Enhanced cardiac contractility after gene transfer of V2 vasopressin receptors in vivo by ultrasound-guided injection or transcoronary delivery

Circulation

Volumn 101, Issue 13, 2000, Pages 1578-1585

  Weig, Hans Jörg ^a   Laugwitz, Karl Ludwig ^a   Moretti, Alessandra ^a   Kronsbein, Kai ^a   Städele, Christian ^a   Brüning, Stefan ^a   Seyfarth, Melchior ^a   Brill, Thomas ^a   Schömig, Albert ^a   Ungerer, Martin ^a,b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Adenovirus; Gene transfer; Myocardium; Vasopressin

Indexed keywords

ARGIPRESSIN; BETA ADRENERGIC RECEPTOR; DESMOPRESSIN; RECOMBINANT RECEPTOR; VASOPRESSIN V2 RECEPTOR;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; CORONARY ARTERY; ECHOCARDIOGRAPHY; GENE EXPRESSION; GENE TARGETING; GENE TRANSFER; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CONTRACTILITY; INOTROPISM; INTRAVASCULAR ULTRASOUND; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; VIRUS RECOMBINANT;

EID: 17144439543     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.101.13.1578     Document Type: Article

References (19)

1. Cohn JN, Levine MB, Olivari T, Garberg V, Lura D, Francis GS, Simon AB, Rector T. Plasma noradrenaline as a guide to prognosis in patients with chronic congestive heart failure. N Engl J Med. 1984;311:819-823.
2. Landry DW, Levin HR, Gallant EM, Ashton RC, Seo S, D'Alessandro D, Oz MC, Oliver JA. Vasopressin deficiency contributes to the vasodilation of septic shock. Circulation. 1997;95:1122-1125.
3. 1-receptor downregulation in heart failure. Circ Res. 1986;59:297-309.
4. 1-adrenergic receptors in failing human heart. Circulation. 1993;87:454-463.
5. Laugwitz KL, Ungerer M, Schöneberg T, Weig HJ, Kronsbein K, Hoffmann K, Moretti A, Schultz G, Schömig A. Adenoviral gene transfer of the human V2 vasopressin receptor improves contractile force of rat cardiomyocytes. Circulation. 1999;99:925-933.
6. Barr E, Caroll J, Kalynych AM, Tripathy SK, Kozarsky K, Wilson JM, Leiden JM. Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirus. Hum Gene Ther. 1994;1:51-58.
7. Guzman RJ, Lemarchand P, Crystal RG, Epstein SE, Finkel T. Efficient gene transfer into myocardium by direct injection of adenovirus vectors. Circ Res. 1993;73:1202-1207.
8. Giordano F, Ping P, McKirnan D, Nozaki S, DeMaria AN, Dillman WH, Mathieu-Costello O, Hammond K. Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart. Nat Med. 1996;2:534-539.
9. Hajjar RJ, Schmidt U, Matsui T, Guerrero JL, Lee KH, Gwathmey JK, Dec GW, Semigran MJ, Rosenzweig A. Modulation of ventricular function through gene transfer in vivo. Proc Natl Acad Sci U S A. 1998; 95:5251-5256.
10. Donahue JK, Kikkawa K, Thomas AD, Marban E, Lawrence JH. Acceleration of widespread adenoviral gene transfer to intact rabbit hearts by coronary perfusion with low calcium and serotonin. Gene Ther. 1998;5: 630-634.
11. He TC, Zhou S, da Costa LT, Yu J, Kinzler KW, Vogelstein B. A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A. 1998;95:2509-2514.
12. Gardin JM, Siri FM, Kitsis RN, Edwards JG, Leinwand LA. Echocardiographic assessment of left ventricular mass and systolic function in mice. Circ Res. 1995;76:907-914.
13. St John Sutton MG, Reichek N, Kastor JA, Giuliani ER. Computerized M-mode echocardiographic analysis of left ventricular dysfunction in cardiac amyloid. Circulation. 1982;66:790-799.
14. Graf BM, Fischer B, Martin E, Bosnjak ZJ, Stowe DJ. Differential effects of arginine vasopressin on isolated guinea pig heart function during perfusion at constant flow and constant pressure. J Cardiovasc Pharmacol. 1996;29:1-7.
15. Koch WJ, Rockman HA, Samama P, Hamilton R, Bond RA, Milano CA, Lefkowitz RJ. Cardiac function in mice overexpressing the β-adrenergic receptor kinase or a βARK inhibitor. Science. 1995;268:1350-1353.
16. Koch WJ, Milano CA, Lefkowitz RJ. Transgenic manipulation of myocardial G protein-coupled receptors and receptor kinases. Circ Res. 1996;78:511-516.
17. Rockman HA, Chien KR, Choi DJ, Iaccarino G, Hunter JJ, Ross J, Lefkowitz RJ, Koch WJ. Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proc Natl Acad Sci U S A. 1998;95:7000-7005.
18. Packer M, Carver JR, Rodehoffer RJ. Effect of oral milrinone on mortality in severe chronic heart failure. N Engl J Med. 1991;325:1468-1475.
19. Hupf H, Grimm D, Riegger GAJ, Schunkert H. Evidence for a vasopressin system in the rat heart. Circ Res. 1999;84:365-370.