ramasamy L: Propagation in cardiac muscle and smooth muscle based on electric field transmission at cell junctions: An analysis by PSpice. IEEE-EMB 2002, 21:130-143.
9. Sperelakis N, Murali KPV: Effect of external resistance on propagation of action potentials in cardiac muscle and visceral smooth muscle in PSpice simulation. J Math & Comp Modelling 2003, 37:1443-1467.
10. Sperelakis N, Mural KPV: Combined electric field and gap junctions on propagation of action potentials in cardiac muscle and smooth muscle in PSpice simulation. J Electrocard 2003, 36(4):279-293.
11. Sperelakis N: Propagation of action potentials between parallel chains of cardiac muscle cells in PSpice simulation. Can J Physiol Pharmacol 2003, 81:1-11.
12. Spach MS, Miller WT, Geselowitz DB, Barr R, Kootsey JM, Johnson EA: The discontinuous nature of propagation in normal canine cardiac muscle. Evidence for recurrent discontinuity of intracellular resistance that affects the membrane currents. Circ Res 1981, 48:39-54.
13. Spach MS, Dolber P, Heldiage JF: Use of computer simulations for combined experimental-theoretical study of anisotropic discontinuous propagation at a microscopic level in the cardiac muscle. In: Electromechanical Activation, Metabolism and perfusion of the heart: Simulation and experimental Models Edited by: Sideman S, Beyar R. The Hague: Martinus Nijhoff; 1987:3-25.
14. Diaz PJ, Rudy Y, Plonsey R: Intercalated discs as a cause for discontinuous propagation in cardiac muscle: A theoretical simulation,. Ann Biomed Eng 1983, 11:177-189.
15. Rudy Y, Quan R: Effects of the discreet cellular structure on electrical propagation in cardiac tissue. in Electromechanical Activation, Metabolism and Perfusion of the Heart: Simulation and Experimental Models Edited by: Sideman S, Beyar R. The Hague: Martinus Nijhoff; 1987:61.
16. Spooner PM, Joyner RW, Jalife J, editors: Discontinous Conduction in the Heart Futura Publishing; 1997:569.
17. Weingart R, Metzger P: Action potential transfer in cell pairs isolated from adult rat and guinea pig ventricles. Circ Res 1988, 63:72-80.
18. Joyner RW, Sugiura H, Tan RC: Unidirectional block between isolated rabbit ventricular cells coupled by a variable resistance. Biophys J 1991, 60:1038-1045.
19. + shifts in early ischemia: Mechanisms and relation to changes in impulse propagation. J Mol Cell Cardiol 1987, 19:35-44.
20. Weidmann S: The diffusion of radiopotassium across intercalated disks of mammalian cardiac muscle. J Physiol 1966, 187:322-342.
21. DiFrancesco D, Noble D: A model of cardiac electrical activity incorporating ionic pumps and concentration charges. Philos Trans R Soc Lond B Biol Sci 1985, 307:353-398.
22. Rudy Y: The ionic mechanisms of conduction in cardiac tissue. J Electrocardial 2001, 34:65-68.
23. Shaw RM, Rudy Y: Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling. Circ Res 1997, 81:727-741.
24. Henriquez AP, Vogel V, Muller-Borer BJ, Henriquez CS, Weingart R, Cascio WE: Influence of dynamic gap junction resistance on impulse propagation in ventricular myocardium: a computer simulation study. Biophys J 2001, 81:2112-2121.
25. Vaidya D, Tamaddon HS, Lo CW, Taffet SM, Delmar M, Morley GE: Null mutation of connexin43 causes slow propagation of ventricular activation in the late stages of mouse embryonic development. Circ Res 2001, 88:1196-1202.
26. Tamaddon HS, Vaidya D, Simon AM, Paul DL, Jalife J, Morley GE: High resolution optical mapping of the right bundle branch in connexin40 knockout mice reveals slow conduction in the specialized conduction system. Circ Res 2000, 87:929-936.
27. Morley GE, Vaidya D, Samie FH, Lo CW, Taffet SM, Delmar M, Jalife J: Characterization of conduction in the ventricles of normal and heterozygous Cx43 knockout mice using optical mapping. J Cardiovasc Electrophysiol 1999, 10:1361-1375.
28. Gutstein DE, Morley GE, Tamaddon H, Vaidya D, Schneider MD, Chen J, Chien KR, Stuhlmann H, Fishman GI: Conduction slowing and sudden arrythmic death in mice with cardiac restricted inactivation of connexin43. Circ Res 2001, 88:333-339.
29. Hogues H, Leon LJ, Roberge FA: A model of study of electric field interactions between cardiac myocytes. IEEE Tans Biomed Eng 1992, 30:1232-1243.
30. Perstov AM, Medvinski AB: Electric coupling in cells without highly permeable cell contacts. Biofizika 1976, 21:698-700.
31. Prosser CL, Sperelakis N: Transmission in ganglion-free circular muscle from the cat intestine. Am J Physiol 1956, 187:536-545.
32. Suenson M: Ephaptic impulse transmission between ventricular myocardial cells in vitro. Acta Physiol Scand 1984, 120:445-455.
33. Barr RC, Plonsey R: Electrophysiological interaction through the interstitial space between adjacent unmyelinated parallel fibers. Biophys J 1992, 61:1164-1175.