Molecular surveillance of the antifolate-resistant mutation I164L in imported African isolates of Plasmodium falciparum in Europe: Sentinel data from TropNetEurop

Malaria Journal

Volumn 2, Issue , 2003, Pages 1-5

  Wichmann, Ole ^a   Jelinek, Tomas ^a   Peyerl Hoffmann, Gabriele ^b   Mühlberger, Nikolai ^a   Grobusch, Martin P ^a,c   Gascon, Joaquim ^g   Matteelli, Alberto ⁱ   Hatz, Christoph ^j   Lafer, Hermann ^k   Schulze, Marco ^d   Burchard, Gerd ^a,e   Da Cunha, Saraiva ^m   Beran, Jiøi ⁿ   McWhinney, Paul ^o   Kollaritsch, Herwig ^l   Kern, Peter ^f   Cuadros, Juan ^h   Alifrangis, Michael ^p   Gjørup, Ida ^p  

^a HUMBOLDT UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d Klinikum St Georg   (Germany)

^e UNIVERSITY OF HAMBURG   (Germany)

^f UNIVERSITY OF ULM   (Germany)

^g HOSPITAL CLÍNIC   (Spain)

^h HOSPITAL UNIVERSITARIO PRÍNCIPE DE ASTURIAS   (Spain)

ⁱ UNIVERSITY OF BRESCIA   (Italy)

^j SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^k Geburtshilfl Gynäkologische Abt Kaiser Franz Josef Spitals Wien   (Germany)

^l KAISER FRANZ JOSEF HOSPITAL   (Austria)

^m CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

ⁿ UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

^o BRADFORD ROYAL INFIRMARY   (United Kingdom)

^p Mental Health Services CPH   (Denmark)

more..

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID ANTAGONIST;

ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; EUROPE; GEOGRAPHIC DISTRIBUTION; HEALTH SURVEY; HUMAN; MOLECULAR BIOLOGY; MUTATION RATE; PARASITE ISOLATION; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; SCREENING; TRAVEL; WILD TYPE;

EID: 3042547164     PISSN: 14752875     EISSN: None     Source Type: Journal    
DOI: 10.1186/1475-2875-2-1     Document Type: Article

References (29)

