Combined Electric Field and Gap Junctions on Propagation of Action Potentials in Cardiac Muscle and Smooth Muscle in PSpice Simulation

Journal of Electrocardiology

Volumn 36, Issue 4, 2003, Pages 279-293

  Sperelakis, Nicholas ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Electric field in junctional cleft; Gap junction connections; Propagation in cardiac muscle; Propagation in smooth muscle; PSpice simulations

Indexed keywords

ACTION POTENTIAL; ARTICLE; COMPUTER PROGRAM; ELECTRIC FIELD; GAP JUNCTION; HEART DEPOLARIZATION; HEART EXCITATION; HEART MUSCLE; PATCH CLAMP; PRIORITY JOURNAL; SIMULATION; SMOOTH MUSCLE;

EID: 0242665507     PISSN: 00220736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jelectrocard.2003.08.001     Document Type: Article

References (22)

1. Sperelakis N, Mann JE Jr: Evaluation of electric field changes in the cleft between excitable cells. J Theor Biol 64:71, 1977
2. Sperelakis N, McConnell K: An electric field mechanism for transmission of excitation from cell to cell in cardiac muscle and smooth muscles, in Mohan RM (ed): Research Advances in Biomedical Engineering. Bombay, Global Research Network, 2001, p 39
3. Sperelakis N, McConnell K: Electric field interactions between closely-abutting excitable cells. IEEE-EMB 21:77, 2002
4. Sperelakis N, Ramasamy L: Propagation in cardiac muscle and smooth muscle based on electric field transmission at cell junctions: An analysis by PSpice. IEEE-EMB 21:177, 2002
5. Sperelakis N, Murali KPV: Effect of external resistance on propagation of action potentials in cardiac muscle and visceral smooth muscle in PSpice simulation. J Math Comp Modelling 37:1443-1467, 2003
6. Spach MS, Miller WT, Geselowitz DB, et al: The discontinuous nature of propagation in normal canine cardiac muscle. Evidence for recurrent discontinuity of intracellular resistance that affects the membrane currents. Circ Res 48:39, 1981
7. Spach MS, Dolber P, Heldiage JF: Use of computer simulations for combined experimental-theoretical study of anisotropic discontinuous propagation at a microscopic level in the cardiac muscle, in Sideman S, Beyar R (eds): Electromechanical Activation, Metabolism and perfusion of the heart: Simulation and experimental Models. The Hague, Martinus Nijhoff, 1987, p 3
8. Diaz PJ, Rudy Y, Plonsey R: Intercalated discs as a cause for discontinuous propagation in cardiac muscle: A theoretical simulation. Ann Biomed Eng 11: 177, 1983
9. Rudy Y, Quan WEffects of the discreet cellular structure on electrical propagation in cardiac tissue, in Sideman S, Beyar R (eds): Electromechanical Activation, Metabolism and Perfusion of the Heart 3/4 Simulation and Experimental Models. The Hague, Martinus Nijhoff, 1987, p 61
10. Spooner PM, Joyner RW, Jalife J, (eds): Discontinous Conduction in the Heart. New York, NY, Futura Publishing, 1997, p 569
11. Joyner RW, Sugiura H, Tan RC: Unidirectional block between isolated rabbit ventricular cells coupled by a variable resistance. Biophys J 60:1038, 1991
12. Weingart R, Metzger P: Action potential transfer in cell pairs isolated from adult rat and guinea pig ventricles. Circ Res 63:72, 1988
13. + shifts in early ischemia: Mechanisms and relation to changes in impulse propagation. J Mol Cell Cardiol 19:35, 1987
14. Weidmann S: The diffusion of radiopotassium across intercalated disks of mammalian cardiac muscle. J Physiol (Lond.) 187:322, 1966
15. Henriquez AP, Vogel R, Muller-Borer BJ, et al: Influence of dynamic gap junction resistance on impulse propagation in ventricular myocardium: A computer simulation study. Biophys J 81:2112, 2001
16. Vogel R, Weingart R: Mathematical model of vertebrate gap junctions derived from electrical measurements on homotypic and heterotypic channels. J Physiol. (Lond.) 510:177, 1998
17. Kucera JP, Rohr S, Rudy Y: Localization of sodium channels in intercalated disks modulates cardiac conduction. Circ Res 91:1176, 2002
18. Rudy Y: The ionic mechanisms of conduction in cardiac tissue. J Electrocardiol 34:65, 2001
19. Shaw RM, Rudy Y: Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling. Circ Res 81:727, 1997
20. Hogues H, Leon LJ, Roberge FA: A model of study of electric field interactions between myocytes. IEEE Trans Biomed Eng 39:1232, 1992
21. Vaidya D, Tamaddon HS, Lo CW, et al: Null mutation of connexin43 causes slow propagation of ventricular activation in the late stages of mouse embryonic development. Circ Res 88:1196, 2001
22. Tamaddon HS, Vaidya D, Simon AM, et al: High-resolution optical mapping of the right bundle branch in connexin40 knockout mice reveals slow conduction in the specialized conduction system. Circ Res 87:929, 2000