Dissolution of ionizable water-insoluble drugs: The combined effect of pH and surfactant

Journal of Pharmaceutical Sciences

Volumn 89, Issue 2, 2000, Pages 268-274

  Jinno, Junichi ^a,c   Oh, Doo Man ^a,d   Crison, John R ^b   Amidon, Gordon L ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b PORT Systems   (United States)

^c OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^d PFIZER INC   (United States)

Author keywords

Diffusivity; Dissolution; Piroxicam; pK(a); Rotating disk method; Solubility

Indexed keywords

DODECYL SULFATE SODIUM; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM; SURFACTANT;

ARTICLE; DIFFUSION COEFFICIENT; DISSOLUTION; DRUG SOLUBILITY; DRUG STRUCTURE; IONIZATION; MICELLE; PH;

EID: 0033997669     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-6017(200002)89:2<268::AID-JPS14>3.0.CO;2-F     Document Type: Article

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