1. White NJ, Nosten F, Looareesuwan S, Watkins WM, Marsh K, Snow RW, Kokwaro G, Ouma J, Hien TT, Molyneux ME, Taylor TE, Newbold CI, Ruebush II TK, Danis M, Greenwood BM, Anderson RM and Olliaro P: Averting a malaria disaster Lancet 1999, 353:1965-1967.
2. Bjorkman A and Phillips-Howard PA: The epidemiology of drug-resistant malaria Trans R Soc Trop Med Hyg 1990, 84:177-180.
3. Sibley CH, Hyde JE, Sims PFG, Plowe CV, Kublin JG, Mberu EK, Cowman AF, Winstanley PA, Watkins WM and Nzila AM: Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what is next? Trends Parasitol 2001, 17:582-588.
4. Sirawaraporn W, Yongkiettrakul S, Sirawaraporn R, Yuthavong Y and Santi DV: Plasmodium falciparum: Asparagine mutant as residue 108 of dihydrofolate reductase is an optimal antifolate-resistant single mutation Exp Parasitol 1997, 87:245-252.
5. Yuthavong Y: Basis for antifolate action and resistance in malaria Microbes Infect 2002, 4:175-182.
6. Plowe CV, Kublin JG and Doumbo OK: P. falciparum dihydrofolate reductase and dihydropteroate synthase mutations: epidemiology and the role in clinical resistance to antifolates Drug Resist Updat 1998, 1:389-396.
7. Nzila-Mounda A, Mberu EK, Sibley CH, Plowe CV, Winstanley PA and Watkins WM: Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase gene Antimicrob Agents Chemother 1998, 42:164-169.
8. Wilairatana P, Kyle DE, Looareesuwan S, Chinwongprom K, Amradee S, White NJ and Watkins WM: Poor efficacy of antimalarial biguanide-dapsone combinations in the treatment of acute, uncomplicated falciparum malaria in Thailand Ann Trop Med Parasitol 1997, 91:125-132.
9. Basco LK, Eldin de Pecoulas P, Wilson CM, Le Bras J and Mazabraud A: Point mutations in the dihydrofolate reductase-thymidylate synthase gene and pyrimethamine and cycloguanil resistance in Plasmodium falciparum Mol Biochem Parasitol 1995, 69:135-138.
10. Plowe CV, Cortese JF, Djimde A, Nwanyanwu OC, Watkins WM, Winstanley PA, Estrada-Franco JG, Mollinedo RE, Avita JC, Cespedes JL, Carter D and Doumbo OK: Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance J Infect Dis 1997, 176:1590-1596.
11. Masimirembwa CM, Phuong-dung N, Phuc BQ, Duc-Dao L, Sy ND, Sköld O and Swedberg G: Molecular epidemiology of Plasmodium falciparum antifolate resistance in Vietnam: genotyping for resistance variants of dihydropteroate synthase and dihydrofolate reductase Int J Antimicrob Agents 1999, 12:203-211.
12. Wongsrichanalai C, Pickard AL, Wernsdorfer WH and Meshnick SR: Epidemiology of drug-resistant malaria Lancet Infect Dis 2002, 2: 209-218.
13. Jelinek T, Schulte C, Behrens R, Grobusch MP, Coulaud JP, Bisoffi Z, Martteello A, Clerinx J, Corachan M, Puente S, Gjorup I, Harms G, Kollaritsch H, Kotlowski A, Bjorkmann A, Delmont JP, Knobloch J, Nielson LN, Cuadros J, Hatz C, Beran J, Schmid ML, Schulze M, Lopez-Velez R, Fleischer K, Kapaun A, McWhinney P, Kern P, Atougia J, Fry G, da Cunha S and Boecken G: Imported Falciparum malaria in Europe: sentinel surveillance data from the European network on surveillance of imported infectious diseases Clin Infect Dis 2002, 34:572-576.
14. Jelinek T, Peyerl-Hoffmann G, Mühlberger N, Wichmann O, Schmider N, Grobusch MP, Corachán M, Hatz C, Harms G, Laferl H, McWhinney P, Schulze M, Kollaritsch H, da Cunha S, Beran J, Kern P, Gjørup I and Cuadros J: Molecular surveillance of drug resistance through imported isolates of Plasmodium falciparum in Europe: sentinel data from TropNetEurop Malar J 2002, 1:11
15. Kain KC and Lanar DE: Determination of genetic variation within Plasmodium falciparum by using enzymatically amplified DNA from filter paper disks impregnated with whole blood J Clin Microbiol 1991, 29:1171-1174.
16. Duraisingh MT, Curtis J and Warhurst DC: Plasmodium falciparum: detection of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes by PCR and restriction digestion Exp Parasitol 1998, 89:1-8.
17. Jelinek T, Rønn AM, Lemnge MM, Curtis J, Mhina J, Duraisingh MT, Bygbjerg IC and Warhurst DC: Polymorphisms in the dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) genes of Plasmodium falciparum and in vivo resistance to sulphadoxine/pyrimethamine in isolates from Tanzania Trop Med Int Health 1998, 3:605-609.
18. Winstanley PA: Chemotherapy for falciparum malaria: the armoury, the problems and the prospects sitol Today 2000, 16:146-153.
19. Peterson DS, Milhous WK and Wellems TE: Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria Proc Natl Acad Sci USA 1990, 87:3018-22.
20. Watkins WM, Mberu PA, Winstanley PA and Plowe CV: The efficacy of antifolate antimalarial combinations in Africa: a predictive model based on pharmacodynamic and pharmacokinetic analyses Parasitol Today 1997, 13:459-464.
21. Mutabingwa T, Nzila A, Mberu E, Nduati E, Winstanley P, Hills E and Watkins W: Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in Tanzania Lancet 2001, 358:1218-1223.
22. Winstanley PA, Watkins W, Muhia D, Szwandt S, Amukoye E and Marsh K: Chlorproguanil/dapsone for uncomplicated Plasmodium falciparum malaria in young children: pharmacokinetics and therapeutic range Trans R Soc Trop Med Hyg 1997, 91:322-327.
23. Kublin JG, Dzinjalamala FK, Kamwendo DD, Malkin EM, Cortese JF, Martino LM, Mukadam RAG, Rogerson SJ, Lescano AG, Molyneux ME, Winstanley PA, Chimpeni P, Taylor TE and Plowe CV: Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria J Infect Dis 2002, 185:380-8.
24. Nzila AM, Mberu EK, Sulo J, Dayo H, Winstanley PA, Sibley CH and Watkins WM: Towards an understanding of the mechanism of pyrimethamnine-sulfadoxine resistance in Plasmodium falciparum: genotyping of dihydrofolate reductase and dihydropteroate synthase of Kenian parasites Antimicrob Agents Chemother 2000, 44:991-6.
25. Eberl KJ, Jelinek T, Aida AO, Peyerl-Hoffmann G, Heuschkel C, el Valy AO and Christophel EM: Prevalence of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes of Plasmodium falciparum isolates from southern Mauritania Trop Med Int Health 2001, 6:756-760.
26. Khalil I, Alifrangis M, Ronn AM, Gabar HA, Jelinek T, Satti GM and Bygbjerg IC: Pyrimethamine/sulfadoxine combination in the treatment of uncomplicated falciparum malaria: relation between dihydropteroate synthase/dihydrofolate reductase genotypes, sulfadoxine plasma levels, and treatment outcome Am J Trop Med Hyg 2002, 67:225-229.
27. Curits J, Maxwell CA, Msuya FHM, Mkongewa S, Alloueche A and Warhurst DC: Mutations in dhfr in Plasmodium falciparum infections selected by chlorproguanil-dapsone treatment J Infect Dis 2002, 186:1861-1864.
28. Hastings MD, Bates SJ, Blackstone EA, Monks SM, Mutabingwa TK and Sibley CH: Highly pyrimethamine-resistant alleles of dihydrofolate reductase in isolates of Plasmodium falciparum from Tanzania Trans R Soc Trop Med Hyg 2002, 96:674-676.
29. Mutabingwa TK, Watkins WM and d'Alessandro U: Monitoring of drug-resistant malaria in Africa Lancet 2002, 360:875.